WorksheetsPSMA REVIEWER
Total questions: 50
Worksheet time: 25mins
This structure was isolated in the 19th century along with physostigmine, an acetylcholinesterase inhibitor. What drug is being represented by the structure?
Morphine
Cocaine
Heroin
Codeine
PABA enchances the bacteriostatic action of sulfonamide-like drugs
True
False
Neither true or false
Complete the reaction:
CH3CH2OH + KMnO4 ______ + H2O
Ethanal
Ethanol
Ethyl Oxide
Isoproyl
Alcohols can be dehydrated to remove the hydroxyl group and which must occur in acidic condition. The product of this reaction will result to the production of water and
alkyne
alkene
alkane
esters
Reaction of a carboxylic acid with an alcohol will form an
ethanol
esters
alkene
ethanoic acid
Ethers with a general formula of R-COOH are slightly polar and can form H-bonds with each other due to the presence of H-atom in their structure.
True
False
Neither of the statement is corret
Amides, which are ammonia or amine derivatives of organic acids can form H-bonds with themselves, and those with up to 5 carbon atoms are soluble in water.
True
False
Neither of the statement is correct
Which of the following compounds of carbon where the signle unit of carbon unites with an element's that is univalent to form only single bonds?
Carbon monoxide
Calcium oxide
Carbon tetrachloride
Calcium hyroxide
Examples of Glutathione Conjugation.
I. Acetaminophen
II. Aniline
III. Bromobenzene
IV. Estrone
I and III
I, II, III
II ad IV
I, II, III, IV
Examples of Methylation.
I. Methyldopa
II. Dopamine
III. Thioracil
IV. Leukotriene
I and IV
II and III
I, II, IV
I, II, III, IV
Lactate dehydrogenase catalyzes the interconversion of lactate and pyruvate.
The enzyme is decrease in plasma in myocardial infarction, acute leukemias, generalized carcinomatosis and acute hepatitis.
The first statement is true and second statement is false.
The first statement is false and second statement is true.
Both statement are true.
Both statement are false.
6-mercaptopurine is a purine analogue used an anticancer and immunosuppressive agent sold under the tradename, purinethol. In its structure this drug contains a thiol functional group.
The first statement is true and second statement is false
The first statement is false and second statement is true
Both statement are true
Both statement are false
Phenylbutazone (Butazolidine) is a non steroidal anti-inflammatory drug.
This drug selectively inhibits the COX-2 enzyme.
The first statement is true and second statement is false
The first statement is false and second statement is true
Both statement is true
Both statement is false
Ascorbic acid is more acidic than aspirin. Theophylline is more acidic than caffeine
The first statement is true and second statement is false
The first statements is false and second statement is true
Both statement is true
Both statement is false
Ionized drug is more readily execretable. Unionized drug is more soluble.
The first statement is true and second statement is false
The first statement is false and second statement is true
Both statements are true
Both statement are false
Secondary R-OH are easily oxidized to
carbonyl reactivity
benzopyrene
aldehyde
ketone
The study of chemical agents which are selectively more toxic to the invading organisms than the host
Therapeutic
Antiseptics
Fungicides
Systemic
Mechanism of action of quinolones:
Injury to plasma membrane
Inhibition of DNA gyrase
Protein Synthesis Inhibition
Production of toxic free radicals
An example of glycine conjugation pathway:
Phenol to phenosulfate
Benzoic acid to hippuric acid
Noradrenaline to epinephrine
Antabuse to dithiocarbamic acid
A glycopeptide antibiotic:
Beta-lactam
Vancomycin
Polymyxin
Probenecid
Presence of electron withdrawing groups attached to the alpha carbon of the amide side chain of penicillins:
Activity against pseudomas
Acid stability
Activity against gram (-) bacteria
Penicillinase Resistanve
Attachment of bulky groups to the alpha carbon of the amide side chain in penicillins render:
Penicillinase resistance
Activity against Pseudomonas
Activity against gram (-) bacteria
Acid Stability
Drug of choice for absence seizures:
Carbamazepine
Ethosumiximide
Phenytoin
Primidone
The most potent anti-bacterial alcohol:
Primary
Secondary
Tertiary
Quaternary
A progesterone derivative which is used for the treatment of endometrial cancer
Tamoxifen
Depo-provera
Flutamide
Goserelin
Anesthetic drug of choice for labor:
Halothone
Enflurance
Nitrous oxide
Methoxyflurane
Pentavalent antimony in the presence hydrochloric acid gives a violet precipitate with this pink dye:
Rhodamine B
Aluminum reagent
P-nitrobenzenr azo-resorcinol
Dimethygloyxime
Derivatives of sulfonylureas are
Oral hypoglycemics
Diuretics
Spasmolytic
Anti-inflammatory
Protaglandins are also known as
Saturated fats
Compound Lipids
Eicosanoids
All of the above
The onset and duration of barbiturate action is mainly function of its
Lipid solubility
Renal Excretion
Plasma Binding
Method of administration
A direutuc that will manifest a competitive inhibition of the action of aldosterone:
Triamterene
Spirinolactone
Furosemide
Clorothiazide
Sulfonamides are metabolized by humans principally by:
Acetylation
Deamination
Oxidation
Methylation
The drug that used in all types of tuberculosis:
Ethambutol
Cycloserine
Streptomycin
P-aminosalicyclic acid
Which of the following is classified as a broad spectrum antibiotic?
Sodium Methicillin
Potassium Phenethicillin
Ampicillin
Penicillin G
Which of the following penicillins is resistant to penicillinase?
Ampicillin
Oxacillin
Carbenicillin
Mezlocillin
This is used as an inhalation anesthetic:
Droperidol
Thiopental
Halothane
Midazolam
These drugs are narcotic analgesics, except:
Morphine
Codeine
Nalbuphine
Mefenamic acid
This drug is used as an osmotic diuretic:
Mannitol
Ethanol
Isopropanol
Glycitol
Levodopa is used in the treatment of:
Leukemia
Parkinson's disease
Alzheimer's Disease
Tay Sach's Disease
The generic name of the brand Diabinese:
Chlopropramide
Glibenclamide
Spirinolactone
Hydrochlorothiazide
Preservatives like parabens increase their preservative property by:
Reducing the parent compound
Decreasing molecular weight
Attaching a halogen to the parent compound
Increasing the molecular weight
Radical reactions may also be proceed using this reagent:
Bromine water
Hydrogen peroxide
Nitric acid
Potassium bitartrate
The functional group attached to the acyl amino group is called an:
Phenoxyethyl
Isoxozyl
Benzyl
Methoxyphenyl
Halogen substituents are best placed in what position:
1,2 substitution
1, 3 substitution
1, 4 substitution
Both A and C
Addition more than 1 chloride atoms in the structure confers what modification on the pharmacokinetic profile of the drug
Metabolism
Absorption
Distribution
Excretion
Sodium pump is an example of:
Enzyme linked tyrosine kinase receptor
Ion channel
Gene transcription-linked receptor
G-protein coupled receptor
What is the reagent needed for the first reaction?
NaOH/ Oxidizing agent
CHCl3/AlCo3
HNO3/H2SO4
NaOH/Reducing agent
The product formed with the reaction is
Benzyl alcohol
Phenol
Benzoic acid
Xylene
Which of the following Cephalosporins is excreted in bile?
Cefixime
Cefotaxime
Ceftriaxone
Moxalactam
Zovirax is effective against the strain of
Varicella
HSV
Vesicular stomatitis virus
All of the above
