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Adv cell bio L05 L6 L07

Total questions: 10

Worksheet time: 6mins

Name
Class
Date
1.

Which of the following is an eg of g protein coupled receptor?

a)

Insulin receptor

b)

Adrenergic Receptor

c)

EGFR

d)

Calcium gated channel

2.

Which of the following is an eg of receptor tyrosine kinase? you can pick > 1 ans

a)

Insulin receptor

b)

Adrenergic Receptor

c)

EGFR

d)

Calcium gated channel

3.

Gαs stimulates adenylyl cyclase (AC) and increases cyclic AMP (cAMP) levels.

True or false?

a)

True

b)

False

4.

Gαi family members activate phospholipase C (PLC), which cleaves phosphatidylinositol bisphosphate (PIP2) into diacylglycerol and inositol triphosphate (IP3). True or False

a)

False

b)

True

5.

RTKs have how many transmembrane domain?

a)

1

b)

3

c)

5

d)

7

6.

For RTKs, cis-autoinhibition occurs when ____?

a)

ligand binds to RTK

b)

there is no ligand

c)

when g protein is active

7.

Which domains bind to RTKs after ligand binding? you can pick > 1 ans

a)

SH2 domain

b)

PTB domain

c)

ATP domain

8.

activation of PLC by GPCRs to generate the two second messengers, which are? you can pick > 1 ans

a)

cAMP

b)

DAG

c)

IP3

d)

PIP2

9.

most common calcium-binding motifs are? you can pick > 1 ans

a)

EF hands

b)

C2 domain

c)

SH2 domain

d)

ATP domain

10.

Phosphorylation adds a phosphate group to ______, threonine, and tyrosine residues in a protein, changing their shapes, and activating or inactivating the protein

a)

Serine

b)

glycine

c)

alanine

d)

cysteine