The most widely used method of tablet granulation preparation, due to the greater probability that the granulation will meet all the physical requirements for the compression of good tablets;

A tablet hardness tester containing a compressible spring held between two plungers. The lower plunger is in contact with the tablet, while the upper plunger is forced against the spring by a threaded bolt and the breaking force is transmitted against a tablet;

An equipments used to produce fine emulsion droplets, by first compressing the liquid with a high pressure and then allowing the liquid to escape radically past a flat disc, held by strong spring mechanism;

A unit operation in which a mixture of liquids and solids, slurry or feed is forced through a porous medium, in which the solids form a cake on the surface and the clear liquid is collected;

High resistant borosilicate glass is also referred to as;

Parenteral adjuvant which contribute to the isotonicity of the product, as well as reduce the pain of injection in areas with sensitive nerve ending;

The USP states that this adjuvant must be added to parenteral preparation contained in multiple dose containers;

A glass type, which is treated with sulphur dioxide and is suitable for buffered parenteral solutions, has a pH of below 7, and is not reactive with glass;

The officially recognized filter media for parenteral solutions, since it provides the best flow rate. It also retains microorganisms on the surface of the filter;

A method wherein ampoules are sealed by heating the neck of the ampoules, below the tip, leaving just enough of the tip from grasping with forceps or other mechanical device;

A finishing procedure for gelatine capsules wherein the bulk-filled capsules are rubbed with an oil-impregnated cloth. It imparts gloss to the capsules as it removes resistant materials;

A system for ensuring that products are consistently produced and controlled according to quality standards. It is designed to minimize the risks of errors involved in any pharmaceutical production, which cannot be eliminated through the final testing of the products;

An ointment base prepared from mixtures of high and low molecular weight polyethylene glycol. It is greaseless by nature and no additional water is required in its preparation;

An ointment base, which act as occlusive dressings. Producing a warm sensation and insensible perspiration is inhibited;

A tablet compressing machine, which contains a head that carries a number of sets of dies and upper/lower punches, which revolve continuously;

Substances of varying densities, which make up the major portion of the tablet, making the compression cycle possible;

A tablet processing problem characterized by the separation of the tablet into several distinct layers;

The most commonly used class of aerosol propellant which is composed of butane, iso-butane and propane gasses. It has excellent solvent powers;

A class of aerosol propellants, which require the use of a non-volatile co solvent. It produces only coarse droplets and is applicable only to surface and topical sprays;

It is a Zwitterionic type of an aerosol propellants;

An aerosol container material, which is lightweight and seamless. And is mostly used for inhalation and topical aerosols;

An aerosol container material, which can be pressurized from the base with compressed gasses. Visible seams make this container visually less appealing;

A special technique for hard gelatine capsules which provides a tamper-proof feature to filled capsules, to prevent its unjoining;

A finishing method for hard gelatine capsules, wherein a polyurethane or cheese cloth material lines the polishing pan. The liner is used to trap removed dust, imparting gloss to capsules;

It measures the time it takes for a tablet to reach a state wherein any tablet residue remains on the screen, resulting to a mass with no palpably visible core;

It determines the homogeneity of distribution of the active/s in the batch of finish tablets;

Tablet adjuvants with cohesive properties, capable of gluing powders together, causing the formation of granules;

A part of tablet compressing machine which control the sizes and shapes of the finished tablets;

The reverse of creaming, wherein less concentrated emulsified droplets separate from the internal phase;

A biological product obtained from poisonous bacterial products that act as antigens and causes the human body to produce specific antibodies to combat its presence;

Fever-producing organic substances arising from microbial contamination and mostly occur in patients following intravenous injection;

Impalpable powders have a particle size of less than;

Non-ionic surfactants composed of higher molecular weight PEG compound are referred to as;

Non-ionic surfactants composed of higher molecular weight PEG compound are referred to as;

A suspension that appear as masses of gels, consisting of floccules of small distinct particles;

A filter aid which forms a fine surface deposit to screen out all solid, preventing the clogging of the supporting filter media;

A filter aid which is used for straining syrupy liquids, and is unaffected by molds and fungus;

It refers to the binding of drug molecules to the polymer material of the plastic container;

Type III glass is referred to as;

It refers to any distinctive combination of letters and/or numbers or both, by which the complete history of the manufacture, control, packaging and distribution of a batch or lot of drug is determined;

Any substance of a drug, which is intended to furnish pharmacological activity or other effect in the diagnosis, cure, mitigation, treatment or prevention of a disease or to affect any structure of function of the body;

It refers to the release or movement of the components of the plastic container into the contents;

A section of the plant department consist of products which have been stripped, bottled or packed, but not yet labelled nor packed into boxes and cartons. As it waits the results of quality control test and assays;

The most useful preservatives in the manufacture of oral liquids, because of its neutral pH and it possess both antifungal and antibacterial properties;

A method of filling viscous liquid preparations in a very large containers;

A class of suspensions which contain finely powdered substances that are insoluble in the dispersion medium, are intended for external applications;

Which of the following statements is true for protective colloids?

A method of particle size reduction in suspensions, wherein the particles are subjected in a turbulent air chamber, thus colliding with each other to fracture and produce particles with sizes 5 microns and below;

It is the reverse of creaming, wherein less concentrated emulsified droplets separates from the internal phase. It usually settles at the bottom of the external phase of the container;

Which of the following is/are official sources of Starch USP?<br /><br />I. Zea mays<br />II. Triticum aestivum<br />III. Manihot esculenta

Which of the following is/are uses of starch in pharmaceutical formulation?<br /><br />I. Lubricant<br />II. Diluent<br />III. Disintegrant

What is the allowable limit of silicon dioxide in gelatin?

What is a pharmaceutical glaze?

Which of the following can be considered as use/s of Directly Compressible Strach?<br /><br />I. Binder<br />II. Diluents<br />III. Disintegrant

Which of the following is obtained by incomplete partial hydrolysis of starch and consists mainly of dextrin, maltose and water?<br /><br />I. Binder<br />II. Diluents<br />III. Disintegrant

Lactose is relatively inexpensive tablet bulking agent. Which of the following types of drug or excipients is/are incompatible with lactose?<br /><br />I. Amine drugs<br />II. Water-based binding solutions<br />III. Alcohol-based binding solutions

Maillard Reactions is a documented incompatibility of certain excipients with acetates, phosphates and lactates. Which of the following excipients can manifest such reaction?<br /><br />I. Anhydrous lactose<br />II. Pregelatinized starch<br />III. Spray-dried lactose

Moisture content of excipients and active drug can affect the properties and production of compressed tablet. Which of the following excipients has the smallest moisture content?

Sodium starch glycollate and croscarmelose are primarily used in tablet formulation as;

135. Which of the following excipients is expected to possess the greatest adhesive property?

Which of the following excipients can be used for direct compression?<br /><br />I. Pregelatinized starch<br />II. Anhydrous lactose<br />III. Mannitol

Which of the following is/are sucrose based tablet diluents-binder?<br /><br />I. Nutab<br />II. Avicel<br />III. Cab-o-sil

What is the concentration of Starch in Starch paste used as a binder solution?

Which of the following principled is/are employed in the use of lubricants in tablet formulation?<br /><br />I. Higher concentrations of lubricants are employed when active drugs and other excipients use have bigger particle sizes<br />II. Lubricants are added together with the rest of the excipients in the initial steps in production<br />III. Lubricants generally increase the disintegration time and reduce dissolution rate

Double compression method of tablet manufacture is the preferred method in which of the following conditions?<br /><br />I. When the initial powder blend has a significant quantity of fine powders<br />II. When the active ingredients are sensitive to moisture or elevated temperature<br />III. When the active ingredients and the excipients are free-flowing

Which of the following mechanisms explain the use of glidants in tablet formulations?

Which of the following precautions are observed during addition of tablet lubricants in formulations<br /><br />I. Add lubricants prior to wetting of powder blends or slugging, as applicable<br />II. Add lubricants at concentrations consisting of about 20-25% of final tablet weight<br />III. Mix lubricants with the rest of the granules for about 2-5 minutes only

Sterotex, Magnseium stearate, and the high melting point waxes can be categorized as<br /><br />I. Water-soluble lubricants<br />II. Glidants<br />III. Water-insoluble lubricants

Talc in tablet formulations is generally used as<br /><br />I. Glidant<br />II. Lubricant<br />III. Anti-adherent

An internal disintegrant is used in which of the following methods of manufacture?<br /><br />I. Wet granulation<br />II. Dry granulation<br />III. Direct compression

What is a “Running powder”?

What are referred to “lakes” in pharmaceutical manufacturing?

Flavors for pharmaceutical oral liquids or chewable tablets are chosen based on the baseline taste of the active ingredient. Which of the following flavors are recommended for drugs with a sour baseline taste? <br /><br />I. Cherry<br />II. Citrus<br />III. Strawberry

Which of the following is/are disadvantage of wet granulation method of tablet manufacture?<br /><br />I. Good color distribution<br />II. Uniform composition of granules during processing, transport and handling<br />III. Useful for heat-sensitive materials

A method of tablet production wherein a granulation solution is sprayed onto the suspended particles which would then be dried rapidly in the suspending air

This granulation process involves the direct formation of granules from a wet granulation using a machine where initially extruded rod-shaped cylindrical particles with size range of 0.5-12mm are passed through appropriate an extruder screen. The extruded segments are then shaped into idealized granules by centrifugal and frictional forces.

Which of the following sequence in tablet manufacture correctly illustrates wet granulation method of manufacturing tablets?

135. Which of the following diluents is/are appropriate choices when producing tablets that are dissolved in solution prior to oral administration?<br /><br />I. Mannitol<br />II. Lactose<br />III. Microcrystalline cellulose

Consider the following formulation:<br /><br />Ingredients Amount/Tablet <br />Aluminium OH & Carbonate CO-dried gel 325.0 mg<br />Mannitol USP Granular 675.0 mg<br />Microcrystalline cellulose 75.0 mg<br />Starch 30.0 mg<br />Calcium Stearate 22.0 mg<br />Flavor qs<br /><br />This tablet formulation is most likely manufactured by what method?<br />

A tablet formulation contains the following: aspirin, sodium carbonate, fumaric acid and citric acid. What is/are the use/s of sodium carbonate, fumaric acid, and citric acid in the formulation?<br /><br />I. Diluents<br />II. Binder<br />III. Disintegrant

Capping and splitting of tablets can be caused by which of the following conditions?<br /><br />I. When there is an excessive quantity of water in the formulation <br />II. When there is an excessive quantity of fines or powder<br />III. When the dies are worn and the punches are imperfect

When the capping and splitting are encountered during tablet compression, which of the following may be employed as remedy/remedies?<br /><br />I. Slowing the rate of tablet compression<br />II. Use of tapered dies<br />III. Increasing the quantity of fines or powder

Which statement is/are correct regarding film tablet coating?<br /><br />I. The Wurster spray coating method provides uniform coating coverage while preventing adjacent tablets from adhering together<br />II. Cellulose acetate phthalate, hydroxypropylmethyl cellulose, and PVP are pH dependent enteric coats<br />III. Nonaqueous film coating solutions consist of a film former, an alloying substance, opaquants, colorants, a glossant and a volatile solvent

What is the correct order of the steps involved in Sugar-coating?

Uneven distribution of color in tablet coating is due to

What problem in film coating arises when the fluid delivery rate exceeds the drying capacity of the process?

An assay of the active ingredient revealed a concentration of 98.5% nitrofurantoin raw material. The USP monograph specifies limit of 90-110%. What is the maximum amount of nitrofurantoin raw material to be used in preparing a 34.2 kilo batch size to accommodate a 5% production overage if a 342 mg tablet contains 100 mg of the drug?

In sugar coating of tablets, the greatest increase in the size of the tablet occurs at what stage of the process?

Which of the following materials is/are suitable for producing sustained-release film coating?<br /><br />I. Acrylic resins<br />II. Cellulose elastomers<br />III. Silicone elastomers

Which of the following mechanisms can explain the effects of controlled drug delivery system?<br /><br />I. Achievement of sustained drug action at a predetermined rate<br />II. Spatial placement of a controlled release system adjacent t or in the diseased tissue or organ to achieve a systemic drug action<br />III. Rate and amount of drug release being determined by the physiologic and therapeutic need of the patient

It is defined as the load in grams required to push a standard a set distance into a prepared gelatine gel (6.66% solution at 10 degree Celsius)

Which of the following is the source of gelatine?

Given the following formulation:<br /><br />Ingredients Amount/Tablet<br /><br />Nitrofurantoin 100 mg<br />Lactose 152 mg<br />PVP 15 mg<br />Microcrystalline cellulose I 15 mg<br />Syloid 2 mg<br />Sterotex 1 mg<br />Which of the given ingredients is the disintegrant?

135. Given the following formulation:<br /><br />Ingredients Amount/Tablet <br />Nitrofurantoin 100 mg<br />Lactose 152 mg<br />PVP 15 mg<br />Microcrystalline cellulose I 15 mg<br />Syloid 2 mg<br />Sterotex 1 mg<br /><br />Which of the given ingredients is the binder?

Plasticizers are useful in which of the following?<br /><br />I. Film coating<br />II. Manufacture of soft-gel capsules<br />III. Manufactured of hard-gelatin capsules

What is the amount of moisture present in soft gelatin capsules?

What is the maximum particle size that can be found in True solutions

Protective colloids classified as clays include which of the following:

Ionamin capsules which contain Phentermine utilize which of the following controlled release systems?