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Total questions: 91
Worksheet time: 47mins
A clinical condition in which scar tissue replaces normal, healthy liver tissue. As the scar tissue replaces the normal liver tissue, it blocks the flow of blood through the organ and prevents the liver from functioning properly
Hepatitis
Cirrhosis
Hepatoma
Reye syndrome
Polyspecific AHG reagents contain:
Anti-C3d
Anti-IgG and anti-IgM
Anti-IgG and anti-C3d
Anti-IgG
In treating hyperbilirubinemia in hemolytic disease of the fetus and newborn, light phototherapy is used to: *
Prevent further hemolysis of fetal red cells
Breakdown unconjugated bilirubin to a nontoxic isomer
Breakdown conjugated into unconjugated bilirubin
Stimulate production of fetal liver enzymes to breakdown unconjugated bilirubin
In liver failure, the prolonged INR improves with vitamin K administration.
False
True
are macrophages that line the sinusoids of the liver and act as active phagocytes capable of engulfing bacteria, debris, toxins, and other substances flowing through the sinusoids
Langerhan's Cells
Kupffer Cells
Microglial cells
Alveolar macrophages
A 10% contamination with 5% dextrose will increase blood glucose by: *
500 mg/dL
1000 mg/dL
50 mg/dL
250 mg/dL
Which of the following is an insulin-like growth factor? *
Somatostatin
Somatomedin
Adrenomedulin
Neurturin
The conversion of amino acids by the liver and other specialized tissue such as the kidney, to substrates that can be converted to glucose is called:
Glycogenesis
Glucogenesis
Glycogenolysis
Gluconeogenesis
Jaundice is usually not noticeable to the naked eye (known as overt jaundice) until bilirubin levels reach
10 mg/dL
15 mg/dL
5 mg/dL
3 mg/dL
A 30-year old man has been fasting for religious reasons for several days. His blood glucose level is now about 60% of its normal value, but he does not feel lightheaded because his brain has reduced its need for serum glucose by using which of the following substances as an alternative energy source.
Beta carotene
BHBA-Beta Hydroxybutyrate
Coenzyme A
Glyceraldehyde-3-phosphate
Signs of Type 2 diabetes mellitus include a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is usually found in body folds, such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead and other areas which is termed as _____. *
Acanthosis nigricans
Generalized pruritis
Dupuytren contractures
Eruptive xanthomas
Kernicterus is caused by the effects of *
Post-hepatic bilirubin
Water insoluble bilirubin
Antibody titer
Anemia
HDFN is characterized by: *
Mostly with the presence of anti-D
IgM antibody
Different RBC antigens between the father and mother
Antibody titer less than 32
The most common cause of chronic liver failure is
Cirrhosis
Hepatitis
Fatty liver disease
Acetaminophen overdose
Which of the following is responsible for the production of blood group antibodies? *
T cells
B cells
Dendritic cells
NK cells
Although many enzymes have been identified as useful in the assessment of liver function, the most clinically useful: I. AST II. ALT III. GGT IV. 5'NT V. ALP
I, II, and III
II, III, and V
III, IV, and V
I, II, III, IV, and V
Glycolysis at refrigeration temperature
7 mg/dL/hr.
2 mg/dL/hr
7 g/dL/hr.
2 g/dL/hr.
The test for weak D is performed by incubating patient's red cells with: *
Different dilutions of anti-D
Anti-D antiserum
Anti-Du antiserum
Antiglobulin antiserum
Enzyme that is most specific for B-D-glucose *
Hexokinase
Glucose-6-phosphate dehydrogenase
phosphohexose isomerase
Glucose oxidase
The main difference between the fetus and the newborn is: *
Size of RBCs
Presence of anemia
Maternal antibody level
Bilirubin metabolism
Kimmelsteil Wilson syndrome is one of the most common complication of diabetes mellitus and is also termed as _____. *
Diabetic Atherosclerosis
Diabetic Retinopathy
Diabetic Ketoacidosis
Diabetic Nephropathy
SELECT ALL THAT APPLIES. Advantages of cordocentesis
Allows direct transfusion of fetal circulation
Decrease the risk of trauma to the placenta
Allows antigen typing of fetal blood
Allows measurement of cordocentesis of fetal hemoglobin and hematocrit levels
Glucose oxidase oxidizes glucose to gluconic acid and ________ *
H2O
CO2
H2O2
HCO3
In the glycogen storage disease, Cori Forbes, what enzyme is deficient?
Brancher
Adenyl Kinase
De Brancher
NOTA
Other terms of pre - hepatic bilirubin:
I. B2
II. B1
III. Conjugated bilirubin I
V. Water- soluble bilirubin
V. Polar bilirubin
VI. Unconjugated bilirubin
VII. Non - polar bilirubin
I, II, III, and V
II, VI, and VII
I, III, V, and VII
I, II, III, IV, V, VI, VII
What produces the hormone that increases plasma glucose by inhibiting insulin secretion, increasing glycogenolysis and promoting lipolysis? *
Adrenal Medulla
Adrenal Cortex
Pancreas
Thyroid
A 29-year old male is hemorrhaging severely. He is AB, Rh-negative. Six units of blood are required STAT. Of the following types available in the blood bank, which would be most preferable for crossmatch? *
AB positive
A positive
A negative
O negative
A woman without prenatal care delivers a healthy term infant. A cord blood sample shows the infant is A-positive with a positive DAT. The workup of the unexpected finding should include: *
ABO and Rh typing of the father
Ant-C3 antiglobulin testing
Maternal ABO testing
DAT using mother's specimen
The purpose of testing with anti-A1B is to detect: *
Anti-A1
Subgroups of O
Subgroups of A
Anti-A2
All of the following are Hyperglycemic Hormones except: * I. Cortisol II. Epinephrine III. Glucagon IV. Growth Hormone
I only
II only
I, II, IV
None of the above
All are true of Diabetes Mellitus type 2, except: *
Hypoglycemic episodes are caused by overzealous treatment
Impaired response of cells to insulin
Insulin-independent treatment
Lifestyle-based
Diabetic Ketonuria is one of the symptoms of Type 1 diabetes mellitus which gives a _____ urine odor
Mousy
Rancid butter
Fruity
Cabbage
All are true of Diabetes mellitus type 1, except: *
Common in children
Beta cell destruction
Absolute insulin deficiency
Dietary causes
Impaired fasting glucose is seen as which of the following results? (mg/dl) *
70-100
100-124
124-200
>200
ABO HDFN differs from Rh HDFN in that: *
The direct antiglobulin test is weaker in Rh HDFN than ABO
Rh HDFN occurs in the first pregnancy
None of these
Rh HDFN is clinically more severe than ABO HDFN
SELECT ALL THAT APPLIES. Blood for intrauterine transfusion
Gamma-irradiated
Compatible with maternal serum
Screened for Cytomegalovirus
More than 7 days old
Effect of high WBC count on blood glucose. *
Increased
Decreased
What is the standard clinical specimen for glucose determination? *
venous plasma glucose
arterial plasma glucose
fasting serum glucose
capillary blood
RhIg is indicated for: *
Mothers who have anti-D
Mothers who are Rh-negative
Infants who have anti-D
Infants who are Rh-negative
SELECT ALL THAT APPLIES: True about sulfhydryl reagents when performing antibody identification: *
Dithiothreitol
J-chain of IgM is destroyed
J-chain of IgG is destroyed
Is used to establish immunoglobulin class of the antibody
_________ is responsible for the yellow coloring in jaundice.
Bilirubin
Carotene
Urobilinogen
AST
This hormone increases plasma glucose by decreasing intestinal entry into the cell and increasing gluconeogenesis, liver glycogen and lipolysis. *
Norepinephrine
Cortisol
Epinephrine
Growth Hormone
The best liver function test is:
INR
Alkaline phosphatase
AST/ALT
Bilirubin
Capillary blood glucose is same with arterial blood glucose. *
FALSE
TRUE
Severe type of HDN-
Rh
ABO
Anemia at birth
Rh
ABO
Weakly positive DAT result
Rh
ABO
Elevated bilirubin at birth
Rh
ABO
Rare pr
ABO
Rh
Most specific non-enzymatic glucose method: *
Neocuproine
Benedict’s
Anthrone condensation
Dubowski Method
Liver disease refers to any abnormal process that affects the liver. *
True
False
Enzyme markers of liver injury: Hepatocellular disorders
AST
ALT
SGOT
SGPT
All of the above
Fasting glucose in serum or plasma is 15% higher than glucose in whole blood.
True
False
It has been described as geneticist's nightmare *
Down syndrome
Type 2 DM
Rabson-Mendengall syndrome
Type 1 DM
A ketone test is recommended when plasma glucose reached 250 mg/dl *
TRUE
FALSE
In a patient with chronic liver disease, all of the following suggest the presence of chronic liver insufficiency, except:
Low albumin
Prolonged prothrombin time
Elevated bilirubin
Elevated aminotransferases
Describes the finding of immature RBCs or erythroblasts in the fetal circulation due to the action of bone marrow in respond to anemia. This term is commonly used now as HDN. *
Kernicterus
Jaundice
Hydrops fetalis
Erythroblastosis fetalis
The most common cause of chronic liver failure is
Cirrhosis
Hepatitis
Fatty liver disease
Acetaminophen overdose
Periodic monitoring of glucose should be requested to avoid diabetic complications. These tests include:
FBS and HBA 1c
SGOT
Late-stage chronic liver disease is called ___________. *
Cirrhosis
Hepatitis
Hyperbilirubinemia
Jaundice
What is the effect of hemolysis on hexokinase? *
Falsely increased
Variable
Falsely decreased
No effect
Which glucose method can employ a polarographic oxygen electrode?
Hexokinase
Glucose oxidase
Glucose dehydrogenase
O-toluidine
It is the accumulation of bilirubin in the brain when jaundice left untreated. Bilirubin reaches the toxic level, generally more than 18 mg/dL. *
Erythroblastosis fetalis
Jaundice
Kernicterus
Hydrops fetalis
______ is greater than _____ in metastatic disease of the liver.
ALT,AST
AST, ALT
Most specific liver enzyme
AST
ALT
True about Kleihauer-Betke test:
Hemoglobin F is resistant to alkaline
Principle is alkaline resistance
is used to quantitate the number of fetal Rhpositive cells in the mother’s circulation as a result of a fetomaternal hemorrhage
All of the above
Type 2 DM, except: *
Macrovascular and microsvascular complications
Microvascularcomplications are involved.
C- peptide levels are measurable
Also known as NIDDM
In liver failure, the prolonged INR improves with vitamin K administration.
True
False
The most common congenital form of glycogen storage disease: *
Von Gierke
Cori Forbes
Andersen
Tarui
Normal Ratio of of B-hydroxybutyrate and acetoacetic acid: *
3:1
2:1
1:1
1:2
The best liver function test is:
Bilirubin
INR
Alkaline phosphatase
AST/ALT
1. Hemolysis and icterisia affect hexokinase method causing false deceased of glucose.
2. Hemolyzed samples containing >0.5 mg hemoglobin/dL are unsatisfactory for Hexokinase *
Both Statements are correct
Statement 1 is incorrect, statement 2 is correct
Both statements are incorrect
Statement 1 is correct, statement 2 is incorrect
It is the development of high-output cardiac failure with generalized edema, effusions and ascites when severe anemia along with hypoproteinemia occurs. *
Kernicterus
Hydrops fetalis
Jaundice
Erythroblastosis fetalis
A Kleihaue-Betke test or flow cytometry indicates 12 fetal cells per 950 adult cells. For a woman with 5,000 mL blood volume, the proper dose of RhIG is:
None of these
2 vials only
1 plus one more vial
3 vials only
Decreased C-Peptide: *
Type 2 DM
Insulinoma
Type1 DM
Type 1 and 2 DM
Selection of blood for intrauterine transfusion.
Group O positive
CMV-negative
Hemoglobin S-positive is acceptable
Hematocrit should be greater than 70%
Blood selected for exchange transfusion must: *
Lack red blood cell antigens corresponding to maternal antibodies
Be <3 days old
Be the same Rh type as the baby
Be ABO compatible with the father
Percentage/level of HbA1c that indicates increased risk for Diabetes (Pre-diabetes)
6.5%
5.7%-6.4%
RhIG is indicated in which of the following circumstances? *
Mother D-positive, infant D-positive
Mother D-positive, infant D-negative
Mother D-negative, infant D-positive
Mother D-negative, infant D-negative
To produce the most reliable results, a specimen for glucose testing should be collected *
After 8 hours of fasting
After 12 hours of fasting
2 hours after eating
Anytime
Increased concentrations of ascorbic acid inhibit chromogen production in which of the following glucose methods? *
Ferricyanide
Ortho-toluidine
Glucose oxidase
Peroxidase
Oxyhemoglobin is considered an interfering substance during spectrophotometric analysis of amniotic fluid bilirubin because:
Its maximum absorbance occurs at 450 nm
None of these
Its maximum absorbance occurs at 410 nm
Its maximum absorbance occurs at 550 nm
This will occur because the fetus liver is not welldeveloped to conjugate the bilirubin after RBC destruction
Hydrops fetalis
Erythroblastosis fetalis
Kernicterus
Jaundice
Patients to be taken an OGTT should ingest:
At least 150 g/day of carbs
At least 150 mg/day of carbs
SELECT ALL THAT APPLIES: ABO HDFN *
Most common cause of HDFN
Can occur in first pregnancy
Most severe cause of HDFN
Antibody is IgM
Why are antibodies formed from the mother in cases of Rh hemolytic disease of the newborn? *
Mother lacks the Rh antigen and the fetus inherits the antigen from the father
Mother happens to be Rh (+) and father is Rh (-)
Amniocentesis can be performed after: *
14th week of gestation
21st week of gestation
Reference value of CSF Glucose
40-70 mg/dl
50-60 mg/dl
WHO standard glucose load: *
75 grams
70 grams
Most commonly used method for bilirubin determination that uses caffeine sodium benzoate as an accelerator: *
Van den Bergh
Jendrassik and Grof
Effects of hemolysis on insulin *
Falsely increased
Falsely decreased
