WorksheetsImmunology exam
Total questions: 40
Worksheet time: 20mins
Choose the true statements about innate immune response
1. Have a rapid response to antigens
2. Have same intensity every tome
3. It is stronger and faster upon re-infection
4. Require more time (days) to develop
5. Is evolutionary older
A) 1, 2, 3
B) 2, 3
C) 2, 5
D) 1, 4
E) 1, 5
Which of the following cells are not APC?
Dendritic cells
B cells
Macrophages
Endothelium
T cells
Which of the following signals on a bacterial pathogen is mainly recognized by toll-like receptor 4?
Uric acid
Advanced glycation end products
Lipopolysaccharide
Mannose
High mobility group box 1 protein
Pattern recognition receptors (PRRs) can be present in all of the following forms EXCEPT which of the following?
As a secreted soluble receptor
Within the cell nucleus
Membrane-bound
Within the cytoplasm
As a cell surface molecule
Choose the right sentence about C1inh
A) His function is to inhibit C1r and C1s serine protease activity
B) Deficiency of C1inh leads to chronic granulomatous disease
C) Deficiency of C1inh leads to hereditary angioedema
D) A + B + C
E) A + C
Choose the common features for neutrophils and macrophages:
1. Can phagocytosis
2. Express of MHC class II on their surface
3. Can release immunoglobulins
4. May release cytokines
5. Can create reactive oxygen species (ROS)
A) 1, 2, 5
B) 1, 3, 5
C) 1, 4, 5
D) 2, 3, 4
E) 2, 4, 5
Cyclic neutropenia is recognize when patient have
<5000/ul (even <2000/ul) (per 3-5 days)
<500/ul (even <200/ul) (per 3-5 days)
<5000/ul (even <2000/ul) (per 3-5 weeks)
<500/ul (even <200/ul) (per 3-5 weeks)
<5000/ul (even <2000/ul) (per 3-5 months)
CGD - chronic granulomatous disease
In this disease, there is a lack of abscesses
Patients will not occur granulomas
The cause is an improper function of T lymphocytes
The cause is the improper function of killing microbes in an oxygen-dependent way
The cause is an improper function of killing microbes in an oxygen-independent way
Opsonins are
IgG, LPS, C3b, MBL
IgG, C3a, C5a, CRP
IgG, C3b, C5b, MBL
IgA, CRP, LPS, C6
IgG, CR1, MBL, C5a
What is the function of C5a?
A) Opsonisation
B) Mast cell and basophil degranulation
C) Neutrophil chemotaxis factor
D) A + B + C
E) B + C
Which of the following can be recognized by pattern recognition receptors?
Damage-associated molecular patterns and pathogen-associated molecular patterns
Damage-associated molecular patterns on pathogens
Pathogen-associated molecular patterns on host cells
Neither damage-associated molecular patterns or pathogen-associated molecular patterns
Toll-like receptors
Activators of the classical pathway of the complement system are
A) CRP
B) IgG4
C) IgM
D) A + B + C
E) A + C
C3 converts of classical pathway are
C2b2a
C4b2a
C2b4a
C3b4a
C4b4a
Which is a factor that prevents the formation of the MAC?
C1inh
C5b
CD59
CD11
CR1
Choose the similarities between adaptive immune response and complement system
A) Opsonisation
B) Antigen recognition
C) Activation of immune cells
D) A + B + C
E) A + C
MHC class I shows peptides to
CD8+cells
CD4+cells
CD9+cells
B cells
Epithelium cells
TCR-T-cell receptor recognize
A) PAMPs
B) DAMPs
C) MHC type I
D) A + B
E) A + B + C
Which antibody is characterized by the ability to complement activation in a classical way, enhancing phagocytosis, ADCC and neutralizing pathogens?
IgM
IgA
IgG
IgE
IgD
Which cells can kill infected cell by fas-fasL and/or perforin-granzyme pathways?
A) NK cells (natural killer)
B) CTL (cytotoxic T cells)
C) B cells
D) Neutrophils
E) A + B
Which cells modulate the immune system to maintain tolerance to self-antigens?
NK cells
Th17
Th1
Th2
T regs (T regulatory cells)
Characteristics of γδ T cells include
A) Contribute around 5% of circulating T cells
B) Have specificity for recognition Ag such as heat shock proteins, phospholipids
C) Are found in the gut mucosa, skin, lungs and uterus
D) Recognize Ag only in assertion with classical MHC class I and II
E) Correct answer are A & B & C
C reactive protein
Protein found in blood plasma, whose circulating concentrations rise in response to inflammation
It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells
It is a member of the pentraxin family of protein
CRP is synthesized by the liver and activate the complement system via C1q
All answers are correct
The first cell type to respond to most infections are
Lymphocytes B
Lymphocytes T
Neutrophils
Monocytes
Dendritic cells
Choose the group of molecules where only DAMP (damage-associated molecular patterns) are listed
A) Uric acid, extracellular ATP, viral RNA, HSP
B) Uric acid, extracellular DNA, HSP, LPS
C) Uric acid, extracellular ATP, HSP, extracellular DNA
D) Uric acid, mannose, viral RNA, HSP
E) A + B
Phagocytic receptors are
TCR, PRR, TLR, FcR
TLR, PRR, FcR, CR
TCR, BCR, PRR, FcR
CR, BCR, TLR, MBL
CPR, MBL, Il6, LPS
Main function of CR - complement receptors are
Facilitating binding and phagocytes by pahocytic cells of particles or cells coated with antibodies
Removal of immune complexes
Regulation (mainly inhibition) of complement activation
Participating in several types of immune response
All of the above
Differentiation of nice T cells into Th2 is mediated by
IL-1
IL-2
IL-3
IL-4
IL-5
Which of the following interleukins roles is to increase body temperature?
IL-1 and IL-3
IL-1 and IL-5
IL-4 and IL-5
IL-1 and IL-6
IL-2 and IL-5
The blood sample from newborn with HDN (Hemolytic disorder of newborns) were taken and tested. Which of the following laboratory results belong to this child?
Anemia, hyperbilirubinemia, Direct Coombs test (positive)
Polycythemia, hyperbilirubinemia, Direct Coombs test (positive)
Anemia, hyperbilirubinemia, indirect Coombs test (positive)
Polycythemia, hyperbilirubinemia, Indirect Coombs test (positive)
None of them are correct
What are the specific and non-specific type of prevention of HDN (Hemolytic disorders of the Newborn)
A. Avoid blood transfusion, especially with blood group type incompatibility
B. Avoid intravenous drugs, heroin etc
C. Anti-D immunoglobulin (RhoGAM)
D. A + B
E. A + B + C
Severe hemolytic disease of newborn are treated with (RBC - Red Blood Cells)
Exchange transfusion with AB Rh negative RBC and phototeraphy
Exchange transfusion with AB Rh positive RBC and phototeraphy
Exchange transfusion with O Rh negative RBC and phototeraphy
Exchange transfusion with O Rh positive RBC and phototeraphy
Only phototherapy are needed
The lymphocyte antigen receptor repertoire is mostly generated
By cutting and splicing V, D, J or D gene segments
Mutation of the TCR
In the periphery following exposure to antigen
Following vaccination
Mutation of BCR and immunoglobulins
Costimulation molecules (second signal) is important in the induction of immune response. They involved: B7 family molecules expressed on antigen presenting cells, CD28 and CTLA-4 on T-cells
True, CD28 has a positive costimulatory effect and CTLA-4 negative
True, however more important is ICOS and GITR
False, costimulation involves HLA class II and T-cell receptor
First sentence is true, second is false
First sentence is false, second is true
Professional APCs are
Dendritic cells, B lymphocytes and Kupffer cells
Monocytes, macrophages and neutrophils
B cells, dendritic cells and basophils
B cells, T cells and NK cells
Monocytes, neutrophils, B cells
Each of the following statements concerning happens is correct EXCEPT
Haptens must be processed by CD8+ cells to become immunogenic
A happen can combine with (bind to) an antibody
A happen cannot induce an antibody by itself; rather, it must be bound to a carrier protein to be able to induce antibody
In both penicillin-induced anaphylaxis and poison ivy, the allergens are happens
CRP
A. Is an acute phase protein
B. Is an opsonins and suppress the phagocytosis
C. Is the pattern recognition receptor and initiate the classical pathway complement activation
D. Incorrect answer is B
E. Correct answer are A & B & C
Choose the right sentence about C1inh
His function is to inhibits C1r and C1s serine protease activity
Deficiency of C1inh leads to chronic granulomatous disease
Deficiency of C1ing leads to hereditary angioedema
Correct answers are A + B + C
Correct answer is A + C
Subset of Th1 cells
A. Produced mainly IL-4, IL-13 and IL-5 that promote the B cells differentiation
B. Produced mainly IFN gamma that stimulate macrophages to phagocytosis and to antigen presentation
C. Produces mainly IL-1 and IL-6 that stimulates neutrophils to phagocytosis
D. Correct answers are B & C
E. All answers are false
C3 is cleaved to form C3a and C3b by C3 converts. C3b is involved in all of the following EXCEPT
Altering vascular permeability
Promoting phagocytosis
Forming alternative-pathway C3 converts
Forming C5 convertase
Is potent in opsonization
Adhesion molecules can control leucocytes migration by
Binding to specific antigen
Changing lymphocyte survival
Binding to ligands on the vascular endothelium
Agglutinating pathogens in the tissues
Binding of opsonizing antibodies to phagocytes
