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Spring 21 PODA 2 Dr Mo Discussion Questions Final

Total questions: 56

Worksheet time: 40mins

Name
Class
Date
1.

WOTF is least likely to be observes as a PCOL action/effect of T3

a)

Increased prod of insulin

b)

Increased prod of bile acid

c)

Decrease in number of LDL receptors

d)

Gluconeogenesis

e)

Hemorrhagic episodes

2.

WOTF would increase the production of thyrotropin (thyrogen) from the anterior pituitary gland?

a)

Tirosint

b)

Protirelin

c)

Thyrogen- brand name of thyrotropin (TSH) is TSH itself

d)

Levothyroxine

e)

Liotrix

3.

WOTF will result in an increase in the effectiveness of synthroid? Concurrent admin of synthroid and

a)

Tamoxifen

b)

Furosemide

c)

Aspirin

d)

Carafate

e)

Calcium Gluconate

4.

WOTF is a pregnane progestin that is beneficial in the mgmt of cachexia?

a)

Provera

b)

Amen

c)

Megace

d)

Zytrin

e)

Micronor

5.

ADME of progestins: A pt is getting a subdermal administration of a progestin and the dosage that has been administered subdermally is a total of 216 mg. WOTF progesting products was the pt receiving?

a)

Endometrin

b)

Crinone

c)

Implanon

d)

Norplant

6.

Activation/Stimulation of PRA (is inhibitory and will affect PRB) will result in the repression of WOTF target genes?

a)

Estrogen

b)

Cortisol

c)

Florinef

d)

Aldosterone

e)

Progesterone

7.

AntiAndrogens: WOTF will produce its antiandrogenic effect by inhibiting 5alfa reductase?

a)

Dutasteride

b)

Bicalutamide

c)

Apalutamide

d)

Goserelin

e)

Abarelix

8.

WOTF above works competitively by inhibiting the androgen receptor site?

a)

Bicalutamide

b)

Apalutamide

9.

WOTF above will inhibit gonadotropins

a)

Abrelix

b)

Goserelin

10.

WOTF is effective in the management of dyspareunia in post menopausal pts

a)

Osphena

b)

Intrarosa

c)

Prastrone

d)

DHEA (Dehydroepiandrosterone)

e)

Femara

11.

Thyroid storm can result from which of the following situations

a)

DKA

b)

Stress

c)

Treatment with i131

d)

Severe infections

e)

Labor

12.

The medical team should consider changing therapy with a thioamide if WOTF occurs

a)

Goiter

b)

Cretinism

c)

Right Upper Quadrant pain

d)

Rash or Dermatitis

e)

Fever or Sore throat

13.

WOTF is least likely to be observed as an effect of levothyroxine on the CV system?

a)

Hypertension

b)

Increase in cardiac output

c)

Vasodilation

d)

Bradycardia

e)

Enlargement of the cardiac muscle

14.

WOTF has been shown to be beneficial in the management of cachexia in AIDS pts/ WOTF can promote weight gain in AIDS?

a)

Megace

b)

Oxandrin

c)

Danazole

d)

Estradiol

e)

Dutsteride

15.

What is the defect in Turner’s syndrome patients?

a)

Chromosomal disorder where the pt only has 1 X chromosome

b)

Xxy chromosomes

16.

What is the defect in a Kline-Fleter’s pt?

a)

Xxy chromosomes

b)

Chromosomal disorder where the pt only has 1 X chromosome

17.

What would you recommend for managing a Kline-Fleter’s pt?

a)

Thyroid Replacement Theray

b)

Testosterone Replacement Therapy

c)

Estrogen Replacement Therapy

18.

How does Grave’s disease differ from Plummer’s disease?

4 lines
19.

How do Grave’s and Plummer differ from Jod- Basedow phenomenon

4 lines
20.

Natesto preferred site of administration

a)

Nasal

b)

Buccal tab

c)

Thighs

d)

Under arm

e)

Shoulder and upper arm

21.

Striant preferred site of administration

a)

Nasal

b)

Buccal tab

c)

Thighs

d)

Under arm

e)

Shoulder and upper arm

22.

Fortesta preferred site of administration

a)

Nasal

b)

Buccal tab

c)

Thighs

d)

Under arm

e)

Shoulder and upper arm

23.

Axiron preferred site of administration

a)

Nasal

b)

Buccal tab

c)

Thighs

d)

Under arm

e)

Shoulder and upper arm

24.

Testim gel preferred site of administration

a)

Nasal

b)

Buccal tab

c)

Thighs

d)

Under arm

e)

Shoulder and upper arm

25.

Testoderm TTS preferred site of administration

a)

Nasal

b)

Scrotal skin

c)

Thighs

d)

Under arm

e)

Shoulder and upper arm

26.

Android (methyltestosterone product) preferred site of administration

a)

Nasal

b)

Scrotal skin

c)

Thighs

d)

Under arm

e)

Oral tablet

27.

Divigel preferred site of administration

a)

Nasal

b)

Scrotal skin

c)

Thigh

d)

Under arm

e)

Oral tablet

28.

Estrasorb preferred site of administration

a)

Nasal

b)

Legs

c)

Thigh

d)

Under arm

e)

Oral tablet

29.

Elestrin preferred site of administration

a)

Nasal

b)

Legs

c)

Thigh

d)

Upper arm

e)

Oral tablet

30.

WOTF would you apply bi-weekly

a)

Orthoevra

b)

Fempatch

c)

Minivelle

d)

Estraderm

e)

Alora

31.

WOTF would be consistent with Iodinism

a)

Brassy taste

b)

Dry mouth (xerostomia) excessive salivation (sialosis)

c)

Acne

d)

Soreness of the teeth and gums

e)

Productive cough

32.

WOTF has been shown to be beneficial in the management of fibrocystic breast disorder/disease

a)

Combo Oral Contraceptives

b)

Danocrine

c)

Testosterone

d)

Decabolin

e)

Ecallantide

33.

WOTF is considered to be a benefit of using COCs?

a)

Decreased chance of iron deficiency anemia

b)

Enlargement of a pre-existing uterine fibroid ← Caution: COCs may cause enlargement of existing uterine fibroid

c)

Regulation of menstruation

d)

Management of fibrocystic breast disease

e)

Decrease in the occurrence of ovarian cysts

34.

The elimination of menstruation may be beneficial in the mangent in which of the following?

a)

Iron deficiency anemia

b)

Painful menstruation (menorrhagia - dysmenorrhea)

c)

Migraine headaches

d)

Epilepsy

e)

Endometriosis

35.

What is one product that will cause elimination of menstruation in one year?

a)

Amethyst

b)

Yaz

c)

Yasmin

d)

Slynd

36.

WOTF is a cautionary statement that you would give to a patient who is starting off on a COC

a)

The COC may cause folic acid deficiency

b)

The COC may cause photosensitivity

c)

Fluid retention may occur during therapy with COC

d)

There may be a deficiency of VitB1

e)

Vomiting and diarrhea may result in a result in a failure of the oral contraceptive

37.

hich vitamin will be deficient in COC administration

a)

Vit B1

b)

Vit B6

c)

Vit B12

d)

Vit B9

38.

Absence of Pyridoxine (B6) may lead to what?

a)

Insomnia

b)

Pruritis

c)

Depression

d)

Ricketts

39.

WOTF may result in a failure of contraception (may decrease the effectiveness of oral contraceptives)

a)

Adenovir

b)

Amprenavir

c)

Phenobarbital

d)

Dilantin

e)

Rifampin

40.

WOTF will be effective in the management of Hypoactive Sexual Desire Disorder

a)

Estradiol

b)

Addyi

c)

Vyleesi

d)

Testosterone

e)

Clomid

41.

WOTF is least likely to be classified as a gonane progestin

a)

Norgestimate

b)

Levonorgestrel

c)

Desogestrel

d)

Norethindrone

42.

WOTF statements is consistent with Hashimoto’s thyroiditis

a)

An autoimmune disease

b)

High rate of incidence in pts Down Syndrome

c)

High rate of incidence in pts Turner’s Syndrome

d)

Coexistence with diabetes mellitus or Addison’s disease

e)

High rate of incidence in pts with Kline-Felter’s Syndrome

43.

WOTF can be used for the mgmt of hypoparathyroidism?

a)

Paricalcitol

b)

Drisdol

c)

Natpara

d)

Calcijex

e)

Hytakerol

44.

WOTF is least likely to be observed as an adverse effect of abaloparatide?

a)

Nausea and Headaches

b)

Abdominal pain

c)

Hypocalciuria

d)

Fatigue

e)

Palpitations

45.

The MOA of Evenity (romosozumab) involves WOTF

a)

Inhibition of the WNT pathway (signaling pathway)

b)

Inhibition of bone formation

c)

Inhibition of resorption

d)

Stimulation of Sclerostin production by osteoclasts

e)

Increased translocation of betacatone into the nucleus of osteoblasts

46.

Secelt the correctly matched cell to the secretion

a)

IL1 and 6 = osteoclasts

b)

RNKL (same as ODF) = Osteoblast

c)

OPG= osteoclast

d)

Sclerostin= Osteocytes

e)

RANK= osteoblast

47.

WOTF is classified as a SERM?

a)

Evista

b)

Nolvadex

c)

Fareston

d)

Viviant

e)

Osphena

48.

WOTF statements about Evista true?

a)

Administered QD

b)

Primarily excreted through feces

c)

Has a long t1/2 27-30 hours

d)

Undergoes extensive 1st pass metabolism

e)

Renal excretion has a linear relationship to CrCl

49.

Usual dosage for Evista?

a)

60 mg PO QD

b)

5 mg PO QD

c)

30 mg PO QD

d)

60 mg PO BID

50.

What are the indications of Duavee?

a)

Vasomotor symptoms

b)

Osteoporosis

c)

Dysparenua

d)

HSDD

51.

WOTF can be observed as an adverse effect of Evista?

a)

Flu like syndrome

b)

Leukorrhea

c)

Chest pain

d)

Increased risk of respiratory infection

e)

Flatulence, NVM

52.

WOTF should caution be exercised before instituting therapy with Prolia?

a)

Hypercholesterolemia

b)

Pre-existing hypocalcemia

c)

Hypocalcemic Tetany

d)

In the presence of bone loss

e)

In the presence of glucocorticoid induced osteoporosis

53.

WOTF drugs can produce jaw necrosis as an adverse effect?

a)

Prolia

b)

Actonel

c)

Fosamax

d)

Xgeva

e)

Evista

54.

Match the MOA

a)

Forteo (teriparatide) = Inhibits RANKL

b)

Calcitrate = supplement of Calcium mineral

c)

Denosumab = PTH supplementation increasing Calcium, promote actions of osteoblast

d)

Risedronate = Prevents synthesis of isoprenoid lipids, inhibits farneyl lipids, inhibits osteoclast functions

55.

WOTF bisphosphonates can be administered both enterally and parenterally?

a)

Aredia

b)

Skelid

c)

Didronel

d)

Reclast

e)

Boniva

56.

What do you counsel patient on when dispensing Actonel

a)

Do not lay down for 30 min

b)

Take on empty stomach

c)

No food or drink for 30 min

d)

Take with full glass of water

e)

Do not crush or chew tablet, swallow whole

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