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WorksheetsGASTRORETENTIVE DRUG DELIVERY SYSTEM
Total questions: 15
Worksheet time: 8mins
Criteria for selection of drug candidate for GRDF includes:
Drugs that degrade in colon
Narrow absorption window in GI tract
Locally active in the stomach
All the above
------------- is the most noticeable disadvantage of gastro retentive floating drug delivery systems.
Requirement of high level of fluids in the stomach
Delay in release
Absorption of acid soluble drugs
Vigorous intestinal movements
To increase the gastric residence time, the following approach is not applicable.
High density system
Floating system
Compressible system
Bioadhesive system
The superporous hydrogel, having an average pore size of:-
> 100 micron
10 micron
10 nm
<100 micron
FDDS or hydrodynamically balanced systems have a bulk density
Higher than gastric fluids
Lower than gastric fluids
Similar to gastric fluids
Higher than water
---------- system is an example of floating drug delivery system.
Effervescent system
Non-effervescent system
Raft forming system
All the above
Which of the following polymer is gel-forming or highly swellable cellulose type:
Polystyrene
Polycarbonate
Hydrocolloids
Polyacrylate
Which of the following is not a hydrocolloid?
HEC
HPC
HPMC
CAT
----------- are prepared by dropping sodium alginate solution into aqueous solution of calcium carbonate
Alginate beads
Alginate microballons
Alginate superporous gel
None of the above
Hollow microspheres are also known as:
Microbeads
Microballons
Floating beads
bioadhesive beads
In high density systems, ---------- is added to increase density by up to 1.5-2.4 gm/cc.
Barium Sulphate
Iron powder
Zinc oxide
All the above
Which of the following GRDDS system is also known as "plug type system"?
Bioadhesive system
Floating system
Swelling system
Effervescent system
------------ is the effervescent agent used to formulate low density system of GRDDS.
Dicalcium phosphate
Citric acid
Lactose
Mannitol
The time taken by the dosage form to float on top of dissolution medium, after it is placed in the medium is termed as:
Floating lag time
Floating time
Transit time
None of the above
GRDDS is evaluated by:
X-Ray/ Gamma scintigraphy
Surface characterization
Swelling study
All the above
