WorksheetsRadiopharmaceuticals
Total questions: 50
Worksheet time: 18mins
Specific activity is defined as _____.
Radioactivity per cubic centimeter of air
Radioactivity per unit volume of a sample
Radioactivity per square centimeter of lead
Radioactivity per unit mass of a radionuclide or a labeled compound
The expiration of a Tc99m elution vial is _____ hrs.
6
12
18
24
Sr-82 and Sr-88 could be contaminants from an eluent of the Rb-82 generator.
True
False
Tc99m MAA particle size should be between 7-90 um in size
True
False
A patient taking ________ can cause altered biodistribution of In111 WBC’s.
Antacids
Antibiotics
Heparin
Beta Blockers
The critical organ when performing a GI bleed study with Tc99m tagged RBC’s is _____.
the colon
small intestine
liver
spleen
The T ½ of Xe-133 is _____.
2.5 days
2.7 days
5.2 days
13 hrs
Cyclotron-produced radionuclides usually decay by _____ or ______.
B+, electron capture
B-, isomeric transition
B-, electron capture
B-, internal conversion
4 properties of Pharmacokinetics
(a)
What is not required of the parent compound in a generator?
It is a different element than the daughter
It is in a state of constant decay
It is able to chemically bind to a carbon foil target
It has a longer T 1/2 than the daughter compound
When there is Mo99m present in a preparation of Tc99m, this is ________ impurity.
Radiopharmaceutical
Radiochemical
Radionuclidic
Radio isobaric
Whenever a 99Mo generator is eluted, the 99mTc is in the form of _______ as the pertechnetate ion.
TcO4-
TcO4+
TcO5-
TcO3+
Whenever thyroid activity is seen on a perfusion lung scan, it most likely indicates:
Free pertechnetate
Hyperthyroidism
Pulmonary embolism
Right to left shunt
Which of the following Tc-99m labeled agents is approved for perfusion brain imaging?
Pentetreotide
Exametazine
Satumomab pentetide
Teboroxime
Based on the day’s clinic schedule shown below, the technologist could order all of the following radiopharmaceuticals EXCEPT:
Patient Procedure
Patient A renal function study
Patient B total body bone scan
Patient C Meckel’s diverticulum localization
Patient D hepatobiliary study
MAA
Mebrofenin
Hydroxymetheylene diphosphonate
mertiatide
The normal adult dose range for a lung perfusion scan is approximately ____ mCi.
2-6
8-10
10-12
12-16
Which of the following radiopharmaceutical kit product is light sensitive?
Sestamibi
MAA
MAG3
DTPA
An eluate of Tc-99m pertechnetate is assayed for Mo-99m contamination with the following results:
Mo-99 45 uCi
Tc-99m 275 mCi
Based on this assay, the technologist should:
Wait for the Mo-99m to decay to an acceptable level before using
Use the eluate for studies requiring Tc-99m labeled agents
Use the eluate for only the next 6 hours
Discard the eluate
What is another name for MDP
(a)
Which is not a target organ for Tc99m DTPA?
Bone
Brain
Kidneys
Lung
The target organ is the organ that has to receive the highest dose in order to produce optimal images.
True
False
Heating is required during the preparation of all of the following Tc-99m labeled radiopharmaceuticals EXCEPT:
Medronate
Mertiatide
Sestamibi
Sulfur Colloid
The presence of free pertechnetate in a MDP kit is considered a
radionuclidic impurity
radiochemical impurity
colloidal impurity
chemical impurity
250 mCi in 6 ml is added to 50 ml. What is the resulting concentration? (mCi/ml)
2.52
4.5
3.4
4.5
The minimum number of radiolabeled particles (MAA, macroaggregated albumin) for a satisfactory lung perfusion scan is:
10,000
30,000
60,000
100,000
Tc04- is seen in what organ after injections
thyroid
salivary glands
gastric mucosa
all of the answers provided
Phosphorus 32 is best described as:
an alpha-emitter
a gamma emitter
a beta emitter
a beta-gamma emitter
99mTc-hexamethyl propylamineoxime (HMPAO) is a lipophilic brain agent also known as:
99mTc-exametazime
99mTc DTPA
Neurolite
Macrotec
What is the dose range of Rb82 chloride (mCi)
5-15
30-50
10-20
25-40
If an MAA kit contains approximately 6 million particles, what reconstituting volume is required to obtain 500,000 particles in 0.4 mL (mL)
0.03
0.21
4.8
12
P-32 has a half-life of 14.3 days. A sample has an original activity of 200 mCi. How much will be left after 3 days (mCi)
173
73
56
1.62
Macroaggregated albumin particles have
uniform particle size
0.1-1 micron-sized particles
10<150 micron-sized particles
an increase in size as dose increases
Mechanism of sulfur-colloid hepatic localization
adsorption
phagocytosis
compartmentalization
transferrin binding
Oxidation of the stannous ion occurs when
air is introduced
carbon dioxide is introduced
water is introduced
nitrogen is introduced
Tc-99m sestamibi
uptake is related to the myocardial blood flow
has no significant redistribution
associated with minimal myocardial washout
all of the answers provided
What is the method of decay for In111
isomeric transition
electron capture
beta emission
none of the answers provided
Which RA/RP is used for thyroid imaging and ablations
I131 sodium iodide
I131 MIBG
I131
I131 Iobenguane
What is the method of production for Ga-67
Cyclotron
Fission
Generator
If there is thyroid activity on a lung scan, you should assume there is a right to left shunt.
True
False
Which radiopharmaceutical is approved to image Pheochromocytoma and Neuroblastoma?
Zevalin
Metastron
Ioflupane
MIBG
The physical half-life of a radiopharmaceutical is 4.0 hours and the biologic half-life is 2.5 hours. What is the effective T 1/2?
0.65 hours
2.2 hours
0.38 hrs
1.5 hours
It is possible for the pretreatment of potassium perchlorate or Lugol's solution to influence the distribution of Tc99m.
True
False
Aminophylline should be available during a stress test if dipyridamole is used, to offset
bronchospasms
flushing
cardiac arrest
GI upset
Radionuclides that are alpha emitters are useful in a few imaging studies, however, they are more applicable to therapeutic applications.
True
False
Name a pharmacological stress agent
(a)
RBC labeling can be done either in vivo or in vitro.
True
False
The Mo99-Tc99m generator is an example of a transient equilibrium
True
False
The T 1/2 of Ga-68 is
32 min
68 min
75 min
76 min
The method of uptake for Sestamibi is
Na+/K+ pump
compartmental
membrane-bound anion transport system
unknown
MAbs can be labeled with In111.
True
False
