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PSMA REVIEWER

Total questions: 50

Worksheet time: 25mins

Name
Class
Date
1.

This structure was isolated in the 19th century along with physostigmine, an acetylcholinesterase inhibitor. What drug is being represented by the structure?

a)

Morphine

b)

Cocaine

c)

Heroin

d)

Codeine

2.

PABA enchances the bacteriostatic action of sulfonamide-like drugs

a)

True

b)

False

c)

Neither true or false

3.

Complete the reaction:

CH3CH2OH + KMnO4 ______ + H2O

a)

Ethanal

b)

Ethanol

c)

Ethyl Oxide

d)

Isoproyl

4.

Alcohols can be dehydrated to remove the hydroxyl group and which must occur in acidic condition. The product of this reaction will result to the production of water and

a)

alkyne

b)

alkene

c)

alkane

d)

esters

5.

Reaction of a carboxylic acid with an alcohol will form an

a)

ethanol

b)

esters

c)

alkene

d)

ethanoic acid

6.

Ethers with a general formula of R-COOH are slightly polar and can form H-bonds with each other due to the presence of H-atom in their structure.

a)

True

b)

False

c)

Neither of the statement is corret

7.

Amides, which are ammonia or amine derivatives of organic acids can form H-bonds with themselves, and those with up to 5 carbon atoms are soluble in water.

a)

True

b)

False

c)

Neither of the statement is correct

8.

Which of the following compounds of carbon where the signle unit of carbon unites with an element's that is univalent to form only single bonds?

a)

Carbon monoxide

b)

Calcium oxide

c)

Carbon tetrachloride

d)

Calcium hyroxide

9.

Examples of Glutathione Conjugation.

I. Acetaminophen

II. Aniline

III. Bromobenzene

IV. Estrone

a)

I and III

b)

I, II, III

c)

II ad IV

d)

I, II, III, IV

10.

Examples of Methylation.

I. Methyldopa

II. Dopamine

III. Thioracil

IV. Leukotriene

a)

I and IV

b)

II and III

c)

I, II, IV

d)

I, II, III, IV

11.

Lactate dehydrogenase catalyzes the interconversion of lactate and pyruvate.

The enzyme is decrease in plasma in myocardial infarction, acute leukemias, generalized carcinomatosis and acute hepatitis.

a)

The first statement is true and second statement is false.

b)

The first statement is false and second statement is true.

c)

Both statement are true.

d)

Both statement are false.

12.

6-mercaptopurine is a purine analogue used an anticancer and immunosuppressive agent sold under the tradename, purinethol. In its structure this drug contains a thiol functional group.

a)

The first statement is true and second statement is false

b)

The first statement is false and second statement is true

c)

Both statement are true

d)

Both statement are false

13.

Phenylbutazone (Butazolidine) is a non steroidal anti-inflammatory drug.

This drug selectively inhibits the COX-2 enzyme.

a)

The first statement is true and second statement is false

b)

The first statement is false and second statement is true

c)

Both statement is true

d)

Both statement is false

14.

Ascorbic acid is more acidic than aspirin. Theophylline is more acidic than caffeine

a)

The first statement is true and second statement is false

b)

The first statements is false and second statement is true

c)

Both statement is true

d)

Both statement is false

15.

Ionized drug is more readily execretable. Unionized drug is more soluble.

a)

The first statement is true and second statement is false

b)

The first statement is false and second statement is true

c)

Both statements are true

d)

Both statement are false

16.

Secondary R-OH are easily oxidized to

a)

carbonyl reactivity

b)

benzopyrene

c)

aldehyde

d)

ketone

17.

The study of chemical agents which are selectively more toxic to the invading organisms than the host

a)

Therapeutic

b)

Antiseptics

c)

Fungicides

d)

Systemic

18.

Mechanism of action of quinolones:

a)

Injury to plasma membrane

b)

Inhibition of DNA gyrase

c)

Protein Synthesis Inhibition

d)

Production of toxic free radicals

19.

An example of glycine conjugation pathway:

a)

Phenol to phenosulfate

b)

Benzoic acid to hippuric acid

c)

Noradrenaline to epinephrine

d)

Antabuse to dithiocarbamic acid

20.

A glycopeptide antibiotic:

a)

Beta-lactam

b)

Vancomycin

c)

Polymyxin

d)

Probenecid

21.

Presence of electron withdrawing groups attached to the alpha carbon of the amide side chain of penicillins:

a)

Activity against pseudomas

b)

Acid stability

c)

Activity against gram (-) bacteria

d)

Penicillinase Resistanve

22.

Attachment of bulky groups to the alpha carbon of the amide side chain in penicillins render:

a)

Penicillinase resistance

b)

Activity against Pseudomonas

c)

Activity against gram (-) bacteria

d)

Acid Stability

23.

Drug of choice for absence seizures:

a)

Carbamazepine

b)

Ethosumiximide

c)

Phenytoin

d)

Primidone

24.

The most potent anti-bacterial alcohol:

a)

Primary

b)

Secondary

c)

Tertiary

d)

Quaternary

25.

A progesterone derivative which is used for the treatment of endometrial cancer

a)

Tamoxifen

b)

Depo-provera

c)

Flutamide

d)

Goserelin

26.

Anesthetic drug of choice for labor:

a)

Halothone

b)

Enflurance

c)

Nitrous oxide

d)

Methoxyflurane

27.

Pentavalent antimony in the presence hydrochloric acid gives a violet precipitate with this pink dye:

a)

Rhodamine B

b)

Aluminum reagent

c)

P-nitrobenzenr azo-resorcinol

d)

Dimethygloyxime

28.

Derivatives of sulfonylureas are

a)

Oral hypoglycemics

b)

Diuretics

c)

Spasmolytic

d)

Anti-inflammatory

29.

Protaglandins are also known as

a)

Saturated fats

b)

Compound Lipids

c)

Eicosanoids

d)

All of the above

30.

The onset and duration of barbiturate action is mainly function of its

a)

Lipid solubility

b)

Renal Excretion

c)

Plasma Binding

d)

Method of administration

31.

A direutuc that will manifest a competitive inhibition of the action of aldosterone:

a)

Triamterene

b)

Spirinolactone

c)

Furosemide

d)

Clorothiazide

32.

Sulfonamides are metabolized by humans principally by:

a)

Acetylation

b)

Deamination

c)

Oxidation

d)

Methylation

33.

The drug that used in all types of tuberculosis:

a)

Ethambutol

b)

Cycloserine

c)

Streptomycin

d)

P-aminosalicyclic acid

34.

Which of the following is classified as a broad spectrum antibiotic?

a)

Sodium Methicillin

b)

Potassium Phenethicillin

c)

Ampicillin

d)

Penicillin G

35.

Which of the following penicillins is resistant to penicillinase?

a)

Ampicillin

b)

Oxacillin

c)

Carbenicillin

d)

Mezlocillin

36.

This is used as an inhalation anesthetic:

a)

Droperidol

b)

Thiopental

c)

Halothane

d)

Midazolam

37.

These drugs are narcotic analgesics, except:

a)

Morphine

b)

Codeine

c)

Nalbuphine

d)

Mefenamic acid

38.

This drug is used as an osmotic diuretic:

a)

Mannitol

b)

Ethanol

c)

Isopropanol

d)

Glycitol

39.

Levodopa is used in the treatment of:

a)

Leukemia

b)

Parkinson's disease

c)

Alzheimer's Disease

d)

Tay Sach's Disease

40.

The generic name of the brand Diabinese:

a)

Chlopropramide

b)

Glibenclamide

c)

Spirinolactone

d)

Hydrochlorothiazide

41.

Preservatives like parabens increase their preservative property by:

a)

Reducing the parent compound

b)

Decreasing molecular weight

c)

Attaching a halogen to the parent compound

d)

Increasing the molecular weight

42.

Radical reactions may also be proceed using this reagent:

a)

Bromine water

b)

Hydrogen peroxide

c)

Nitric acid

d)

Potassium bitartrate

43.

The functional group attached to the acyl amino group is called an:

a)

Phenoxyethyl

b)

Isoxozyl

c)

Benzyl

d)

Methoxyphenyl

44.

Halogen substituents are best placed in what position:

a)

1,2 substitution

b)

1, 3 substitution

c)

1, 4 substitution

d)

Both A and C

45.

Addition more than 1 chloride atoms in the structure confers what modification on the pharmacokinetic profile of the drug

a)

Metabolism

b)

Absorption

c)

Distribution

d)

Excretion

46.

Sodium pump is an example of:

a)

Enzyme linked tyrosine kinase receptor

b)

Ion channel

c)

Gene transcription-linked receptor

d)

G-protein coupled receptor

47.

What is the reagent needed for the first reaction?

a)

NaOH/ Oxidizing agent

b)

CHCl3/AlCo3

c)

HNO3/H2SO4

d)

NaOH/Reducing agent

48.

The product formed with the reaction is

a)

Benzyl alcohol

b)

Phenol

c)

Benzoic acid

d)

Xylene

49.

Which of the following Cephalosporins is excreted in bile?

a)

Cefixime

b)

Cefotaxime

c)

Ceftriaxone

d)

Moxalactam

50.

Zovirax is effective against the strain of

a)

Varicella

b)

HSV

c)

Vesicular stomatitis virus

d)

All of the above