These undergo spontaneous radioactive decay accompanied by the release of energy

Drug products that contain radioactive elements and are used for diagnostic or therapeutic effects

The amount of time needed to decay 50% of its original mass

The amount of time required for the body to eliminate one half of the administered dose

Which is the fundamental unit of radioactivity?

Which is the international unit of radioactivity?

What are the diagnostic and therapeutic roles of radiopharmaceuticals?

Which type of radiation consists of 2 protons and 1 neutron; most particles are unable to pierce the skin or penetrate a thin piece of paper and not useful in medical imaging?

Which type of radiation is either positively or negatively charged electrons and is not useful in medical imaging?

Which type of radiation uses electromagnetic vibrations of shorter wavelength, are very penetrating, and are easily detected and converted into imaging data?

Which type of radiation is used for diagnostic radiography and crystallography?

What is the international unit of radiation absorbed dose?

Formulated to be placed within a target organ; following oral administration is taken by thyroid cells

Evaluate patient's response to drug therapy and surgery (perfusion lung imaging), help monitor drug therapy (used to determine risk of doxorubicin therapy)

Most commonly used radionuclide in diagnostic imaging, half life is 6 hours and gamma emission is of the nature of 140keV, efficiently detected by the gamma camera

Radionuclide which gets deposited in the thyroid gland and is used for hyperthyroidism; emits both radiations, gamma rays (used diagnostically) and beta rays (used therapeutically)

No other technology can image body chemistry with such sensitivity, such that moment to moment change in concentration of a tracer in a blood or tissue can be determined in absolute units

Based on the portrayal of the distribution of attenuation of x-rays passing through the body

Visualizes the structure and function of the body without ionizing radiation, but uses a powerful magnetic field to align the magnetization of hydrogen atoms in the body

There are 6 techniques used to produce biotechnology products: recombinant DNA, monoclonal antibodies, PCR, gene therapy, nucleotide blockage/antisense, and peptide technology.

Glycoproteins which stimulate red blood cell production:

A humanized IgGI kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein, HER2.

This inhalation solution is a sterile, clear, highly purified solution of rhDNase, an enzyme which selectively cleaves DNA; used to improve breathing and reduce the risk of lung infections in people with cystic fibrosis, protein is produced by genetically engineered Chinese hamster ovary (CHO) cells containing DNA encoding for human proteins DNase.

Advantages of therapeutic nanoparticles: solubility of poorly soluble drugs is worsened

Advantages of therapeutic nanoparticles: reducing immunogenicity

Advantages of therapeutic nanoparticles: prolongation of a drug's systemic circulation

Advantages of therapeutic nanoparticles: release of drug sustained

Advantages of therapeutic nanoparticles: administration frequency increased

Advantages of therapeutic nanoparticles: targeted delivery minimizes systemic effects

Advantages of therapeutic nanoparticles: deliver two or more drugs at the same time

Advantages of therapeutic nanoparticles: different go in combination-synergistic effect

______ encapsulate the protein-based compound in a liquid complex-combination of phosphattidycholine, cholesterol, phosphatidylglycerol, other glycolipids, phospholipids

What are the advantages of pegylation?

In general, should biotech products be frozen?

An example of a delayed-release system would be?

A window of ________ of half life may be used for the ER delivery systems

The most widely used measure of margin of safety is ________________

What equation is this?

Pumps made of biocompatible and long-lasting titanium can be implanted how?

What is an example of a swelling system?

This is used in transdermal delivery and is facilitated movement of the ions across a membrane under the influence of externally applied field.

Which colloidal drug carrier is not suitable for administration by IV injection?

Which colloidal drug carrier is: vesicles made of non-ionic surfactants, prepared by similar techniques as used for liposomes?

What is the limiting step in colloidal drug carriers?

Antibody directed at a tumor-associated antigen to vector an enzyme to tumor sites (nontoxic prodrug)

The gene encoding of the prodrug-activating enzyme is used

___________ of the drug in erythrocytes occurs by hypo-osmotic lysis, electrical breakdown, endocytosis, membrane perturbation with amphotericin B and lipid fusion.

_________ are used to increase the residence time for the drug at the mucosal site.