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HEMATOLOGY - 1

Total questions: 20

Worksheet time: 15mins

Name
Class
Date
1.

Which of the following is true about the counting grid in the following instrument?

a)

Larger grid is used to measure RBCS

b)

Smaller grid is used to measure WBCs

c)

Larger grid is used to measure WBCS

d)

Both A and B

2.

Hemoglobin first appears during which step of erythropoiesis?

a)

Proerythroblast

b)

Early normoblast

c)

Intermediate normoblast

d)

Late normoblast

3.

The counts of the cell shown below would be found raised in all except:

a)

Lead Poisoning

b)

Atopic Dermatitis

c)

Loeffler’s Pneumonia

d)

Ascariasis

4.

A child is given Phylloquinone just after the birth. Which of these conditions will not improve after the dosage?

a)

Factor VII deficiency

b)

Factor VIII deficiency

c)

Factor IX deficiency

d)

Factor X deficiency

5.

A 30 year old man brought to the casualty with severe burns. FFP has to be given to the patient at the earliest. Which of these blood group would be safest to be given if the blood group of the man is unknown?

a)

O

b)

A

c)

B

d)

AB

6.

What should be the correct sequence of collection of blood sample?

a – label the sample

b- check the patient’s case file

c- Ask the patient his/her details

d- collect the blood

e- Greet the patient

a)

abcde

b)

ecbad

c)

ecbda

d)

badce

7.

Which of the following factor assessment would represent the activity of Extrinsic pathway of Coagulation?

a)

Stable Factor

b)

Labile Factor

c)

Stuart Prower Factor

d)

Christmas Factor

8.

A 15 year old boy was presented with history of bleeding gums, sub-conjunctival bleed and purpuric rash. Hb-6.4 gm%, TLC- 26,500/mm3 and Platelets = 35,000/mm3. Following cells are found in the peripheral smear. What is the most likely flow cytometry pattern in this case?

a)

HLA-DR, CD117, CD13, CD33+

b)

HLA-DR ,CD117, CD14,CD64

c)

HLA-DR, Glycophorin A, CD71

d)

HLA-DR, CD41,CD61

9.

How many of these is/are acute immune mediated transfusion reaction/s?

1: Air embolism

2: Non-immune hemolysis

3: Febrile Non-hemolytic transfusion reaction

4: Sepsis

5: TACO

6: TRALI

7: Urticaria

a)

3

b)

4

c)

5

d)

6

10.

A fifty-one-year old male patient presented in a private clinic in Baroda with the complaints of fever for one day, anorexia and vomiting. He was advised amoxycillin 500 mg twice daily and paracetamol. The patient was a resident of Gwalior and had come to Baroda only for a short period of time. At Gwalior he was working in a nursing home. He was non-diabetic, did not use tobacco or drugs. No other family member had fever or any other illness. He had no history of splenectomy or blood transfusion. On the following day the patient got very high grade fever and had taken 650 mg of paracetamol. He was brought to the hospital where after examination he was admitted with the complaints of high grade fever, anorexia, vomiting, profuse sweating, chills, mild headache and arthralgia. On examination, the patient had fever of 1020 F, pulse rate 97/minute, blood pressure of 110/70 mm Hg. The liver and spleen were palpable. The patient had scleral icterus. He was passing dark coloured urine. The peripheral blood smear was stained with Giemsa Stain. What is the drug of choice for the given case?

a)

Dipropionate

b)

Atovaquone

c)

Primaquine

d)

Chloroquine

11.

Which of the following is true with respect to massive blood transfusion?

a)

More than 30% of the blood volume in 4hrs.

b)

More than 1 blood volume in 24 hrs

c)

More commonly associated with metabolic acidosis

d)

Commonly associated with hypercalcemia

12.

‘Blintatumumab’ is a monoclonal antibody approved for

a)

B-ALL

b)

T-ALL

c)

CML

d)

AML

13.

A 40 year old patient has raised serum calcium, raised serum creatinine and Hemoglobin of 8mg/dl. Skull X ray shows following findings. Which of these is a monoclonal antibody for this condition?

a)

Denosumab

b)

Daratumumab

c)

Trastuzumab

d)

Pembrolizumab

14.

Imatinib is a drug for choice for:

1: Chronic Myeloid Leukemia

2: Gastro-intestinal Stromal tumor

3: Renal cell carcinoma

4: Cutaneous mastocytosis

a)

1 and 2

b)

1,2 and 3

c)

1 and 3

d)

All of these

15.

‘Denileukin Deftitox’ is used in treatment of :

a)

Diffuse large B cell lymphoma

b)

Cutaneous T cell lymphoma

c)

Burkitt’s lymphoma

d)

Follicular lymphoma

16.

To monitor the iron overload in long standing thalassemia, which is the best investigation?

a)

•Liver iron measurement by MRI

b)

Cardiac Iron measurement by MRI

c)

Serum free iron measurement

d)

Bone marrow aspiration for ferritin levels

17.

A patient is having bilateral proptosis. The histopathology of retroorbital sample is as shown. Which of these is not associated with the given scenario?

a)

AML M0

b)

AML M1

c)

AML M2

d)

AML M3

18.

A 17 year old boy with TLC 13800 with 80% blasts on smear. Chest radiogram as given.Most likely immunophenotype of the blasts?

a)

Null phenotype

b)

Tdt,CD34, CD7+

c)

CD13,CD33+

d)

CD19,CD20+

19.

Most common mutation associated with the shown condition is :

a)

KRAS

b)

BRAF

c)

p53

d)

PTEN

20.

A 25 year old man , a known case of Hemophilia A has to undergo a dental tooth extraction. What should be the treatment protocol to be followed?

a)

Single dose of cryoprecipitate before surgery only

b)

Single dose of cryoprecipitate before surgery followed by tablet Tranexamic acid for 5 days

c)

Single dose of cryoprecipitate before surgery followed by one dose of cryoprecipitate for 4days and tablet Tranexamic acid for 5 days

d)

tablet Tranexamic acid for 5 days only