Which is being altered at the amino acid structure of hemoglobin in Hemoglobin O-Arab Disease? (DLT)

Which is being altered at the amino acid structure of hemoglobin in Hemoglobin D Disease? (DLT)

Which is being altered at the amino acid structure of hemoglobin in Hemoglobin G Disease? (DLT)

Hg O-Arab and Hg- E disease tests positive in Hemoglobin solubility test. Hg- D and Hg- G tests negative. (DLT)

In the choices below, which are the defects in megaloblastic anemia caused by Vitamin B12 and Folate Deficiency? (DLT)

Which of the following is the blood picture for megaloblastic anemia?(DLT)

Which clinical manifestation is seen in Vitamin B12 deficiency and is not normally seen Folate Deficiency? (DLT)

Main features of megaloblastic anemia except? (DLT)

All of the following causes false increase in Vitamin B12 deficiency assays except? (DLT)

Which of the following is the structure of hemoglobin structure of Hb A? (MRRC)

Which of the following is the structure of hemoglobin? (MRRC)

This inherited RBC membrane structure is more widespread in Southeast Asia's malaria belt. (JZL)

It is considered as the most common form of hereditary non-spherocytic hemolytic anemia of (JZL)

True or False: Splenectomy is not recommended in the treatment of Hereditary Hydrocytosis (HH). (JZL)

Which of the following has a mutated gene: PIEZO 1 Protein, KCNN4? (JZL)

Which of the following categories of autoimmune hemolytic anemia is the most encountered? (JZL)

It is also referred to as Frank Hemoglobinuria or March hemoglobinuria. (JZL)

Which of the following is characterized by RBC fragmentation and thrombocytopenia? (JZL)

he most common RBC enzyme deficiency, with the highest prevalence in malaria-endemic areas (Africa, Mediterranean). (JZL)

Initial investigations of laboratory diagnosis for thalassemia includes all the given choices. EXCEPT: (MRRC)

Which of the following is the most common compound heterozygous syndrome? (MRRC)

All of the following are causes of reduced or absent globin chain. EXCEPT: (MRRC)

In which of the following geographic areas is beta thalassemia most commonly seen? (MRRC)

True or False. Normal adults produce Hb A (95%), Hb A2 (less than 3.5%), and Hb F (less than 1% to 2%). (MRRC)

Is it the key to maintaining the RBC shape, which is a biconcave discoid? (JZL)

Which hereditary in the RBC membrane structure is caused by an issue with vertical interaction? (JZL)

Which of the given choices has the highest risk for pernicious anemia? (MRRC)

Which infectious agent is characterized by fever and non-respiratory flu-like symptoms? (MRRC)

Which anemia should be suspected if the patient has refractory anemia, reticulocytopenia, hypercellular bone marrow with markedly ineffective erythropoieses, and distinctive dysplastic changes in bone marrow erythroblasts? (MRRC)

True of false: A mother is Rh negative and her child is Rh positive. The child is susceptible to fetal Hemolytic Disease. (-ghent)

what is the primary cause of Idiopathic TTP?

Acquired HUS is typically due to (-ghent)

In the differentiation of TTP to HUS, one thing that is important to consider is: (ghent)

TRUE or FALSE: Rh negative mother and Rh negative baby is at risk of developing fetal hemolysis. (-ghent)

At what stage of iron deficiency anemia does exhaustion of the storage of iron occur? (TII)

What is the first treatment for iron deficiency anemia? (TII)

Microangiopathic hemolytic anemia (TII)

Drying artifact on Wrightstained peripheral blood films: (TII)

Leakage of sodium and potassium from the RBCs: (TII)

True dietary deficiency of vitamin B12 is possible for strict vegetarians. (TII)

somerization of methylmalonyl coenzyme A (CoA) to succinyl CoA DOES NOT require vitamin B12. (TII)

Hemochromatosis is "bronzed diabetes." (TII)

What stage of iron deficiency anemia is characterized by a progressive loss of storage iron? (TII)

Drug that may induce sideroblastic anemia: (TII)

Epsilon and zeta chains are part of which of the following hemoglobins? (RLC)

Which globin chains do Gower-II possess? (RLC)

Which globin chains do Portland possess? (RLC)

Which globin chains do Hgb F possess? (RLC)

Which globin chains do Hgb A possess? (RLC)

Which globin chains do Hgb A2 possess? (RLC)

TRUE or FALSE. Deoxyhemoglobin S is less soluble than deoxyhemoglobin A or oxyhemoglobin S. (LCF)

TRUE or FALSE. Anemia of CKD is due to the high production of erythropoietin. (LCF)

TRUE or FALSE. In the treatment of IDA, we should treat the IDA first before the underlying condition (VJEQ)

TRUE or FALSE. Both Vitamin B12 and Folate deficiencies have a clinical manifestation of neurological disturbance such as neuropathy, spastic paresis, etc. (VJEQ)

All of the following are features of aplastic anemia. EXCEPT: (AMDM)

Typically seen in marked intravascular hemolysis. (AMDM)

Mostly occurs in extravascular hemolysis. (AMDM)

Mostly occurs in intravascular hemolysis. (AMDM)

True or False. Myelophthisis is the replacement of hemopoietic bone marrow tissue by elements that do not form blood cells. (AMDM)

It is the most common inherited hemolytic disease among individuals of Northern European descent. (AMDM)

It is made of calcium bilirubinate and may lead to cholecystitis. (AMDM)

It is a severe form of Hereditary Elliptocytosis. (AMDM)

It is an inherited disorder caused by genetic mutationsaffecting the globin chain component of thehemoglobin (Hb) tetramer. (CMTM)

The lifespan of a red blood cell? (CMTM)

Present at levels of > 90%, with Hb F at < 7% and Hb A2 at approximately 2%. (RPR)

In Shwachman-Diamond Syndrome the pancreatic insufficiency associated with ______? (CMTM)

It is normocytic, normochromic anemiacharacterized by a severe reduction in circulatingreticulocytes. (CMTM)

When one a gene is deleted (a-/aa), a patient has: (RPR)

TRUE or FALSE. Sickle cell trait is an asymptomatic heterozygous condition characterized by the presence of both hemoglobin S and hemoglobin A. (RPR)

A deficiency of, or antibody to, intrinsic factor results in: (RPR)

Poorly hemoglobinized red blood cell (RBC) that is present in hemoglobinopathies, thalassemia, and liver disease. (RPR)

Anisocytosis is associated with anemias especially: (RPR)

In hemoglobin SC, what is the common associated bacteria in the respiratory tract infections? (RPR)

The most common hemoglobinopathy, resulting from asubstitution of valine for glutamic acid at position 6 of the b globin chain, and primarily affects people of African descent. (CMTM)

It polymerizes in the RBCs because of abnormal interaction with adjacent tetramers when it is in the deoxygenated form, producing sickle-shaped RBCs. (CMTM)

Found primarily in people of African descent. (CMTM)

The median life expectancy of patients with SCD has been extended to approximately? (CMTM)

It can result from increased serum unconjugated bilirubin during any hemolytic anemia. (CMTM)

Usually caused by a deletion of one, two,three, or all four of the a-globin genes, resulting in reduced or absent production of a chain. (CMTM)

Irregular reddish cytoplasmic red blood cell crystal described as a "glove" or "pistol." (RPR)

It is the metabolically active form of vitamin B12. (FDC)

It is the most common compound heterozygous syndrome that results in a structural defect in the hemoglobin molecule in which different amino acid substitutions are found on each of two beta-globin chains.

It is the treatment of choice for patients with severe aplastic anemia who are younger than 40 years of age and have a human leukocyte antigen (HLA)- identical sibling. (FDC)

It is also called as "Haptoglobin scavenger receptor". (FDC)

It is the differential diagnosis for hemolytic anemia—chronic, macrophage-mediated. (FDC)

All of the following are hemoglobins associated with decreased oxygen affinity except: (FDC)

Carrión disease is caused by which infectious agent (FDC)

Plasmodium species are transmitted to humans by ticks. Mosquitoes are the vector for Babesia. (FDC)

The terms disease and trait are also commonly used to refer to the _____ and _____ states. (FDC)

It is a common first step in the confirmation of hemoglobinopathies, including SCD. (FDC)

There is a delayed increase in unconjugated bilirubin in the plasma and an increase in urobilinogen in the stool and urine. (CVU)

A substantial decline in the serum haptoglobin level indicates what? (CVU)

Serum lactate dehydrogenase activity is an activity that is often increased inpatients with fragmentation hemolysis due to the release of the enzyme from ruptured RBCs. This activity can also be increased by other conditions like myocardial infarction and liver disease. (CVU)

The presence of these imparts coffee-brown color in the plasma and root beer-colored urine. (CVU)

Pyruvate kinase deficiency and uremia are hemolytic disorders associated with what RBC morphology? (CVU)

A condition where symptoms may first appear in infancy, childhood,or adulthood, or even at an advanced age. Symptoms include anemia, jaundice, and splenomegaly. (CVU)

Confirmation of PNH requires demonstration of GPI deficientcells in the peripheral blood. (CVU)

It can be accomplishedby sequencing the exons, flanking regions, and promoter regionof the PKLR gene. (CVU)

Treatment used for of all malaria, except for disease caused by strains of P. falciparum and P. vivax acquired from areas known to harbor chloroquine-resistant organisms, are either Chloroquine or hydroxychloroquine. (CVU)

Hemolytic anemia caused by other red blood cell injury hasbeen reported after bites from poisonous snakes (cobras and pit vipers), brown recluse spider (Loxosceles reclusa and Loxosceles laeta), and after multiple stings (50 or more) by flies. (CVU)

Hallmark of HS (RJAU)

True or FalseSS is the most severe form of sickle cell disease (RJAU)

True or False. Eosin-5 is the confirmatory test for HS (RJAU)

Which of the following is the laboratory findings for March Hemoglobinuria? (RJAU)

Hallmark of SCD (RJAU)

Vertical - structural integrity : __________ - mechanical stability (RJAU)

Which of the following is the severe form of heredity elliptocytosis? (RJAU)

Exercise- Induced Hemoglobinuria is also known as Frank Hemoglobinuria. The plasma increase is one of its laboratory findings (RJAU)

Ability to bend, stretch, distort and return to normal (RJAU)

It can be used to identify membrane protein deficiencies by electrophoretic separation of the various proteins in solubilized RBC mem branes with quantitation of the proteins by densitometry. (PMQV)

In extensive burns, the severity of burns is acute hemolytic anemia due to warm temperature. What degrees of Celsius? (PMQV)

Unstable hemoglobin variants result from genetic mutations to globin genes creating hemoglobin products that precipitate in vivo, producing Heinz bodies and causing a hemolytic anemia. How many unstable hemoglobin variants are exist? (PMQV)

Since there are seven hemoglobin variants in hemoglobin M. Which of the following is unstable hemoglobin variants? (PMQV)

Unstable hemoglobin disorder is usually detected in early childhood in patient with hemolytic anemia accompanied by: (PMQV)

Rh deficiency syndrome comprises a group of rare hereditary conditions in which the expression of Rh membrane proteins is absent/_____ or decreased/_____. (PMQV)

Hb M variants have altered oxygen affinity and are inherited as autosomal dominant disorders. Affected individuals have 30% to 50% methemoglobin (healthy individuals have less than 1%) and may appear cyanotic. (PMQV)

Which of the following is the type of hemologlobin that it caused by a variety of mutations in the α-, β-, and γ-globin genes, all of which result in production of methemoglobin? (PMQV)

True or False. Pliancy is the ability of the spectrum to fold and unfold by itself. (RJAU)

Which of the following is a type of syndrome that due to the damage of the cells in the glomerular vasculature and it is most common among children but sometimes also present in adults. (PMQV)

Which of the following is not a conditions that associated with Microangiopathic Hemolytic Anemia? (PMQV)

What is the most significant public health concern? (TLE)

Iron overload involves mechanisms of processes which the body's rate of acquisition greater than the rate which is usually 1 mg/day. Decreased amounts of iron in parenchymal cells throughout the body. (TLE)

What is the another name for hemochromatosis? (TLE)

Which of the following does not see in Lead poisoning? (TLE)

Therapeutic phlebotomy is the first line treatment for iron overload (TLE)

Too much intake of glutathione may cause: (TLE)

Liver biopsy with assessment of iron staining and degree of scarring in liver specimens is not essential to determining the degree of organ damage. (TLE)

Which of the following drugs does not delete iron in hemochromatosis? (TLE)

Before menopause, women lose iron via menstruation and pregnancy, which slows down iron accumulation within the body. As a result, symptom onset occurs later in (typically postmenopausal) than in men. (TLE)

These common clinical features of Porphyrins except: (TLE)