A 4 y/o Hispanic M presents with fatigue and spontaneous bruising. His mother has notice a slight decrease in his weight and, on exam, the pt has noted LAD and splenomegaly. Which of the following is a likely diagnosis? (1,24)

Which of the following are associated with chronic myeloid leukemia? (1, 26 - 30)

40 y/o M presents with "a little" fatigue. CBC reveals an increased Ferritin, but decreased TIBC. Genetic testing reveals that there is a mitochondrial defect that prevents the incorporation of iron into hemoglobin. What is the likely diagnosis?

Cessation of hematopoiesis resulting in bone marrow hypocellularity and pancytopenia is - (1, 38)

Polycythemia Vera is associated with -

(select all that apply) (1, 45)

Essential Thrombocytosis is associated with -

(select all that apply)

A 31 y/o M, with a PMHx of EBV, presents w/ severe CP that began minutes after ingesting 2–3 sips of alcohol. This reaction had been occurring for the previous 3 months. The patient felt no pain when swallowing other liquids or solids.

In addition to the pain in his chest, the patient had periodic fevers, night sweats and general malaise. A biopsy of an enlarged right paratracheal lymph node showed many large abnormal cells with bilobed nuclei, consistent with Reed–Sternberg cells, Which of the following is a likely diagnosis? (1, 56)

Which lab findings are concerning for multiple myeloma? (1, 57)

Neutropenic fever, if left untreated, can lead to - (1,63)

67 yo old male presents for fatigue and abdominal pain. He has no complaints. Pertinent CBC reveals leukocytosis with WBC of 38K/uL. Absolute neutrophil count 27.6. Hemoglobin 10.9. Platelets 567K. A review of the blood smear reveals smudge cells. What is the most likely diagnosis?

A high Mean Corpuscular Volume is indicative of a cell that is - (3, 16)

Which of the following is associated with iron deficiency? (3, 27)

Which of the following are high risk for anemia? (3, 29)

Which of the following is true concerning alpha Thalassemia? (Select all that apply) (1, 38)

Which of the following are microcytic anemias?

A vegan pt, with a PMHx of pancreatitis, presents with diarrhea. On exam, pt exhibits glossitis and hypersegmented neutrophils on CBC and MCV is 112. Which of the following is a likely diagnosis? (3, 46-48)

B12 Deficiency in pernicious anemia is associated with all of the following EXCEPT - (3, 48)

Systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease are associated with which of the following? (3, 52)

Hemolytic anemia will have:

________________ reticulocyte count

________________ haptoglobin

Spherocytes are ________________

With autoimmune hemolytic anemia:

______ is generally rare and is caused by ________

_______ is 80 to 90% of cases and is caused by ___________

(3, 57)

An X linked disorder characterized by hemolysis of RBC due to their inability to deal with oxidative stress and Heinz bodies on PBS is - (3, 61)

___________ is associated with an autosomal recessive substitution mutation where symptoms develop after hemoglobin F declines. (3, 62)

Which of the following are treatments for sickle cell disease? (3, 68)

T/F: Hemochromatosis is associated with a decrease in serum iron due to overproduction of iron regulatory hormone, hepcidin. (3, 71)

T/F: One of the hallmark signs of polycythemia vera is pruritis after a hot bath and splenomegaly.

All of the following are potential causes of secondary polycythemia vera with the exception of:

Sickle cell disease should not exceed a post transfusion hemoglobin of ______ when they are chronically infused.

A pt presents with epistaxis. On exam, the pt has petechiae and mucosal bleeding. Labs show elevated platelet destruction. What would be the best treatment for this pt? (3, 86)

A 55 y/o pt presents 12 days post splenectomy after a ground level fall. He has no other symptoms, but has thrombocytosis on his CBC. Which of the following would be the best treatment? (3, 87-89)

A pt presents c/o a fever. Labs display, Hemolytic anemia, Thrombocytopenia, an elevated retic count, and a noted AKI. Pt also has an AMS and schistocytes are seen on blood smear. What is the likely diagnosis and what treatment could be utilized? (3, 90-92)

The most common bleeding disorder that is characterized by prolonged bleeding due to inability to form a platelet plug is ___________. What is the first line treatment? (3, 103)

A CD4 count below _______, is an indication that defines HIV as AIDS. (4)

Which of the following is associated with screening recommendations for HIV? (4)

T/F: HIV-1 p24 Antigen can be detected via 4th generation immunoassay as early as 15 days after HIV infection. (4)

True/ False: HIV Transmission-> ARS-> Recovery and Seroconversion-> Asymptomatic HIV-> Symptomatic HIV/AIDS-> Death is the natural course of untreated HIV. (4)

Which of the following P's is not considered in the pt's sexual history? (4)

Progressive Outer Retinal Necrosis (PORN) is an emergent eye infection that leads to rapid loss of vision and displays white lesions with no hemorrhage or exudates. This condition is caused by - (4)

Which of the following malignancies is associated with HIV infections (4)? (Select all that apply)

PCP is the most common OI associated with AIDS/HIV. S/s include progressive dyspnea, fever, non-productive cough and chest pain. Which of the following is the prophylaxis treatment? (4)

Which of the following is the bests ART for pts with HIV? (4)

Which of the following is a concern associated with taking NRTI medications? (4)