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WorksheetsAntigen & Antibody Interactions
Total questions: 61
Worksheet time: 31mins
Name
Class
Date
1.
An antigen is a molecule capable of stimulating an immune response by activating .
a)
Leukocytes
b)
T lymphocytes
c)
B lymphocytes
d)
All of the above
2.
Which of the following is NOT trueregarding effective immunogens?
a)
Foreign to the host
b)
Fairly large (molecular weight > 6000)
c)
Chemically complex (e.g. proteins made of many nucleotide bases)
d)
Requires a carrier-conjugate to cause the generation of antibodies
3.
Which of the following best describes penicillin, a hapten?
a)
Large in size and can induce an immune response alone
b)
Large in size and needs to be coupled to induce an immune response
c)
Small in size and can induce an immune response alone
d)
Small in size and needs to be coupled to induce an immune response
4.
Which of the following differentiates an antigen from an immunogen?
a)
An antigen is a foreign molecule
b)
An antigen can cause the production of antibodies
c)
An antigen does not always elicit an immune response
d)
Antigens are usually proteins or polysaccharides
5.
Which of the following statement is true?
a)
All immunogens are antigens but all antigens are not immunogens.
b)
All immunogens are antigens and all antigens are immunogens.
c)
All immunogens are not antigens but all antigens are immunogens.
d)
All immunogens are proteins and all proteins are immunogens.
6.
Which of the following is false about foreign antigen?
a)
Originate from outside the body.
b)
Originate within the body.
c)
Produced by viruses or microorganisms
d)
Components of serum and red blood cells from other individuals.
7.
Antigens can be
a)
Proteins
b)
Carbohydrates
c)
Nucleic Acid
d)
All of these
8.
Majority of antigens are:
a)
Carbohydrates
b)
Proteins
c)
Nucleic Acid
d)
Lipids
9.
Which of the following antigen generates maximum immunogenicity
a)
Polysacchrides
b)
Proteins
c)
Lipids
d)
Nucleic acid
10.
Which of the following is true for antigen except
a)
Higher the foreignness of the antigen ,higher is immunogenicity
b)
Higher the molecular size of antigen, higher is immunogenicity
c)
Molecular mass of 14,000 to 6,00,000 Da is highly antigenic
d)
Insulin (5700 Da) is highly antigenic.
11.
Proteins are generally more immunogenetic because
a)
Protein are more complex in structure
b)
They have high molecular weight
c)
Both of them
d)
None of them
12.
The particulate antigen has more immunogenicity than a soluble antigen.
a)
True
b)
False
13.
Denatured antigens are less immunogenic than the native form
a)
True
b)
False
14.
Small chemical groups on antigen molecules, that binds to the antibody is called
a)
Paratope
b)
Epitope
c)
Isotope
d)
Allotope
15.
Which of the following statement is true about antigen specificity except
a)
Autologous or self-antigens are ordinarily immunogenic
b)
Organ specific antigen shares specificity between the species
c)
Antibodies of one species can act as antigen for other species eg. blood antibodies
d)
On the surface of antigens are regions, called antigenic determinants (epitopes), that fit and bind to receptor molecules of antibodies
16.
Substances that can enhance the immune response, without having any specific antigenic effect by itself
a)
Hapten
b)
Adjuvants
c)
Carrier
d)
Antigens
17.
Which of the following is true about antigen
a)
generally self- antigen and low molecular weight antigens are less immunogenic
b)
Heteropolymer are more immunogenic than homopolymers
c)
Generally have many epitopes
d)
All of these
18.
Which of the following statement is true for antigen immunogenicity except
a)
Very young and the very old have a diminished ability to elicit an immune response
b)
Antigens that are easily phagocytosed are generally more immunogenic.
c)
Dose of antigen doesnot effect immune response
d)
The subcutaneous route is better than the intravenous or intragastric routes.
19.
The other name for antibody is
a)
Immunogens
b)
Immunoglobulins
c)
Haptens
d)
Antigen
20.
Which of the following is true about
a)
All immunoglobulin are antibodies but all antibodies are not immunoglobulin
b)
All immunoglobulin are antibodies and all antibodies are immunoglobulin
c)
All immunoglobulin are not antibodies but all antibodies are immunoglobulin
d)
All immunoglobulin are not antibodies and all antibodies are not immunoglobulin
21.
Any substance or molecules that interact with antibodies are called
a)
Antigen
b)
Antibodies
c)
Epitope
d)
All of them
22.
Antibodies consist of
a)
2 light chains and 2 heavy chains arranged in a Y shaped configuration
b)
1 light chain and 2 heavy chains arranged in a Y shaped configuration
c)
2 light chains and 1 heavy chain arranged in a Y shaped configuration
d)
All of these
23.
Light chains and heavy chains are joined by
a)
Covalent bond
b)
Hydrogen bond
c)
Di-sulphide bond
d)
lonic bond
24.
The antigen binding site on antibody is called?
a)
Antitope
b)
Epitope
c)
Paratope
d)
Endotope
25.
Which part of the antibody binds to epitope of antigen
a)
Variable part of light chain and constant part of heavy chain
b)
Variable part of light chain and Variable part of heavy chain
c)
Constant part of light chain and variable part of heavy chain
d)
Constant part of light chain and constant part of heavy chain
26.
Which of the following is largest immunoglobulin
a)
IgE
b)
IgG
c)
IgM
d)
IgA
27.
Which of the following is the most abundant immunoglobulin
a)
IgE
b)
IgG
c)
IgM
d)
IgA
28.
Which is the Ig that can cross the placenta and provide passive immunity to new born
a)
IgE
b)
IgG
c)
IgM
d)
IgA
29.
Antibody present in secretion like tears, saliva,colostrum is
a)
IgE
b)
IgG
c)
IgM
d)
IgA
30.
Which of the following statement is true?
a)
IgM is involved in primary immune response
b)
IgG is involved in primary immune response
c)
IgM and IgG both are involved in primary immune response
d)
BothA&B
31.
The first antibody to be synthesized by new born is
a)
IgE
b)
IgG
c)
IgM
d)
IgA
32.
The immunoglobulin that mediates allergic response is
a)
IgE
b)
IgG
c)
IgM
d)
IgA
33.
IgM is?
a)
Pentamer with 10 antigen binding sites
b)
Dimer with 4 antigen binding sites
c)
Tetramer with 8 antigen binding sites
d)
Monomer with 2antigen binding sites
34.
Antigen can be
a)
Bacteria
b)
Virus
c)
Foreign substance
d)
All of the above
35.
Immune system stimulates the production of
a)
Antigen
b)
Antibody
c)
Both A and B are CORRECT
d)
None of the above
36.
Immune system kills or neutralize the
a)
Antigen
b)
Antibody
c)
Both A and B are CORRECT
d)
None of the above
37.
B cell is a part of
a)
Antigen
b)
Bacteria
c)
Immune system
d)
All of the above
38.
Bcell produces
a)
Antigen
b)
Bacteria
c)
Antibody
d)
Both A & B are correct
39.
Which of the following is correct? 1. Specificity means that the antibodies that match the antigens are created. 2. Antigen stimulates the production of antibody by the immune system
a)
Only 1 is correct
b)
Only 2 is correct
c)
Both 1 and 2 are INCORRECT
d)
Both 1 and 2 are CORRECT
40.
What is an immune complex formation?
a)
Binding of antigen and antibody go
b)
All the components of immune system are together called as immune complex
c)
It is the complex product formed after any immune reaction takes place
d)
All of the above
41.
What is the role of agglutination?
a)
Cause inflammation and cell lysis
b)
Reduces the number of infectious units
c)
Coating of antigen with antibody to increase phagocytosis
d)
Blocks adhesion of bacteria to mucosa
42.
What is the role of complement activation?
a)
Coating of antigen with antibody to increase phagocytosis
b)
Blocks adhesion of bacteria to mucosa
c)
Reduces the number of infectious units
d)
Cause inflammation and lysis of cells
43.
What is the role of opsonization? 1. Coating of antigen with antibody to increase phagocytosis, 2. Cause inflammation and lysis of cells
a)
Only 1 is correct
b)
Only 2 is correct
c)
Both 1 and 2 are CORRECT
d)
Both 1 and 2 are INCORRECT
44.
What is the role of antibody-dependent cellular cytotoxicity (ADCC)? 1. Blocks adhesion of bacteria to mucosa, 2. Antibodies attached to target cells cause destruction by macrophages, NK cells, etc.
a)
Only 1 is correct
b)
Only 2 is correct
c)
Both 1 and 2 are correct
d)
Both 1 and 2 are incorrect
45.
What is the role of neutralisation?
a)
Cause inflammation and lysis of cells
b)
Blocks adhesion of bacteria to mucosa
c)
Coating of antigen with antibody to increase phagocytosis
d)
Both A and B
46.
Which of the following is correct: 1. Antibody-dependent cell- mediated cytotoxicity is done after antibody binds to antigen., 2. Neutralisation is done after antibody binds to antigen.
a)
Both 1 and 2 are correct
b)
Both 1 and 2 are incorrect
c)
Only 1 is correct
d)
Only 2 is correct
47.
Cytotoxicity means
a)
Toxicity (harmful) to cells go
b)
Toxicity to antibodies
c)
Both of the above
d)
None of the above
48.
Components of complement activation pathway are formed by
a)
Spleen
b)
Liver
c)
Red Blood Cells
d)
Bone marrow
49.
End action of both the pathways of complement activation is
a)
Formation of antibody
b)
Formation of antigen
c)
Infected cell swell and bursts
d)
Formation of complement
50.
The burst of cell at the end of complement system activation is done by
a)
Membrane attack complex
b)
Macrophage
c)
Bacteria
d)
Antibody
51.
—— together form the Membrane Attack Complex (MAC)
a)
Antibodies
b)
Antigens
c)
Bacteria and viruses
d)
Complements (C5b, C6,C7,C8andc9)
52.
Which of the following does phagocytosis (cell- eating)?
a)
B- Cell
b)
Macrophage
c)
Both A and B
d)
None of the above
53.
Opsonisation makes the macrophage:
a)
easy to eat the bacteria
b)
easy to form antibodies
c)
easy to activate B cell
d)
All of the above
54.
Neutralisation is the other name of Opsonisation
a)
True
b)
False
55.
After neutralization __is not able to attach on the human body cells
a)
Bacteria
b)
Antigen
c)
Both A and B
d)
None of the above
56.
Binding site is formed by:
a)
Epitope
b)
Paratope
c)
Both A and B
d)
None of the above
57.
Epitope is the part of
a)
Antigen
b)
Antibody
c)
Both A and B
d)
None of the above
58.
Paratope is the part of
a)
Antibody
b)
Antigen
c)
Both A and B
d)
None of the above
59.
Which of the following is the type of antigen-antibody binding force?
a)
Electrostatic interactions
b)
Hydrogen bonds
c)
Van der Waals forces
d)
All of the above
60.
The strength with which an epitope binds to a paratope is called as:
a)
Affinity
b)
Conductivity
c)
Antigen antibody bond
d)
Immune strength
61.
Antigen-antibody binding force is the force through which :
a)
Antigen antibody binds with the macrophage
b)
Antigen and complement bind with the antibody
c)
Antigen and antibody bind with each other
d)
Antigen and antibody bind with the receptor of the cell
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