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WorksheetsCEUTICS 3 EXAM 2 TDDS MIR...
Total questions: 48
Worksheet time: 4hrs 33mins
Which of the following statements are TRUE regarding Transdermal Scop (Scopolamine = an alkaloid extracted from Solanaceae)? Select all that apply
applies on the skin behind the ear
transdermal patch
used to prevent nausea and vomiting associated with travel
applies on the skin near the stomach
undergoes first pass metabolism (short half life of 4.5 hrs.)
Scopolamine is formulation to the skin to deliver a drug through the SKIN into the general CIRCULATION for _________
local effect
systemic effect
Which of the following layers is a formidable drug barrier that is 10 micrometers when dry and 40 micrometers when wet ?
stratum corneum
stratum lucidum
stratum granulosum
Which of the following are TRUE regarding the Shunt Routes? Select all that apply
Through the keratocytes up to the dermis
via the sweat pores
Through the hair follicles with the associated sebaceous glands
via the hair erector muscle
Which of the following are physiological factors affecting permeation? Select all that apply
Pathological conditions of the skin
body site
race
age
skin hydration (hydration favors percutaneous absorption)
Which of the following are TRUE about Physicochemical Properties of a Permeant? Select all that apply
Log P values between 1-4 are preferable
MW<500 Da is believed to be ideal for TDDS
The effective dose of a drug
Must be relatively low (~10 mg/day)
Nonpolar drugs tend to cross the cell barrier through lipid-rich regions (transcellular route)
Polar drugs favor transport between cells (intercellular route)
Which of the following routes Nonpolar drugs tend to cross the cell barrier through lipid-rich regions?
intercellular route
transcellular route
Which of the following routes Polar drugs favor transport between cells ?
intercellular route
transcelullar route
Which of the following the effective dose of a drug must be?
relatively high (~40 mg/day)
relatively low (~10 mg/day)
moderate (~25 mg/day)
very high (75mg/day) since it needs to go though the membrane
Which of the following molecular weights is believed to be ideal for TDDS?
MW<3000 Da
MW<500 Da
MW<1000 Da
MW<50000 Da
Log P values between 1-4 are preferable as Physicochemical Properties of a Permeant.
True
False
Which of the following statements are TRUE regarding Formulation Factors? Select all that apply
The amount of drug absorbed percutaneously decreases with an increase in the concentration of the drug in the TTDS
The amount of drug absorbed percutaneously increases with an increase in the concentration of the drug in the TTDS
The smaller the TTDS, the more drug is absorbed
The larger the TTDS, the more drug is absorbed
What are some of the ADVANTAGES of TDDS? Select all that apply
Avoiding gastrointestinal degradation/irritation
Bypass the first-pass metabolism
Provides continuous and controlled drug delivery
Can be self-administered
Noninvasive and painless ROA , and thus patient friendly
What are some of the ADVANTAGES of TDDS? Select all that apply
Therapy can be initiated and terminated as needed
Transdermal vaccine delivery could improve immune responses by targeting delivery to immunogenic cells in the skin
Generally inexpensive
DOES NOT provide continuous and controlled drug delivery
Transdermal Patch is a dosage form designed to deliver a constant and controlled therapeutic dosage across skin over extended periods of time for systemic therapy.
True
False
Which of the following Systems will go through the membrane?
Drug-in-Adhesive (DIA)
Matrix-type
(Drug-in-Matrix)
Reservoir system
Which of the following are TRUE about the Protective Liner? Select all that apply
To be REMOVED before application to enable drug release
Usually occlusive
Temporarily covers the adhesive
Maintains contact with the skin
Which of the following are TRUE about the Adhesive? Select all that apply
Maintains contact with the skin AND Serves as the matrix for DIA systems
Crucial component of all transdermal patches
Non-irritating and non-allergenic
Compatibility with the drug and excipients
Enables painless and complete removing
Which of the following protects the patch system from environmental entry, drug evaporation and moisture evaporation?
Adhesive
Backing Layer
Protective Liner
Which of the following is the blend of a drug and polymer in TDDS of cellulose derivatives, PVP and POVIAC?
Adhesive
Backing Layer
Protective Liner
Drug Matrix
Which of the following are specific for the reservoir in TDDS? Select all that apply
Drug Reservoir
Matrix
Membrane
Which of the following is a DIA system for smoking cessation in which the API is sandwiched between backing layer and liner ?
Fentanyl
Nicotrol
Which of the following controls the drug release rate in Nicotrol (DIA System)?
Polymer matrix
Disposable liner
Membrane
Protective liner
The viscosity of the reservoir content is critical.
True
False
Which of the following formulations is characterized WITHOUT EXCESS OF DRUG and possess a plateau in the permeation profile?
Finite Dose Formulation
Infinite Dose Formulation
know these differences! I have given 10 minutes so you can review and memorize.
Yes
No
Which of the following are TRUE about Duragesic® (Fentanyl) as A Reservoir System? Select all that apply
Hypothermic patients may not get
adequate pain relief
opioid analgesic for chronic pain
Absorption of fentanyl is affected by skin temperature
Febrile patients may absorb more drug,
needing dose decrease
a patch for smoking cessation with local effect
Which of the following are DISADVANTAGES for Fentanyl Patch (Duragesic)? Select all that apply
Patches typically contain a large amount of residual drug
Some patients may develop severe response like DERMATITIS
Only small, unionized, moderately lipophilic drugs are able to passively permeate the skin
Only potent drugs are considered suitable candidates to maintain therapeutic concentrations in plasma
Because the Protective liner in this patch DERMATITIS is not a problem
Which of the following statements is TRUE regarding Chemical Permeation Enhancers?
Increase skin permeability by reversibly damaging or altering the physicochemical nature of the stratum corneum to reduce its diffusion resistance
Increase skin permeability by irreversibly damaging or altering the physicochemical nature of the stratum corneum to reduce its diffusion resistance
Increase skin permeability by irreparably damaging or altering the physicochemical nature of the stratum corneum to reduce its diffusion resistance
Which of the following statements are TRUE regarding Chemical Permeation Enhancers mechanisms of action? Select all that apply
Increasing the hydration state of the stratum corneum
Expanding intercellular lipids and lipoproteins channels
Decreasing the hydration state of the stratum corneum
Which of the following are examples of Chemical Permeation Enhancers? Select all that apply
Water, Fatty acids
Solvents
Surfactants
LMW alcohols
DMSO
Which of the following is based on the concept of columbic force (like repels like), involving three transport mechanisms and the passage of a constant electrical current onto the skin?
Electroporation
Iontophoresis
Sonophoresis
Microneedles
Which of the following are the three transport mechanisms in Iontophoresis? Select 3 of the choices
Electroosmosis (flow of solvents and neutral molecules)
Electromigration (movement of ions)
Passive diffusion
Active diffusion
Which of the following is a disadvantage of Iontophoretic Devices?
applicable for the charged molecules, can lead to skin irritation
may cause cell death and muscle contraction, instrumentation
Drug is mixed with a coupling agent (gel, ointment, or cream), which transfers ultrasonic energy
Potential technology foe vaccine delivery
Which of the following is an advantage of Iontophoretic Devices?
applicable for the charged molecules, can lead to skin irritation
may cause cell death and muscle contraction, instrumentation
reduces inter/ intrasubject variability
The skin remain permeable for several hours
Which of the following may cause cell death and muscle contraction, instrumentation?
Iontophoresis
Electroporation
Sonophoresis
Microneedles
Which of the following is a creation of aqueous pores in the lipid bilayers by the application of short electrical pulses and suitable for lipophilic and hydrophilic drugs, large-molecular-weight drugs, DNA?
Microneedles
Ionophoresis
Electroporation
Sonophoresis
Which of the following are TRUE about Sonophoresis (Phonophoresis)? Select all that apply
The skin remain permeable for several hours
Uses low- or high-frequency ultrasound to produce cavitation, microstreaming, and heating.
Drug is mixed with a coupling agent (gel, ointment, or cream),
Potential technology foe vaccine delivery
Which of the following are the Sonophoresis advantages? Select all that apply
Shows a synergistic effect with chemical enhancers
The drugs need NOT be ionized
Delivery of a high molecular weight drugs
reduces inter/ intrasubject variability
Which of the following are TRUE about Microneedles? Select all that apply
Potential technology foe vaccine delivery
Minimally invasive devices that disrupt the stratum corneum by creating microchannels
The drugs need NOT be ionized
Delivery of a high molecular weight drugs
Determines the ability to properly adhere to a patient’s skin
and measures the force required to remove a patch from a standardized surface
RELEASE LINER PEEL TEST
PEEL ADHESION TEST
ROLLING BALL TEST
In vitro Release Testing
Measure the force required to remove the release liner from an adhesive patch.
RELEASE LINER PEEL TEST
PEEL ADHESION TEST
ROLLING BALL TEST
In vitro Release Testing
Determines how quickly an adhesive can from a bond with another surface.
RELEASE LINER PEEL TEST
ROLLING BALL TEST
PEEL ADHESION TEST
In vitro Release Testing
Determine the route and the amount of drug permeated trough the skin, measured using diffusion Franz diffusion cell.
RELEASE LINER PEEL TEST
In vitro Release Testing
PEEL ADHESION TEST
In vitro Release Testing
Franz Diffusion Cell is o measure diffusion coefficients, drug is added to the donor chamber, and the amount of the drug that penetrates into the receiver chamber is measured as a function of time.
True
False
Which of the following are Factors Affecting Permeation? Select all that apply
Physiological factors
Physicochemical properties of a permeant
Formulation Factors
Which of the following is the movement of drug through the membrane?
Penetration
Permeation
Percutaneous absorption
Partitioning
I don't see this relevant to be tested, but you can look at it, common sense.
Yes
No
