WorksheetsnovoCare Quiz
Total questions: 16
Worksheet time: 8mins
Insulin detemir (IDet) differs from human insulin
with the omission of aspartic acid at position 30 and attachment of myristic acid at position 29 by acylation.
with the additon of threonine at position 30 and attachment of myristic acid at position 30 by acylation.
with the omission of threonine at position 30 and attachment of myristic acid at position 29 by acylation.
with the omission of proline at position 29 and attachment of myristic acid at position 29 by acylation.
Insulin Detemir is produced by a process including recombinant DNA technology using
Saccharomyces cerevisiae
E. Coli
Both A & B
What are the main mechanisms underlying the prolonged action of insulin determir.
Increased insulin self-association in the subcutaneous depot
interstitial albumin binding
plasma albumin binding
All of above
While insulin detemir is
hexameric upon injection
dimeric upon injection
monomeric upon injection
none of above
none of above
Once in the bloodstream
99% of these monomers bind to plasma albumin
100% of these monomers bind to plasma albumin
>98% of these monomers bind to plasma albumin
97% of these monomers bind to plasma albumin
In insulin aspart, substitution of amino acid ________ with ________ at position _____ is done.
Arginine – Aspartic Acid – A28.
Proline – Aspartic Acid – B28.
Glycine – Myristic Acid – B23
Lysine – Glutamic Acid – B30
NovoMix® 30 should only be administered?
Subcutaneously
Intra muscular injection
Intra venous injection
Both a and b
What is most common undesirable effect of NovoMix®?
Neuropathy
Retinopathy
Hypoglycaemia
Nephropathy
What is the mechanism of action of NovoMix® 30?
a) Facilitated uptake of glucose following binding of insulin to receptors on muscle and fat cells.
b) Increase Incretin effect
c) Inhibition of hepatic glucose output
d) Both A & C
Facilitated uptake of glucose following binding of insulin to receptors on muscle and fat cells.
Increase Incretin effect
Inhibition of hepatic glucose output
Both A & C
The onset of action of BiAsp 30 is:
30-40 minutes
30-40 minutes
10-20 minutes
5-8 minutes
As compared to BHI 30, BiAsp 30 can be given:
0-10 minutes before the meal
30 minutes before the meal
Immediately after or during the meal
Both A & C
Limitation of premixed insulins regimen include all EXCEPT
Variability in glycaemic control
Incomplete 24-hour basal coverage
Need for re-suspension
Complex titration schedule
Co formulation of a basal insulin with a bolus in a single injection can
Mimic physiological insulin secretion closely
Avoid shoulder effect and variability of protaminated premix insulin
Simplify the insulin regimen and lower the injection burden
All the above
Upon injection into the subcutaneous space the Insulin Aspart ___________ rapidly dissociate and enter the blood stream, while insulin degludec forms _____________ chains that slowly dissociate.
Hexamers, multihexamer
Monomers, multihexamer
Monomers, dihexamers
Hexamers, dihexamers
Upon injection ___________ diffuses rapidly and change the conformation of dihexamers of insulin degludec to link together via side-chain contacts to assemble in long multihexamer chains.
Chlorine
Phenol
Zinc
Glutamic acid
The mean half life of Insulin Degludec is longer than ___________ hours.
12
25
42
19
