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WorksheetsBone Marrow Histology Final Exam
Total questions: 47
Worksheet time: 38mins
Bone marrow transitions from ______ to _______ as the animal matures.
Yellow to yellow
Red to yellow
Yellow to red
Red to red
True/False: ALL blood cells are derived from hematopoietic stem cells.
True
False
Red bone marrow is primarily composed of _______.
Red blood cells and precursors
While blood cells and precursors
Unilocular adipose tissue
Multilocular adipose tissue
Yellow bone marrow is composed of ________.
Red blood cells and precursors
White blood cells and precursors
Unilocular adipose tissue
Multilocular adipose tissue
The stroma of red bone marrow is composed of ________.
Muscle fibers and myocytes.
Lamellar bone and osteoblasts
CT fibers and fibroblasts
Reticular fibers and reticular cells
Blood supply is brought through bone marrow through ________ capillaries made up of _________ and __________ endothelial cells (multiple correct answers).
Discontinuous
Continuous
Sinusoidal
Fenestrated
Hematopoiesis means:
Making new blood cells
Consuming blood cells
Making new reticular cells
Consuming reticular cells
Which term describes a cell committed to a certain lineage but able to give rise to any cell within that lineage.
Differentiated
Progenitor
Stem cell
Colony-forming unit
Which term describes a cell that gives rise to a single, differentiated cell product?
Progenitor
Stem cell
Colony-forming unit
Differentiated
What is a colony stimulating factor that responds to low oxygen and stimulates red blood cell generation?
Granulopoietin
Interleukin-2
Interleukin-1
Erythropoietin
Which of the following is true?
Immature cells are generally larger than mature cells
Immature cells generally have more euchromatic nuclei
Immature cell cytoplasm will become clearer as it matures in all cells
Immature cells can lose cytoplasm as they mature
List the order of hematopoiesis in organs starting at earliest in development (1) and latest in development (4). Do NOT use number 5.
At maturity, the majority of hematopoiesis occurs in the ____________.
Bone marrow
Liver
Spleen
Lymph nodes
True/False: Stem, progenitor, and colony-forming units are morphologically distinguishable on H&E.
True
False
Are reticulocytes a biconcave shape?
Yes
No
Maybe
Yeah... like I know
Erythropoiesis refers to ____________ formation.
Platelet
Lymphocyte
White blood cell
Red blood cell
Lymphopoiesis refers to ___________ formation.
Platelet
Lymphocyte
Monocyte
Erythrocyte
Monopoiesis refers to ____________ formation.
Monocyte
Lymphocyte
Platelet
Red blood cell
Thrombopoiesis refers to ____________ formation.
Monocyte
Platelet
Granulocyte
Red blood cell
Platelets originate from _____________.
Reticulocytes
Macrophages
Megakaryocytes
Osteoclasts
What is the first identifiable cell in the erythroid series called? Is it a large or small cell?
Proerythroblast; small cell
Proerythroblast; large cell
Proerythrocyte; large cell
Proerythrocyte; small cell
Describe the appearance of a proerythroblast.
Which of the following is the correct order of maturation of nuclei in erythropoiesis?
Euchromatic to pyknotic to heterochromatic to extrusion
Heterochromatic to euchromatic to pyknotic to extrusion
Pyknotic to euchromatic to heterochromatic to extrusion
Euchromatic to heterochromatic to pyknotic to extrusion
True/False: An immature red blood cell is called a reticulocyte.
False
True
True/False: Neutrophils, eosinophils, and basophils are all formed form a single common progenitor cell.
True
False
True/False: Granulopoiesis is stimulated by colony stimulating factors which are only produced during an inflammatory response to an antigen.
True
False
At a later stage in granulopoiesis, does the cytoplasmic to nuclear volume ratio increase or decrease?
Increase
Decrease
Where do we find precursors for B and T lymphocytes, respectively?
Bone marrow; bone marrow
Bone marrow; thymus
Thymus; thymus
Thymus; bone marrow
True/False: It can be normal to find plasma cells in bone marrow.
False
True
Granulopoiesis refers to ____________ formation.
Granulocyte
Monocyte
Lymphocyte
Red blood cell
Macrophages are formed from __________.
Plasma cells
T lymphocytes
B lymphocytes
Monocytes
Describe the difference between osteoclasts and megakaryocytes.
A stimulus for platelet production is thrombopoietin, a hormone that is produced mainly in the __________.
Bone marrow
Kidney
Liver
Spleen
True/False: Granulocytes take a shorter time to develop than erythrocytes.
True
False
True/False: Granulocytes have a shorter lifespan than erythrocytes.
True
False
What term refers to the removal of cells from circulation?
Confiscation
Elimination
Withdrawal
Clearance
How are red blood cells removed from blood?
Turnover
Macrophages
Migration to the gut and respiratory tract
Have long lifespan so just move between tissue and blood
How long can T lymphocytes live?
One year
8-10 hours
Weeks to months
5-10 days
How long can B lymphocytes live?
One year
8-10 hours
Weeks to months
5-10 days
How long can monocytes live?
One year
8-10 hours
Weeks to months
5-10 days
How long can platelets live?
One year
8-10 hours
Weeks to months
5-10 days
How long can tissue macrophages live?
Months to years
8-10 hours
Weeks to months
5-10 days
Please annotate this image to show different cell types (look at both red and white blood cells).
How long do red blood cells live?
70-160 days
2-3 weeks
Full life span
1 day
True/False: Lymphocytes live longer in tissues than in circulation.
True
False
Please share an analogy you use to remember what pro-platelets are.
True/False: Osteoclasts are fusions of monocytes.
True
False
