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Herpesviridae

Total questions: 55

Worksheet time: 2hrs 50mins

Name
Class
Date
1.

The family Herpesviridae consists of

a)

more than 10 viruses that infect vertebrates and invertebrates.

b)

more than 100 viruses that infect vertebrates and invertebrates.

c)

more than 10 viruses that do not infect vertebrates and invertebrates.

d)

more than 100 viruses that do not infect vertebrates and invertebrates.

2.

The family Herpesviridae is divided in

a)

2 subfamlies : Alphaherpesvirinae, Betaherpesvirinae

b)

3 subfamlies : Alphaherpesvirinae, Betaherpesvirinae, Gammaherpesvirinae

c)

4 subfamlies : Alphaherpesvirinae, Betaherpesvirinae, Gammaherpesvirinae, Deltaherpesvirinae

d)

The family is not divided in subfamilies.

3.

Genus Herpes simplex virus is in

a)

Alphaherpesvirinae

b)

Betaherpesvirinae

c)

Gammaherpesvirinae

d)

Deltaherpesvirinae

4.

Genus Varicella-zoster is in

a)

Alphaherpesvirinae

b)

Betaherpesvirinae

c)

Gammaherpesvirinae

d)

Deltaherpesvirinae

5.

Genus Cytomegalovirus is in

a)

Alphaherpesvirinae

b)

Betaherpesvirinae

c)

Gammaherpesvirinae

d)

Deltaherpesvirinae

6.

Genus Roseolovirus is in

a)

Alphaherpesvirinae

b)

Betaherpesvirinae

c)

Gammaherpesvirinae

d)

Deltaherpesvirinae

7.

Genus Lymphocryptovirus is in

a)

Alphaherpesvirinae

b)

Betaherpesvirinae

c)

Gammaherpesvirinae

d)

Deltaherpesvirinae

8.

Human herpes virus (HHV-6 and HHV-7) are in genus

a)

Herpes simplex virus

b)

Varicella-zoster

c)

Roseolovirus

d)

Lymphocryptovirus

9.

Epstein Barr virus (EBV) and HHV-8 are in genus

a)

Herpes simplex virus

b)

Varicella-zoster

c)

Roseolovirus

d)

Lymphocryptovirus

10.

General structure of the family Herpesviridae

a)

Non-enveloped, helical capsid

b)

Non-enveloped, icosahedral capsid

c)

Enveloped, helical capsid

d)

Enveloped, icosahedral capsid

11.

General structure of the family Herpesviridae

a)

120 - 200 nm of diameter, dsDNA, 152 kbp

b)

120 - 200 nm of diameter, ssRNA, 152 kbp

c)

120 - 300 nm of diameter, dsDNA, 152 kbp

d)

120 - 200 nm of diameter, dsDNA, 162 kbp

12.

Virus in the subfamily Alphaherpesvirinae is latent in

a)

Sensory ganglia

b)

Blood, lymphoid tissue, secretory glands and kidneys

c)

Lymphocytes, some epithelial cells and endothelial cells

d)

All answers are possible.

13.

Virus in the subfamily Betaherpesvirinae is latent in

a)

Sensory ganglia

b)

Blood, lymphoid tissue, secretory glands and kidneys

c)

Lymphocytes, some epithelial cells and endothelial cells

d)

All answers are possible.

14.

Virus in the subfamily Gammaherpesvirinae is latent in

a)

Sensory ganglia

b)

Blood, lymphoid tissue, secretory glands and kidneys

c)

Lymphocytes, some epithelial cells and endothelial cells

d)

All answers are possible.

15.

Herpes simplex virus is latent in

a)

Sensory ganglia

b)

Trigeminal ganglia

c)

Sacral ganglia

d)

All answers are correct.

16.

The initial virus-cell interaction for penetration of the herpes simplex virus occurs when

a)

2 viral envelope glycoproteins : glycoprotein C (gC) and glycoprotein B (gB) bind to a cell surface particle called herparan sulfate.

b)

the major receptor-binding protein, glycoprotein D (gD), binds to at least one of 3 known entry receptors : herpesvirus entry mediator (HVEM), nectin-1 and 3-O sulfated heparan sulfate

c)

the nectin receptors produce cell-cell adhesion, to provide a strong point of attachment for the virus to host cell.

d)

glycoprotein D (gD) changes its conformation and interacts with viral glycoprotein H (gH) and L (gL), which form a gH/gL complex.

17.

The initial virus-cell interaction for penetration of the herpes simplex virus occurs when

a)

2 viral envelope glycoproteins : glycoprotein C (gC) and glycoprotein B (gB) bind to a cell surface particle called herparan sulfate.

b)

the major receptor-binding protein, glycoprotein D (gD), binds to at least one of 3 known entry receptors : herpesvirus entry mediator (HVEM), nectin-1 and 3-O sulfated heparan sulfate

c)

the nectin receptors produce cell-cell adhesion, to provide a strong point of attachment for the virus to host cell.

d)

glycoprotein D (gD) changes its conformation and interacts with viral glycoprotein H (gH) and L (gL), which form a gH/gL complex, once bounds to HVEM.

18.

Herpes simplex virus enters the cell through its capsid entry pore, which is produced by

a)

interaction between glycoprotein D (gD) with at least one of known substances : herpesvirus entry mediator (HVEM), nectin-1 and 3-O sulfated heparan sulfate

b)

interaction between glycoprotein B and C with heparan sulfate

c)

interaction between glycoprotein B with gH/gL complex

d)

12 copies of portal protein, UL6, arranged as a ring adhered to each other due to a leucine zipper sequence of amino acids

19.

Herpes simplex virus releases its genome into the host cell nucleus via its capsid portal, which is formed by

a)

interaction between glycoprotein D (gD) with at least one of known substances : herpesvirus entry mediator (HVEM), nectin-1 and 3-O sulfated heparan sulfate

b)

interaction between glycoprotein B and C with heparan sulfate

c)

interaction between glycoprotein B with gH/gL complex

d)

12 copies of portal protein, UL6, arranged as a ring adhered to each other due to a leucine zipper sequence of amino acids

20.

During herpes simplex virus enters "replication" stage, protein synthesis of the host is shut off by

a)

HVEM (Herpesvirus entry mediator)

b)

UL6

c)

VHS or UL46

d)

α-TSF

21.

Which of the following herpes virus proteins form the capsid and the receptors on the surface of the virus?

a)

Immediate-early proteins

b)

Early proteins

c)

Late proteins

d)

All answers are correct.

22.

Which of the following herpes virus proteins regulate the genetic replication of the virus?

a)

Immediate-early proteins

b)

Early proteins

c)

Late proteins

d)

All answers are correct.

23.

Viral assembly of herpes simplex virus occurs in which part of the host cell?

a)

Cytoplasm

b)

Nucleus

c)

Cytoplasm and nucleus

d)

Golgi apparatus

24.

Release of herpes simplex virus :

a)

A. Primary envelopment : acquired by budding into the inner nuclear membrane of the host cell. This then fuses with the outer nuclear membrane, releasing a naked capsid into the cytoplasm.

b)

B. Secondary envelopment : the virus acquires its final envelope by budding into cytoplasmic vesicles.

c)

A and B are correct.

d)

None of which is correct.

25.

Clinically, pathogenic herpes simplex virus includes

a)

Oral herpes

b)

Genital herpes

c)

Ocular herpes

d)

Otic herpes

e)

Vascular herpes

26.

Oral herpes includes gingivostomatitis and recurrent labial herpes :

a)

is often caused by HSV-1

b)

is often caused by HSV-2

c)

is often caused by HSV-1, rarely by HSV-2

d)

is often caused by HSV-2, rarely by HSV-1

27.

Genital herpes :

a)

is often caused by HSV-1

b)

is often caused by HSV-2

c)

is often caused by HSV-1, sometimes by HSV-2

d)

is often caused by HSV-2, sometimes by HSV-1

28.

Ocular herpes :

a)

is often caused by HSV-1

b)

is often caused by HSV-2

c)

is often caused by HSV-1, rarely by HSV-2

d)

is often caused by HSV-2, rarely by HSV-1

29.

Severe forms of herpes simplex virus infection (neonatal herpes, herpes encephalitis, retinitis, necrosis, herpes hepatitis) are treated using

a)

Acyclovir

b)

Epivir

c)

Amodiaquine

d)

Metronidazole

30.

Primary infection of varicella-zoster virus is

a)

Chickenpox

b)

Shingles

c)

AIDS

d)

Epilepsy

31.

Reactivated infection of varicella-zoster virus is

a)

Chickenpox

b)

Shingles

c)

AIDS

d)

Epilepsy

32.

Varicella-zoster virus is cultivated in

a)

Human embryonic fibroblasts

b)

Human embryonic lung cells

c)

Murine kidney cells

d)

Embryonated egg

33.

Transmission of varicella-zoster virus :

a)

By aerosol

b)

By respiratory droplets

c)

Mother-to-fetus transmission

d)

By eye contact with infected patients

e)

By talking to each other on phone

34.

Mother-to-fetus transmission of varicella-zoster virus occurs

a)

before the 24th week of pregnancy

b)

during the 24th week of pregnancy

c)

after the 24th week of pregnancy

d)

All answers are correct.

35.

Incubation period of varicella-zoster virus :

a)

7 days

b)

14 days

c)

21 days

d)

28 days

36.

General symptoms of chickenpox :

a)

Fever, sometimes abdominal pain, rash all over the body

b)

Localized, unilateral infection (limited in 1 area innervated by 1 sensory ganglion, with neuralgia)

c)

Prostatitis, urethritis, genital discharges, dysuria

d)

Lactose intolerance, malabsorption

37.

General symptoms of shingles :

a)

Fever, sometimes abdominal pain, rash all over the body

b)

Localized, unilateral infection (limited in 1 area innervated by 1 sensory ganglion, with neuralgia)

c)

Prostatitis, urethritis, genital discharges, dysuria

d)

Lactose intolerance, malabsorption

38.

Treatment of varicella-zoster virus :

a)

Antiseptic, acyclovir, famciclovir, foscavir, cidofovir

b)

Antiseptic, antibiotics, acyclovir

c)

Chloroquine, doxycycline, atovaquone/proguanil, mefloquine

d)

Metronidazole, tinidazole, tenoquinol

39.

Vaccines of varicella-zoster virus :

a)

Live-attenuated vaccine (1 dose = 0.5 mL) : SC or IM

b)

Convalescent zoster immunoglobulin

c)

Interferon α and ribavirin

d)

Antiseptics, acyclovir, famciclovir, foscavir and cidofovir

40.

Genome structure of cytomegalovirus :

a)

Double-stranded linear DNA

b)

Double-stranded circular DNA

c)

Single-stranded linear RNA

d)

Double-stranded circular RNA

41.

Incubation period of cytomegalovirus :

a)

14 days

b)

21 days

c)

30 days

d)

50 days

42.

Cytopathic effect (CPE) of cytomegalovirus appears in

a)

1 week

b)

1 - 5 weeks

c)

5 - 10 weeks

d)

10 - 15 weeks

43.

Cytomegalovirus is excreted through

a)

saliva

b)

pharyngeal secretions

c)

tears

d)

urine

e)

cervicovaginal secretions, semen

44.

Clinical signs of primary cytomegalovirus infection :

a)

Prolonged fever, headache, myalgia, splenomegaly and hepatomegaly (rare), mononucleosis with lymphocytosis, elevations of serum transaminases (hypertransaminasemia), frequent moderate thrombocytopenia

b)

Acute hepatitis, meningoencephalitis, pneumonitis, colitis

c)

Severe anemia, hemoglobinuria, oliguria, pulmonary edema, hypoglycemia, acute kidney failure, metabolic acidosis, low blood pressure, acute respiratory distress syndrome (ARDS), cerebral malaria, hyperparasitemia, abnormalities in blood coagulation

d)

Lymphadenopathy, fever, rash, headache, diarrhea, sore throat, fatigue, neurological manifestation, loss of appetite, weight loss

45.

Complications of primary cytomegalovirus infection :

a)

Prolonged fever, headache, myalgia, splenomegaly and hepatomegaly (rare), mononucleosis with lymphocytosis, elevations of serum transaminases (hypertransaminasemia), frequent moderate thrombocytopenia

b)

Acute hepatitis, meningoencephalitis, pneumonitis, colitis

c)

Severe anemia, hemoglobinuria, oliguria, pulmonary edema, hypoglycemia, acute kidney failure, metabolic acidosis, low blood pressure, acute respiratory distress syndrome (ARDS), cerebral malaria, hyperparasitemia, abnormalities in blood coagulation

d)

Lymphadenopathy, fever, rash, headache, diarrhea, sore throat, fatigue, neurological manifestation, loss of appetite, weight loss

46.

Laboratory diagnoses of cytomegalovirus infection :

a)

Cytology

b)

Viral isolation and culture

c)

Detection of viral antigens

d)

PCR test for viral DNA

e)

Serology

47.

Structure of EBV (Epstein Barr virus) :

a)

Capsid : 100 nm, Envelop : 200 nm

b)

Capsid : 125 nm, Envelop : 200 nm

c)

Capsid : 150 nm, Envelop : 250 nm

d)

Capsid : 200 nm, Envelop : 300 nm

48.

Envelop of the EBV derives from

a)

Nuclear membrane

b)

Golgi apparatus

c)

Mitochondria

d)

Ribosomes

e)

Endoplasmic reticulum

49.

Replication of the EBV occurs in

a)

Nucleus

b)

Golgi apparatus

c)

Mitochondria

d)

Endoplasmic reticulum

50.

Tropism of Epstein Barr virus :

a)

Sensory ganglia

b)

Salivary glands

c)

B-lymphocytes

d)

Epithelial cells

e)

Endothelial cells

51.

Latency of Epstein Barr virus :

a)

Sensory ganglia

b)

Salivary glands

c)

B-lymphocytes

d)

Epithelial cells

e)

Endothelial cells

52.

Latency of Epstein Barr virus :

a)

Sensory ganglia

b)

Salivary glands

c)

B-lymphocytes

d)

Epithelial cells

e)

Endothelial cells

53.

Epstein Barr virus primarily infects :

a)

Endothelial cells

b)

Salivary glands

c)

B-lymphocytes

d)

Oropharyngeal epithelial cells

54.

Epstein Barr virus is released through

a)

Endothelial cells

b)

Saliva

c)

B-lymphocytes

d)

Oropharyngeal epithelial cells

55.

Kaposi's sarcoma lesions contain :

a)

HSV-1 and HSV-2

b)

Cytomegalovirus

c)

Epstein Barr virus

d)

HHV-8

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