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PHA 051 P1 LEC & LAB

Total questions: 60

Worksheet time: 30mins

Name
Class
Date
1.

 

The following may affect drug metabolism, EXCEPT:

a)

Race

b)

Age

c)

Gender

d)

Social Status

2.

 

Dimercaprol is a chelating agent used in the treatment of:

a)

Arsenic poisoning

b)

Lead poisoning

c)

Iron poisoning

d)

Vanadium poisoning

3.

An important protein that binds most of the basic drugs:

a)

Alpha1-acid glycoprotein

b)

Albumin

c)

Globulin

d)

Transferrin

4.

The phenol derivative used as toothache drops:

a)

Thymol

b)

Eugenol

c)

Chlorocresol

d)

Cresol

5.

 

Which of the following statements describe pharmacodynamic process?

a)

I, II, and III

b)

II, III, and IV

c)

I, III, and V

d)

III, IV, and V

6.

What are bioisosteres?

a)

Functional groups which have similar spatial and electronic character, but they retain the activity or parent.

b)

Substituents or groups with similar physical or chemical properties that impart similar biological properties to a chemical compound.

c)

Enhance the desired biological or physical properties of a compound without making significant changes in chemical structure

d)

All of the choices

7.

 

The phenol derivative extracted from the oil of Thymus vulgaris:

a)

Isopropyl-m-cresol

b)

4-chloro-3-methoxyphenol

c)

4-chloro-2-methoxyphenol

d)

p-chloro-m-xylenol

8.

 

Evaluate the following statements regarding preservatives:

a)

Only statement I is correct.

b)

Only statement I and II are correct

c)

Only statement I and III are correct

d)

Only statement II and III are correct

9.

The most important enzyme system of phase I metabolism is cytochrome P-450 (CYP450). CYP450 enzymes can be induced or inhibited by many drugs causing drug interactions in which one drug may reduce the therapeutic effect of another drug or enhance the toxicity of the other drug

a)

Only the 1st statement is CORRECT.

b)

Only the 2nd statement is CORRECT.

c)

Both statements are CORRECT.

d)

Both statements are INCORRECT.

10.

Both statements are INCORRECT.

a)

Lipophilic medium

b)

Hydrophobic medium

c)

Hydrophilic medium

d)

None of the choices

11.

 

By protein binding of drugs, their:

a)

half-life increased

b)

Area under the curve increased

c)

Clearance increased

d)

Volume of distribution increased

12.

 

Which of the following statement/s refer/s to oxidizing agents:

a)

I only

b)

II only

c)

I and IV

d)

I, II, III, and IV

13.

 

Which of the following is a race for fast acetylators?

a)

Caucasian

b)

Eskimos

c)

Mediterranean Jews

d)

Egyptians

14.

 

The following are examples of functionalization reactions, EXCEPT:

a)

Oxidation

b)

Reduction

c)

Hydrolysis

d)

Acetylation

15.

 

The most common conjugative pathway of drug metabolism:

a)

Sulfate conjugation

b)

Glucuronidation

c)

Methylation

d)

Acetylation

16.

The enzyme that lacks in infants to metabolize Chloramphenicol:

a)

Glucuronic acid

b)

Glucuronyl transferase

c)

Cytochrome P450 oxidase

d)

N-acetyltransferase

17.

Which of the following is resistant to oxidation?

a)

Ketones

b)

Aldehydes

c)

Primary alcohols

d)

Secondary alcohols

18.

Which of the following statements describe receptors?

a)

I and II

b)

I, II, and III

c)

I, II, III, and IV

d)

I, II, III, IV, and V

19.

The following drugs extensively undergo first pass metabolism and are not usually recommended to be taken orally, EXCEPT:

a)

Metoprolol

b)

Nitroglycerin

c)

Lidocaine

d)

Isoproterenol

20.

The following statements is FALSE about drug design?

a)

Designing a drug that can be synthesized efficiently and cheaply is one of the priorities

b)

The aim of drug optimization can be achieved by different strategies or approaches on the lead compound's SAR

c)

Maximize the interactions of a drug with its target binding site in order to improve activity, selectivity, and to minimize side effects.

d)

None of the choices

21.

Drugs that bind to and activate the receptor which directly or indirectly brings about the effect:

a)

Agonists

b)

Antagonists

c)

Analogists

d)

Antargonists

22.

The main route of drug excretion:

a)

Liver

b)

Kidney

c)

Heart

d)

Bile duct

23.

 

This anti-infective acts on the sulfhydryl groups in the enzymes

a)

Mercury-containing compounds

b)

Dyes

c)

Phenols

d)

Alcohols

24.

Evaluate the following statements regarding dyes;

a)

Only statement I is correct.

b)

Only statements I and II are correct.

c)

Only statements I and III are correct.

d)

All statements are correct.

25.

 

CYP-450 enzymes are ____________.

a)

heme proteins

b)

usually found in the liver.

c)

responsible for transferring an oxygen atom to the substrate R-H

d)

All of the choices

26.

 

Skin, brain and placenta are also sites of drug metabolism. However, few drugs are only biotransformed to these sites due to its selectivity and limited capacity of reactions.

a)

Only the 1st statement is CORRECT.

b)

Only the 2nd statement is CORRECT.

c)

Both statements are CORRECT.

d)

Both statements are INCORRECT.

27.

Which of the following is a weak acid drug?

a)

Cocaine

b)

Ephedrine

c)

Morphine

d)

ASA

28.

Do not generally increase water solubility but serve mainly to terminate or attenuate pharmacological activity.

a)

Sulfate conjugation

b)

Glucuronic acid conjugation

c)

Glycine conjugation

d)

Acetylation

29.

 

The following statement/s is/are TRUE regarding acetylation, EXCEPT:

a)

II and III

b)

IV only

c)

I, III, and IV

d)

I and IV

30.

 

NDA is filed by innovator company to FDA at which stage?

a)

After Phase II

b)

Before Phase II

c)

After Phase III

d)

Before Phase III

31.

 

Carbachol exhibits greater resistant to hydrolysis by acetylcholinesterase and therefore produces:

a)

 

longer duration of action

b)

faster onset of action

c)

higher bioavailability

d)

shorter duration of action

32.

More likely to be associated with movement disorders known as extrapyramidal symptoms:

a)

Haloperidol

b)

Paliperidone

c)

Aripiprazole

d)

Ziprasidone

33.

Side chains at position 5 is essential for activity of Barbiturates. Branched, cyclic or unsaturated side chain at C-5 position increases the duration of action of barbiturates

a)

Only the first statement is CORRECT.

b)

Only the second statement is CORRECT.

c)

both statements are CORRECT.

d)

both statements are INCORRECT

34.

 

Which of the following is used in the long-term treatment and prophylaxis of mood swings with Bipolar Affective Disorder.

a)

Chlorpromazine

b)

Phenobarbital

c)

Risperidone

d)

Lithium Carbonate

35.

 

SSRI acts by:

a)

Inhibit the reuptake of the neurotransmitters; serotonin and norepinephrine into their respective nerve terminals

b)

Serotonin reuptake inhibition

c)

Inhibition of alpha lanosterol

d)

Inhibition of cyclooxygenase

36.

 

Which of the following is NOT  Piperazine derivative of phenothiazines?

a)

Mesoridazine

b)

Chlorpromazine

c)

Thioridazine

d)

All of the choices

e)

None of the choices

37.

 

Which of the following is NOT an Aliphatic derivative of phenothiazines?

a)

Thioridazine

b)

Promazine

c)

Chlorpromazine

d)

All of the choices

e)

None of the choices

38.

 

Identify the structure:

a)

Diazepam

b)

Phenobarbital

c)

Ramelteon

d)

Buspirone

39.

A phenyl ring C at position 5 promotes activity of benzodiazepines. Benzodiazepines with 3-hydroxyl group are nonpolar.

a)

Only the first statement is CORRECT

b)

Only the second statement is CORRECT.

c)

both statements are CORRECT.

d)

both statements are INCORRECT

40.

 

First generation antipsychotic drug:

a)

Risperidone

b)

Quetiapine

c)

Haloperidol

d)

Olanzapine

41.

Which of the following is a carbamate?

a)

Neostigmine

b)

Atropine

c)

Soman

d)

Malathion

42.

 

Which of the following is an advantage of newer antiepileptics over others?

a)

 

Less effect on cognitive function

b)

Complex pharmacokinetic action

c)

Multiple adverse events

d)

High dose of drug

43.

 

GABA is a/an:

a)

Excitatory neurotransmitter

b)

Inhibitory neurotransmitter

c)

Autacoid

d)

Hormone

44.

Which of the following drugs contain heterocylic ring: Dibenzazepine?

a)

Imipramine

b)

Diphenhydramine

c)

Furosemide

d)

Acetylcholine

45.

 

Which of the ff. is a serotonin 5-HT1A receptor agonist?

a)

Lorazepam

b)

Phenobarbital

c)

Zaleplon

d)

Buspirone

46.

Identify the structure:

a)

Carbachol

b)

Betanechol

c)

Acetylcholine

d)

Norepinephrine

47.

The greater the lipid solubility of the drug the faster its redistribution. Effects of thiopental is terminated not by metabolism but by redistribution.

a)

Only the first statement is CORRECT.

b)

Only the second statement is CORRECT.

c)

both statements are CORRECT.

d)

both statements are INCORRECT

48.

 

Compounds that mimic the action of acetylcholine at parasympathetic nervous system are called:

a)

Anticholinergics

b)

Parasympathomimetics

c)

Sympathomimetics

d)

Adrenergic agents

49.

 

The following antipsychotics blocks both serotonin and dopamine receptors, EXCEPT:

a)

Risperidone

b)

Quetiapine

c)

Haloperidol

d)

Olanzapine

50.

 

Which of the following is NOT an antidepressant drug?

a)

Imipramine

b)

Indomethacin

c)

Amitriptyline

d)

Clomipramine

51.

Which of the following does not fit to the criteria for the design of new antidepressant drug?

a)

Rapid onset of antidepressant response.

b)

Broader efficacy

c)

Fewer adverse effect

d)

Delayed onset

52.

 

Identify the structure:

a)

Diazepam

b)

Flurazepam

c)

Midazolam

d)

Triazolam

53.

Chemically related to TCA with anticonvulsant and analgesic activity:

a)

Ethosuximide

b)

Valproic acid

c)

Carbamazepine

d)

Phenytoin

54.

 

TCA acts by:

a)

Inhibit the reuptake of the neurotransmitters; serotonin and norepinephrine into their respective nerve terminals

b)

Serotonin reuptake inhibition

c)

Inhibition of folic acid synthesis

d)

Inhibition of dihydropteroate synthase

55.

 

Identify the structure

a)

Carbamazepine

b)

Valproic acid

c)

Ethosuximide

d)

Diazepam

56.

 

Which of the following is/are Acetylcholinesterase inhibitor/s?

a)

I only

b)

I and II

c)

II and III

d)

III only

57.

 

Structurally related to hydantoin:

a)

Ethosuximide

b)

Oxazolidinedione

c)

Phenytoin

d)

All of the choices

58.

Pilocarpine is derived from:

a)

Quinoline alkaloids

b)

Indole alkaloids

c)

Steroidal alkaloids

d)

Imidazole alkaloids

59.

MAO is a / an:

a)

Hormone

b)

Enzyme

c)

Autacoid

d)

Carbohydrate

60.

 

Which of the following is a clinical use of Diazepam?

a)

Drug of first choice for status epilepticus.

b)

Used to treat neuropathic pain

c)

Used with Vancomycin to prevent Red man syndrome

d)

Used with Carbidopa for Parkinson's disease

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