WorksheetsExam 2 - Austin
Total questions: 25
Worksheet time: 14mins
What is pharmacokinetics
what the body does to the drug
what the drug does to the body
What is pharmacodynamics
what the body does to the drug
what the drug does to the body
What does the A in ADME stand for
absorption
activity
association
abuse
What does the D in ADME stand for
distribution
drug
delivery
dope
What does the M in ADME stand for
metabolism
mediation
medicine
medicinal
What does the E in ADME stand for
elimination
excess
effective
ecstasy
When does drug interactions occur
Absorption
Distribution
Metabolism
Elimination
What describes the semipermeable lipid bilayer
hydrophobic core
small, lipophilic molecules
hydrophilic core
large, lipophilic molecules
What do carrier proteins do
facilitate transport across the membrane
block the transport through the membrane
facilitate transport around the body
What type of barriers are present in the blood-brain barrier (BBB)
endothelial tight junctions
astrocyte projections
transport vesicles
intracellular space
What is the equation for bioavailability
F = amount of drug that reaches circulation / amount of drug that is administered
F = amount of drug that is administered / amount of drug that reaches circulation
If there is a significant effect on drug concentration vs time, what does that effect
efficacy
toxicity
absorption
administration
What is the equation for volume of distribution
v = drug absorbed / plasma concentration
v = plasma concentration / drug absorbed
What are the different types of metabolism-based drug interactions
inhibition
induction
competition
Select all the types of agonists
full
partial
inverse
competitive
noncompetitive
Select all the types of antagonists
uncompetitive
physiological
inverse
competitive
noncompetitive
What is intrinsic efficacy based on
max response to ligand
min response to ligand
What is potency
drug concentration that produces half-maximal effect
drug concentration that produces full maxmimal effect
drug concentration that produces minimal effect
The greater the potency
the smaller the dose at which EC50 occurs
the larger the dose at which EC50 occurs
What is ED50
effective dose for half of a population
concentration of 50% max effect
maximum plasma concentration and time it is reached
range of doses that produces desired effect without unacceptable adverse effects in a population
What is TD50/LD50
toxic/lethal dose for half of a population
TD50/ED50 or MTC/MEC
maximum plasma concentration and time it is reached
range of doses that produces desired effect without unacceptable adverse effects in a population
What is Cmax/Tmax
area under the curve; assessment of exposure to drug
TD50/ED50 or MTC/MEC
maximum plasma concentration and time it is reached
range of doses that produces desired effect without unacceptable adverse effects in a population
What is Therapeutic window
area under the curve; assessment of exposure to drug
TD50/ED50 or MTC/MEC
maximum plasma concentration and time it is reached
range of doses that produces desired effect without unacceptable adverse effects in a population
What is Therapeutic index
area under the curve; assessment of exposure to drug
TD50/ED50 or MTC/MEC
maximum plasma concentration and time it is reached
range of doses that produces desired effect without unacceptable adverse effects in a population
What is AUC
area under the curve; assessment of exposure to drug
TD50/ED50 or MTC/MEC
maximum plasma concentration and time it is reached
range of doses that produces desired effect without unacceptable adverse effects in a population
