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Worksheets

12 Biology

Total questions: 22

Worksheet time: 18mins

Name
Class
Date
1.

What is the purpose of signal transduction pathways in cells?

a)

To amplify electrical signals

b)

To modify proteins

c)

To release glucose from glycogen

d)

To convert ATP into cAMP

2.

What is the purpose of signal transduction pathways in cells?

a)

To amplify electrical signals

b)

To modify proteins

c)

To release glucose from glycogen

d)

To convert ATP into cAMP

3.

What is the role of ligands in signal transduction pathways?

a)

To attach to receptors

b)

To convert ATP into cAMP

c)

To activate protein kinases

d)

To release glucose from glycogen

4.

Which protein is responsible for converting ATP into cAMP?

a)

G-protein

b)

Adenylyl cyclase

c)

Protein kinase

d)

Phosphorylase

5.

What happens when cAMP binds to the regulatory portions of protein kinase?

a)

Protein kinase becomes inactivated

b)

Protein kinase becomes activated

c)

Protein kinase releases glucose from glycogen

d)

Protein kinase converts ATP into cAMP

6.

What is the purpose of cyclic AMP (cAMP) in signal transduction pathways?

a)

To amplify electrical signals

b)

To modify proteins

c)

To release glucose from glycogen

d)

To serve as a secondary messenger

7.

Which molecule acts as a ligand in the signal transduction pathway described?

a)

Epinephrine

b)

G-protein

c)

Adenylyl cyclase

d)

Phosphorylase

8.

What is the role of the alpha subunit in the signal transduction pathway?

a)

To attach to adenylyl cyclase

b)

To convert ATP into cAMP

c)

To activate protein kinase

d)

To release glucose from glycogen

9.
A signal molecule that binds to a plasma-membrane protein is a
a)
ligand
b)
second messenger
c)
protein kinase
d)
receptor protein
10.

Type of cell signaling where the ligand is produced at a location distant from its target cell(s)

a)

autocrine signaling

b)

juxtracrine signaling

c)

paracrine signaling

d)

endocrine signaling

11.
1.  Each of the following numbered processes are involved in signal transduction pathways:  
 I.  Response
 
II.  Amplification
 
 III.  Reception
 
IV.  Transduction
Which of the following represents the sequence of events in a typical signal transduction pathway?
a)
I, II, III, IV
b)
III, I, IV, II
c)
II, IV, I, III
d)
III, IV, II, I
12.
Protein kinases activate other relay proteins by adding a(n) ____ to them.
a)
phosphate
b)
ATP molecule
c)
cAMP
d)
GTP
13.
What type of transmembrane receptor is being shown?
a)
G-protein receptor
b)
tyrosine kinase receptor
c)
gated ion channel
14.

Adrenaline is released from your adrenal glands to affect various systems in the body. This is an example of ____ signaling.

a)

juxtacrine (direct cell to cell contact)

b)

endocrine (long distance)

c)

paracrine (short distance)

d)

autocrine (self-signaling)

15.

What type of signaling is shown here?

a)

autocrine (self-signaling)

b)

juxtacrine (direct cell-to-cell contact)

c)

endocrine (long-distance)

d)

paracrine (short distance)

16.

Many cancer cells signal themselves to grow and divide. This is an example of ______ signaling.

a)

endocrine (long distance)

b)

autocrine (self-signaling)

c)

paracrine (short distance)

d)

hormone (long distance)

17.

After a cellular response is achieved, how is it terminated?

a)

the ligand and receptor separate

b)

block the transduction pathway

c)

the cell will keep responding

d)

send out a different signal

18.

Which part of the signaling pathway could consist of protein modification, second messenger production, amplification or a phosphorylation cascade?

a)

Reception

b)

Transduction

c)

Response

d)

All of these

19.

Once GTP replaces GDP, the alpha subunit always goes on to activate succeeding proteins.

a)

True

b)

False

20.
The three stages of cell signalling are
a)
paracrine, local, and synaptic
b)
reception, transduction, and response
c)
transcription, translation, and folding
d)
alpha, beta, and gamma
21.
Consider this pathway: epinephrine --> receptor --> cAMP --> protein kinase --> transcription factors. 

Identify the secondary messenger.
a)
epinephrine
b)
G protein-coupled receptor
c)
adenylyl cyclase
d)
cAMP
22.

Which of the following can activate a protein by transferring a phosphate group to it?

a)

cAMP

b)

G proteins

c)

phosphodiesterase

d)

protein kinase