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Mutation

Total questions: 20

Worksheet time: 20mins

Name
Class
Date
1.

Which of the following is not the type of gene mutation

a)

Base substitution

b)

Base deletion

c)

Deletion

d)

Base insertion

2.

Give on example of chemical mutagen

a)

X-ray

b)

Cosmic radiation

c)

Colchicine

d)

Nuclear bomb

3.

What causes the sickle cell anaemia in human

a)

Deletion of the short arm of chromosome 5

b)

Base substitution, Thymine replaced by Adenine

c)

Base deletion

d)

Doubling of chromosome number

4.

Base deletion can lead to what condition in DNA

a)

Stop codon become start codon

b)

One codon become affected

c)

Silent mutation

d)

Frameshift mutation

5.

Based on the condition of the above karyotype. The individual probably suffer with what genetic disorder

a)

Cat syndrome

b)

Down syndrome

c)

Cri du chat

d)

Sickle cell anaemia

6.

The mutation cause the codon to change into stop codon. Which of the following related to this mutation.

a)

Missense mutation

b)

Silent mutation

c)

No mutation

d)

Nonsense mutation

7.

A segment of a chromosome is break off at two points and rotate through 180° within a chromosome, and rejoined with a reversed orientation.

The above situation refer to

a)

Inversion

b)

Deletion

c)

Duplication

d)

Translocation

8.

What is nondisjunction

a)

Homologous chromosomes fail to separate properly during meiosis II

b)

Homologous chromosomes fail to separate properly during meiosis I

c)

Doubling of chromosome number

d)

Gamete become monosomy

9.

Monosomy 21 produced when..

a)

Abnormal gamete (n-1) fertilize normal gamete (n)

b)

Abnormal gamete (n-1) fertilize abnormal gamete (n-1)

c)

Abnormal gamete (n+1) fertilize normal gamete (n)

d)

Abnormal gamete (n-1) fertilize abnormal gamete (n+1)

10.

When abnormal gamete (22+XY) fertilize with normal gamete (22+X), which of the following related to this situation

a)

Turner syndrome developed

b)

Down syndrome developed

c)

The individual is male with feminine body characteristics

d)

It is Trisomy 21

11.

When abnormal gamete (22+0) fertilize with normal gamete (22+X), which of the following related to this situation

a)

Turner syndrome

b)

Down syndrome

c)

The individual is male with feminine body characteristics

d)

It is Trisomy 21

12.

The karyotype shown above is the karyotype of what disorder

a)

Turner syndrome

b)

Down syndrome

c)

Klinefelter syndrome

d)

Cri du chat

13.

Individual that has more than two chromosome sets that are all derived from a same (single) species known as..

a)

Autophagy

b)

Polyploidy

c)

Autopolyploidy

d)

Allopolyploidy

14.

The hybrid between Species A and Species B produce new infertile Species C. What causes the Species C to be infertile?

a)

Presence of homologous chromosomes

b)

Reproduce asexually

c)

No pairing of homologous chromosome during meiosis I

d)

Doubling of chromosomes number

15.

In allopolyploidy the ploidy number of fertile tetraploid plants is

a)

4n

b)

6n

c)

2n

d)

3n

16.

"Hybridisation of two types of plant produced sterile hybrid with 24 chromosomes number, after many years the plant become fertile"

Name the process that causes the plant become fertile

a)

Allopolyploidy

b)

Spontaneous mutation

c)

Non disjunction

d)

Non homologous

17.

"Hybridisation of two types of plant produced sterile hybrid with 24 chromosomes number, after many years the plant become fertile"

What is the chromosomes number for the fertile plant

a)

24

b)

48

c)

14

d)

42

18.

Base substitution can cause the formation of abnormal polypeptide in haemoglobin. What is the name of the genetic disorder?

a)

Leukemia

b)

Anemia

c)

Thalassemia

d)

Sikle cell anaemia

19.

When abnormal gamete (22+XY) fertilised with normal gamete (22+X), which of the following related to this situation

a)

Klinefelter syndrome

b)

Down syndrome

c)

Turner syndrome

d)

Trisomy 23

20.

What causes the cri du chat syndrome

a)

Deletion of the short arm of chromosome 5

b)

Base substitution, Thymine replaced by Adenine

c)

Base deletion

d)

Doubling of chromosome number