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2EMT - TCA and ETC

Total questions: 35

Worksheet time: 18mins

Name
Class
Date
1.

In TCA cycle, what kind of reaction type does step 1 has/have?

a)

hydrolysis

b)

nonhydrolytic cleavage

c)

oxidation-reduction

d)

isomerization-rearrangement

2.

In TCA cycle, what is the general reaction of step 1?

a)

formation of ATP cleavage

b)

condensation

c)

oxidation-reduction

d)

isomerization-rearrangement

3.

In TCA cycle, what is the general reaction of step 2?

a)

formation of ATP cleavage

b)

condensation

c)

nonhydrolytic cleavage

d)

isomerization-rearrangement

4.

In TCA cycle, supply the enzyme for Step 1: Oxaloacetate + Acetyl CoA -> Citrate

a)

malate dehydrogenase

b)

citrate synthase

c)

fumarase

d)

succinate dehydrogenase

5.

In TCA cycle, supply the enzyme for Step 2: Citrate -> Isocitrate

a)

aconitase

b)

citrate synthase

c)

fumarase

d)

isocitrate dehydrogenase

6.

In TCA cycle, supply the enzyme for Step 3: Isocitrate -> [Oxalosuccinate] -> alpha-ketoglutarate

a)

aconitase

b)

citrate synthase

c)

fumarase

d)

isocitrate dehydrogenase

7.

In TCA cycle, supply the enzyme for Step 4: alpha-ketoglutarate -> Succinyl-CoA

a)

aconitase

b)

citrate synthase

c)

alpha-ketoglutarate dehydrogenase

d)

isocitrate dehydrogenase

8.

In TCA cycle, supply the enzyme for Step 5: Succinyl-CoA -> Succinate

a)

Succinyl - CoA synthetase

b)

citrate synthase

c)

alpha-ketoglutarate dehydrogenase

d)

isocitrate dehydrogenase

9.

In TCA cycle, supply the enzyme for Step 6: Succinate -> Fumarate

a)

Succinyl - CoA synthetase

b)

succinate dehydrogenase

c)

alpha-ketoglutarate dehydrogenase

d)

isocitrate dehydrogenase

10.

In TCA cycle, supply the enzyme for Step 7: Fumarate -> L-Malate

a)

aconitase

b)

fumarase

c)

malate dehydrogenase

d)

isocitrate dehydrogenase

11.

In TCA cycle, supply the enzyme for Step 8: L-Malate -> Oxaloacetate

a)

aconitase

b)

fumarase

c)

malate dehydrogenase

d)

isocitrate dehydrogenase

12.

In TCA cycle, what are the reaction types involved in step 3?

a)

formation of ATP cleavage

b)

oxidation-reduction

c)

nonhydrolytic cleavage

d)

isomerization-rearrangement

13.

In TCA cycle, what are the reaction types involved in step 4?

a)

formation of ATP cleavage

b)

oxidation-reduction

c)

nonhydrolytic cleavage

d)

isomerization-rearrangement

14.

In TCA cycle, what is the general reaction of step 4?

a)

formation of ATP cleavage

b)

condensation

c)

nonhydrolytic cleavage

d)

oxidative decarboxylation

15.

In TCA cycle, what is the general reaction of step 5?

a)

formation of ATP cleavage

b)

phosphoryl group transfer

c)

nonhydrolytic cleavage

d)

oxidative decarboxylation

16.

In TCA cycle, what is the general reaction of step 6?

a)

formation of ATP cleavage

b)

phosphoryl group transfer

c)

nonhydrolytic cleavage

d)

oxidation-reduction

17.

In TCA cycle, what is the general reaction of step 7?

a)

formation of ATP cleavage

b)

phosphoryl group transfer

c)

nonhydrolytic cleavage

d)

oxidation-reduction

18.

In TCA cycle, what is the general reaction of step 8?

a)

formation of ATP cleavage

b)

phosphoryl group transfer

c)

nonhydrolytic cleavage

d)

oxidation-reduction

19.

This is the process of transporting metabolites between mitochondria and cytosol

a)

metabolic mechanisms

b)

shuttle mechanisms

c)

transport mechanism

d)

proton mechanisms

20.

Identify the metabolite

a)

oxaloacetate

b)

pyruvate

c)

glucose

d)

citrate

21.

Identify the metabolite

a)

oxaloacetate

b)

pyruvate

c)

glucose

d)

citrate

22.

Identify the molecule

a)

acetyl-CoA

b)

pyruvate

c)

glucose

d)

citrate

23.

Identify the metabolite

a)

oxaloacetate

b)

pyruvate

c)

Isocitrate

d)

citrate

24.

Identify the metabolite

a)

succinyl-Coa

b)

alpha-ketoglutarate

c)

Fumarate

d)

succinate

25.

Identify the metabolite

a)

succinyl-Coa

b)

alpha-ketoglutarate

c)

Fumarate

d)

succinate

26.

Identify the metabolite

a)

succinyl-Coa

b)

alpha-ketoglutarate

c)

Fumarate

d)

succinate

27.

Identify the metabolite

a)

succinyl-Coa

b)

L-Malate

c)

Fumarate

d)

succinate

28.

How many ATP are produced for each molecule of cytosolic NADH in MA Shuttle?

a)

2.5 or 3 molecules of ATP

b)

1.5 or 2 molecules of ATP

c)

1 molecules of ATP

d)

4 molecules of ATP

29.

How many ATP are produced for each molecule of cytosolic NADH in GP Shuttle?

a)

2.5 or 3 molecules of ATP

b)

1.5 or 2 molecules of ATP

c)

1 molecules of ATP

d)

4 molecules of ATP

30.

In 3 rounds of ETC, electrons are carried by X NADH and Y FADH2.

a)

X = 3; Y = 1

b)

X = 6; Y = 2

c)

X = 12; Y = 4

d)

X = 9; Y = 3

31.

A health condition that affects the nervous system of infants (microcephaly).

a)

Fumarase deficiency

b)

aconitase deficiency

c)

succinate dehydrogenase deficiency

d)

mitochondrial disease

32.

A health condition that affects the mitochondrial complex II, and is linked in ETC.

a)

Fumarase deficiency

b)

aconitase deficiency

c)

succinate dehydrogenase deficiency

d)

mitochondrial disease

33.

An extremely rare health condition that is characterized by encelopathy and hyperlactatemia.

a)

alpha-ketoglutarate dehydrogenase deficiency

b)

aconitase deficiency

c)

succinate dehydrogenase deficiency

d)

mitochondrial disease

34.

A rare inborn metabolic disorder characterized by neonates in the onset of developmental delay.

a)

alpha-ketoglutarate dehydrogenase deficiency

b)

oxoglutaric aciduria

c)

succinate dehydrogenase deficiency

d)

mitochondrial disease

35.

A congenital disorder of TCA cycle.

a)

alpha-ketoglutarate dehydrogenase deficiency

b)

oxoglutaric aciduria

c)

succinate dehydrogenase deficiency

d)

mitochondrial disease

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