WorksheetsGPAT_I_Pharmaceutics
Total questions: 20
Worksheet time: 12mins
Name
Class
Date
1.
IND application is filled at which of the following stage?
a)
Before Phase I
b)
After Phase III
c)
After Phase II
d)
During preclinical stages
2.
Humectants added in cosmetic preparations generally act by
a)
Complex formation
b)
Hydrogen bond formation
c)
Covalent bond formation
d)
London forces
3.
The Noyes-Whitney equation is used to describe
a)
Mixed order kinetics
b)
First order kinetics
c)
Dissolution
d)
Diffusion
4.
Study the following two statements: [X] : If the gas is cooled below its critical temperature, less pressure is required to liquefy it. [Y] : At critical temperature and critical pressure, the liquid will have highest vapor pressure. Choose the correct combination of statements.
a)
Both X and Y are correct
b)
X ix correct, Y is wrong
c)
X is wrong , Y is correct
d)
Both X and Y are wrong
5.
When used as granulating agent PEG 6000 improves dissolution rate of the dosage form as it forms a complex with better solubility.
a)
Agree
b)
Disagree
6.
Containers for aerosol should withstand a pressure of
a)
140-180psig at 130°F
b)
120-140psig at 130°F
c)
140-180psig at 150°F
d)
120-140psig at 150°F
7.
Based on Henderson - Hasselbach equation, at what pH value a weak acid would be 99.9% ionized
a)
At pH equivalent to pKa -3
b)
At pH equivalent to pKa +3
c)
At pH equivalent to pKa -1
8.
Calculate the approximate % of codeine present as free base in the small intestine(pH=6.5). pKa codeine =7.9
a)
0.103
b)
0.38
c)
0.038
d)
0.0103
9.
What quantities of 95 %v/v and 45%v/v alcohols are required to prepare 100ml of 65% alcohol?
a)
40ml of 95% and 60ml of 45%v/v alcohol
b)
60ml of 95% and 40ml of 45%v/v alcohol
c)
30ml of 95% and 70ml of 45%v/v alcohol
d)
70ml of 95% and 30ml of 45%v/v alcohol
10.
Substance used to reduce friction during tablet compression and facilitate the ejecion of tablets from the cavity is
a)
Glidant
b)
Humectant
c)
Anti-adherant
d)
Lubricant
11.
The following properties are characteristic of microemulsions? Except
a)
Homogenous
b)
Transparent systems
c)
High emulsifier content
d)
Thermodynamically unstable
12.
The effective net charge on the zwitterion is zero at the isoelectric point.
a)
True
b)
False
13.
Surface tension arises because of the downward pull of molecules in the water.
a)
Yes
b)
No
14.
Which method is used by pharmacists for complete blending of potent powders with larg quantities of diluent?
a)
Trituration
b)
levigation
c)
Geometric dilution
d)
Spatulation
15.
First-order kinetcs half-life is equal to
a)
0.693/k
b)
C/2k
c)
2k+1
d)
1+k
16.
Following is not the method for determining the surface area of particles:
a)
Adsorption method
b)
Mercury displacement method
c)
BET method
d)
Air permeability method
17.
Air permeability method is used to determine the ___________ of powder.
a)
Volume
b)
Density
c)
mass
d)
Specific surface area
18.
Ordinarily, interfacial tensions are _________ than surface tension
a)
Greater
b)
Same
c)
Lesser
d)
Cannot relate
19.
Higher the HLB value of surfactant, more __________ it is
a)
Non ionic
b)
hydrophilic
c)
lipophilc
d)
amphoteric
20.
Reynold’s number (Re) for streamline flow of a fluid is
a)
<0.2
b)
>0.2
c)
<0.8
d)
>0.8
100 %
