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Radiopharmaceuticals

Total questions: 50

Worksheet time: 18mins

Name
Class
Date
1.

 Specific activity is defined as _____.

a)

Radioactivity per cubic centimeter of air

b)

Radioactivity per unit volume of a sample

c)

Radioactivity per square centimeter of lead

d)

Radioactivity per unit mass of a radionuclide or a labeled compound

2.

The expiration of a Tc99m elution vial is _____ hrs.

a)

6

b)

12

c)

18

d)

24

3.

Sr-82 and Sr-88 could be contaminants from an eluent of the Rb-82 generator.

a)

True

b)

False

4.

Tc99m MAA particle size should be between 7-90 um in size

a)

True

b)

False

5.

A patient taking ________ can cause altered biodistribution of In111 WBC’s.

a)

Antacids

b)

Antibiotics

c)

Heparin

d)

Beta Blockers

6.

The critical organ when performing a GI bleed study with Tc99m tagged RBC’s is _____.

a)

the colon

b)

small intestine

c)

liver

d)

spleen

7.

The T ½ of Xe-133 is _____.

a)

2.5 days

b)

2.7 days

c)

5.2 days

d)

13 hrs

8.

Cyclotron-produced radionuclides usually decay by _____ or ______.

a)

B+, electron capture

b)

B-, isomeric transition

c)

B-, electron capture

d)

B-, internal conversion

9.

4 properties of Pharmacokinetics

(a)  

10.

What is not required of the parent compound in a generator?

a)

It is a different element than the daughter

b)

It is in a state of constant decay

c)

It is able to chemically bind to a carbon foil target

d)

It has a longer T 1/2 than the daughter compound

11.

When there is Mo99m present in a preparation of Tc99m, this is ________ impurity.

a)

Radiopharmaceutical

b)

Radiochemical

c)

Radionuclidic

d)

Radio isobaric

12.

Whenever a 99Mo generator is eluted, the 99mTc is in the form of _______ as the pertechnetate ion. 

a)

TcO4-

b)

TcO4+

c)

TcO5-

d)

TcO3+

13.

Whenever thyroid activity is seen on a perfusion lung scan, it most likely indicates:

a)

Free pertechnetate

b)

Hyperthyroidism

c)

Pulmonary embolism

d)

Right to left shunt

14.

Which of the following Tc-99m labeled agents is approved for perfusion brain imaging?

a)

Pentetreotide

b)

Exametazine

c)

Satumomab pentetide

d)

Teboroxime

15.

Based on the day’s clinic schedule shown below, the technologist could order all of the following radiopharmaceuticals EXCEPT:

Patient              Procedure

Patient A          renal function study

Patient B          total body bone scan

Patient C          Meckel’s diverticulum localization

Patient D          hepatobiliary study

a)

MAA

b)

Mebrofenin

c)

Hydroxymetheylene diphosphonate

d)

mertiatide

16.

The normal adult dose range for a lung perfusion scan is approximately ____ mCi.

a)

2-6

b)

8-10

c)

10-12

d)

12-16

17.

Which of the following radiopharmaceutical kit product is light sensitive?

a)

Sestamibi

b)

MAA

c)

MAG3

d)

DTPA

18.

An eluate of Tc-99m pertechnetate is assayed for Mo-99m contamination with the following results:

Mo-99              45 uCi

Tc-99m            275 mCi

Based on this assay, the technologist should:

a)

Wait for the Mo-99m to decay to an acceptable level before using

b)

Use the eluate for studies requiring Tc-99m labeled agents

c)

Use the eluate for only the next 6 hours

d)

Discard the eluate

19.

What is another name for MDP

(a)  

20.

Which is not a target organ for Tc99m DTPA?

a)

Bone

b)

Brain

c)

Kidneys

d)

Lung

21.

The target organ is the organ that has to receive the highest dose in order to produce optimal images.

a)

True

b)

False

22.

Heating is required during the preparation of all of the following Tc-99m labeled radiopharmaceuticals EXCEPT:

a)

Medronate

b)

Mertiatide

c)

Sestamibi

d)

Sulfur Colloid

23.

The presence of free pertechnetate in a MDP kit is considered a

a)

radionuclidic impurity

b)

radiochemical impurity

c)

colloidal impurity

d)

chemical impurity

24.

250 mCi in 6 ml is added to 50 ml. What is the resulting concentration? (mCi/ml)

a)

2.52

b)

4.5

c)

3.4

d)

4.5

25.

The minimum number of radiolabeled particles (MAA, macroaggregated albumin) for a satisfactory lung perfusion scan is:

a)

10,000

b)

30,000

c)

60,000

d)

100,000

26.

Tc04- is seen in what organ after injections

a)

thyroid

b)

salivary glands

c)

gastric mucosa

d)

all of the answers provided

27.

Phosphorus 32 is best described as:

a)

an alpha-emitter

b)

a gamma emitter

c)

a beta emitter

d)

a beta-gamma emitter

28.

99mTc-hexamethyl propylamineoxime (HMPAO) is a lipophilic brain agent also known as:

a)

99mTc-exametazime

b)

  99mTc DTPA

c)

Neurolite

d)

Macrotec

29.

What is the dose range of Rb82 chloride (mCi)

a)

5-15

b)

30-50

c)

10-20

d)

25-40

30.

If an MAA kit contains approximately 6 million particles, what reconstituting volume is required to obtain 500,000 particles in 0.4 mL (mL)

a)

0.03

b)

0.21

c)

4.8

d)

12

31.

P-32 has a half-life of 14.3 days. A sample has an original activity of 200 mCi. How much will be left after 3 days (mCi)

a)

173

b)

73

c)

56

d)

1.62

32.

Macroaggregated albumin particles have

a)

uniform particle size

b)

0.1-1 micron-sized particles

c)

10<150 micron-sized particles

d)

an increase in size as dose increases

33.

Mechanism of sulfur-colloid hepatic localization

a)

adsorption

b)

phagocytosis

c)

compartmentalization

d)

transferrin binding

34.

Oxidation of the stannous ion occurs when

a)

air is introduced

b)

carbon dioxide is introduced

c)

water is introduced

d)

nitrogen is introduced

35.

Tc-99m sestamibi

a)

uptake is related to the myocardial blood flow

b)

has no significant redistribution

c)

associated with minimal myocardial washout

d)

all of the answers provided

36.

What is the method of decay for In111

a)

isomeric transition

b)

electron capture

c)

beta emission

d)

none of the answers provided

37.

Which RA/RP is used for thyroid imaging and ablations

a)

I131 sodium iodide

b)

I131 MIBG

c)

I131

d)

I131 Iobenguane

38.

What is the method of production for Ga-67

a)

Cyclotron

b)

Fission

c)

Generator

39.

If there is thyroid activity on a lung scan, you should assume there is a right to left shunt.

a)

True

b)

False

40.

Which radiopharmaceutical is approved to image Pheochromocytoma and Neuroblastoma?

a)

Zevalin

b)

Metastron

c)

Ioflupane

d)

MIBG

41.

The physical half-life of a radiopharmaceutical is 4.0 hours and the biologic half-life is 2.5 hours. What is the effective T 1/2?

a)

0.65 hours

b)

2.2 hours

c)

0.38 hrs

d)

1.5 hours

42.

It is possible for the pretreatment of potassium perchlorate or Lugol's solution to influence the distribution of Tc99m.

a)

True

b)

False

43.

Aminophylline should be available during a stress test if dipyridamole is used, to offset

a)

bronchospasms

b)

flushing

c)

cardiac arrest

d)

GI upset

44.

Radionuclides that are alpha emitters are useful in a few imaging studies, however, they are more applicable to therapeutic applications.

a)

True

b)

False

45.

Name a pharmacological stress agent

(a)  

46.

RBC labeling can be done either in vivo or in vitro.

a)

True

b)

False

47.

The Mo99-Tc99m generator is an example of a transient equilibrium

a)

True

b)

False

48.

The T 1/2 of Ga-68 is

a)

32 min

b)

68 min

c)

75 min

d)

76 min

49.

The method of uptake for Sestamibi is

a)

Na+/K+ pump

b)

compartmental

c)

membrane-bound anion transport system

d)

unknown

50.

MAbs can be labeled with In111.

a)

True

b)

False