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Diuretics- Khan

Total questions: 42

Worksheet time: 24mins

Name
Class
Date
1.

Which of the following is not a thiazide or thiazide -like diuretic?

a)

Hydrochlorothiazide

b)

Chlorothiazide

c)

Chlorthalidone

d)

Torsemide

2.

Which of the following is essential for thiazide activity?

a)

Electron withdrawing group at position 6

b)

Sulfonamide group at position 7

c)

Alkyl substitution with CH3 on the 2-N position

d)

Hydrophobic substitution at position 3

e)

Saturation of 3-4 bond

3.

Which of the following increases the potency for thiazides?

a)

Electron withdrawing group at position 6

b)

Sulfonamide group at position 7

c)

Alkyl substitution with CH3 on the 2-N position

d)

Hydrophobic substitution at position 3

e)

Saturation of 3-4 bond

4.

Which of the following increases the duration of action for thiazides?

a)

Electron withdrawing group at position 6

b)

Sulfonamide group at position 7

c)

Alkyl substitution with CH3 on the 2-N position

d)

Hydrophobic substitution at position 3

e)

Saturation of 3-4 bond

5.

Thiazides act on which part of the nephron?

a)

Proximal Tubule

b)

Distal Tubule

c)

Loop of Henle

d)

Medullary collecting duct

6.

Which transporter is inhibited by thiazides?

a)

apical membrane NaCl co-transporter

b)

basolateral membrane Na/K ATPase

c)

basolateral membrane Cl channels

d)

apical membrane calcium channel

7.

What effects do thiazides have when combined with other classes of antihypertensives?

a)

additive

b)

synergistic

c)

antagonistic

d)

no effect

8.

Giving patients with nephrogenic diabetes insipidus thiazides ___________ urine volume.

a)

increases

b)

decreases

9.

What are the acute antihypertensive effects of thiazides?

a)

increase sodium excretion

b)

increase intravascular volume

c)

increase cardiac output

d)

decrease blood pressure

10.

What is the chronic antihypertensive effects of thiazides?

a)

Normal volume

b)

Normal cardiac output

c)

decreased vascular resistance

d)

decreased blood pressure

11.

Adverse effects of thiazides include electrolyte changes. Which of the following electrolytes has the potential to become too high while taking thiazides?

a)

calcium

b)

magnesium

c)

sodium

d)

potassium

12.

Which of the following is NOT a metabolic adverse effect of thiazides?

a)

Hyperuricemia

b)

Hyperglycemia

c)

Hyperlipidemia

d)

Hypercalcemia

13.

Which of the following has a synergistic interaction with thiazides?

a)

furosemide

b)

losartan

c)

NSAIDs

d)

dofetilide

14.

Which of the following has an additive interaction with thiazides?

a)

furosemide

b)

losartan

c)

NSAIDs

d)

dofetilide

15.

Which of the following can blunt the response of thiazides?

a)

furosemide

b)

losartan

c)

NSAIDs

d)

dofetilide

16.

Which of the following can cause severe arrhythmia if taken with thiazides?

a)

furosemide

b)

losartan

c)

NSAIDs

d)

dofetilide

17.

Which class has therapeutic indications for edema, hypertension, heart failure, nephrolithiasis, and nephrogenic diabetes insipidus?

a)

Thiazides

b)

Loop diuretics

c)

Aldosterone antagonists

d)

Osmotic diuretics

e)

ENaC inhibitors

18.

Which class has therapeutic indications for acute pulmonary edema; hypertension; edema of hepatic, cardiac and renal origin; acute renal failure; hyperkalemia; and hypercalcemia?

a)

Thiazides

b)

Loop diuretics

c)

Aldosterone antagonists

d)

Osmotic diuretics

e)

ENaC inhibitors

19.

Which class has therapeutic indications for acute renal failure, reduction of intracranial pressure, reduction of intraocular pressure?

a)

Thiazides

b)

Loop diuretics

c)

Aldosterone antagonists

d)

Osmotic diuretics

e)

ENaC inhibitors

20.

Which class has therapeutic indications for hypertension, edema, CHF, hypokalemia, primary aldosteronism, and female hirsutism?

a)

Thiazides

b)

Loop diuretics

c)

Aldosterone antagonists

d)

Osmotic diuretics

e)

ENaC inhibitors

21.

Which class has therapeutic indications for hypokalemia and combination with other diuretics for CHF and hypertension?

a)

Thiazides

b)

Loop diuretics

c)

Aldosterone antagonists

d)

Osmotic diuretics

e)

ENaC inhibitors

22.

Which loop diuretics is not used often due to ototoxicity?

a)

furosemide

b)

bumetanide

c)

torsemide

d)

ethacrynic acid

23.

Which loop diuretic contains an ortho-amino benzoic acid?

a)

furosemide

b)

torsemide

c)

bumetanide

24.

Which loop diuretic contains an meta-amino benzoic acid?

a)

furosemide

b)

torsemide

c)

bumetanide

25.

What is the site of action for loop diuretics?

a)

ascending limb

b)

descending limb

c)

distal tubule

d)

collecting duct

26.

Which of the following is inhibited by loop diuretics resulting in increased sodium excretion?

a)

apical membrane Na/K/2Cl transporter

b)

basolateral membrane Na/K/2Cl transporter

c)

apical membrane K channel

d)

basolateral membrane Na/K ATPase

27.

Hypokalemic Metabolic Alkalosis is the result of increased sodium and water delivery to the collecting duct causing enhanced excretion of K and H resulting in bicarbonate buildup. This is an adverse effect of which diuretic?

a)

Loop

b)

K-sparing

c)

Thiazide

d)

Osmotic

28.

Loop diuretics are not often used for HTN due to their

a)

potency

b)

duration of action

c)

cost

d)

drug interactions

29.

Which of the following is not a drug interaction with loop diuretics?

a)

Potentiate digoxin toxicity in CHF

b)

interaction with aminoglycoside may cause hearing loss

c)

increases Li concentrations

d)

antagonistic effect on antihypertensive drugs

e)

NSAIDs interfere with loop diuretic action

30.

K-sparing diuretics site of action is the

a)

cortical collecting tubule

b)

descending limb

c)

proximal tubule

d)

distal tubule

31.

Which of the following K-sparing diuretics is an aldosterone antagonist?

a)

Spironolactone

b)

Eplerenone

c)

Triamterene

d)

Amiloride

32.

Which of the following K-sparing diuretics is an epithelial sodium channel inhibitor?

a)

Spironolactone

b)

Eplerenone

c)

Triamterene

d)

Amiloride

33.

Aldosterone causes what physiological effects?

a)

Na retention

b)

K excretion

c)

water excretion

34.

Which of the following has the active metabolite canrenone?

a)

furosemide

b)

spironolactone

c)

eplerenone

d)

hydrochlorothiazide

35.

The thio-acetyl group is present on which aldosterone antagonist?

a)

spironolactone

b)

eplerenone

36.

Spironolactone inhibits

a)

aldosterone interaction with the mineralocorticoid receptors

b)

ENaC channels in the apical membrane

c)

K channels in the apical membrane

d)

Na/K ATPase in the basolateral membrane

37.

Triamterene inhibits

a)

aldosterone interaction with the mineralocorticoid receptors

b)

ENaC channels in the apical membrane

c)

K channels in the apical membrane

d)

Na/K ATPase in the basolateral membrane

38.

Which has fewer endocrinological side effects due to being more selective?

a)

eplerenone

b)

spironolactone

39.

Which ENaC inhibitor is not plasma protein bound and excreted unchanged in the urine?

a)

Amiloride

b)

Triamterene

40.

Which ENaC inhibitor is 60% plasma protein bound and is extensively metabolized in the liver?

a)

Amiloride

b)

Triamterene

41.

Which of the following is not true of osmotic diuretics?

a)

No receptor involved

b)

administered orally

c)

Sugar alcohol

d)

Pharmacologically inert

42.

What is the site of action of osmotic diuretics?

a)

Proximal tubule

b)

descending limb

c)

ascending limb

d)

distal tubule

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