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WorksheetsChapter 14
Total questions: 94
Worksheet time: 3hrs 29mins
What are Nucleotides?
Nucleotides are monomer components of nucleic acid
Nucleotides are polymer components of nucleic acid
Nucleotides are monomer components of proteins
What is Deletion Mutation?
a type of mutation that involves the addition of one or more nucleotides into a segment of DNA.
a type of genetic mutation that involves the removal of a portion of the genetic material
a mutation in which a single pair of nucleotides at a certain point in the gene sequence is altered.
What is a nucleotide made up of?
A protein, a phosphate, and a nucleic acid
A sugar, a phosphate, and a nitrogenous base (adenine, thymine, cytosine, guanine, or uracil)
A nucleic acid, a fatty acid, and a sugar
Sugar and Phosphate come together to create what?
A code of the DNA molecule
A protein of the DNA molecule
A backbone of the DNA molecule
A nitrogen of the DNA molecule
What are the nitrogen bases?
The Code (information for life)
The Protein
The Backbone
The Nitrogen
What is DNA?
DNA is a single strand
DNA is a double helix polymer made up of repeating nucleotides (monomers) bound covalently to each other.
What do the two polymer strands do?
The two polymer strands run parallel from one another.
The two polymer strands run vertically and horizontally
The two polymer strands run in opposite directions. They are directional and antiparallel.
What are the two polymer strands held together by?
Held together by specific complementary hydrogen bonds between opposing nitrogen bases (A-T and C-G)
Held together by specific nitrogen bonds between opposing hydrogen bases
Thymine will always be with…
Guanine (G to C)
Cytosine (C to G)
Adenine (T to A) or (A to T)
Uracil
Guanine will always be with…
Guanine (G to C)
Cytosine (C to G)
Adenine (T to A) or (A to T)
Uracil
What is Conservative Replication?
Parent strand unwinds and separates (relaxing) by actions of helicase (DNA)
Original parent double strands remain intact and two completely new double helix strands are synthesized and created.
What is Semi-Conservative Replication?
Parent strand unwinds and separates (relaxing) by actions of helicase (DNA)
Original parent double strands remain intact and two completely new double helix strands are synthesized and created.
In Semi-Conservative Replication new DNA molecules will become
New and identical
Old and not identical
Half old and half new and exactly identical
half old and not identical
How are new strands formed?
Through nitrogen base pairing by actions of DNA polymerase
Through complementary base pairing by actions of DNA polymerase (builds)
Through protein base pairing by actions of DNA polymerase
What does DNA Ligase do?
Creates new DNA molecules
Replicates and dying DNA molecules
Creates new proteins
Seals any breaks in the sugar-phosphate backbone.
What does Replication do?
Replication potentially shortens the ends of eukaryotic chromosomes.
Replication creates eukaryotic chromosomes
Replication replicates dying DNA molecules
How are the ends of linear chromosomes maintained?
Maintained by the action of the ribosomes
Maintained by the actions of the DNA molecules
Maintained by the action of the telomerase enzyme.
Maintained by the actions of the fatty acids
What is Dispersive Replication?
Both original parent strands are created and incorporated into newly synthesized strands
Both original parent strands are broken up into small pieces and incorporated into newly synthesized strands.
What are Mutations?
Mutations are changes in the protein sequence of the DNA strands
Mutations are created only in animal cells
Mutations are created in the fatty acid of the DNA strands
Mutations are changes in the nucleotide sequence (info for life) of the DNA strands.
Mutations can lead to what?
Mutations can lead to changes in the protein sequence encoded by the DNA.
Mutations can lead to creations in the protein sequence encoded by the DNA
Mutations can only occur in animal cells
What is Point Mutation?
a type of mutation that involves the addition of one or more nucleotides into a segment of DNA.
a type of genetic mutation that involves the removal of a portion of the genetic material
a mutation in which a single pair of nucleotides at a certain point in the gene sequence is altered.
What is Insertion Mutation?
a type of mutation that involves the addition of one or more nucleotides into a segment of DNA.
a type of genetic mutation that involves the removal of a portion of the genetic material
a mutation in which a single pair of nucleotides at a certain point in the gene sequence is altered.
What is Deletion Mutation?
a type of mutation that involves the addition of one or more nucleotides into a segment of DNA
a type of genetic mutation that involves the removal of a portion of the genetic material
a mutation in which a single pair of nucleotides at a certain point in the gene sequence is altered.
What is the location of Transcription
In the cytoplasm and endoplasmic reticulum
In the nucleus
What is the location of Translation?
In the cytoplasm and endoplasmic reticulum
In the nucleus
What is Central Dogma?
genetic information flows only in one direction, from DNA, to RNA, to protein, or RNA directly to protein (from gene to protein)
genetic information flows only in two directions, from DNA, to RNA, to tRNA
What is a Fact about Translation
DNA serves as a backbone to make mRNA
DNA serves as a template to make tRNA
DNA serves as a template to make mRNA
Small Fact about Translation
rRNA and tRNA assist
mRNA and tRNA assist
What does Genetic Code do?
Translates proteins to amino acids
Translates amino acids into fatty acids
Translates from nucleic acids to amino acids
What is a Triplet in Genetic Code?
1 nucleotide sequence in DNA
2 nucleotide sequences in DNA
3 nucleotide sequence in DNA
4 nucleotide sequence in DNA
What is a codon?
3 nucleotide sequence in DNA
3 nucleotide sequence in mRNA
How many amino acids are encoded in a codon?
One Single Amino Acid
Two Amino Acids
Three Amino Acids
Four Amino Acids
A Ribonucleic acid (RNA)
contains a protein
Contains a sugar ribose
Uses Thymine (uses T, C, G like DNA)
Is single-stranded
Uses Uracil (uses A, C, and G like DNA)
Messenger RNA (mRNA)
Is produced in the nucleus from DNA template
Carries genetic message to lysosomes
Is produced in the cytoplasmic reticulum from DNA Template
Carries genetic message to ribosomes
Transfer RNA (tRNA)
Dissolves amino acids
Produced in the nucleus from DNA template
Transfers amino acids to ribosomes
Produced in the endoplasmic reticulum
Each type carries only one type of amino acid
Ribosomal RNA (rRNA)
Produced in the nucleolus of the nucleus from DNA template
Joins with fatty acids to form ribosomes
Ribosomes may be free or in polyribosomes (clusters) or attached to ER
Joins with proteins to form ribosomes
Is Messenger RNA (mRNA) a codon or anticodon?
Codon
Anticodon
Is Transfer RNA (tRNA) a codon or anticodon?
Codon
Anticodon
How many nucleotides make a codon?
One
Two
Three
Four
Where is DNA found?
In the Endoplasmic Reticulum
In the Nucleus
Where is RNA found?
In the Endoplasmic Reticulum
Nucleus
Cytoplasm
During transcription complementary _____ is made from a _______ ___________
tRNA; DNA template
mRNA; DNA template
RNA; DNA template
What happens during Transcription?
RNA polymerase adds complementary nucleotides to make the mRNA
Portion of DNA unwinds and unzips at the point of attachment of RNA polymerase
mRNA joins in order to replicate the DNA strands
Bases join in the ordwer dictated by the sequence of bases in the template DNA strand
Transcription Initiation
RNA polymerase adds complementary nucleotides (A, U, C, G) to make the mRNA
Promoter is a piece of DNA upstream that indicates where the RNA polymerase should bind and start
STOP
Transcription Elongation
Promoter is a piece of DNA upstream that indicates where the RNA polymerase should bind and start
STOP
RNA polymerase adds complementary nucleotides (A, U, C, G) to make the mRNA
Transcription Termination
Promoter is a piece of DNA upstream that indicates where the RNA polymerase should bind and start
STOP
RNA polymerase adds complementary nucleotides (A, U, C, G) to make the mRNA
mRNA Processing
Newly made premature mRNA must be processed
Addition of a 5' methylguanosine cap and a 3' poly-A tail provides stability and protection (cytoplasm)
(Now mature mRNA leaves nucleus and associates with ribosome on cytoplasm)
Processes proteins
Intron Splicing
coding regions for amino acids
Removal of the non-coding regions
Exons
coding regions for amino acids
Removal of the non-coding regions
tRNA brings in what?
proteins
fatty acids
energy
amino acids
Anticodon
sequence of three nucleotides that corresponds with a specific amino acid or stop signal
group of three bases complementary to a specific codon of mRNA
After translation is complete what happens?
a protein contains the sequence of amino acids originally specified in the DNA
a fatty acid contains the sequence of amino acids originally specified in the DNA
Translation Initiation
tRNAs move in with the appropriate amino acid, the amino acid chain grows
mRNA attaches to the smaller subunit of the ribosome
The larger subunit of the ribosome then joins
AUG is the start codon- a tRNA with the appropriate anticodon (UAC) attaches
Translation Elongation
mRNA attaches to the smaller subunit of the ribosome
AUG is the start codon- a tRNA with the appropriate anticodon (UAC) attaches
The larger subunit of the ribosome then joins
tRNAs move in with the appropriate amino acid, the amino acid chain grows
Translation Termination
1 of 3 STOP codons are reached
tRNAs move in with the appropriate amino acid, the amino acid chain grows
The amino acid chain is then processed
The larger subunit of the ribosome then joins
In eukaryotes, the amino acid chain moves into the endoplasmic reticulum to be further processed.
tRNAs carrying the correct amino acid recognize the proper codons on the mRNA because
the anticodon of the tRNA hydrogen binds to the codon of the mRNA by complementary base pairing
the codon of the tRNA binds to the anticodon of the ribosome by complementary base pairing
the amino acid binds to the anticodon of the mRNA and brings the correct tRNA with it
the codon of the mRNA binds the correct amino acid, and the tRNA stabilizes this interaction
The central dogma of molecular biology states that the information contained within genes flows in which direction?
DNA to DNA to protein
mRNA to DNA to protein
DNA to mRNA to protein
DNA to tRNA to mRNA to protein
If an organism's DNA contains 20% adenine nucleotides, what percentage of its DNA is composed of guanine nucleotides?
10%
20%
30%
40%
DNA replication is called semiconservative because
one of the two resulting DNA molecules is new.
the two resulting DNA molecules each have one new DNA strand and one old strand from the original DNA molecule
both of the resulting DNA molecules are composed of new strands of nucleotides
the sequence of nucleotides in one strand is conserved, whereas the new DNA molecule consists of a unique sequence of nucleotides
Which base is found in DNA, but not in RNA?
cytosine
uracil
thymine
adenine
If RNA polymerase malfunctions,
one of the subunits of rRNA will not be transcribed from DNA.
amino acids will not be joined to their tRNA.
mRNA cannot bind to rRNA.
an mRNA will not be formed.
Which process requires the participation of all three types of RNA?
Transcription
Translation
RNA processing
replication
The stages of translation are
transcription, mRNA processing, and termination
DNA replication, transcription, and termination
initiation, transcription, elongation cycle, and termination
initiation, elongation cycle, and termination
DNA replication makes a(n) __________ copy of the DNA strand, while transcription makes a(n) _________ copy of the DNA strand.
mRNA; DNA
DNA;mRNA
DNA;tRNA
mRNA; tRNA
Which of the following processes does not occur within the nucleus?
DNA replication
Transcription
intron removal
translation
The sequence of the mRNA that would result from transcribing the DNA template stand TAC GCT AAT
AUG CGA UUA
AUU AGC GUA
ATG CGA TTA
UAA UCG CAU
Which of the following events in gene expression control does not occur in the nucleus?
chromatin condensation
mRNA translation
DNA transcription
mRNA processing
The protein derived from a particular gene is different when it is found in a neuron than in a muscle cell. This is most likely due to
alternative mRNA processing.
regulation of mRNA translation.
alteration of protein activity.
mRNA editing.
An intervening sequenced of DNA that is not expressed is called a(n)
intron
exon
gene
promoter
A silent mutation is more likely to occur as a result of
a frameshift mutation.
a point mutation that does not change the amino acid encoded within the gene.
the movement of a transposon into an exon.
a point mutation that alters the amino acid encoded within the gene.
What is a frameshift mutation?
insertion or deletion of nucleotide bases in numbers that are not multiples of three
a mutation in which a single pair of nucleotides at a certain point in the gene sequence is altered.
a type of mutation that involves the addition of one or more nucleotides into a segment of DNA.
a type of genetic mutation that involves the removal of a portion of the genetic material
What is a phenotype?
the characterisitc version of a trait that we actually see
the specific combination of "hereditary particles" carried by an individual that cause a phenotype
Homozygote
when both alleles for the same trait are in the same. Example PP or pp (true breeding)
when alleles for the same trait differ. Example pp (non-true breeding)
What is Homozygous Dominant (PP)?
a genotype where an individual inherits two copies of a dominant gene
carries two copies of a recessive gene
having different alleles for a particular trait
Homozygous Recessive (pp)
a genotype where an individual inherits two copies of a dominant gene
carries two copies of a recessive gene
having different alleles for a particular trait
Heterozygous (Pp)
a genotype where an individual inherits two copies of a dominant gene
carries two copies of a recessive gene
having different alleles for a particular trait
Locus
place of interest on a chromosome, usually a gene
place in the DNA strand that encodes information causing a trait
Law of Segregation
Each individual has two factors for each trait
The factors segregate (separate) during the formation of the gametes
Each gamete contains only one factor from each pair of factors
Law of Independent Assortment
the alleles of two (or more) different genes get sorted into gametes independently of one another
each gamete contains only one factor from each pair of factors
each pair of factors segregates (assorts) independently of the other pairs
all possible combinations of factors can occur in the gametes
What is the ratio of independent assortments
9:3:3:1
3:3:1:3
Incomplete Dominance
an inheritance pattern where two alleles blend to create a new phenotype.
the alleles of two (or more) different genes get sorted into gametes independently of one another
Sex-Linked Inheritance
Females are XX
Males are XY
X is much large and carries more genes
What is X-linked
gene on X chromosome
gene on Y chromosome
What is an allele?
alternative forms of a gene
place in the DNA strand that encodes information causing a trait
What is a carrier?
a female who carries an X-linked trait but does not express it.
a male who carries an X-linked trait but does not express it
X-linked recessive disorder
Sons inherit trait from mothers- son's X comes from mother
more males than females have disorder- allele on X is always expressed in males
Females who have the condition inherited the mutant allele from both their mother and their father
Conditions appear to pass from grandfather to grandson
What is pleiotropy?
the phenomenon in which a single locus affects two or more apparently unrelated phenotypic traits
codominance
Skin Color is coded for by several different genes which results in a range of skin colors from very dark to very light. This is an example of
polygenic inheritance
pleiotropy
codominance
incomplete dominance
Sickle-cell disease is caused by a single mutation in the DNA of a particular gene. A person with this disease has red blood cells that lose their original donut shape and form a sickle shape. People with this disorder suffer from low energy levels, blood clots, and strokes. This is an example of
a multifactorial trait
pleiotropy
codominance
incomplete dominance
A couple has three children, two of which have blonde hair. The third child and both parents have dark hair. What can be determined about the gene for hair color in this family?
Blonde hair color is an autosomal recessive trait
Blonde hair color is an autosomal dominant trait
Blonde hair color is a sex-linked dominant trait
Blonde hair color is a sex-linked recessive trait.
If both parents express a particular trait, but their child does not, what does this indicate about the trait?
The trait is an autosomal dominant trait
The trait is an autosomal recessive trait
The trait is sex-linked dominant
This is a lethal trait
What is Multifactorial inheritance?
when more than 1 factor causes a trait or health problem, such as a birth defect or chronic illness.
a pattern of inheritance characteristic of some genetic disorders.
What is Autosomal dominant?
a pattern of inheritance characteristic of some genetic disorders
when more than 1 factor causes a trait or health problem, such as a birth defect or chronic illness.
Parents with the dominant phenotype cannot have offspring with the recessive phenotype.
True, because the dominant gene must be passed down from each parent
True, because at least one dominant gene will be passed down from each parent
False, because one parent could carry the recessive allele
False, because both parents could carry the recessive allele
