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Exam 5 Reproduction and Thyroid

Total questions: 82

Worksheet time: 50mins

Name
Class
Date
1.

WOTF produces its pharmacological effect by preventing the Wolff-Chaikoff "escape"?

a)

131I131_I  

b)

PTU

c)

Methimazole

d)

Iodide

e)

Thiourea

2.

WOTF will decrease the GI absorption of levothyroxine? (SATA)

a)

Questran

b)

Aluminum hydroxide

c)

Calcium hydroxide

d)

Ferrous sulfate

e)

Carafate

3.

WOTF is a T4-only preparation? (SATA)

a)

WP-Thyroid

b)

Armour Thyroid

c)

NP-Thyroid

d)

Tirosint

e)

Levothyroxine

4.

WOTF statements about Carbimazole is correct?

a)

Carbimazole is inhibits TPO

b)

Carbimazole is a Oxazolidine analog

c)

Carbimazole is a prodrug

d)

Carbimazole is a pro-hormone

e)

Carbimazole is a tripeptide

5.

WOTF statements about L-thyroxine is correct?

a)

L-thyroxine is a weak base

b)

L-thyroxine is a pro-hormone

c)

L-thyroxine is a weak acid

d)

L-thyroxine is a tripeptide

e)

L-thyroxine is a dipeptide

6.

WOTF is an analog of thyrotropin-releasing hormone?

a)

Thyrel

b)

Thyrogen

c)

Thytropar

d)

Thyrolar

e)

Triostat

7.

WOTF statements about liothyronine is correct?

a)

Liothyronine is a weak base

b)

Liothyronine is a pro-hormone

c)

Liothyronine is a weak acid

d)

Liothyronine is a tripeptide

e)

Liothyronine is an amphoteric compound

8.

WOTF is effective in the treatment of hyperthyroidism because it inhibits the uptake of iodide into they thyroid gland? SATA

a)

Perchlorate

b)

Thiocyanate

c)

Amiodarone

d)

Carbimazole

e)

Thyrolar

9.

(SATA) TRH contains:

a)

Pyroglutamic acid

b)

Lysine

c)

Proline

d)

Histidine

e)

Indole

10.

WOTF is an indication of 131I131_I  ? (SATA)

a)

Grave's disease

b)

Plummer's disease

c)

Hyperthyrotoxicosis in elderly patients

d)

Thyroid cancer

e)

Diagnosis of "hot" thyroid nodules

11.

To which class of compounds does this structure belong?

a)

Thiazolidinediones

b)

Biguanides

c)

Oxazolidine

d)

Carbohydrates

e)

SUs

12.

WOTF is LEAST LIKELY to be observed as an adverse effect of Synthroid?

a)

Anxiety and emotional liability

b)

Menstrual irregularities

c)

Sweating and fever

d)

Palpitations and increased bone mineral denisty

e)

Tremors and insomnia

13.

Select the INCORRECT statement: A concurrent administration of Synthroid and _____ will result in a decrease in the effectiveness of Synthroid?

a)

Androgens

b)

Tamoxifen

c)

5-fluorouracil

d)

Estrogens

e)

Selective Estrogen Receptor Modulators

14.

WOTF is LEAST LIKELY to be observed as an adverse effect of Thioamides?

a)

Agranulocytosis

b)

Leukocytosis

c)

Hepatitis

d)

Dermatitis

e)

Thrombocytopenia

15.

The following reaction is catalyzed by

a)

Type I deiodinase

b)

Type II deiodinase

c)

Type III deiodinase

16.

WOTF statements about L-Thyroxine is/are correct?

a)

L-Thyroxine has one chiral center

b)

L-Thyroxine is negatively charged under physiological conditions

c)

L-Thyroxine is an amphoteric compound

d)

L-Thyroxine is a weak base

e)

L-Thyroxine is a pro-hormone

17.

What is the name of the following thyroid drug?

a)

TSH

b)

L-thyroxine

c)

Liothyronine

d)

TRH

e)

Propylthiouracil

18.

WOTF statements about Liothyronine (T3) (pKa 8.4) is/are correct?

a)

Liothyronine has one chiral center. L isomer is the active isomer

b)

Liothyronine has one chiral center. D isomer is the active isomer

c)

L-Thyroxine (T4) has a longer half-life than Liothyronine (T3)

d)

Liothyronine is an active hormone

e)

Liothyronine is an amphoteric compound

19.

WOTF compounds is/are active hormone (T3)?

a)
b)
c)
20.

The following structure is Methimazole. Which function does this molecule have?

a)

Inhibits 5-deiodinase enzyme

b)

Inhibits 5'-deiodinase enzyme

c)

Inhibits thyroid peroxidase enzyme

d)

Inhibits TRH receptor

e)

Inhibits TSH receptor

21.

The following structure is propylthiouracil. Which function does this molecule have?

a)

Inhibits 5-deiodinase enzyme

b)

Inhibits 5'-deiodinase enzyme

c)

Inhibits thyroid peroxidase enzyme

d)

Inhibits TRH receptor

e)

Inhibits 2'-deiodinase enzyme

22.

What is the name of the following thyroid drug?

a)

TSH

b)

L-thyroxine

c)

Liothyronine

d)

TRH

e)

Propylthiouracil

23.

AOTF statements about Estradiol is true except

a)

Estradiol biosynthesis requires the key enzyme aromatase

b)

Estradiol exhibiting high potency when administered parenterally

c)

Estradiol is a achiral compound

d)

Steroid analog

e)

Estradiol exhibiting high potency when administered orally

24.

What is the purpose of the ethinyl group at C-17?

a)

Ethinyl is a chemically inert group and prevent glucuronide conjugation of C17 hydroxyl group

b)

Ethinyl is a chemically inert group and prevent metabolic oxidation of C17 hydroxyl group

c)

Ethinyl is a chemically inert group and prevent metabolic oxidation of C3 hydroxyl group

d)

Ethinyl is a chemically inert group and prevent metabolic reduction of C17 hydroxyl group

e)

Ethinyl is a chemically inert group and prevent metabolic oxidation of C17 alkyne group

25.

WOTF statements about ethinyl estradiol/Mestranol is/are correct?

a)

Mestranol is a prodrug

b)

Mestranol is a prodrug of ethinyl estradiol

c)

Ethinyl estradiol undergoes extensive first-pass metabolism

d)

Ethinyl estradiol undergoes extensive enterohepatic recycling

e)

Mestranol is a 3-O-methyl ether of ethinyl estradiol

26.

The agonist potency of the exogenous estrogens

a)

Estradiol > Estriol > Estrone

b)

Estriol > Estradiol > Estrone

c)

Estrone > Estradiol > Estriol

d)

Estrone > Estriol > Estradiol

e)

Estradiol > Estrone > Estriol

27.

(SATA) The structure illustrated below

a)

Is a triazole analog

b)

Is an aromatase inhibitor

c)

Is a CYP19 inhibitor

d)

Is a steroid analog

e)

Inhibits the conversion of testosterone to estrogens

28.

(SATA) Ethisterone

a)

Is a synthetic progestin

b)

Is an exogenous estrogen

c)

15-fold more active than progesterone when administered orally

d)

Is a steroid analog

e)

15-fold more active than progesterone when administered subcutaneously

29.

(SATA) Norethindrone

a)

Acetylation of the 17 beta-OH of norethindrone increases the duration of action of the drug

b)

Acetylation of the 17 beta-OH of norethindrone enhances progestin activity

c)

Norethindrone is a synthetic progestin

d)

Norethindrone is a steroid analog

e)

Norethindrone is a aromatase inhibitor

30.

(SATA) Testosterone

a)

Testosterone is more active when administered parenterally than orally

b)

Testosterone 17beta-propionate is available of IM admnistration

c)

Testosterone 17beta-enanthate is a prodrug

d)

Testosterone 17beta-enanthate has a longer duration of action of 2 to 4 weeks

e)

Testosterone 17beta-cypionate has a shorter duration of action of 1 to 2 weeks

31.

(SATA) Fluoxymesterone

a)

is a synthetic testosterone

b)

Orally active

c)

Is a steroid analog

d)

The presence of a 17 alpha alkyl group reduces susceptibility to hepatic oxidative metabolism

e)

Is a synthetic progestin

32.

(SATA) The structure illustrated below

a)

Is a triazole analog

b)

Is an aromatase inhibitor

c)

Is a CYP19 inhibitors

d)

Inhibits the conversion of testosterone to estrogens

e)

Is a steroid analog

33.

WOTF compounds is/are pro-hormone (T4)?

a)
b)
c)
34.

(SATA) WOTF will result in a decreased effectiveness of Synthroid? Concurrent administration of Synthroid and _____

a)

Lasix

b)

Carafate

c)

Testosterone

d)

Estradiol

e)

Aluminum hydroxide

35.

WOTF is NOT matched with its recommended primary site of administration?

a)

Androgel (upper arms and thighs)

b)

Axiron (underarms)

c)

Testoderm (scrotal skin)

d)

Fortesta (thing)

e)

Testim (shoulder and upper arms)

36.

WOTF statements about Hashimoto's thyroiditis is FALSE?

a)

It frequently coexists with diabetes mellitus

b)

It is an autoimmune hypothyroidic state

c)

It occurs more in females than in males

d)

It frequently coexist with endocrine disorder

e)

It seldom occurs in patients with Turner's syndrome

37.

WOTF is a transient hyperthyroid state that is characterized by non-toxic goiters?

a)

Myxedema

b)

Grave's disease

c)

Plummer's disease

d)

Jod-basedow phenomenon

e)

Dequervains thyroiditis

38.

WOTF produces its pharmacological effects by inhibiting 5-alpha reductase?

a)

Femara

b)

Proscar

c)

Avodart

d)

Propecia

e)

Saw palmetto

39.

A patient who is on _____ is expected to have only 4 menstrual periods per year because the drug is an extended-cycle birth control pill. SATA

a)

Quasence

b)

Seasonale

c)

Seasonique

d)

Jolessa

e)

Amethia

40.

An individual who is severely allergic to Drospirenone should NOT be prescribed WOTF? SATA

a)

Slynd

b)

Angeliq

c)

Yaz

d)

Yasmin

e)

Beyaz

41.

WOTF is LEAST LIKELY to be observed as an adverse effect of Estradiol?

a)

Increased incidence of fungal infections

b)

Increased blood pressure

c)

Thromboembolic disorders

d)

Weight loss

e)

Spotting and cramping

42.

WOTF is NOT a pharmacological action of effect of Estradiol?

a)

Decreased secretion of transforming growth factor

b)

Increased secretion of insulin-like growth factor

c)

Decreased release of follicle-stimulating hormones from the pituitary gland

d)

Decreased release of interleukin-1 and interleukin-6

e)

Stimulation of hepatic synthesis of thyroxine-binding globulin

43.

WOTF is LEAST LIKELY to be an adverse effect of Thiomides?***

a)

Goiter and jaundice

b)

Dermatitis, rash, urticaria

c)

Right upper quadrant pain

d)

Fever and sore throat

e)

Leukocytosis and thrombocytosis

44.

While _____ has the advantage of being available for oral administration, it is a testosterone preparation that is NOT indicated in management of age-related hypogonadism.

a)

Testovis

b)

Xyosted

c)

Jatenzo

d)

Delatestryl

e)

Depotest

45.

WOTF is an indication of Androgen? SATA

a)

Postpartum breast engorgement

b)

Gynecomastia

c)

Angioedema

d)

Climacteric symptoms

e)

Klinefelter's syndrome

46.

OBA. Goitrin

a)

Inhibits TRH receptor

b)

Inhibits 7'-deiodinase enzyme

c)

Inhibits 2'-deiodinase enzyme

d)

Inhibits thyroid peroxidase enzyme

e)

Inhibits 1-deiodinase enzyme

47.

TRH is a

a)

Hexapeptide

b)

Dipeptide

c)

Decapeptide

d)

Pentapeptide

e)

Tripeptide

48.

The following structure is Ethinyl estradiol. What is the purpose of the ethinyl group at C-17?

a)

Ethinyl is a chemically inert group and prevent metabolic reduction of C17 hydroxyl group

b)

Ethinyl is a chemically inert group and prevent metabolic oxidation of C17 alkyne group

c)

Ethinyl is a chemically inert group and prevent metabolic oxidation of C17 hydroxyl group

d)

Ethinyl is a chemically inert group and prevent metabolic oxidation of C3 hydroxyl group

e)

Ethinyl is a chemically inert group and prevent glucuronide reduction of C17 hydroxyl group

49.

Fluoxymesterone is a

a)

Synthetic insulin analog

b)

Synthetic progesterone analog

c)

Synthetic thyroxine analog

d)

Synthetic estrogen analog

e)

Synthetic testosterone analog

50.

WOTF statements false? The concurrent administration of Synthroid and _____ is likely to result in _____

a)

Coumadin; reduced hemorrhagic episodes

b)

Dilantin; increased metabolism of Synthroid

c)

Salicylates increased effectiveness of Synthroids

d)

Insulin: a need for the administration of more insulin

e)

Glyburide; reduced effectiveness of glyburide

51.

WOTF is NOT a pharmacological action of methimazole? Inhibition of

a)

Peroxidase

b)

Thyroid stimulating immunoglobulin

c)

Peripheral deiodination of T4

d)

Coupling

e)

Iodination of Tyrosine

52.

WOTF is NOT an indication of Iodide?

a)

Hyperthyroidism

b)

Neurologic cretinism

c)

Protection of the thyroid gland from thyroid cancer caused by radioactive iodine

d)

Grave's disease

e)

Endemic cretinism

53.

WOTF statements about the use of radioactive iodine is FALSE?

a)

When employed in the ablation of thyroid carcinoma, it should be administered concurrently with Thyrogen

b)

It is effective in treating hyperthyroidism that results from a long-standing Grave's disease

c)

Prior to its use in ablating thyroid carcinoma, the patient should be pretreated with PTU

d)

It is effective in managing hyperthyroidism in elder patients with a heart disease

e)

It can be used to diagnose non functional thyroid nodules

54.

Considering the physiologic action of thyroid hormone, WOTF is LEAST LIKELY to be observed during therapy with levothyroxine?

a)

Increased stroke volume

b)

Incresed insulin secretion

c)

Increased number of LDL receptors

d)

Decreased production of bile acid

e)

Decreased peripheral vascular resistance

55.

WOTF contains T1, T2, T3, and T4? (SATA)

a)

Levothroid

b)

Armour thyroid

c)

NP-Thyroid

d)

WP-Thyroid

e)

Liotrix

56.

WOTF is triiodothyronine preparation that is administered intravenously only?

a)

Liotrix

b)

Trisint

c)

Unithroid

d)

Cytomel

e)

Triostat

57.

When taken concurrently with Synthroid, WOTF will decrease the GI absorption of Synthroid? (SATA)

a)

Carafate

b)

Aluminum hydroxide

c)

Cholestyramine

d)

Calcium carbonate

e)

Ferrous sulfate

58.

WOTF is MOST LIKELY to decrease the binding of levothyroxine to thyroxine binding globulin?

a)

Raloxifene

b)

Furosemide

c)

Tamoxifen

d)

Estradiol

e)

5-FU

59.

WOTF is LEAST LIKELY to be observed as an adverse effect of Thioamides?

a)

Agranulocytosis

b)

Leukocytosis

c)

Hepatitis

d)

Dermatitis

e)

Thrombocytopenia

60.

WOTF is effective in the treatment of hyperthyroidism because it inhibits the uptake of iodide into the thyroid gland? SATA

a)

Perchlorate

b)

Thiocyanate

c)

Amiodarone

d)

Carbimazole

e)

Thyrolar

61.

WOTF statements is correct?

a)

PTU has a higher plasma protein-binding capability than methimazole

b)

PTU has a lower plasma protein-binding capability than methimazole

62.

(SATA) WOTF statements about the MOA of Synthroid is FALSE?*

a)

It binds to its receptor which is located in the nucleus

b)

It TR-alpha 2 receptor is present in the pituitary gland only

c)

The Synthroid receptor complex will bind the THRE at the promoter region of specific genes

d)

Its TR-beta 1 receptor is present in all cells in the body

e)

The Synthroid receptor THRE complex causes the transcription of specific genes

63.

WOTF is LIKELY to result from therapy with clomiphene?

a)

Induction of ovulation

b)

Blockage of negative biofeedback effect of estrogen on the hypothalamic release

c)

Increased release of LH from the pituitary gland

d)

Increased sperm count

64.

WOTF contraceptives has been shown to be beneficial in the management of endometriosis, epilepsy, anemia, and menorrhagia?

a)

Amethyst

b)

****

65.

Letrozole are competitive inhibitors of aromatase and selectively inhibit the conversion of

a)

Testosterone to estrogen

b)

****

66.

SATA. A patient who is specially and severely allergic to levonorgestrel should avoid ingesting WOTF?

a)

Aviane

b)

Plan B

c)

Tri-Levlen

67.

What is the analog of TSH?

a)

Thyrogen

b)

***

68.

Which provides post coital prevention of the implantation of a blastocyst in the endometrium?

a)

Mifepristone

b)

****

69.

WOTF is effective in the management of Cushing's disease because it inhibits 11-beta-hydroxylase?

a)

Lysodren

b)

Comerig

c)

Metopirone

d)

Cytadren

e)

Pasireotide

70.

OBA. Gonadotropin-releasing hormone (GnRH) is a

a)

Decapeptide

b)

Octapeptide

c)

Pentapeptide

d)

Hexapeptide

e)

Nonapeptide

71.

Why don't you want to give estrogen concurrently with Evista (raloxifene)?

a)

Increase risk of thromboembolism

b)

Decrease risk of thromboembolism

72.

Can you use Combipatch to manage hot flashes?

a)

Yes

b)

No

73.

WOTF is an indication of mifepristone?

a)

Postcoital contraception

b)

Procurement of abortion

c)

Induction of labor

d)

Endometriosis

e)

Adrenal failure

74.

Select the correct ROA

a)

Axiron: Underarm/armpit

b)

Striant: Buccal

c)

Jactenzo: Oral

d)

Divigel: Upper thighs

e)

Androgel: Should, Upper Arm, Abodomen

75.

WOTF is consistent with incidence of hereditary angioedema?

a)

Swollen face

b)

Swollen tongue

c)

Swollen larynx

d)

C-1-esterase inhibitor protein defect

e)

Airway obstruction

76.

WOTF can you use to manage/treat angioedema?

a)

Stanozolol (Anaysynth)

b)

Danocrine (Danazol)

c)

Ecallantide (Kalbitor)

d)

Icatibant (Firazyr)

e)

Halotestin (Fluoxymesterone)

77.

WOTF is likely observed in a patient who is taking estrogen?

a)

Weight gain

b)

Increase in blood pressure

c)

Increase incidence of migraine

d)

Increase hepatic synthesis of coagulation factors 2, 7, 8, 9, 10

e)

Increase synthesis of antithrombin 3

78.

Estrogens _____ fungal infections?

a)

Increase

b)

Decrease

79.

You would get just 4 episodes of menstruations in a patient who is taking WOTF combination of oral contraceptives?

a)

Amethyst/Lybrel

b)

Beyaz

c)

Seasonale

d)

Seasonique

e)

Lo-Ovral

80.

If you have a patient who is severely allergic to levonorgestrel, WOTF should be avoided in that patient?

a)

Aviane

b)

NorQD

c)

Plan B

d)

Levora

e)

Yazmin

81.

Can you list 3 agents/drugs that can increase plasma protein binding of levothyroxine?

a)

SERM

b)

Estrogen

c)

Clofibrate

82.

What are symptoms of vasomotor syndrome of menopause?

a)

Chills

b)

Sweating

c)

Mood change

d)

Paresthesia

e)

Hot flashes

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