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WorksheetsBiochemical synthesis 2
Total questions: 17
Worksheet time: 6mins
Which of the following is NOT a function of cholesterol?
Generation of energy
Components of cell membranes
Synthesis of bile acids
Synthesis of vitamin D
Which of the following is correct about cholesterol biosynthesis
Acetyl CoA that is used as precursor mainly originates from fatty acid oxidation
Biosynthesis is inhibited when ATP levels are low
It is only synthesised in the liver
The regulatory enzyme is acetyl CoA carboxylase
The hypocholesterolaemic drug, statins, can
inhibit cholesterol absorption from the intestine
inhibit HMG CoA synthase
increase cholesterol-rich lipoprotein clearance from the circulation
increase conversion of cholesterol to bile acids
The pentose phosphate pathway
Requires ATP
Requires NADPH
Generates NADH
Generates ribose 5-phosphate
The pentose phosphate pathway is active in the fasting state
True
False
Which of the following pathways requires NADPH?
Beta oxidation
Glycolysis
Synthesis of fatty acids
Synthesis of triglycerides
Which of the following are the final products of the non-oxidative phase of the pentose phosphate pathway?
Fructose 6-phosphate and erythrose 4-phosphate
Fructose 6-phosphate and glyceraldehyde 3-phosphate
Glyceraldehyde 3-phosphate and fructose 1-phosphate
Xylulose 5-phosphate and ribose 5-phosphate
The major products of the pentose phosphate pathway are
Ribulose and NADPH
Ribulose and NADH
Ribulose and NAD+
Ribulose and ATP
Which of the following statements is correct about the oxidative phase of the pentose phosphate pathway?
It generates fructose 6-phosphate
It oxidizes NADPH to NADP+
It produces ribose 5-phosphate and NADPH
Glucose 6-phosphatase catalyzes the rate limiting reaction of the pathway
Which of the following statements is correct about the pentose phosphate pathway?
It uses transaldolase and transketolase in the non-oxidative phase
It generates 38 moles of ATP per mole of glucose consumed
It is a reductive pathway that consumes NADH
It is present in plants but not in animals
NADPH is used by most cells as
a substrate for the electron transport chain
a reducing agent in detoxification reactions
an oxidizing agent in reductive biosynthesis
a substrate for transketolase reactions
A patient has hemolytic anaemia due to consumption of fava beans. She has a deficiency of the enzyme ______________ and would not be able to synthesize enough ________
Glucose 6-P dehydrogenase; oxidized glutathione
Glucose 6-P dehydrogenase; NADPH
6-Phosphogluconate dehydrogenase; reduced glutathione
6-Phosphogluconate dehydrogenase; NADH
Which of the following is a function of glutathione?
It is an antioxidant
It helps recycle NADP+ to NADPH
It promotes formation of Heinz bodies
All of the following enzymes/metabolites are found in the pathway for neutralization of H2O2, EXCEPT:
NADP+
Glutathione peroxidase
Reduced glutathione
Glucose 6-phosphate dehydrogenase
Almost all tissues can synthesise cholesterol
True
False
Free cholesterol is normally found as
Components of cell membrane
Components of triglycerides
Storage form in adipose tissue
Which of the following is required for cholesterol synthesis?
Acetyl CoA, NADH
ATP, NADPH
CO2, NAD+
O2, FADH2
