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WorksheetsPathophysiology Exam 1 (Neuro Review)
Total questions: 63
Worksheet time: 36mins
Which of the following are major sensory pathways? Select all that apply
Corticospinal tract
Extrapyramidal tract
Spinothalamic tract
Dorsal column system
Which of the following are considered motor pathways? Select all that apply
Corticospinal tract
Extrapyramidal tract
Spinothalamic tract
Dorsal column system
The dorsal column sensory pathway is responsible for which of the following? Select all that apply
Pain
Proprioception
Temperature
Fine touch
The spinothalamic tract sensory pathway is responsible for which of the following? Select all that apply
Pain
Temperature
Proprioception
Which of the following describes the role of the trigeminal pathway?
Carries somatosensory information from the face, head, mouth, and nasal cavity.
Carries sensory information, like touch and proprioception from the feet.
Carries sensory information, like heat and pressure from the arms.
All of these are correct
Which of the following is the relay center through which sensory nerves transmit signals from the spinal cord and brainstem on the way to the cerebral cortex?
Thalamus
Hypothalamus
Medulla oblongata
Pons
Pituitary gland
Depolarization of the presynaptic nerve terminal causes opening of the voltage-gated _____ channels, leading to the release of neurotransmitters.
Ca2+
K+
Na+
Cl-
Inhibitory Postsynaptic Potential (IPSP) cause which of the following:
Causes the local nerve membrane to become hyperpolarized and less excitable
Decreased internal resistance, which results in faster conduction down the nerve
Causes graded potentials that prematurely propagate down the neuron
Causes depolarization of the postsynaptic membrane
An autoimmune disease associated with autoantibodies directed against acetylcholine receptors is -
Lupus Cerebritis
Myasthenia gravis
Cerebral Palsy
Guillain-Barre
The third-order neurons of the spinothalamic tract project their axons to the -
precentral gyrus
postcentral gyrus
thalamus
cerebellum
Which of the following are true when concerning the spinothalamic tract? Select all that apply
Responsible for pain and temperature sensations.
Decussation occurs at the same level where the neuronal information entered the spinal cord.
Decussation occurs in the medulla of the brain stem
It is separated into 2 component tracts, the fasciculus gracilis and the fasciculus cuneatus
Responsible for touch and proprioception.
Which of the following are true when concerning the Dorsal column system? Select all that apply
Responsible for pain and temperature sensations.
Decussation occurs at the same level where the neuronal information entered the spinal cord.
Decussation occurs in the medulla of the brain stem
It is separated into 2 component tracts, the fasciculus gracilis and the fasciculus cuneatus
Responsible for touch and proprioception.
Which of the following are functions of the basal ganglia? (Select all that apply)
Heavily involved in movement
Rugulates inhibition and disinhibition pathways between the thalamus and cerebral cortex
Regulates sensory neurons prior to their synapse on the postcentral gyrus
Involved with cognition and perception
A patient presents c/o "jitters". On exam the patient has involuntary flinging of the limbs and involuntary dance-like movements. Gait is normal. Which of the following regions/areas is most likely affected?
Basal Ganglia
Wernicke's area
Broca's area
Pons
Which of the following is essentialliy involved in maintaining homeostasis?
Hypothalamus
Cerebellum
Thalamus
Basal Ganglia
The main sensory nuclei for the Trigeminal nerve, CN V, are loacated in the -
Midbrain
Pons
Medulla
Thalamus
The resting membrane potential of the neuron is about -
+30 mV
-30 mV
+70 mV
-70 mV
0 mV
One of the most common drug targets found in relatively every cell is the (a) .
The neurons of the sympathetic division of the autonomic nervous system release ________ from the postganglionic neuron.
Dopamine
Acetylcholine
Epi/Norepinephrine
Serotonin
Glutamate is the primary ___(1)___ neurotransmitter in the brain and has been implicated in ___(2)___ . It targets ___(3___.
(1)excitatory (2)Multiple sclerosis (3)GPCR & Ion channels
(1)excitatory (2)Alzheimer's and Parkinson's (3)GPCR & Ion channels
(1) inhibitory (2)Alzheimer's and Parkinson's (3)Ca2+ channels
(1) inhibitory (2)Multiple sclerosis (3)Ca2+ channels
___________ is the primary inhibitory neurotransmitter in the brain, but it can also be excitatory depending on what ion channel it binds to.
Glycine
GABA
Glutamate
_________ is the neurotransmitter that is important for reward-related behavior.
Dopamine
GABA
Glycine
Norepinephrine
__________ is predominantly produced in the gut, helps with bowel motility, and has been implicated in several psychological disorders.
NMDA
Glutamate
GABA
Dopamine
Serotonin
Which of the following neurotransmitters is involved in wakefulness, feeding, and motivation and regulates several hypothalamic functions and neuroendocrine responses?
GABA
Histamine
Glycine
Dopamine
Myasthenia gravis and Dementia are primarily treated with inhibitory medications that affect which neurotransmitter?
Norepinephrine
Histamine
Serotonin
GABA
Acetylcholine
Which of the following pathogens can lead to complications associated with meningoencephalitis? select all that apply
Cryptococcus
Acanthamoeba spp
Naegleria fowleri
West Nile Virus
EBV
Progressive multifocal leukoencephalopathy is an opportunistic infection caused by _____(1)_______ , leading to _______(2)________.
(1) JC Virus (2) damage to the Schwann cells and axonal shearing.
(1) JC Virus (2) infected oligodendrocytes, demyelination, and extensive white matter lesions.
(1) Polio Virus (2) damage to the Schwann cells and axonal shearing.
(1) Polio Virus (2) infected oligodendrocytes, demyelination, and extensive white matter lesions.
Which of the following are characteristics of Syringomyelia? Select all that apply
Loss of pain and temperature in the upper extremities
Occurs due to the formation of a fluid-filled cavity in the center portion of the spinal cord
Occurs due to demyelination in the peripheral nervous system
Damage to the dorsal column occurs due to the excess CSF in the central canal
Which of the following describes and epidural hematoma: Select all that apply
Typically associated with a skull fracture
Due to a meningeal artery rupture
Causes separation of the dura from the periosteum
Occurs due to traumatic displacement of the brain leading to tears in the veins where they penetrate the dura.
The dura is still attached to the skull
Which of the following describes and subdural hematoma: Select all that apply
Typically associated with a skull fracture
Due to a meningeal artery rupture
Causes separation of the dura from the periosteum
Occurs due to traumatic displacement of the brain leading to tears in the veins where they penetrate the dura.
The dura is still attached to the skull
If a patient presents with clinical stroke symptoms that resolve within 24 hours, the event is termed -
Transient Ischemia
hemorrhagic ischemia
Hypoxic ischemia
Cerebral ischemia
T/F: Lacunar infarcts can be clinically silent or cause severe impairment.
True
False
_____________ is a neurological disease resulting from thiamine (B1) deficiency and is marked by short-term memory disturbances.
Alzheimer's
Wernicke-Korsakoff syndrome
Leigh syndrome
Dementia
Kugelberg-Welander disease
Which illness is charachterized by:
i. Acute onset of macrophages stripping the myelin from the axon
ii. Inflammation of the peripheral nerves
iii. Typically preceded by an infection
Lupus Cerebritis
Myasthenia Gravis
Guillain-Barre
Encephalitis
Which illness is charachterized by:
i. Antibodies against neurons
ii. Proteases and free radicals cause damage to the endothelium of arteries
iii. Causes cerebral vasculitis
Guillain-Barre
Lupus Cerebritis
Myasthenia gravis
Dementia
Meningoencephalitis
The pathologic process that is common across most of the neurodegenerative diseases is:
the lack of/degeneration of dopamine
premature release of neurotransmitters in the synaptic cleft
the accumulation of protein aggregates
delayed neuronal action potentials
___________________ is/are a rapidly progressive dementia caused by aggregation and intercellular spread of a misfolded mutated PrPSC protein.
Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome [Prion diseases]
Alzheimer's Disease
Huntington's Disease
Parkinson's Disease
Amyotrophic lateral sclerosis
Pathologic hallmarks of _______________, particularly evident in the end stages of the illness, are amyloid plaques and neurofibrillary tangles.
Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome [Prion diseases]
Alzheimer's Disease
Huntington's Disease
Parkinson's Disease
Amyotrophic lateral sclerosis
___________________is a neurodegenerative disease marked by a hypokinetic movement disorder that is caused by loss of dopaminergic neurons from the substantia nigra.
Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome [Prion diseases]
Alzheimer's Disease
Huntington's Disease
Parkinson's Disease
Amyotrophic lateral sclerosis
Which illness is characterized by the following?
i. Degeneration of striatal neurons and CAG expansion
ii. Progressive movement disorder and dementia
iii. Jerky, hyperkinetic, sometimes dystonic movements involving all parts of the body (chorea)
iv. Affected individuals may later develop bradykinesia and rigidity.
Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome [Prion diseases]
Alzheimer's Disease
Huntington's Disease
Parkinson's Disease
Amyotrophic lateral sclerosis
When contrasting dementia and delirium, which of the following pertains to delirium:
1. Abrupt onset
2. Impaired attention
3. Duration is months to years
4. Slow declining disorder
1 and 2
2 and 3
1, 2, and 4
1 and 3
T/F: ALS is a progressive disorder in which there is loss of upper motor neurons in the cerebral cortex and lower motor neurons in the spinal cord and brainstem.
True
False
Which of the following cerebrovascular diseases results from rupture of CNS vessels and has a common etiology that includes hypertension and vascular anomalies?
Ischemic
Hemorrhagic
Thrombotic occlusion
Embolic
The most frequent cause of spontaneous subarachnoid hemorrhage is -
the rupture of atherosclerotic plaques
the rupture of a saccular aneurysm in a cerebral artery.
pieces of the thrombus break off and travel to smaller vessels and cause ischemia
What is the “at-risk” portion of the brain called surrounding a stroke?
Penumbra
Infarcts
Lesions
Lacunae
Lobar
Spinal cord lesions to LMNs will result in which of the following? Select all that apply.
Hypertonia
Hypotonia
Flaccid paralysis
Spastic paralysis
Spinal cord lesions to UMNs will result in which of the following? Select all that apply.
Hypertonia
Hypotonia
Flaccid paralysis
Spastic paralysis
Hyperreflexia
Most patients develop unilateral optic neuritis with visual deficits in (a) . This is the most common presentation. Neuroimaging shows demylination of the axon.
During an acute meningitis infection, a patient's lab values would consist of decreased glucose levels due to which of the following?
Increased levels of viral load within the cerebrospinal fluid
increased cellular respiration occurring due to the presence of bacteria.
possible decrease in glucose transportation into the CSF due to the mechanisms being impaired by the inflammation.
there is an increased uptake of glucose from the CSF by the glial cells
Neuroimaging was performed for a patient with suspected encephalitis. Visible inflammation of the temporal lobe was noted. Which of the following is most likely the causative agent?
Herpes Simplex
Rabies
Poliomyelitis
HIV
Which of the following soil fungi is worrisome due to its ability to cause infection and destroy healthy tissue? The infection starts in the sinuses and erodes through the bone and tissue.
Candida
Cryptococcus
Blastomyocytes
Histoplasma
Mucor
An action potential that's propagated down a nerve fiber with an increased diameter would have _____(1)_____ internal resistance which means _________ conduction.
(1)Decreased, (2)Faster
(1)Decreased, (2)Slower
(1)Increased, (2)Faster
(1)Increased, (2)Slower
Which of the following cell types is responsible for the myelination of neurons in the central nervous system?
Astrocytes
Oligodendrocytes
Schwann cells
Microglial cells
Which of the following cell types is responsible for the myelination of neurons in the peripheral nervous system?
Astrocytes
Oligodendrocytes
Schwann cells
Microglial cells
Which of the following cell types are specialized macrophages within the central nervous system?
Astrocytes
Oligodendrocytes
Schwann cells
Microglial cells
Which of the following cell types is responsible for:
1. Creating tight junctions to control the permeability of the blood-brain barrier
2. Removing excess neurotransmitter (glutamate) from synapses
3. Removes excess K to avoid interference with the action potential
Astrocytes
Oligodendrocytes
Schwann cells
Microglial cells
Which of the following cells lines the ventricles and responsible for the secretion of CSF?
Microglial cells
Astrocytes
Ependymal cells
Schwann Cells
Oligodendrocytes
Which of the following is not a component of the CSF?
Protein
Glucose
Red blood cells
Sodium
T/F: Gray matter is composed of nerve cell bodies while white matter is composed of myelinated nerve bundles.
True
False
Which of the following is NOT a nuclei within the basal ganglia?
caudate nucleus
substantia nigra
putamen
globus pallidus
hypothalamus
The frontal lobe is mostly responsible for ____________.
Intellect and personality
Speech
Motor functions
Vision
Memory
An infarct that affects__________ area leads to nonaffluent aphasia where the patient understands the conversation but can't find the proper words to relay their message.
Broca's
Wernicke's
"Hello Bill! How are you feeling today?"
"Well the water fountains are looking pretty nice and the cats need to fly to San Francisco."
This is an example of:
Wernicke's Aphasia
Broca's Aphasia
