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WorksheetsHistory of DNA Discovery
Total questions: 27
Worksheet time: 14mins
Before 1928, scientists didn't know what carried
genetic information.Many believed _______ were the molecule directly
responsible for inheritance.
Lipids
Proteins
Nucleic Acid
Carbohydrates
Which of the following are not one of the three key experiments contributed to our current
understanding of hereditary material?
Griffith's Transformation Experiment
Avery-MacLeod-McCarty Experiment
Watson and Crick
Hershey-Chase Experiment
What was the name of the bacterium that Frederick Griffith studied?
Streptococcus pneumonia
Staphylococcus epidermis
Salmonella
E. coli
Through
experimentation and
research of __________,
Griffith discovered the
process of
transformation.
Streptococcus pneumonia and rabbits
Streptococcus pneumonia and mice
Staphylococcus epidermis and rabbits
Staphylococcus epidermis and mice
Bacterial transformation is the process of a
bacterium uptaking external, exogenous genetic
material and incorporating it into their own
genome.
augmentation
absorption
transformation
conjugation
One of the biggest implications we now know of
is the transfer of advantageous genes, such as
antibiotic resistance, through __________.
absorption
augmentation
conjugation
transformation
What is the meaning of a virulent bacteria?
smooth-strain, non-infectious, disease-causing
smooth-strain, infectious, disease-causing
rough-strain, infectious, disease-causing
rough-strain, infectious, non-disease causing
What is the meaning of a non-virulent bacteria?
smooth-strain, non-infectious, disease-causing
smooth-strain, non-infectious, non-disease-causing
rough-strain, infectious, disease-causing
rough-strain, non-infectious, non-disease causing
When Griffith injected mice with the virulent bacteria, _____________
mice died
mice survived
When Griffith injected mice with the non-virulent bacteria, _________.
mice died
mice survived
When Griffith injected mice with heat-treated (killed) virulent
bacteria, ___________
mice died
mice survived
When Griffith injected mice with heat-treated virulent
bacteria and living non-virulent bacteria, _________.
mice died
mice survived
When Griffith injected mice with both forms of the virus that
had been heat-treated, ________.
mice died
mice survived
The scientific trio, Avery, Macleod, and McCarty expanded upon Griffith’s work in
order to answer the question of ____________.
what molecule was being absorbed to turn the virulent bacteria non-virulent.
what molecule was being absorbed to turn the non-virulent bacteria virulent.
what molecule was being transferred to turn the virulent bacteria non-virulent.
what molecule was
being transferred to turn the non-virulent bacteria
virulent.
Avery, MacLeod, and McCarty isolated and purified molecules from the
heat-treated bacteria, including all of the following except for ______.
carbohydrates
lipids
proteins
nucleic acids
Avery, MacLeod, and McCarty isolated and purified molecules from the
heat-treated bacteria, including all of the following except for ______.
carbohydrates
lipids
proteins
nucleic acids
Avery, MacLeod, and McCarty inoculated mice through a reductive
process to deduce which molecule was killing
the mice.
True
False
Avery, MacLeod, and McCarty experimented with inoculating mice by adding lipase to remove lipids from the dead bacteria.
Mice died
Mice survived
Avery, MacLeod, and McCarty experimented with inoculating mice by adding carbohydrase to remove sugars from the dead bacteria.
Mice died
Mice survived
Avery, MacLeod, and McCarty experimented with inoculating mice by adding
protease to remove proteins.
Mice died
Mice survived
Avery, MacLeod, and McCarty experimented with inoculating mice by adding
RNase to remove RNA.
Mice died
Mice survived
Avery, MacLeod, and McCarty experimented with inoculating mice by adding
DNase to remove DNA.
Mice died
Mice survived
In Avery, McLeod, and McCarty's experiment of inoculating mice, once DNA was removed, mice died. This lead to the conclusion that DNA was the genetic material.
True
False
While the Avery-MacLeod-McCarty experiment was
well received as proving DNA as the genetic
material, it was still only a theory.There was no definitive way to say, with
certainty, that it was DNA being taken up by
the bacteria in Avery, MacLeod, and McCarty’s
setup.
True
False
Since Avery-MacLeod-McCarty's experiment was just a theory, Hershey and Chase turned to radioactive labeling to provide substantiating visual evidence
True
False
a virus that infects bacteria
anti-bacteriophage
bacteriophage
anti-virusphage
virusphage
With radioactive labeling, a bacteriophage can be marked or “labeled”
with radioactive __________.
isomers
isotopes
