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mutation

Total questions: 84

Worksheet time: 1hrs 5mins

Name
Class
Date
1.

Which type of mutation occurs when there is an addition or removal of a base?

a)

missense mutation

b)

nonsense mutation

c)

frameshift mutation

d)

point mutation

2.

What type of mutation is shown in the diagram?

a)

Point mutation - missense

b)

Frameshift Mutation - deletion

c)

Frameshift Mutation - addition

d)

Point mutation - nonsense

3.

A type of mutation that affect every codon beyond the point of mutation.

a)

Point Mutation

b)

Silent Mutation

c)

Nonsense Mutation

d)

Frameshift Mutation

4.

What type of mutation is this?

a)

Nonsense mutation

b)

Missense mutation

c)

Silent mutation

d)

Frameshift mutation

5.

Occurs when the DNA change does not alter the amino acid sequence of the polypeptide.

a)

Frameshift Mutation

b)

Insertion

c)

Missense mutation

d)

Silent Mutation

6.

TRUE or FALSE. The removal of one base to the DNA sequence might lead to a change on the succeeding (next) codon.

a)

True

b)

False

7.

Name the process happening at number 1 in the diagram.

a)

DNA Replication

b)

Translation

c)

Mutation

d)

Transcription

8.

Which of the following statement is NOT true?

a)

Point mutation involves a chemical change in just one base pair.

b)

Frameshift mutation occurs when there is an addition or removal of a base.

c)

Nonsense mutation occurs when the DNA change creates a stop codon that causes the translation to terminate early.

d)

Point mutation affect every codon beyond the point of mutation .

9.
Non disjunction of chromosomes occurs during
?
a)
Meiosis
b)
Mitosis
c)
Replication 
10.
Mutations affect the ________ of a protein. Because of this the proteins ______ is affected as well. 
a)
gene, function 
b)
sequence, gene
c)
shape,function
11.
Why are framshift mutations harmful?
a)
They cause chromosomes to break
b)
Every amino acid following the mutation will be different
c)
They cause the DNA to relocated
d)
They burn out your clutch
12.
mutations cause changes in traits because?
a)
mutations affect nucleosynthesis 
b)
Mutations affect gamete production 
c)
mutation affect meiosis
d)
mutations affect protein synthesis
13.
Mutations during translation are harmful because
a)
Everything after the mutation will be translated more quickly
b)
everything after the mutation is translated incorrectly
c)
Translation will fail to start
14.
What situation causes a duplication?
a)
Part of the chromosome is missing
b)
Part of the chromosome is attached backwards
c)
Part of the chromosome breaks off and attaches to a different chromosome
d)
Part of a chromosome is duplicated 
15.
What situation causes a translocation?
a)
Part of the chromosome is missing
b)
Part of the chromosome is attached backwards
c)
Part of the chromosome breaks off and attaches to a different chromosome
d)
Part of a chromosome is duplicated 
16.
What situation causes an inversion ?
a)
Part of the chromosome is missing
b)
Part of the chromosome is attached backwards
c)
Part of the chromosome breaks off and attaches to a different chromosome
d)
Part of a chromosome is duplicated 
17.
In an unmutated strand of DNA having 40 molecules of thymine means you also have 400 molecules of?
a)
Adeninie
b)
Cytosine
c)
Guanine
18.
A scientists who manipulates organismal DNA (like cloning) is called a?
a)
Genetic Engineer 
b)
Geneticist 
c)
Doctor
d)
Teacher 
19.
What mutation would cause a protein to be shorter then normal?
a)
Insertion
b)
Start codon found
c)
Stop Codon Found
d)
Inversion
20.
a)
Suspect 1
b)
Suspect 2
c)
Suspect 4
d)
Suspect 4
21.
a)
Dad 1
b)
Dad 2
c)
Dad 3
22.
Why are insertion and deletion mutations so harmful?
a)
They change all of the codons from the mutation on down the line, which changes the amino acid sequence
b)
They insert things that an organism doesn't need.
c)
They often delete things that organisms need.
d)
Insertion and deletions are not any more harmful than substitution mutations.
23.

chromosomal mutations cause a segment of the chromosome to repeat itself during replication.

a)

inversion

b)

duplication

c)

translocation

d)

deletion

24.

Point mutation involves

a)

deletion

b)

insertion

c)

duplication

d)

changes in single base pair

25.

A change in a gene, group of genes or chromosome that results in a change in the proteins

a)

Replication

b)

Mutations

c)

Translation

d)

Transcription

26.

Mutations that effect gametes and that will be passed on

to the next generation

a)

Genetic change

b)

Protein synthesis

c)

Apoptosis

d)

Cell membrane

27.

A permanent change in the DNA sequence

which can affect a single gene or group of genes

a)

Homeostasis

b)

Somatic Cell

c)

Chromosomal Mutation

d)

Gene Mutation

28.

One nucleotide base is changed so only one amino acid

is affected

a)

Substitution Mutation

b)

Point Mutation

c)

Translocation

d)

Inverse Mutation

29.

A substitution mutation that has no effect

on amino acids sequence

a)

Insertion Mutation

b)

Translocation

c)

Silent Mutation

d)

Deletion Mutation

30.

A mutation that results in an amino acid change

a)

Translocation

b)

Homeostasis

c)

Silent Mutation

d)

Expressed Mutation

31.

A nucleotide base is inserted or deleted shifting the entire DNA sequence. Entire protein will be changed.

a)

Substitution Mutation

b)

Silent Mutation

c)

Frameshift Mutation

d)

Translocation

32.

A frameshift mutation where a nucleotide base is added

to the DNA sequence

a)

Insertion Mutation

b)

Deletion Mutation

c)

Substitution Mutation

d)

Chromosomal Mutation

33.

Part of a chromosome

is deleted

a)

Deletion Mutation-Gene

b)

Translocation

c)

Deletion Mutation -Chromosomal

d)

Crossing Over

34.

Part of a chromosome is repeated

a)

Gene Mutation

b)

Point Mutation

c)

Deletion Mutation

d)

Duplication Mutation

35.

Failure of homologous chromosomes

to separate during meiosis.

Results in gametes with either one extra or one missing chromosome.

a)

Translocation

b)

Nondisjunction

c)

Replication

d)

Transcription

36.

A point mutation where DNA adenine (A)

is replaced by thymine (T) resulting in a single amino acid change during translation(affects blood cell

shape and function)

a)

Encephelitis

b)

Hemophilia

c)

Sickle Cell Anemia

d)

Influenza

37.

Condition caused by nondisjunction at pair 21 during meiosis.

Individuals have an extra chromosome

at pair 21, or a total of 47 chromosomes.

Also called Trisomy 21.

a)

Cystic Fibrosis

b)

Translocation

c)

Hemophilia

d)

Down Syndrome

38.

Analyzes the inheritability of Sickle Cell Anemia,

a recessive trait that must be passed on

from both parents.

a)

Nondisjunction Punnett Square

b)

Hemophilia Punnett Sqaure

c)

Cyctic Fibrosis Punnett Square

d)

Sickle Cell Anemia Punnett Square

39.

A point mutation where DNA adenine (A)

is replaced by thymine (T) resulting in a single amino acid change during translation(affects blood cell

shape and function)

a)

Encephelitis

b)

Hemophilia

c)

Sickle Cell Anemia

d)

Influenza

40.
What amino acid is represented by the codon UUA?
a)
Phenylalanine
b)
Tyrosine
c)
Leucine
d)
Stop codon
41.
Are all mutations bad?
a)
Yes
b)
No
42.
Notice the abnormal 23rd chromosome.  This individual suffers from which chromosomal genetic disorder?
a)
Klienfelter's Syndrome
b)
Down Syndrome
c)
Cris-du-Chat Syndrome
d)
Andrew's Syndrome
43.
The following karyotype illustrates an example of which syndrome?
a)
Turner's Syndrome
b)
Klienfelter's Syndrome
c)
Edward's Syndrome
d)
Down Syndrome
44.

A mutation that occurs in the gametes of an

organism will most likely be transferred to which of

the following?

a)

The siblings of the organism

b)

The offspring of the organism

c)

The other organisms living nearby

d)

The mating partner of the organism

45.

When do random, or spontaneous, mutations happen?

a)

During cell division

b)

When cells are exposed to hazardous chemicals

c)

When cells are exposed to certain viruses

d)

When cells are exposed to radiation

46.

Mutations that effect gametes and that will be passed on

to the next generation

a)

Genetic change

b)

Protein synthesis

c)

Apoptosis

d)

Cell membrane

47.

Peristiwa terjadinya perubahan struktur materi genetik yang dapat diwariskan kepada keturunannya adalah…

a)

Mutagen

b)

Mutagenesis

c)

Mutasi

d)

Mutan

e)

Aberasi

48.

Mutations can benefit humans because they can:

a)

Cause illness

b)

Make an organism more suited to live in its environment.

c)

Make organisms live shorter lives

d)

Cause organisms to grow extra limbs.

49.

ATTTGAGCC- Original

ATTGAGCC - Mutated

The example above is an example of a

a)

Insertion

b)

Point mutation

c)

Deletion

d)

Substitution

50.

Mutations are random.

a)

True

b)

False

51.

Mutations are SOMETIMES helpful to the organism.

a)

true

b)

false

52.

In order for offspring to get a genetic mutation, the mutation must occur in what type of cell?

a)

Cells with no nucleus.

b)

Any body cell after birth.

c)

Cells with no cell wall or cell membrane.

d)

Cells like eggs or sperm cells that are undergoing reproduction.

53.

What mutation has occurred here?

T-G-A-C-C-A

T-G-A-G-C-A

a)

Substitution

b)

Deletion

c)

Insertion

d)

Frameshift

54.

DNA molecule segment is : TTACGCAAG

The mutated DNA segment is TTACGCAAC. This is an example of ___ mutation.

a)

Substitution

b)

Insertion

c)

Inversion

d)

Translocation

55.
Any change in the sequence of DNA is...
a)
transgenic shift
b)
Single Genotype
c)
Monohybrid Trait
d)
Mutation
56.

What are the building blocks of proteins called?

a)

DNA

b)

RNA

c)

Ribosomes

d)

Amino Acids

57.

ATT-TGA-GCC- Original

ATT-GAG-CC - Mutated

The example above is an example of a

a)

Insertion- Frameshift

b)

Deletion- Substitution

c)

Deletion -Frameshift

d)

All of the above

58.

DNA molecule segment is : TTA-CGC-AAG

The mutated DNA segment is TTC-GCA-AG. This is an example of ___ mutation.

a)

Substitution

b)

Deletion

c)

Insertion

d)

Inversion

59.

Original DNA: CAT GAT CCA

New DNA: CAT TGA TCC A

What mutation occurred?

a)

deletion

b)

substitution

c)

tranverse

d)

insertion

60.
Original: ATC CAT
Mutation: ATC GCAT
What mutation occurred?
a)
deletion
b)
insertion
c)
silent
d)
transverse
61.

What type of gene mutation has occurred here? Normal-

AGA-TTC-ATA-GCG

Mutant-

AGA-TTC-AAT-AGC-G

a)

deletion frameshift

b)

insertion frameshift

c)

substitution

d)

nonsense

62.
Mutated DNA sequences that can be passed from parent to offspring --
a)
occur in somatic cells (body cells)
b)
occur in gametic cells (sex cells)
c)
are rejected by meiosis
d)
only occur if the parent is exposed to harmful substances
63.

Why are insertion and deletion mutations so harmful?

a)

They change all of the codons from the mutation on down the line, which changes the amino acid sequence

b)

They insert things that an organism doesn't need.

c)

They often delete things that organisms need.

d)

Insertion and deletions are not any more harmful than substitution mutations.

64.

What is the building block of DNA

a)

Monosaccharide

b)

Amino Acid

c)

Fatty Acid

d)

Nucleotide

65.
Identify the mutation in the picture.
a)
Inversion
b)
Duplication
c)
Deletion
d)
Translocation
66.
Identify the mutation in the picture.
a)
Deletion
b)
Inversion
c)
Duplication
d)
Translocation
67.
When can a mutation be passed on to offspring?
a)
only when the mutation is present during or occurs during mitosis
b)
only when the mutation is present during or occurs during meiosis
c)
when the mutation occurs during mitosis or meiosis
d)
when the mutation occurs in somatic cells
68.

Inversion

a)

When a segment of a chromosome breaks off.

b)

When a segment of a chromosome breaks off, flips, and reattaches.

c)

When a segment of a chromosome is copied or doubles.

d)

When a segment of a chromosome breaks and attaches to a non homologous chromosome.

e)

When entire chromosomes don't separate evenly during meiosis.

69.

Nondisjunction

a)

When a segment of a chromosome breaks off.

b)

When a segment of a chromosome breaks off, flips, and reattaches.

c)

When a segment of a chromosome is copied or doubles.

d)

When a segment of a chromosome breaks and attaches to a non homologous chromosome.

e)

When entire chromosomes don't separate evenly during meiosis.

70.
Trisomy 21 means you have what?
a)
Three copies of chromosome 21
b)
Twenty one copies of chromosome 3
c)
Three omies and 21 means
d)
Two copies of chromosome 21
71.
What type of karyotype is shown here?
a)
Male with Turner Syndrome
b)
Male with Klinefelter Syndrome
c)
Female with Down Syndrome
d)
Female with Klinefelter Syndrome
72.
What's the gender and disorder?
a)
Male - Downs Syndrome
b)
Female - Downs Syndrome
c)
Male - Turner Syndrome
d)
Female - Turner Syndrome
73.
What are chromosomes 1-22 called?
a)
Autosomes
b)
Sex Chromosomes
c)
Chromotids
d)
Xenosomes
74.
Which term refers to a picture of an individual’s chromosomes, used to detect genetic conditions? 
a)
synapsis
b)
tetrad
c)
centriole
d)
karyotype
75.
Which of the following is NOT a characteristic of Turner's Syndrome?
a)
Webbed neck
b)
Shorter stature
c)
Ear malformations
d)
Slanted eyes
76.
Which of the following is NOT a characteristic of Klinefelter Syndrome?
a)
Tall stature
b)
Development of male breasts
c)
Poor muscle tone
d)
Webbed neck
77.
What is a Gene?
a)
A segment of RNA that encodes for a protein
b)
A chromosome
c)
A segment of DNA that encodes for a protein
d)
Your genome
78.
Normal-
GAG-CTC-GAC-AGA
Mutant
GAG CTC-CAC-AGA
a)
no mutation
b)
substitution
c)
insertion
d)
deletion
79.
What pairs with Guanine (G)?
a)
Adenine (A)
b)
Thymine (T)
c)
Cytosine (C)
d)
Guanine (G)
80.
What pairs with Thymine (T)?
a)
Adenine (A)
b)
Thymine (T)
c)
Guanine (G)
d)
Cytosine (C) 
81.
Why is DNA important?
a)
it is very small and very complicated
b)
it's in everything
c)
it serves as the blueprint for traits of all living things
d)
because we eat it every day for energy
82.
What do hurtful mutations do? 
a)
Decrease chances of survival 
b)
Increases changes of survival 
c)
Decreases likelihood of developing cancer
d)
Increases likelihood of developing cancer
83.
What do helpful mutations do? 
a)
Increases chances of survival 
b)
Decreases changes of survival 
c)
Increases chances of developing cancer
d)
Decreases skills
84.
Which of the following is an example of a hurtful mutation? 
a)
Developing cancer
b)
Makes the organism faster
c)
Makes the organism a predator 
d)
Develops sharp claws