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WorksheetsAUBF MODULE 7 AND 8 QUIZ
Total questions: 87
Worksheet time: 1hrs 6mins
Which of the following statements about renal diseases is true?
Glomerular renal diseases are usually immune mediated (caused by antibody).
Vascular disorders induce renal disease by increasing renal perfusion.
All structural components of the kidney are equally susceptible to disease.
Tubulointerstitial renal diseases usually result from antibody-antigen and complement interactions.
In glomerular diseases, morphologic changes in the glomeruli include all of the following except
cellular proliferation
erythrocyte congestion
leukocyte infiltration
glomerular basement membrane thickening
In glomerular renal disease, glomerular damage results from
deposition of infectious agents
a decrease in glomerular perfusion
changes in glomerular hemodynamics
toxic substances induced by immune complex formation.
Clinical features that are characteristic of glomerular damage include all of the following except
edema
hematuria
proteinuria
polyuria
Which of the following disorders frequently occurs following a bacterial infection of the skin or throat?
Acute glomerulonephritis
Chronic glomerulonephritis
Membranous glomerulonephritis
Rapidly progressive glomerulonephritis
Which of the following disorders is characterized by cellular proliferation into Bowman’s space to form cellular “crescents”?
Chronic glomerulonephritis
Membranous glomerulonephritis
Minimal change disease
Rapidly progressive glomerulonephritis
Which of the following disorders is the major cause of the nephrotic syndrome in adults?
IgA nephropathy
Membranoproliferative glomerulonephritis
Membranous glomerulonephritis
Rapidly progressive glomerulonephritis
Which of the following glomerular diseases is the major cause of the nephrotic syndrome in children?
IgA nephropathy
Minimal change disease
Membranous glomerulonephritis
Rapidly progressive glomerulonephritis
Which of the following statements regarding IgA nephropathy is true?
It often follows a mucosal infection.
It is associated with the nephrotic syndrome.
It is characterized by leukocyte infiltration of the glomeruli.
It often occurs secondary to systemic lupus erythematosus.
Eighty percent of patients who develop chronic glomerulonephritis previously had some type of glomerular disease. Which of the following disorders is implicated most frequently in the development of chronic glomerulonephritis?
IgA nephropathy
Membranous glomerulonephritis
Poststreptococcal glomerulonephritis
Rapidly progressive glomerulonephritis
Chronic renal failure often develops in each of the following diseases except
amyloidosis
diabetes mellitus.
diabetes insipidus
systemic lupus erythematosus
Which of the following features characterize the
nephrotic syndrome?
1. Proteinuria
2. Edema
3. Hypoalbuminemia
4. Hyperlipidemia
1, 2, and 3 are correct
1 and 3 are correct
Only 4 is correct
All are correct
When a patient has the nephrotic syndrome, microscopic examination of their urine sediment often reveals
granular casts
leukocyte casts
red blood cell casts
waxy casts
Which of the following has not been associated with acute tubular necrosis?
Antibiotics
Galactosuria
Hemoglobinuria
Surgical procedures
Which formed element in urine sediment is characteristic of toxic acute tubular necrosis and aids in its differentiation from ischemic acute tubular necrosis?
Collecting tubular cells
Granular casts
Proximal tubular cells
Waxy casts
Which of the following disorders is characterized by the urinary excretion of large amounts of arginine, cystine, lysine, and ornithine?
Cystinosis
Cystinuria
Lysinuria
Tyrosinuria
Generalized loss of proximal tubular function is a characteristic of
Fanconi’s syndrome
nephrotic syndrome
renal glucosuria
renal tubular acidosis
Which of the following changes is not associated with renal tubular acidosis?
Decreased glomerular filtration rate
Decreased renal tubular secretion of hydrogen ions
Decreased proximal tubular reabsorption of bicarbonate
Increased back-diffusion of hydrogen ions in the distal tubules
Which of the following disorders is considered a lower urinary tract infection?
Cystitis
Glomerulonephritis
Pyelitis
Pyelonephritis
Most urinary tract infections are caused by
yeast, such as Candida spp.
gram-negative rods.
gram-positive rods
gram-positive cocci
Which of the following formed elements when present in urine sediment is most indicative of an upper urinary tract infection?
Bacteria
Casts
Erythrocytes
Leukocytes
The most common cause of chronic pyelonephritis is
cystitis
bacterial sepsis
drug-induced nephropathies
reflux nephropathies
Eosinophiluria, fever, and skin rash are characteristic clinical features of
acute pyelonephritis
acute interstitial nephritis
acute glomerulonephritis
chronic glomerulonephritis
Cessation of the administration of a drug is the fastest and most effective treatment for
acute pyelonephritis
acute interstitial nephritis
acute glomerulonephritis
chronic glomerulonephritis
Yeast is considered part of the normal flora in each of the following locations except in the
gastrointestinal tract
oral cavity
urinary tract
vagina
Acute renal failure can be caused by all of the following except
hemorrhage
acute tubular necrosis
acute pyelonephritis
urinary tract obstruction
Which of the following statements about chronic renal failure is true?
It can be reversed by appropriate treatment regimens
It eventually progresses to end-stage renal disease
It is monitored by periodic determinations of renal blood flow
Its onset involves a sudden decrease in the glomerular filtration rate
Isosthenuria, significant proteinuria, and numerous casts of all types describes the urinalysis findings from a patient with
acute renal failure
acute tubular necrosis
chronic renal failure
renal tubular acidosis
Approximately 75% of the renal calculi that form in patients contain
calcium
cystine
oxalate
uric acid
The formation of renal calculi is enhanced by
an increase in urine flow
the natural “acid-alkaline tide” of the body
increases in protein in the urine ultrafiltrate
increases in chemical salts in the urine ultrafiltrate
An overflow mechanism is responsible for the aminoaciduria present
cystinosis
cystinuria
tyrosinuria
phenylketonuria
Which of the following hereditary diseases results in the accumulation and excretion of large amounts of homogentisic acid?
Alkaptonuria
Melanuria
Phenylketonuria
Tyrosinuria
Which of the following substances oxidizes with exposure to air, causing the urine to turn brown or black?
Melanin
Porphyrin
Tyrosine
Urobilinogen
Which of the following diseases is related to tyrosine production or metabolism?
1. Tyrosinuria
2. Melanuria
3. Phenylketonuria
4. Alkaptonuria
1, 2, and 3 are correct
1 and 3 are correct
4 is correct
All are correct
Which of the following diseases can result in severe mental retardation if not detected and treated in the infant?
1. Phenylketonuria
2. Maple syrup urine disease
3. Galactosuria
4. Alkaptonuria
1, 2, and 3 are correct
1 and 3 are correct
4 is correct
All are correct
Which of the following is a characteristic feature of type 2 diabetes mellitus?
Daily insulin injections are necessary.
Onset of the disease is usually sudden
Strong tendency to develop ketoacidosis
The disease usually presents after 40 years of age
Which of the following abnormalities is not a clinical feature of an infant with galactosuria?
Cataract formation
Liver dysfunction
Mental retardation
Polyuria
Galactose is produced in the normal metabolism of
fructose
glucose
lactose
sucrose
Which of the following features is not a characteristic of diabetes insipidus?
Polyuria
Polydipsia
Increased production of antidiuretic hormone
Urine with a low specific gravity
Porphyria is characterized by
increased heme degradation.
increased heme formation
decreased globin synthesis
decreased iron catabolism.
Which of the following statements regarding porphyrin and porphyrin precursors is true?
1. Porphyria can be inherited or induced.
2. Porphyrin precursors are neurotoxins.
3. Porphyrins can be dark red or purple.
4. Porphyrin precursor accumulation causes
skin photosensitivity
1, 2, and 3 are correct
1 and 3 are correct
4 is correct
All are correct
Most glomerular disorders are caused by
Sudden drops in blood pressure
Immunologic disorders
Exposure to toxic substances
Bacterial infections
Dysmorphic RBC casts would be a significant finding with all of the following except:
Goodpasture syndrome
Acute glomerulonephritis
Chronic pyelonephritis
Henoch-Schönlein purpura
Occasional episodes of macroscopic hematuria over periods of 20 or more years are seen with:
Crescentic glomerulonephritis
IgA nephropathy
Nephrotic syndrome
Wegener granulomatosis
Antiglomerular basement membrane antibody is seen with:
Wegener granulomatosis
IgA nephropathy
Goodpasture syndrome
Diabetic nephropathy
Antineutrophilic cytoplasmic antibody is diagnostic for:
IgA nephropathy
Wegener granulomatosis
Henoch-Schönlein purpura
Goodpasture syndrome
Respiratory and renal symptoms are associated with all of the following except:
IgA nephropathy
Wegener granulomatosis
Henoch-Schönlein purpura
Goodpasture syndrome
The presence of fatty casts is associated with all of the following except:
Nephrotic syndrome
Focal segmental glomerulosclerosis
Nephrogenic diabetes insipidus
Minimal change disease
The highest levels of proteinuria are seen with:
Alport syndrome
Diabetic nephropathy
IgA nephropathy
Nephrotic syndrome
Ischemia frequently produces:
Acute renal tubular necrosis
Minimal change disorder
Renal glycosuria
Goodpasture’s syndrome
A disorder associated with polyuria and low specific gravity is:
Renal glucosuria
Minimal change disease
Nephrogenic diabetes insipidus
Focal segmental glomerulosclerosis
An inherited disorder producing a generalized defect in tubular reabsorption is:
Alport syndrome
Acute interstitial nephritis
Fanconi syndrome
Renal glycosuria
A teenage boy who develops gout in his big toe and has a high serum uric acid should be monitored for
Fanconi syndrome
Renal calculi
Uromodulin-associated kidney disease
Chronic interstitial nephritis
The only protein produced by the kidney is:
Albumin
Uromodulin
Uroprotein
Globulin
The presence of renal tubular epithelial cells and casts is an indication of
Acute interstitial nephritis
Chronic glomerulonephritis
Minimal change disease
Acute tubular necrosis
Differentiation between cystitis and pyelonephritis is aided by the presence of:
WBC casts
RBC casts
Bacteria
Granular casts
The presence of WBCs and WBC casts with no bacteria is indicative of:
Chronic pyelonephritis
Acute tubular necrosis
Acute interstitial nephritis
None of the given choices
End-stage renal disease is characterized by all of the following except:
Hypersthenuria
Isosthenuria
Azotemia
Electrolyte imbalance
Prerenal acute renal failure could be caused by
Massive hemorrhage
Acute tubular necrosis
Acute interstitial nephritis
Malignant tumors
The most common composition of renal calculi is
Calcium oxalate
Magnesium ammonium phosphate
Cystine
Uric acid
Urinalysis on a patient with severe back pain being evaluated for renal calculi would be most beneficial if it
showed:
Heavy proteinuria
Low specific gravity
Uric acid crystals
Microscopic hematuria
Newborn screening is required for PKU for early:
Modifications of diet
Administration of antibiotics
Detection of diabetes
Initiation of gene therapy
All of the following disorders can be detected by newborn
screening except
Tyrosyluria
Maple Syrup Urine Disease
Melanuria
Galactosemia
The best specimen for early newborn screening is a:
Timed urine specimen
Blood specimen
First morning urine specimen
Fecal specimen
Abnormal urine screening tests categorized as an overflow disorder include all of the following except:
Alkaptonuria
Galactosemia
Melanuria
Cystinuria
Which of the following disorders is not associated with the phenylalanine-tyrosine pathway?
MSUD
Alkaptonuria
Albinism
Tyrosinemia
The least serious form of tyrosylemia is:
Immature liver function
Type 1
Type 2
Type 3
An overflow disorder of the phenylalanine-tyrosine pathway that would produce a positive reaction with the reagent strip test for ketones is:
Alkaptonuria
Melanuria
Maple Syrup Urine Disease
Tyrosyluria
An overflow disorder that could produce a false-positive reaction with Clinitest procedure is:
Cystinuria
Alkaptonuria
Indicanuria
Porphyrinuria
A urine that turns black after sitting by the sink for several hours could be indicative of:
Alkaptonuria
MSUD
Melanuria
Melanuria and alkaptonuria
Ketonuria in a newborn is an indication of:
MSUD
Isovaleric acidemia
Methylmalonic acidemia
All of the given choices
Urine from a newborn with MSUD will have a significant:
Pale color
Yellow precipitate
Milky appearance
Sweet odor
Hartnup disease is a disorder associated with the metabolism of:
Organic acids
Tryptophan
Cystine
Phenylalanine
5-HIAA is a degradation product of:
Heme
Indole
Serotonin
Melanin
Elevated urinary levels of 5-HIAA are associated with:
Carcinoid tumors
Hartnup disease
Cystinuria
Platelet disorders
False-positive levels of 5-HIAA can be caused by a diet high in:
Meat
Carbohydrates
Starch
Bananas
Blue diaper syndrome is associated with
Lesch-Nyhan syndrome
Phenylketonuria
Cystinuria
Hartnup disease
Homocystinuria is caused by failure to metabolize
Lysine
Methionine
Arginine
Cystine
The classic urine color associated with porphyria is
Dark yellow
Indigo blue
Pink
Port wine
Hurler, Hunter, and Sanfilippo syndromes are hereditary disorders affecting metabolism of:
Porphyrins
Purines
Mucopolysaccharides
Tryptophan
Many uric acid crystals in a pediatric urine specimen may
indicate:
Hurler syndrome
Lesch-Nyhan disease
Melituria
Sanfilippo syndrome
Sulfur odor
PKU
Cystinuria
Indicanuria
Alkaptonuria
Isovaleric acidemia
Sweaty feet odor
PKU
Cystinuria
Indicanuria
Alkaptonuria
Isovaleric acidemia
Orange sand in diaper
PKU
Lesch-Nyhan disease
Indicanuria
Alkaptonuria
Isovaleric acidemia
Mousy odor
PKU
Lesch-Nyhan disease
Indicanuria
Alkaptonuria
Isovaleric acidemia
What is the most common method used in newborn screening.
Gas Chromatography/Mass Specrtrometry
Tandem mass spectrophotometry
ELISA
CTAB
What is the most commonly test in detecting mucopolysaccharidoses.
Gas Chromatography/Mass Specrtrometry
Tandem mass spectrophotometry
ELISA
CTAB
