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Pharmaceutics 2- Exam 2

Total questions: 60

Worksheet time: 37mins

Name
Class
Date
1.

What is the most preferable solvent for liquid preparations?

a)

Purified Water, USP

b)

Glycerin, USP

c)

Alcohol, USP

d)

Mineral Oil, USP

2.

Which of the following can be used externally?

a)

Alcohol, USP- 94.9-96% v/v

b)

Diluted Alcohol, NF ~49%

c)

Rubbing Alcohol- 70% v/v

3.

Which of the following can be used internally?

a)

Alcohol, USP- 94.9-96% v/v

b)

Diluted Alcohol, NF ~49%

c)

Rubbing Alcohol- 70% v/v

4.

What is the alcohol content limit in OTC oral products for pediatric patients < 6 years?

a)

NMT 0.5%

b)

NMT 5%

c)

NMT 10%

d)

NMT 1%

5.

What is the alcohol content limit in OTC oral products for pediatric patients 6-12 years?

a)

NMT 0.5%

b)

NMT 5%

c)

NMT 10%

d)

NMT 1%

6.

What is the alcohol content limit in OTC oral products for pediatric patients >12 years?

a)

NMT 0.5%

b)

NMT 5%

c)

NMT 10%

d)

NMT 1%

7.

T/F Glycerin is a viscous liquid with a sweet taste that is suitable for internal use, has preservative properties and is immiscible with both water and ethanol.

a)

True

b)

False

8.

Which of the following can be used as solvents/co-solvents in solutions?

a)

Mineral Oil, USP

b)

Rubbing Alcohol

c)

Propylene Glycol, USP

d)

Sorbic Acid

9.

Sodium Benzoate 0.1% is an example of __________ in solutions.

a)

an antimicrobial preservative

b)

a buffer

c)

a solvent

d)

a sweetner

10.

Acetates, phosphates and citrates are examples of

a)

an antimicrobial preservative

b)

a buffer

c)

a solvent

d)

a sweetner

11.

Which sweetener has the potential for a sulfa allergy reaction?

a)

Saccharine sodium

b)

Sorbitol

c)

Sucrose

d)

Aspartame

12.

Which sweetener should be avoided in children and diabetic patients?

a)

Saccharine sodium

b)

Sorbitol

c)

Sucrose

d)

Aspartame

13.

Which sweetener can cause headache and hypersensitivity?

a)

Saccharine sodium

b)

Sorbitol

c)

Sucrose

d)

Aspartame

14.

Which of the following are viscosity modifiers?

a)

MCC, CMC, HPMC

b)

Sucrose

c)

Tweens, Spans

d)

Menthol

15.

Which of the following are surfactants?

a)

MCC, CMC, HPMC

b)

EDTA

c)

Tweens, Spans

d)

Menthol

16.

Which of the following are chelating agents?

a)

MCC, CMC, HPMC

b)

EDTA

c)

Tweens, Spans

d)

Menthol

17.

Which of the following is the most common method of preparation of syrups?

a)

Solution w/ the aid of heat

b)

Solution by agitation w/o the aid of heat

c)

Percolation

d)

Addition of sucrose to a liquid medication

18.

What is the concentration of a simple syrup?

a)

85% w/v

b)

5-40% v/v

c)

15-80%

d)

over 60%

19.

What is the concentration of an elixir?

a)

85% w/v

b)

5-40% v/v

c)

15-80%

d)

over 60%

20.

What is the alcohol content of spirits?

a)

85% w/v

b)

5-40% v/v

c)

15-80%

d)

over 60%

21.

What is the alcohol content of tinctures?

a)

85% w/v

b)

5-40% v/v

c)

15-80%

d)

over 60%

22.

T/F Elixirs are sweetened, aqueous solutions that contain flavoring and coloring agents.

a)

False

b)

True

23.

Which of the following is the most common method of preparation of elixirs?

a)

Solution w/ the aid of heat

b)

Solution by agitation w/o the aid of heat

c)

Percolation

d)

Addition of sucrose to a liquid medication

24.

T/F A limitation of elixirs is it cannot be administered to patients on antidepressant medication.

a)

True

b)

False

25.

T/F Syrups are an aqueous solution.

a)

True

b)

False

26.

Which of the following is true of Keppra?

a)

It is the R-enantiomer of etiracetam

b)

It is administered orally and by IV solution

c)

It is used to treat epilepsy

d)

It can be used to treat neuropathic pain

27.

Which of the following is NOT an available tablet/solution strength of Keppra?

a)

1250mg

b)

250mg

c)

500mg

d)

750mg

e)

1000mg

28.

What colorants are in a 250mg Keppra tablet?

a)

FD&C Blue #2

b)

Yellow iron oxide

c)

FD&C Yellow #6

d)

Red iron oxide

29.

What colorants are in a 500mg Keppra tablet?

a)

FD&C Blue #2

b)

Yellow iron oxide

c)

FD&C Yellow #6

d)

Red iron oxide

30.

What colorants are in a 750mg Keppra tablet?

a)

FD&C Blue #2

b)

Yellow iron oxide

c)

FD&C Yellow #6

d)

Red iron oxide

31.

What are limitations of tablets as a dosage form?

a)

difficulty swallowing

b)

hydrophobic drug formulation problems

c)

hydrophilic drug formulation problems

d)

Portability and compactness

e)

Physical -Chemical stability of drugs

32.

What is a solution for formulating hydrophobic drugs in tablet dosage form?

a)

Use a surfactant

b)

Use a binder

c)

Use a disintegrating agent

d)

Use a lubricant

33.

What is the most common surfactant?

a)

Sodium lauryl sulfate

b)

Magnesium stearate

c)

Lactose

d)

Starch Paste

34.

Which of the following are common diluents?

a)

lactose

b)

dry starch

c)

sorbitol

d)

mannitol

e)

dicalcium phosphate

35.

What is one of the best general binding agents?

a)

Starch paste

b)

Warm gelatin solution

c)

Dry acacia

d)

PVP

36.

Which binder would be used with an API that is susceptible to hydrolysis?

a)

Acacia mucilage

b)

Starch Paste

c)

PVP

d)

Warm gelatin solution

37.

Cellulose derivatives can be used as a

a)

binder

b)

anti-adherent

c)

flavorant

d)

colorant

38.

Methylcellulose can be used as a

a)

binding agent

b)

suspending agent

c)

disintegrating agent

d)

emulsifying agent

39.

Acacia and tragacanth can be used as a

a)

binding agent

b)

suspending agent

c)

disintegrating agent

d)

emulsifying agent

40.

Corn starch can be used as a

a)

binding agent (only in paste form)

b)

anti-adhering agent

c)

disintegrating agent

d)

emulsifying agent

41.

What is the most common type of lubricant?

a)

Magnesium stearate (<1%)

b)

Starch Paste

c)

SLS

d)

Pre-gelatinized starch

42.

T/F Dyes are water soluble and Lakes are insoluble.

a)

True

b)

False

43.

Which of the following will have the least amount of mottling ?

a)

Pastel shades

b)

Red

c)

Blue

d)

highly concentrated colors

44.

T/F Drying granules slowly at high temperature with intermittent stirring will reduce mottling.

a)

True

b)

False

45.

Which of the following can lead to tablet capping?

a)

High powder porosity

b)

poor compressibility

c)

inadequate binding agent and compressional force

d)

Too much moisture

e)

Inadequate anti-adherent

46.

Which of the following can lead to picking?

a)

High powder porosity

b)

poor compressibility

c)

inadequate binding agent and compressional force

d)

Too much moisture

e)

Inadequate anti-adherent

47.

Which of the following is an excellent anti-adherent but a poor lubricant?

a)

Corn starch

b)

Talc

c)

Stearic acid

d)

Carbowax 4000

48.

Which of the following are water soluble lubricants?

a)

Carbowax 4000

b)

Sodium Lauryl Sulfate

c)

Talc

d)

Magnesium Stearate

49.

T/F Lubricants, glidants and anti-adherents should be very fine particle sizes in order to form a thin film.

a)

True

b)

False

50.

Which of the following excipients are required in tablets as a dosage form?

a)

binding agent

b)

diluent

c)

disintegrating agent

d)

lubricant

51.

Which tests are required by USP and NF for tablets?

a)

Dissolution

b)

Weight variation

c)

Drug content uniformity

d)

Friability

52.

Permitted weight variation by USP for a tablet up to 130mg

a)

Not more that 2 tablets differ from the mean weight by more than ± 10%

b)

None differ from the mean weight by more than ± 20%

c)

None differ from the mean weight by more than ± 15%

d)

Not more that 2 tablets differ from the mean weight by more than ± 5%

53.

Permitted weight variation by USP for a tablet 130-324mg

a)

Not more that 2 tablets differ from the mean weight by more than ± 7.5%

b)

None differ from the mean weight by more than ± 20%

c)

None differ from the mean weight by more than ± 15%

d)

Not more that 2 tablets differ from the mean weight by more than ± 5%

54.

Permitted weight variation by USP for a tablet >324mg

a)

Not more that 2 tablets differ from the mean weight by more than ± 7.5%

b)

None differ from the mean weight by more than ± 20%

c)

None differ from the mean weight by more than ± 10%

d)

Not more that 2 tablets differ from the mean weight by more than ± 5%

55.

Which of the following apply to drug content uniformity tests for a tablet when 10 tablets are assayed individually?

a)

each tablet must be within 85-115% of labeled active ingredient

b)

None of the tablets must be outside outside the 75-125% range

c)

If 1 tablet is outside of the 85-115% range an additional 20 tablets must be assayed individually

56.

T/F All tablets that contain the same API (regardless of formulation) have the same drug dissolution profile

a)

True

b)

False

57.

T/F Molality is temperature dependent.

a)

True

b)

False

58.

T/F Equilibrium Vapor pressure is independent of weight of the liquid or the atmospheric pressure.

a)

True

b)

False

59.

Which properties are colligative properties of solutions?

a)

Vapor pressure

b)

Boiling Point

c)

Freezing Point

d)

Osmotic Pressure

60.

ΔTf of an isotonic solution with biofluids is

a)

0.52 °\degree  

b)

0.58 °\degree  

c)

0.50 °\degree  

d)

0.56 °\degree  

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