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WorksheetsMAJOR HISTOCOMPATIBILITY COMPLEX
Total questions: 15
Worksheet time: 8mins
Transplants last longer if the HLA antigens from the recipient and the donor are closely matched.
Paternity testing
Platelet transfusion
Transplantation
HLA loci are polymorphic and recombination is rare. HLA inheritance patterns can exclude fathers with approximately 99% accuracy
Paternity testing
Platelet transfusion
Transplantation
HLA B-27 is associated with
Ankylosing spondylitis
Myeloperoxidase (MPO) deficiency
Chronic granulomatous disease
Combination of inherited HLA alleles
HLA
Haplotype
Genotype
Two haplotypes (one from each parent)
HLA
Haplotype
Genotype
Are cell surface markers that allow immune cells to distinguish "self from "nonself."
HLA
Haplotype
Genotype
HLA complex located in;
Chromosome 3
Chromosome 6
Chromosome 9
HLA Antigens found on
All nucleated cells
Red blood cells
White blood cells
Complement proteins, TNFa and (3, and other proteins (e.g., heat shock protein) not associated with cell membrane surfaces
Class I
Class II
Class III
Molecules located on the surface of monocytes, macrophages, B cells, activated T cells, dendritic cells, Langerhans' cells, and some epithelial cells
Class I
Class II
Class III
Molecules found on nearly every nucleated cell surface
Class I
Class II
Class III
HLA-A2; A is the_____.
Locus
Allele
HLA-A2; 2 is the _____.
Locus
Allele
HLA was first described on:
Red blood cells
White blood cells
Plasma cells
Primary cause of immune mediated platelet transfusion refractoriness
I HLA
II HLA
III HLA
