NEW
Font size
WorksheetsImmunology
Total questions: 66
Worksheet time: 33mins
CYTOKINES are produced by many cell population (endothelial cells, fibroblasts, epithelial cells, and others), they ARE MAINLY THE PRODUCTS OF:
B cells
Macrophages
B cells and macrophages
T cells and macrophages
It BINDS IRON, an essential nutrient from some microbes:
Defensins
Lactoferrin
Lysozyme
Nitric oxide
It permeabilize some bacterial and some fungal membranes:
Defensins
Lactoferrin
Lysozymes
Nitric oxide
Large granular lymphocyte (LGL) is synonymous with:
B cells
T helper cell
T cytotoxic cell
Natural killer cell
C-reactive protein is synthesized in the:
bone marrow
lymphatics
RES
epithelial cells
This cytokine stimulates the hepatic cells to secrete C-reactive protein (CRP):
interleukin 1
interleukin 6
interleukin 12
tumor necrosis factor
The HLA genes are located on chromosome number:
4
28
6
10
The majority of HLA antibodies are:
lgD
lgE
lgG
lgM
Of the following diseases, which one has the highest relative risk in association with an HLA antigen?
Ankylosing spondylitis
Juvenile diabetes
Narcolepsy
Rheumatoid arthritis
Which class of immunoglobulin can fix 2 homologous basophils and mediate atopic allergies?
lgA
lgD
lgE
lgG
lgM
lgG subclass most efficient at complement fixation but is not capable of binding the Fc portion of the molecule to staphylococcal protein A:
lgG1
lgG2
lgG4
lgG3
Which immunoglobulins can activate the classic pathway of the complement systems?
lgA and lgM
lgG and lgA
lgG1, lgG2, lgG3 and lgM
lgE and lgD
The three complement activation pathways converge at the point of cleavage of complement component ____________________.
C3
C5
C2 solo
C8
Antibody detection and identification:
direct AHG test
indirect AHG test
medj direct AHG test
all of these
Macrophages have specific names according to their tissue location. Macrophages in the liver are:
Alveolar macrophages
Microglial cells
Kupffer cells
Histiocytes
In which are of the lymph node are T cells mainly foound:
Germinal center
Paracortex
Primary follicles
Sinusoids
Antigen given intravenously are mainly trapped in the:
Lungs
Spleen
Lymph node
Tonsils
Nitroblue tetrazolium test is of value in the diagnosis of:
Bruton's agammaglobulinemia
Kahler's disease
Franklin's disease
Chronic granulomatous disease
Variation in variable regions that give individual antibody molecules specificity:
isotype
allotype
idiotype
all of these
The hinge region of an immunoglobulin is flexible because it contains a large amount of which amino acid?
serine
threonine
cystine
proline
Which of the following statements does not apply to lgG?
Appears early in the immune responsse
Can fix complement
Crosses the human placenta
Opsonizes bacteria
The key cells involved in meditating DELAYED hypersensitivity are:
neutrophils
T cells
Mast cells, basophils
B cells
RAST measures:
Antigen concentration
lgE antibodies
lgM antibodies
lgG antibodies
Helper T cells recognize antigen on antigen-presenting cells as antigen:
With MHC class I product
With both class I and class II product
With MHC class II product
With complement
MHC class II molecules are found on:
Virtually all cells in the body
B cells, dendritic cells and macrophages
Virtually all nucleated cells in the body
Only on virally infected cells
At least one of the functions of CD8 on the surface of lymphocytes interacting with another cell is to:
Bind antigen
Bind to MHC class I molecules
Bind surface immunoglobulin
Bind to MHC class II molecules
Transfer of tissues and organs between genetically identical individuals such as identical twins:
Autograft
Xenograft
Syngraft
Allograft
Fetus can be considered as an:
Autograft
Isograft
Allograft
Xenograft
Which term applies to the most accelerated type of graft rejection?
Acute rejection
Hyperacute rejection
Chronic rejection
Accelerated rejection
Susceptibility to AUTOIMMUNE DISEASE is usually linked to:
HLA Class I alleles
HLA Class II alleles
HLA Class III alleles
Anti-mitochondrial antibodies are demonstrated in:
Myasthenia gravis
Primary biliary cirrhosis
Chronic active hepatitis
Anti-smooth muscle antibodies are demonstrated in:
Myasthenia gravis
Primary biliary cirrhosis
Chronic active hepatitis
Carcinoembryonic antigen is characteristically secreted by tumors of the:
Kidney
Lungs
Bones
Gastrointestinal tract
A hybridoma is a cell formed by fusion of a:
Plasma cell with a plasma cell of another species
T cell with a myeloma cell
Plasma cell with a myeloma cell
T cell with a B cell
The PROZONE phenomenon can:
1. Result from excessive antibody concentration
2. Result in false positive reaction
3. Result in false negative reaction
4. Be overcome by serially diluting the antibody containing serum
1 and 3
2 and 4
1, 2 and 3
1, 3 and 4
Reverse passive agglutination:
1. Antigen is attached to carrier particle
2. Antibody is attached to carrier particle
3. Agglutination occurs if patient antibody is present
4. Agglutination occurs if patient antigen is present
1 and 3
2 and 4
1, 2 and 3
1, 2, 3 and 4
In FLUORESCENCE POLARIZATION IMMUNOASSAY (FPIA), the degree of fluorescence polarization is ______ proportional to concentration of the analyte.
Direct
Inverse
Variable
No effect
the rapid plasma reagin (RPR) for syphilis does not need to be read microscopically because the antigen because the antigen is:
Cardiolipin
Complexed to latex
Complexed to charcoal
Complexed to bacteria
Antibodies to which of the following viral antigens are usually the first to be detected in HIV infection?
gp120
gp160
gp41
p24
The outward expression of genes:
Allele
Genotype
Phenotype
Pink stopper tubes are specifically used for:
Blood banking
Chemistry
Hematology
Microbiology
First time a blood transfusion was recorded in history.
Queen Victoria
Pope Pius
Pope Innocent
WASHING CORD CELLS ______ times should alleviate spontaneous rouleaux due to WHARTON'S JELLY which is a viscous mucopolysaccharide material present on cord cells.
Two to three times
Three to four times
Six to eight times
Eight to ten times
Which blood group system is known for showing dosage?
I
P
Kidd
ABO
Which antibody is enhanced by acidifying the patient's serum?
Anti-D
Anti-Fya
Anti-M
Anti-Jka
which of the following is the most common antibody seen in the blood banks after ABO and RH antibodies?
Anti-Fyb
Anti-k
Anti-Jsa
Anti-K
A common antibody found in many normal persons as well as in those with acquired hemolytic anemia of the COLD antibody type:
Anti-I1
Anti-I
Anti-P
Anti-P1
In 1956, Weiner and coworkers, gave a name to one such agglutinin. The ANTIBODY REACTED WOTH MOST BLOOD SPECIMENS TETSED.
Anti-P
Anti-I
Anti-Rh
Anti-M
Mutation in the carrier molecule for this blood group system may result in charges of red blood cell shape in the forms of elliptocytosis, acanthocytosis and ovalocytosis?
DI
CO
PJ
If a simple must be taken from an IV line:
Not acceptable
sample can be obtained anytime
The line should be disconnected for 5 to 10 minutes, the first 10 mL of blood drawn should be discharged, and then the sample should be obtained
A woman begins to breathe rapidly while donating blood. Choose the correct course of action.
continue the donation; rapid breathing is not a reason to discontinue a donation
withdraw the needle, raise her feet, and administer ammonia
Discontinue the donation and provide a paper bag
Tell her to sit upright and apply a cold compress to her forehead
Immunization for RUBELLA would result in a temporary deferral for:
2 weeks
4 weeks
8 weeks
Cardiopulmonary bypass is an essential system for open heart surgery. Which of the following prevents coagulation during CPB?
ACP
CPD
CPDA-1
Heparin
Blood can be stored in CPDA-1 at 1 to 6oC for how many days?
21 days
42 days
35 days
7 days
Additive solution are approved for blood storage for how many days?
21 days
42 days
35 days
7 days
ALL BUT ONE of these factors will influence platelet metabolism and function in a closed system?
Total platelet count
Duration of storage
Temperature of storage
Fibrinogen concentration
When platelet concentrate are stored at 22oC, continuous gentle agitation must be used to:
Prevent platelet aggregation
Facilitate gas exchange
The minimum interval allowed between plateletpheresis component collection procedures is:
24 hours
48 hours
7 days
8 weeks
Each unit of cryoprecipitate, prepared from WB, should contain approximately how many units of AHF activity?
40 IU
80 IU
120 IU
160 IU
Blood donor and recipient samples used in crossmatching must be stored for a minimum of how many days following transfusion?
2
5
7
10
When a suspected hemolytic reactions occurs the first thing to do is:
Slow the transfusion rate and call the physician
Administer medication to stop reaction
Stop the transfusion, but keep the intravenous line open with saline
First inform the laboratory to begin the investigation
Which listed transfusion reaction is most associated with transfused patients lacking lgA immunoglobulin?
Anaphylactic
Hemolytic
Febrile
TACO
Hemolytic disease of the newborn is characterized by:
lgM antibody
Nearly always anti-D
different RBC antigens between mother and father
Antibody titer less than 32
The advantages of cordocentesis include all of the following, Except:
Allows measurement of fetal hemoglobin and hematocrit levels
Allows antigen typing of fetal blood
Allows direct transfusion of fetal circulation
Decrease risk of trauma to the placenta
PCR technology can be used to:
Amplify small amounts of DNA
Clone fragments of RNA
Digest genomic DNA into small fragments
Repair broken pieces of DNA
A connection between two blood vessels, either direct or through connecting channels:
Anastomosis
Network
Matrix
Reticulum
