Which of the following lipids will be most lipophilic (provided all of them have same fatty acid chain length)?

Which of the following is NOT applicable to lipoproteins?

Omega-3 fatty acids have most significant effect on decreasing ___________.

Gemfibrozil has significant drug interaction with which of the following drugs?

Which of the following enzymes help in formation of chylomicrons?

Diet is the primary source of cholesterol while liver is the secondary source.

Pitavastatin is associated with myopathy

Apo E are involved during formation of chylomicrons

Phospholipids are considered to be amphipathic in nature.

Which of the following drugs target pancreatic lipase?

Which of the following is/are adverse effect(s) typically observed with statins? [Select All That Apply]

Colestipol interacts with absorption of _______________ if taken together. [Select all that apply]

Which of the following is/are potential target(s) for anti-hyperlipoproteinemic drug therapy? [Select all that apply]

Precursor for androgens, estrogens, progesterone, adrenocorticoids and bile acids

Highly concentrated stores of metabolic energy. When required for energy production, they are hydrolyzed by lipase enzymes

linoleic acid and linolenic acid are ESSENTIAL.

Long carbon chain (~12-24 Cs) having –COOH at the end

Fatty acids are mostly absorbed from diet

Role of the fatty acids (Select all that apply)

What is the major source of FFAs?

Pancreatic lipase is inhibited by Orlistat (Alli®): drug used to treat obesity

Which of the following are the side effects of Alli (Orlistat) Select all that apply

NPC1L1 receptor blocker: Ezetimibe (vytorin in combination with simvastatin)

Which of the following are TRUE about Bile Salts? Select all that apply

Helps in interaction with aqueous compartment

Helps in vDw interactions with lipids

Which of the following drugs inhibits MTTP?

Which of the following are TRUE about Lipoproteins? Select all that apply

What are the roles of Apoproteins? Select all that apply

Know this

Apoproteins present in HDL? Select all that apply

Apoproteins present in LDL?

Apoproteins present in Chylomicron? Select all that apply

Mipomersan inhibits mRNA responsible for production of _________

Less ApoB100 leads to decreased LDL and VLDL

Familial Hypercholesterolemia means which of the following? Select all that apply

Know this

Which of the following Inhibitors of PCSK9 are approved for familial hypercholesterolemia? Select all that apply

Which of the following drugs increases recycling of LDL-R helping in removal of LDL from circulation? Select all that apply

Mutation in which of the following causes hypertriglyceridemia? Select all that apply

Which two enzymes does ApoA1 activate for cholesterol extraction?

kNOW THIS

Secondary disturbances for Dyslipidemia. Select all that apply

The dyslipidemia main reasons are? Select all that apply

NPC1L1 receptor blocker

inhibits MTTP in the liver, formation of chylomicrons

Inhibits mRNA responsible for production of ApoB100. Less ApoB100 leads to decreased LDL and VLDL, an antisense oligonucleotide

Approved for familial hypercholesterolemia. These drugs increases recycling of LDL-R helping in removal of LDL from circulation. Select all that apply

Which of the following Interferes with cholesterol absorption in intestine and Blocks NPC1L1?

Zetia (know this)

To reduce LDL, total cholesterol, apolipoprotein B, and non-HD cholesterol in patients with homozygous familial hypercholesterolemia (HoFH)

Which of the following can cause fatty acid liver?

 To treat patients with a rare type of high cholesterol called homozygous familial hypercholesterolemia (HoFH), mild to moderate injection site reactions and flu-like symptoms can occur.

CETP and ACAT inhibitors

ACYL CoA-CHOLESTEROL TRANSFRASE (ACAT) INHIBITOR has three beneficial effects- Blocks CE formation in? Select all that apply

Know this

 PJ is a 4.5-year-old boy. At his checkup, the pediatrician notices cutaneous xanthomas and orders a lipid panel. Repeated measures confirm that the patient’s serum cholesterol levels are high (936 mg/dL). Further testing confirms a diagnosis of homozygous familial hypercholesterolemia. Which of the following interventions will be LEAST effective in this patient?

3,5-dihydroxy acid in HMGRIs mimics the tetrahedral intermediate produced by HMG-CoA reductase

Know this

Lactones represents prodrugs