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History of DNA Discovery

Total questions: 27

Worksheet time: 14mins

Name
Class
Date
1.
  • Before 1928, scientists didn't know what carried
    genetic information.

    Many believed _______ were the molecule directly
    responsible for inheritance.

a)

Lipids

b)

Proteins

c)

Nucleic Acid

d)

Carbohydrates

2.
  • Which of the following are not one of the three key experiments contributed to our current
    understanding of hereditary material?

a)
  • Griffith's Transformation Experiment

b)
  • Avery-MacLeod-McCarty Experiment

c)

Watson and Crick

d)
  • Hershey-Chase Experiment

3.

What was the name of the bacterium that Frederick Griffith studied?

a)

Streptococcus pneumonia

b)

Staphylococcus epidermis

c)

Salmonella

d)

E. coli

4.

Through
experimentation and
research of __________,
Griffith discovered the
process of
transformation.

a)

Streptococcus pneumonia and rabbits

b)

Streptococcus pneumonia and mice

c)

Staphylococcus epidermis and rabbits

d)

Staphylococcus epidermis and mice

5.

Bacterial transformation is the process of a
bacterium uptaking external, exogenous genetic
material and incorporating it into their own
genome.

a)

augmentation

b)

absorption

c)

transformation

d)

conjugation

6.
  • One of the biggest implications we now know of
    is the transfer of advantageous genes, such as
    antibiotic resistance, through __________.

a)

absorption

b)

augmentation

c)

conjugation

d)

transformation

7.

What is the meaning of a virulent bacteria?

a)

smooth-strain, non-infectious, disease-causing

b)

smooth-strain, infectious, disease-causing

c)

rough-strain, infectious, disease-causing

d)

rough-strain, infectious, non-disease causing

8.

What is the meaning of a non-virulent bacteria?

a)

smooth-strain, non-infectious, disease-causing

b)

smooth-strain, non-infectious, non-disease-causing

c)

rough-strain, infectious, disease-causing

d)

rough-strain, non-infectious, non-disease causing

9.
  • When Griffith injected mice with the virulent bacteria, _____________

a)

mice died

b)

mice survived

10.
  • When Griffith injected mice with the non-virulent bacteria, _________.

a)

mice died

b)

mice survived

11.
  • When Griffith injected mice with heat-treated (killed) virulent
    bacteria, ___________

a)

mice died

b)

mice survived

12.
  • When Griffith injected mice with heat-treated virulent
    bacteria and living non-virulent bacteria, _________.

a)

mice died

b)

mice survived

13.
  • When Griffith injected mice with both forms of the virus that
    had been heat-treated, ________.

a)

mice died

b)

mice survived

14.

The scientific trio, Avery, Macleod, and McCarty expanded upon Griffith’s work in
order to answer the question of ____________.

a)

what molecule was being absorbed to turn the virulent bacteria non-virulent.

b)

what molecule was being absorbed to turn the non-virulent bacteria virulent.

c)

what molecule was being transferred to turn the virulent bacteria non-virulent.

d)

what molecule was
being transferred to turn the non-virulent bacteria
virulent.

15.
  • Avery, MacLeod, and McCarty isolated and purified molecules from the
    heat-treated bacteria, including all of the following except for ______.

a)

carbohydrates

b)

lipids

c)

proteins

d)

nucleic acids

16.
  • Avery, MacLeod, and McCarty isolated and purified molecules from the
    heat-treated bacteria, including all of the following except for ______.

a)

carbohydrates

b)

lipids

c)

proteins

d)

nucleic acids

17.
  • Avery, MacLeod, and McCarty inoculated mice through a reductive
    process to deduce which molecule was killing
    the mice.

a)

True

b)

False

18.
  • Avery, MacLeod, and McCarty experimented with inoculating mice by adding lipase to remove lipids from the dead bacteria.

a)

Mice died

b)

Mice survived

19.
  • Avery, MacLeod, and McCarty experimented with inoculating mice by adding carbohydrase to remove sugars from the dead bacteria.

a)

Mice died

b)

Mice survived

20.
  • Avery, MacLeod, and McCarty experimented with inoculating mice by adding

  • protease to remove proteins.

a)

Mice died

b)

Mice survived

21.
  • Avery, MacLeod, and McCarty experimented with inoculating mice by adding

  • RNase to remove RNA.

a)

Mice died

b)

Mice survived

22.
  • Avery, MacLeod, and McCarty experimented with inoculating mice by adding

  • DNase to remove DNA.

a)

Mice died

b)

Mice survived

23.
  • In Avery, McLeod, and McCarty's experiment of inoculating mice, once DNA was removed, mice died. This lead to the conclusion that DNA was the genetic material.

a)

True

b)

False

24.
  • While the Avery-MacLeod-McCarty experiment was
    well received as proving DNA as the genetic
    material, it was still only a theory.

    • There was no definitive way to say, with
      certainty, that it was DNA being taken up by
      the bacteria in Avery, MacLeod, and McCarty’s
      setup.

a)

True

b)

False

25.
  • Since Avery-MacLeod-McCarty's experiment was just a theory, Hershey and Chase turned to radioactive labeling to provide substantiating visual evidence

a)

True

b)

False

26.

a virus that infects bacteria

a)

anti-bacteriophage

b)

bacteriophage

c)

anti-virusphage

d)

virusphage

27.

With radioactive labeling, a bacteriophage can be marked or “labeled”
with radioactive __________.

a)

isomers

b)

isotopes