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Haemoglobin

Total questions: 27

Worksheet time: 13mins

Name
Class
Date
1.
The diagram shows a haemoglobin molecule. Which identifies the different parts of the molecule?
a)
1: alpha helix, 2: beta pleated sheet, 3: binding site, 4: hydrophobic amino acids
b)
1: hydrophobic amino acids, 2: beta pleated sheet, 3: prosthetic group, 4: binding site
c)
1: prosthetic group, 2: hydrophobic amino acids, 3: alpha helix , 4: hydrophilic amino acids
d)
1: prosthetic group, 2: hydrophilic amino acids, 3: alpha helix , 4: hydrophobic amino acids
2.

The ion found in the haem group is what

a)

Mg2+

b)

O2-

c)

Fe2+

d)

Fe3+

3.

Which of the following is NOT the structure of haemoglobin?

a)

Each haemoglobin molecule contains 4 haem groups

b)

Haemoglobin has a quaternary structure

c)

Each haem group in haemoglobin can bind with 4 molecules of oxygen

d)

Each haemoglobin molecule has 2 α-chain and 2 β-chain polypeptide subunits

4.

The main blood vessel responsible for taking oxygenated blood to the body is the

a)

pulmonary artery

b)

aorta

c)

vena cava

d)

pulmonary veins

5.

What is the name of the molecule formed when oxygen binds to haemoglobin?

a)

oxyhaemoglobin

b)

oxygen-haemoglobin

c)

carbaminohaemlobin

d)

oxyglobin

6.

Carbon dioxide and water combine to form

a)

hydrogen carbonate ions

b)

hydrogen ions

c)

carbonic acid

d)

hydrogen bicarbonate

7.

Oxyhaemoglobin gives up O2 when …

a)

CO2 partial pressures are high

b)

Body temperature is lowered

c)

pH values are high

d)

O2 partial pressure are high

8.

The Bohr Effect/Shift moves the oxygen saturation curve in what direction

a)

up and left

b)

down and right

c)

down and left

d)

up and right

9.

At the highest partial pressures of oxygen, the saturation of oxygen slows down because

a)

the haemoglobin becomes saturated

b)

the haemoglobin becomes denatured

c)

the haemoglobin is too cold

d)

the oxygen is displaced by carbon dioxide

10.

which of the following explains the meaning of the Bohr effect?

a)

The effect of the partial pressure of oxygen in blood on the affinity of haemoglobin towards carbon dioxide.

b)

The effect of the partial pressure of carbon dioxide on the dissociation of oxyhaemoglobin.

c)

The affinity of haemoglobin toward oxygen.

d)

The affinity of haemoglobin towards carbon dioxide.

11.

The blue line on the graph indicates

a)

the Bohr effect

b)

regular haemoglobin

c)

fetal haemoglobin

d)

haemoglobin during exercise

12.

What colour line represents the oxygen saturation curve during intense exercise?

a)

blue

b)

black

c)

red

13.

The blood vessel responsible for taking deoxygenated blood to the lungs for excretion is the

a)

pulmonary artery

b)

pulmonary vein

c)

aorta

d)

vena cava

14.

When carbon dioxide binds directly with haemoglobin it forms

a)

carbaminohaemoglobin

b)

carboxyhaemoglobin

c)

carbon diooxyhaemoglobin

d)

carboglobin

15.

Each haemoglobin molecule can bind reversibly with

a)

one atom of oxygen

b)

one molecule of oxygen

c)

two molecules of oxygen

d)

four molecules of oxygen

16.
1  The correct shape of a globular protein is maintained by several types of bond.   
1 = disulfide 2 = hydrogen 3 = ionic 
4  = peptide  
Which bond types are involved in maintaining the different levels of structural complexity of a globular protein?
a)
Primary: 4 
Secondary:3
 Tertiary:1,2,3
b)
Primary: 2 
Secondary:1
 Tertiary:2,3,4
c)
Primary: 2 
Secondary:4
 Tertiary:2,3,4
d)
Primary: 4 
Secondary:2
 Tertiary:1,2,3
17.

When CO2 partial pressures are increased, how does this affect the affinity of Hb to oxygen?

a)

It increases

b)

It decreases

c)

It stays the same

18.
Which of the following is true about the plot of the oxygen dissociation curve?
a)
The partial pressure of oxygen is on the y axis, and the partial pressure of haemoglobin is on the x axis
b)
The partial pressure of oxygen is on the x axis and the partial pressure of haemoglobin on the y axis
c)
The partial pressure of oxygen is on the x axis and the percentage saturation of haemoglobin is on the y axis
d)
The partial pressure of oxygen is on the x axis and the percentage saturation of oxygen is on the y axis
19.

Which statement truly represents the difference between the two curves?

a)

Curve A represents an haemoglobin that has higher affinity for oxygen at all partial pressures of oxygen

b)

Curve A represents a curve that has higher affinity for haemobloby at only at low partial pressures of oxygen

c)

Curve A represents haemoglobin that will readily release oxygen at all partial pressures

d)

Curve A represents haemoglobin that will not readily bind to oxygen even at high partial pressure of oxygen

20.

At partial pressure of 20mmHg, ………………………

a)

Adult haemoglobin has a higher affinity for oxygen than myoglobin

b)

Adult haemoglobin is less saturated with oxygen compared to myoglobin

c)

Adult haemoglobin is completely deoxygenated while myoglobin is not

d)

Adult haemoglobin still has capacity to release a large amount of oxygen compared to myoglobin

21.

Gaseous exchange happens because of...

a)

Osmosis

b)

Respiration

c)

Diffusion

d)

Semi-permeable membranes

22.

Normal hemoglobin content in blood is

a)

18g%

b)

25g%

c)

15g%

d)

50g%

23.
Blood arriving in the capillary from the body has a...
a)
Higher concentration of carbon dioxide (CO2) and a lower concentration of oxygen (O2)
b)
Higher concentration of oxygen (O2) and a lower concentration of carbon dioxide (CO2)
24.

Oxygen-hemoglobin dissociation curve is shifted to right in the following conditions:

a)

Decrease in partial pressure of oxygen

b)

Bohr effect

c)

Increase in hydrogen ion concentration and decrease in pH

d)

Excess of DPG in RBC

e)

All of the above

25.

Oxygen-hemoglobin dissociation curve is shifted to left or right by various factors

a)

Shift to left indicates acceptance (association) of oxygen by hemoglobin

b)

Shift to left indicates dissociation of oxygen from hemoglobin.

c)

Shift to right indicates acceptance (association) of oxygen from hemoglobin.

d)

Shift to right indicates dissociation of oxygen from hemoglobin.

26.

Oxygen-hemoglobin dissociation curve is shifted to left in the following conditions:

a)

Decrease in hydrogen ion concentration and increase in pH

b)

Decrease in partial pressure of oxygen

c)

In fetal blood because, fetal hemoglobin has got more affinity for oxygen than the adult haemoglobin

d)

Increase in partial pressure of carbon dioxide

27.

Normally in the blood, hemoglobin is saturated with oxygen only up to

a)

80%

b)

95%

c)

75%

d)

50%