WorksheetsExam 2 Advanced Hematology
Total questions: 46
Worksheet time: 25mins
How many blast cells in a bone marrow aspirate smear are necessary for a diagnosis of acute myeloid leukemia using the WHO criteria?
20%
15%
25%
30%
What cytochemical stain is best for differentiating AML from ALL?
Alpha-napthyl acetate
Nonspecific esterase
Myeoperoxidase
Periodic acid Schiff
Which peripheral blood morphology is associated with dysmyelopoieisis?
Hyposegmentation
Hypogranulation
Schistocytes
Presence of Heinz Bodies
Which Leukemia is more common in Children?
Acute myelomonocytic leukemia
Acute Lymphoblastic leukemia
Acute Myelogenous leukemia
Acute myeloid leukemia with minimal maturation
Which chromosome abnormality is associated with mantle cell lymphoma?
t(11;14)
t(16;16)
t(14;18)
Trisomy 8
Which of the following pairs of cytochemical stains provide essentially the same information with regard to blast cell identity in acute leukemia cases?
chloroacetate esterase and Sudan Black B
acid phosphatase and myeloperoxidase
Periodic acid-Schiff and alkaline phosphatase
alpha napthyl acetate esterase and myeloperoxidase
Which of the following is a key marker for Chronic Lymphocytic Leukemia (CLL)?
CD5+ and CD23+
CD10+ and BCL2+
CD19+ and CD20-
CD15+ and CD30+
Which lymphoma subtype is characterized by Reed-Sternberg cells?
Diffuse Large B-Cell Lymphoma
Hodgkin Lymphoma
Follicular Lymphoma
Burkitt Lymphoma
Which B-cell neoplasm is associated with an aggressive clinical course and CD10 positivity?
Chronic Lymphocytic Leukemia
Burkitt Lymphoma
Plasma Cell Myeloma
Mycosis Fungoides
Which of the following phenotypes is characteristic of hairy cell leukemia?
CD11c+, CD19+, CD103+
CD3+, CD4+, CD7+
CD11c+, CD3+, CD10+
CD13+, CD19+, CD25+
Polycythemia vera can be differentiated from secondary polycythemia by measuring:
erythropoeitin
hematocrit
plasma volume
hemoglobin
Which of the following is a hallmark finding in Myelodysplastic Syndromes (MDS)?
Presence of Reed-Sternberg cells
Ineffective hematopoiesis and increased apoptosis
Presence of Auer rods in peripheral blood
t(9;22) translocation
Pseudo–Pelger–Huët anomaly is a characteristic finding in which condition?
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Chronic Myeloid Leukemia
Follicular Lymphoma
Which immunophenotypic marker is most characteristic of B-cell Acute Lymphoblastic Leukemia (B-ALL)?
CD34+, CD19+, TdT+
CD3+, CD4+, CD8+
CD33+, MPO+
CD15+, CD30+
The presence of Auer rods is a defining feature of which leukemia subtype?
ALL
CLL
AML
MDS
Which cytogenetic abnormality is associated with a poor prognosis in Acute Lymphoblastic Leukemia (ALL)?
t(12;21)(p13;q22)
t(9;22)(q34;q11)
inv(16)(p13;q22)
t(8;21)(q22;q22)
Which genetic mutation is most commonly associated with Polycythemia Vera (PV)?
BCR-ABL1
JAK2 V617F
CALR mutation
MPL mutation
Chronic Myeloid Leukemia (CML) is characterized by which chromosomal translocation?
t(9;22)(q34;q11)
t(15;17)(q24;q21)
t(11;14)(q13;q32)
t(8;14)(q24;q32)
Which of the following poikilocytes is a characteristic finding in primary myelofibrosis (PM)?
teardrop cell
schistocyte
spherocyte
target cell
Which stain is used to identify the presence of fibrosis in the bone marrow?
(a)
In which category does Refractory Anemia (RA) fall according to the WHO classification of Myelodysplastic Syndromes (MDS)?
MDS with excess blasts (MDS-EB)
MDS with single lineage dysplasia (MDS-SLD)
MDS with multilineage dysplasia (MDS-MLD)
MDS with isolated del(5q)
Which of the following best describes the bone marrow findings in Refractory Anemia (RA)?
Dysplasia affecting multiple cell lineages
Presence of >5% blasts in the bone marrow
Dysplasia limited to the erythroid lineage with <5% blasts
Increased megakaryocytes with abnormal morphology
What is the blast percentage cutoff in the peripheral blood for diagnosing Refractory Anemia (RA)?
<1%
5-10%
10-20%
>20%
Which of the following is NOT a typical characteristic of Refractory Anemia (RA)?
Anemia as the primary cytopenia
Ringed sideroblasts present in all cases
No Auer rods in peripheral blood or bone marrow
Low risk of progression to acute leukemia
Which chromosomal translocation is most commonly associated with Acute Promyelocytic Leukemia (APL)?
t(8;21)
t(15;17)
t(9;22)
t(11;14)
Which immunophenotypic marker is most characteristic of B-cell Acute Lymphoblastic Leukemia (B-ALL)?
CD3+, CD4+, CD8+
CD33+, MPO+
CD15+, CD30+
CD34+, CD19+, TdT+
Myeloblasts are ( positive or negative) for Myeloperoxidase stain? write the correct answer below
(a)
Nonspecific esterae Alpha-Naphthyl acetate separates monoblasts from myeloblasts. Monoblasts stain ( positive or negative)
(a)
What is the genetic alteration for Chronic Eosinophilic leukemia?
BCR/ABL1
JAK2
Trisomy 8
CSFR3r
What is the genetic alteration for PMF
JAK2
CALR
MPL
BCR/ABL1
Which genetic mutation is most commonly associated with Polycythemia Vera (PV)?
BCR-ABL1
JAK2 V617F
CALR mutation
MPL mutation
The key characteristic for distinguishing between myelodysplastic syndrome and acute leukemia is:
percent of bone marrow blasts
bone marrow cellularity
Plasma cell infiltrate
None of these
Which chromosome abnormality is specifically associated with myelodysplastic syndrome?
translocation between chromosomes 17 and 22
loss of the Y chromosome
addition of chromosome 7
deletion of long arm of chromosome 5
Which chromosome abnormality gives rise to the hybrid gene, MYC/IGH?
t(8;21)
t(9;22)
t(15;17)
t(8;14)
The cytochemical stain, chloroacetate (specific) esterase is useful for identifying blast cells of:
lymphoid lineage
monocytic lineage
erythroid lineage
myeloid lineage
Which genetic abnormality gives rise to the hybrid gene CBFB/SMMHC
t(12;21)
t(8;21)
t(9;11)
t(16;16)
Malignancies associated with which genetic mutation can be successfully treated with Gleevec?
JAK2(V617F)
BCR/ABL
RAR/PML
FRK(K423W)
Which laboratory tests would help distinguish myelodysplastic syndrome from megaloblastic anemia?
reticulocyte count
myeloperoxidase stain
serum folate and vitamin B12
lactate dehydrogenase
What cytochemical stain is used to help differentiate a leukemoid reaction from CML?
Myeloperoxidase
New Methylene Blue
Leukocyte Alkaline Phosphatase
Perl's Prussian Blue
Which of the following markers is expressed in most cases of AML?
CD2
CD10
CD11b
CD117
What is the typical M:E ratio in patients with CML (chronic myelogenous leukemia)? Select the best answer.
1:10
1:5
15:1
3:1
Which of the following is consistent with leukemoid reaction?
Low WBC Count
Basophilia
Presence of ph chromosome
High LAP
Which phase of CML carries the worst prognosis and is generally unresponsive to treatment?
Chronic
Accelerated
Blastic
Refractory
Which of the following myeloproliferative disorders is characterized by a decreased LAP score?
CML
PMF
ET
PV
Review the attachment and answer the following question:
What is the probable diagnosis based on the result?
ALL
CML
CLL
AML
Review the attachment and answer the following question:
Which lab result is most helpful in obtaining a diagnosis?
The identification of the BCR/ABL1 is most helpful in offering a diagnosis.
The identification of the Myeoblast is most helpful in offering a diagnosis.
PLT Count of 70
None of the choices listed
