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WorksheetsDR. MIROSHNYK Solutions as a Dosage Form
Total questions: 58
Worksheet time: 2hrs 5mins
Liquid preparations that contain one or more chemical substances molecularly dispersed in a suitable solvent or mixture of mutually miscible solvents.
Pharmaceutical Solutions
Biochemical Solutions
Which of the following are considered Advantages of the Pharmaceutical Solutions? Select all that apply
Enhanced bioavailability
Fast onset of activity
Homogeneity (= dose uniformity)
Flexible dosage
Ease of administration
Which of the following are considered Disadvantages of the Pharmaceutical Solutions? Select all that apply
Stability issues, Leakage from container
Patient inaccuracy
More pronounced taste
API solubility issues
Bulky
Which of the following are considered the Common Pharmaceutical Solvents? Select all that apply
Glycerin, USP, Mineral Oil, USP
Alcohol, USP, Propylene Glycol, USP
Purified Water, USP
Diluted Alcohol, NF
Alcohol, Rubbing
Which of the following is the most most preferable solvent for liquid preparations with a Dry residue NMT 0.001%?
Alcohol, USP
Alcohol, Rubbing
Glycerin, USP
Purified Water, USP
Which of the following are considered Non-Aqueous Solvents? Select all that apply
Purified Water, USP
Alcohol, USP
(Ethanol)
Diluted Alcohol, NF
Rubbing Alcohol
Which of the following is the most useful solvent for external and internal use?
Alcohol, USP
(Ethanol)
Diluted Alcohol, NF
Rubbing Alcohol
Which of the following is the Hydroalcoholic solvent for external and internal use?
Diluted Alcohol, NF
Rubbing Alcohol
Alcohol, USP
(Ethanol)
Which of the following is for External use only?
Rubbing Alcohol
Diluted Alcohol, NF
Alcohol, USP
(Ethanol)
Which of the following statements are TRUE about Alcohol? Select all that apply
Disadvantage: Undesired pharmacologic and toxic effects
Recommended limits for pediatric OTC oral products
>12 years = NMT 10%
< 6 years = NMT 0.5 %
Which of the following is used externally as a vehicle for topical formulations and as a soothing rub and rubefacient?
Isopropyl Rubbing Alcohol
Purified Water (USP)
Which of the following statements are TRUE about Isopropyl Rubbing Alcohol? Select all that apply
About 70% (v/v) isopropyl alcohol + water, stabilizers and perfume oils
Used externally as a vehicle for topical formulations and as a soothing rub and rubefacient
Clear syrupy liquid with a sweet taste
Viscous liquid à slow dissolution of solids
What is the %/strength for the Alcohol USP (Ethanol)?
94.9%-96.0% v/v
70% v/v
Approx. 49% (the mixture of equal volumes of Alcohol USP and Purified Water, USP).
True
False
Approx. 50% which means half (the mixture of equal volumes of Alcohol USP and Purified Water, USP).
True
False
Rubbing alcohol has which of the following?
95% (v/v) Ethanol + perfume oils and stabilizers
70% (v/v) Ethanol + perfume oils and stabilizers
Recommended limits for OTC oral products with Alcohol in a kid which is 13 years old:
NMT 0.5 %
NMT 5 %
NMT 10%
Which of the following are TRUE about Glycerin, USP (Glycerol)? Select all that apply
Suitable for internal use
Clear syrup liquid with a sweet test
Miscible with both water and ethanol
Viscous liquid à slow dissolution of solids
Preservative properties
Which of the following Non-Aqueous Solvents has reported adverse reactions such as contact dermatitis and lactic acidosis?
Propylene Glycol, USP
Glycerin, USP (Glycerol)
Isopropyl Rubbing Alcohol
All of the above
Which of the following is often substituted for glycerin in external and internal formulations?
Glycerin, USP (Glycerol)
Propylene Glycol, USP
Isopropyl Rubbing Alcohol
All of the above
Which of the following are TRUE about Propylene Glycol, USP? Select all that apply
contact dermatitis and lactic acidosis as reported adverse reactions.
Miscible with water and ethanol
Viscous liquid
Often substituted for glycerin in external and internal formulations.
According to BCS, drugs whose highest administration dose strength dissolves in ≤250 ml of water between pH 1 and 7.5 are highly soluble; otherwise, they are considered to be poorly water soluble.
True
False
If we have a drug that dose strength dissolves in 150 ml of water with a pH of 4 , how is considered this drug?
highly soluble
poorly water soluble
If we have a drug that dose strength dissolves in 600 ml of water with a pH of 9 , how is considered this drug?
highly soluble
poorly water soluble
Which of the following drugs is an example of Complexation as an approach and Cyclodextrines as a solubilizing agent?
Itraconazole
Digoxin
Atropine Sulfate
Which of the following drugs is an example of Salt formation as an approach and Counter-ions as a solubilizing agent?
Itraconazole
Atropine sulfate
Digoxin
Which of the following drugs is an example of Co-solvents as an approach and 20% v/v alcohol as a solubilizing agent?
Itraconazole
Atropine sulfate
Digoxin
Which of the following are considered Buffers? Select all that apply
acetates
citrates
phosphates
Sodium benzoate
Which of the following are considered Antimicrobial preservatives? Select all that apply
methyl-/propylparabens
sodium benzoate (0.1%)
benzoic acid
alcohol 15-20%
sorbic acid
Which of the following are considered Sweeteners? Select all that apply
Aspartame (headahe and hypersensitivity
saccharine sodium (sulfonamide => sulfa allergies)
sorbitol
sucrose (avoid in children and diabetic patients)
Which of the following are considered Flavorants? Select all that apply
volatile oils
vanillin
menthol
sucrose
Which of the following are considered Viscosity modifiers? Select all that apply
MCC
CMC
HPMC
Sucrose
Which of the following are considered Surfactants? Select all that apply
Tweens
HPMC
Spans
CMC,
MCC
Which of the following is considered a Chelating agent?
Ethylenediaminetetraacetic acid disodium)
Tweens
Spans
CMC
MCC
Aqueous solutions are simple solutions mostly oral Syrups.
True
False
Which of the following are considered Aqueous solutions?
Aromatic waters (solutions saturated with volatile oils)
elixirs
mouthwashes
gargles
tinctures
Which of the following are considered Non- Aqueous solutions (Hydroalcoholic solutions)? Select all that apply
Aromatic waters (solutions saturated with volatile oils)
elixir
mouthwashes
gargles
tinctures
Which of the following are TRUE about Non-Aqueous solutions? Select all that apply
Hydroalcoholic solutions
elixirs, mouthwashes, gargles, tinctures
Oily preparations
Aromatic waters (solutions saturated with volatile oils
Sorbitol is considered a sugar substitute.
True
False
Concentrated, aqueous preparations of sugar (sucrose) or sugar substitutes (e.g. sorbitol) intended for oral administration of bitter-tasting drug substances.
Syrups
Flavorants
Colorants
Emulsions
Know this
Yes
No
Which of the following are TRUE about the Preservation of Syrups? Select all that apply
Self-preserving by high sucrose concentration
Refrigerating
By preservatives (glycerin, benzoic acid, alcohol). Free water is preserved by 18% of absolute (100%) alcohol
DO NOT refrigerate
Which of the following are TRUE about Simple Syrup, USP? Select all that apply
Simple Syrup, USP (85% w/v) is self-preserved due to its high sugar concentration.
Simple syrup (sp.gr = 1.313) contains 46.3 mL of water/100 mL of solution => 85 g of sucrose preserves 46.3 mL of water (1 g preserves 0.54 mL of water)
If a syrup containing less sucrose is formulated, free water must be preserved
Contain flavoring agents to enhance palatability
Which of the following are TRUE about Elixirs? Select all that apply
Clear, sweetened, hydroalcoholic (5%-40% v/v) solutions intended for oral use
Contain flavoring agents to enhance palatability
Contain coloring agents
(85% w/v) is self-preserved due to its high sugar concentration.
Which of the following cannot be administered to pediatric patients and patients on antidepressant medication?
Syrups
Elixirs
Which of the following is less viscous and contain less sugar?
Elixirs
Syrups
Elixirs are prepared mostly by simple solution with agitation method.
True
False
Elixirs must be stored in tight, light resistant containers and protective from excessive heat.
True
False
Alcoholic or hydroalcoholic solutions prepared from vegetable materials or from crude chemical substances (iodine).
Elixirs
Tinctures
The alcohol content in Tinctures ranges from ?
15-25%
15-80%
Which of the following are TRUE about Tinctures? Select all that apply
Alcohol content ranges from 15-80%.
Can also be extracted in vegetable glycerin or apple cider vinegar
Low patient compliance
Alcoholic or hydroalcoholic solutions prepared from vegetable materials or from crude chemical substances (iodine)
Saturated solutions of aromatic or volatile substances in water with NO therapeutic action (Internal or external use).
Aromatic Waters
Tinctures
Aromatic Waters are used as flavoring or perfuming vehicles.
True
False
Alcoholic or hydroalcoholic solutions of volatile substances.
Aromatic Waters
Spirits
Which of the following can be used internally, externally, or by inhalation?
Spirits
Aromatic Waters
What is the Spirits alcoholic concentration?
typically over 40%
typically over 60%
Alcohol content ranges from 15-80%
5%-40% v/v
85% w/v
Spirits are used as flavoring agents or as therapeutics.
True
False
Know this
Yes
No
