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MIXTISQUE 1

Total questions: 74

Worksheet time: 43mins

Name
Class
Date
1.

Which of the following is diffusion limited gas

a)

O2

b)

CO2

c)

CO

d)

none

2.

which of the following causes left shift of ODC

a)

2,3 BPG

b)

increase in temperature

c)

increase in ph

d)

Anemia

3.

Venous blood with high hematocrit is seen in:

a)

RBC high chloride

b)

Plasma high Na

c)

Plasma high HCO3

d)

. RBC high K

4.

Haldane effect

a)

Effect of 2,3-BPG

b)

Dissociation of CO2 on oxygenation

c)

Dissociation of O2 on oxygenation

d)

Chloride shift

5.

Percentage of O2 carried in chemical combination

a)

97

b)

66

c)

3

d)

7

6.

The fraction of inspired air in mouth to-mouth respiration is

a)

0.16

b)

0.20

c)

0.24

d)

0.21

7.

Arterial O2 content is reduced in one of the following

a)

stagnant hypoxia

b)

Anemic hypoxia

c)

Histotoxic hypoxia

d)

Ischemic hypoxia

8.

Oxygen therapy is least useful in:

a)

Anemia

b)

ARDS

c)

Alveolar damage

d)

COPD

9.

Which of the following variants of hypoxia does not stimulate peripheral chemoreceptors?

a)

Hypoxic hypoxia

b)

Anaemic hypoxia

c)

Stagnant hypoxia

d)

Histotoxic hypoxia

10.

Which of the point on the following figure represent arterial blood in severely anemic person?

a)

Point E

b)

Point B

c)

Point C

d)

Point D

11.

While doing thoracocentesis it is advisable to introduce needle along

a)

Upper border of the rib

b)

Lower border of the rib

c)

In the centre of intercostal space

d)

In the anterior of intercostal space

12.

Structure not passing through the oesophageal hiatus

a)

Left phrenic nerve

b)

Right vagus nerve

c)

Left vagus nerve

d)

Left gastric artery

13.

Anterior diaphragmatic hernia is through

a)

Oesophageal opening

b)

Para oesophageal opening

c)

Foramen of morgagni

d)

Bochdolek foramen

14.

Bochdolek's hernia occurs through

a)

Anteromedial part of diaphragm

b)

Posterolateral part of diaphragm

c)

Central tendon of diaphragm

d)

Hiatus hernia

15.

True about Anterior Intercostal Artery

a)

Present in 1st to 11th space

b)

Each Intercostal space has two arteries

c)

Branch of internal thoracic artery

d)

Branch of Aorta

16.

Right superior Intercostal vein drains to

a)

Brachiocephalic vein

b)

Azygos vein

c)

IVC

d)

None

17.

Level of lower border of lung at mid axillary line is

a)

6th rib

b)

8th rib

c)

10th rib

d)

12th rib

18.

Aal of the following are characteristics of Bronchopulmonary segments except

a)

It is surgically resectable

b)

It is named according to the segmental bronchus supplying it

c)

It is drained by independent intrasegmental veins

d)

It is largest subdivision of a lobe

19.

The normal narrowing of the middle of oesophagus is caused by

a)

Azygos vein

b)

Hemiazygous vein

c)

Right main stem bronchus

d)

Left main stem bronchus

20.

An inhaled foreign body is likely to lodge in the right lung for all except

a)

Right bronchus is more vertical then left bronchus

b)

Tracheal bifurcation directs the foreign body to right

c)

Right lung is shorter and wider then left

d)

Right inferior bronchus is in continuation with right principal bronchus

21.

The root of right lung does not lie behind

a)

Right atrium

b)

Right vagus

c)

Superior vena cava

d)

Phrenic nerve

22.

The root of right lung does not lie behind

a)

Right atrium

b)

Right vagus

c)

Superior vena cava

d)

Phrenic nerve

23.

Vitamin K is involved in the post-translational

modification of

a)

Glutamate

b)

Lysine

c)

Aspartate

d)

Proline

24.

Which of the following is true about vitamin K?

a)

Vit K dependent factors undergo post-tran-

scriptional modification

b)

Prothrombin is a vitamin K dependent factor

c)

Stuart-Prower factor is not vitamin K

dependent

d)

Menadione is a natural water insoluble vitamin

K used in clinical practice

25.

Biotin act as a coenzyme for all except:

a)

Pyruvate to Oxaloacetate

b)

Acetyl CoA to Malonyl CoA

c)

Propionyl CoA to Methyl Malonyl CoA

d)

Glutamate to Gamma Carboxy Glutamate

26.

A vitamin derived from amino acid is

a)

Biotin

b)

Pantothenic acid

c)

Niacin

d)

Folic acid

27.

Vitamin for which RDA is based on protein

intake is:

a)

Niacin

b)

Riboflavin

c)

Pyridoxine

d)

Thiamine

28.

Which of the vitamin deficiency lead to lactic

acidosi

a)

Riboflavin

b)

Niacin

c)

Thiamine

d)

Pantothenic

29.

Vitamin which is excreted in urine

a)

Vitamin A

b)

Vitamin C

c)

Vitamin D

d)

Vitamin K

30.

Thiamine deficiency causes decreased energy

production because:

a)

t is required for the process of transamination

b)

It is a cofactor in oxidative reduction

c)

It is a coenzyme for transketolase in pentose

phosphate pathway

d)

t is a coenzyme for pyruvate dehydrogenase

and alpha ketoglutarate dehydrogenase

31.

Not needed in TCA cycle:

a)

Pyridoxine

b)

Thiamine

c)

Niacin

d)

Niacin

32.

Identify the vitamin deficiency:

(

a)

Riboflavin

b)

Niacin

c)

Ascorbic Acid

d)

Biotin

33.

The form of THFA used in treatment is:

a)

N10 Formyl THFA

b)

N5 Formyl THFA

c)

N 5 Formimino THF

d)

N5 Methyl THFA

34.

Excess of avidin causes deficiency of:

a)

Biotin

b)

Choline

c)

Vitamin B12

d)

Folate

35.

Thiamin act as a cofactor in

a)

Malonate to Oxaloacetate

b)

Pyruvate to Oxaloacetate

c)

Succinate to Fumarate

d)

Pyruvate to Acetyl CoA

36.

The given coronary artery angiogram is from a 68-year-old man with recurrent angina. It reveals 90% stenosis of the left anterior descending (LAD) artery, indicated by the white arrow. Based upon this finding, which portion of the heart is most likely susceptible to ischemic damage?

a)

Anterior two thirds of interventricular septum

b)

Posterior one third of interventricular septum

c)

Atrioventricular (AV) node

d)

Diaphragmatic surface of left ventricle

37.

Sebhoreic Dermatitis is produced by deficiency

of:

a)

Vitamin A

b)

Vitamin B1

c)

Vitamin B2

d)

Vitamin C

38.

Severe thiamine deficiency is associated with:

a)

Decreased RBC transketolase activity

b)

Increased clotting time

c)

Decreased RBC transaminase activity

d)

Increased xanthurenic acid excretion

39.

A child is born at home without difficulty. Two weeks later, the mother takes the infant to her doctor, reporting that he “turns blue” when he cries. Physical examination reveals the infant is cyanotic and has a distinct systolic heart murmur. The physician suspects the baby has a tetralogy of Fallot (TOF). Which of the following conditions is a component of this syndrome?

a)

Transposition of the great vessels

b)

Hypertrophy of the left ventricle

c)

Interatrial septal defect

d)

Pulmonary infundibular stenosis

40.

A 22-year-old woman gives birth to an infant with an abnormally small coronary sinus that limits cardiac venous drainage. The coronary sinus is derived from which of the labeled structures in the given diagram of the primitive heart?

a)

A

b)

B

c)

C

d)

D

41.

A 40-year-old man goes to his family physician for an annual examination. Which of the following locations is ideal for placement of the stethoscope for auscultation of the tricuspid valve of the heart?

a)

E

b)

B

c)

C

d)

D

42.

A genetic coding defect in an early embryo results in absence of the lower part of the vertical portion of the cross of the endocardial cushions in the developing heart. Which of the following malformations is most likely present?

a)

Atrial septal defect

b)

Membranous ventricular septal defect (VSD)

c)

Transposition of the great vessels

d)

Muscular ventricular septal defect

43.

One finding during autopsy of a newborn infant that died soon after birth is a significant ventricular septal defect at the upper end of the interventricular septum, as shown in the given photo. This malformation may have been related to maldevelopment of which of the following embryonic structures?

a)

Septum secundum

b)

Bulbus cordis

c)

Endocardial cushions

d)

Truncus arteriosus

44.

A male baby is born with Down syndrome (trisomy 21) and associated cardiac defects. The given apical four-chamber view echocardiogram shows a complete atrioventricular canal defect that includes a primum atrial septal defect and a posterior inlet ventricular septal defect. What embryonic structures normally fuse to close the foramen primum?

a)

Septum secundum and the septum primum

b)

Septum secundum and the fused endocardial cushions

c)

Septum primum and the fused endocardial cushions

d)

Septum primum and the septum spurium

45.

A 24-year-old man who has been overweight and sedentary most of his life experiences shortness of breath and cyanosis on exertion when he attempts to start an exercise program for the first time. A thorough physical examination by his physician reveals an aortic valve defect and an aortic murmur. This murmur is best detected with the stethoscope placed over which of the indicated sites?

a)

A

b)

B

c)

C

d)

D

e)

E

46.

A 15 year old male has polished rice as a major component of his diet.He us hospitalized with symptoms of poor appetite, peripheral neuropathy and muscular weakness. What is the probable disorder?

a)

Pellagra

b)

Beri beri

c)

Anemia

d)

Night Blindness

47.

Which of the labeled structures in the given PA radiograph of the chest indicates the right atrium?A

a)

B

b)

C

c)

D

d)

A

e)

E

48.

A newborn infant has difficulty breathing and swallowing. Radiographic examination reveals constrictions of both the trachea and esophagus in the same plane. Which of the following congenital malformations is the most likely cause of this condition?

a)

Double aortic arch

b)

Persistent right 2nd aortic arch

c)

Coarctation of the aorta

d)

Patent ductus arteriosus

e)

Persistent left 4th aortic arch

49.

A small 3 year child was brought with bow legs , protruding forehead , pigeon chest , depressed ribs and kyphosis. The child is suffering from the deficiency of

a)

Vitamin A

b)

Vitamin D

c)

Vitamin E

d)

Vitamin K

50.

Which of the following is not derived from vitamins

a)

CoA

b)

TPP

c)

PLP

d)

CoQ

51.

Antihemorrhagic vitamin is

a)

Vitamin A

b)

Vitamin D

c)

Vitamin E

d)

Vitamin K

52.

Which of the following is required for collagen synthesis

a)

Folic acid

b)

Ascorbic acid

c)

Pantothenic acid

d)

Nicotinic acid

53.

Which of the following vitamins can be synthesized by a pathway that involved PLP and an aromatic amino acid

a)

Vitamin B1

b)

Vitamin B3

c)

Vitamin B5

d)

Vitamin D

54.

Deficiency of which of the following may lead to hemolytic Anemia

a)

Vitamin A

b)

Vitamin D

c)

Vitamin E

d)

Vitamin K

55.

Which of the following vitamin provides coenzyme for transamination reactions

a)

Vitamin B3

b)

Vitamin B6

c)

Vitamin B9

d)

Vitamin B12

56.

Which of the following Vitamin act as a coenzyme for transfer of one carbon units?

a)

Niacin

b)

Thiamine

c)

Folic acid

d)

Pyridoxine

57.

In a laboratory study, volunteers were made experimentally vitamin B6 deficient, and much to the investigator’s surprise, a mild hypoglycemia, with ketosis, was noted. The hypoglycemia is a result of which of the following?

a)

Inhibition of phosphoenolpyruvate carboxykinase

b)

Inhibition of pyruvate carboxylase

c)

Reduced activity of glucose-6-phosphatase

d)

Reduced activity of liver glycogen phosphorylase

e)

Reduced insulin secretion

58.

An individual has developed pancreatitis, and with it, steatorrhea. The patient also reports problems with his night vision, although visual acuity appears normal. Another expected finding in this patient would be which of the following?

a)

Nystagmus

b)

Easy bruising

c)

Dermatitis

d)

Orange tonsils

59.

True about right atrium is

a)

Related to central tendal of diaphragm at T10 level

b)

Coronary sinus lies between fossa ovalis and IVC

c)

SVC opening is guarded by endocardial valve

d)

None

60.

A 6-year-old girl has a history of seizures, which are only marginally relieved by standard medications. Switching her diet to which of the following may help her condition?

a)

80% fat, 20% combined carbohydrate and protein, by weight

b)

50% fat, 50% combined carbohydrate and protein, by weight

c)

20% fat, 80% combined carbohydrate and protein, by weight

d)

75% protein, 25% combined carbohydrate and fat, by weight

61.

Boundary of KOCH triangle is not formed by

a)

Tricuspid valve ring

b)

Fossa ovalis

c)

Coronary sinus

d)

Tendon of todaro

62.

The base of the heart is formed by

a)

Right atrium

b)

Left atrium

c)

Right ventricle

d)

Left ventricle

63.

A patient has had a series of blood clots, and has been placed on warfarin to reduce such incidents. Warfarin exerts its effect by blocking which of the following?

a)

Platelet biogenesis

b)

Phospholipid synthesis

c)

Clotting factor synthesis

d)

Formation of γ-carboxyglutamate

64.

The right coronary artery supplies all except

a)

SA node

b)

AV node

c)

Right bundle branch

d)

Left bundle branch

65.

True about Ondine’s curse is:

a)

Voluntary control of respiration is disrupted

b)

Automated control of respiration intact

c)

Seen in spinal poliomyelitis

d)

Such patients can stay alive by breathing voluntarily

66.

Administration of pure O2 to hypoxic

patients is dangerous because:

a)

Apnea occurs due to hypo-stimulation of peripheral chemoreceptors

b)

Pulmonary edema

c)

DPG

d)

Convulsions

67.

Nitrogen narcosis is caused due to

a)

Nitrogen inhibits dismutase

b)

Increased production of nitrous oxide

c)

Increased solubility of nitrogen in cell membrane

d)

Decrease in oxygen free radicals

68.

During acclimatization to high altitude all of the following take place except

a)

Increase in minute ventilation

b)

Increase in sensitivity of chemoreceptors

c)

Increase in sensitivity of carotid body to hypoxia

d)

Shift of oxygen dissociation curve to left

69.

What will be the effect on respiration if a transmission is made between the

pons and medulla

a)

Apnea

b)

Irregular and gasping

c)

No effect

d)

Slow and deep

70.

Moderate exercise tachypnea is due to stimulation of which receptor

a)

Propioceptor

b)

Lung receptor

c)

J receptor

d)

Barorecptor

71.

A high-protein low-carbohydrate diet has, as its biochemical basis, the potential to lead to weight loss due to which of the following?

a)

Allosteric inhibition of fatty acid synthesis

b)

Increased glucagon release

c)

Minimal insulin release

d)

Reduced cortisol release

72.

You are treating a patient with a fat malabsorption problem, and you suggest that the patient switch his or her diet to one that contains which of the following?

a)

Triglycerides with long-chain fatty acids

b)

Triglycerides with medium-chain fatty acids

c)

Triglycerides with short-chain fatty acids

d)

Triglycerides with a mixture of long-chain and short-chain fatty acids

73.

A 42-year-old woman presents with tiredness and lethargy. She has tingling in her hands and feet. Blood work shows a macrocytic anemia, along with elevated homocysteine levels. One would also expect to see elevated levels of which metabolite?

a)

Acetic acid

b)

Ketone bodies

c)

Methylmalonic acid

d)

Propionic acid

74.

V/Q is maximum at

a)

Apex

b)

Base

c)

Middle lobe

d)

None