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WorksheetsPharmacodynamics CTSET
Total questions: 7
Worksheet time: 6mins
Targets for drug action include
Hormones
Enzymes
Ion channels
DNA
Receptors
Regarding drug-receptor interaction:
An agonist will always elicit a 100% response
An antagonist will always prevent ligand/agonist binding
An inverse agonist will produce an opposite response compared to agonist
A partial agonist will produce a submaximal antagonistic response
Cell surface receptor activation will
prevent the passage of ions.
activate 2nd messenger systems.
inhibit protein phosphorylation.
inhibit gene transcription.
Activators of intracellular 2nd messenger systems include
adenylyl cyclase.
calcium ion.
acetylcholine.
phospholipase C.
Affinity is
how well a drug likes a receptor.
how strong a drug binds to its receptor.
affected by pKa.
stronger with smaller Kd.
Regarding spare receptors:
They indicate the sensitivity of a cell/tissue type towards its agonist.
A tissue with 90% spare receptors is easier to block with an antagonist.
A tissue with 10% spare receptors is easier to stimulate by its agonist.
They indicate the receptor occupancy rate needed to get 100% response.
Regarding dose-response curves (DRC):
Graded DRC shows potency.
Graded DRC shows efficacy.
Quantal DRC shows therapeutic index.
Quantal DRC shows receptor affinity.
