Font size
WorksheetsMEDL 279 Chemistry Review Part II
Total questions: 88
Worksheet time: 44mins
What does osmolality measure?
The total concentration of dissolved particles in a solution
The total volume of a solution
The pH of a solution
The color of a solution
Which of the following is a direct method to measure osmolality?
Freezing point depression
Boiling point elevation
Colorimetric analysis
Titration
Fill in the blank: The formula for calculated osmolality is _________.
2Na+Glucose/18+BUN/2.8
Na+K+Cl
2K+Glucose/18+BUN/2.8
Na+Glucose/18+BUN/2.8
Magnesium levels increase in which condition?
Renal failure
Cardiac disorders
Diabetes Mellitus
Alcohol use
Magnesium levels decrease in all of the following EXCEPT:
Cardiac disorders
Diabetes Mellitus
Renal failure
Use of diuretics, alcohol, and other drugs
Which analysis methods are used for magnesium?
Colorimetric and Atomic absorption
Titration and Spectrophotometry
Chromatography and Electrophoresis
Immunoassay and ELISA
Calcium combines with _______ in the bone.
phosphate
sulphate
chloride
carbonate
Which hormone increases ionized Ca++?
PTH
Calcitonin
Insulin
Glucagon
Hypercalcemia can be caused by all of the following EXCEPT:
Hyperparathyroidism
Cancer with bone metastasis
Multiple myeloma
Hypoparathyroidism
Which method measures ionized Ca++?
ISE
Colorimetric
Fluorometric
Titration
The majority of phosphate in the body is expressed as ________, and the lab only measures inorganic phosphorous PO4 only.
phosphorous
calcium
magnesium
potassium
Phosphorous has an inverse relationship with which ion?
Na+
K+
Ca++
Mg++
An increase in phosphorous levels can be caused by which of the following?
Hypoparathyroidism
Chronic renal failure
Excess Vitamin D
All of the above
A decrease in phosphorous levels can be caused by ________ and impaired renal absorption.
hyperparathyroidism
hypoparathyroidism
hyperkalemia
hypokalemia
Spectrophotometric methods for phosphorous analysis use ________ to combine with PO4 ions.
molybdate
sulphate
chloride
nitrate
Over 65% of iron in the body is in the form of ________ for O2 transport.
hemoglobin
myoglobin
ferritin
transferrin
Iron is transported in the body by which of the following?
Transferrin
Haptoglobin
Hemopexin
All of the above
Iron is stored in the body as ________ and hemosiderin.
ferritin
albumin
globulin
myoglobin
Serum iron analysis should avoid ________.
hemolysis
lipemia
hyperglycemia
alkalosis
Ferritin is used to assess ________ storage and lab assessment of iron.
iron
calcium
glucose
potassium
What is the formula for the Henderson-Hasselbalch equation?
pH = pKa + log [HCO3]/[H2CO3]
pH = pKa - log [HCO3]/[H2CO3]
pH = pKa + [HCO3]/[H2CO3]
pH = pKa - [HCO3]/[H2CO3]
According to the Henderson-Hasselbalch equation, what should the ratio of [HCO3] to [H2CO3] be?
20:1
10:1
2:1
1:1
Urines with large amounts of porphyrins will show what color?
Blue
Red or "port wine"
Green
Yellow
In the Watson-Schwartz test, porphobilinogen will react with Ehrlich's reagent to form what color?
Blue
Green
Red
Yellow
The Jendrassik-Grof method uses which substance as an accelerator?
Caffeine-benzoate
Sodium chloride
Glucose
Urea
Direct bilirubin is also known as ______ and is ______ soluble.
conjugated and is water soluble.
unconjugated and is fat soluble.
conjugated and is fat soluble.
unconjugated and is water soluble.
Indirect bilirubin is also known as ______ and is ______ in water.
unconjugated and is insoluble in water.
conjugated and is soluble in water.
unconjugated and is soluble in water.
conjugated and is insoluble in water.
Which of the following can falsely increase bilirubin results in specimen collection?
Extremely light sensitive
Lipemia
Hemolysis
All of the above
In pre-hepatic jaundice (hemolytic anemia), increase in RBC destruction leads to increase in ______ bilirubin.
unconjugated
conjugated
direct
mixed
In hepatic jaundice (viral hepatitis, cirrhosis), what happens to unconjugated and conjugated bilirubin levels?
Increase in both unconjugated and conjugated bilirubin.
Decrease in both unconjugated and conjugated bilirubin.
Increase in unconjugated but decrease in conjugated bilirubin.
Decrease in unconjugated but increase in conjugated bilirubin.
Conjugated and unconjugated bilirubin cannot be metabolized properly, therefore they back-up into the ________.
plasma
urine
intestine
liver
What color may stool become due to a decrease in urobilinogen?
clay colored
bright red
green
black
Which of the following is the gold standard for confirmation and screening in Toxicology/TDM?
Immunochemical methods
Gas Chromatography-Mass Spec
FPIA
EMIT methods
How many half-lives does it take to reach a steady state for therapeutic monitoring?
2
3
5 ½
7
Trough specimen is drawn immediately _______ the next dose.
before
after
during
with
Which aminoglycoside is less toxic to kidneys?
Gentamycin
Tobramycin
Chloramphenicol
Digoxin
Toxic levels of _______ can result in aplastic anemia.
chloramphenicol
paracetamol
amoxicillin
ibuprofen
Lidocaine is measured using which laboratory methods?
Immunoassay, HPLC
ELISA, PCR
Western blot, Electrophoresis
Spectrophotometry, Colorimetry
Which of the following is NOT an anticonvulsant?
Carbamazepine
Phenobarbital
Lithium
Phenytoin (Dilantin)
Name one use of lithium in medicine.
Used in treating manic depression
Used as a painkiller for headaches
Used to treat bacterial infections
Used to lower blood sugar levels
Theophylline is a type of:
Anticonvulsant
Psychotropic
Bronchodilator
Heavy Metal
Severe toxicity of theophylline can cause which of the following?
Cardiac arrhythmias
Seizures
Death
All of the above
Which laboratory method is used for both lidocaine and theophylline?
HPLC
ELISA
Nephelometry
Colorimetry
Which of the following is most commonly associated with metabolic acidosis and respiratory alkalosis?
Iron
Salicylates
Lead
Arsenic
What is the most common alcohol involved in acute poisoning?
Ethanol
Methanol
Isopropanol
Ethylene glycol
Lead is classified under which type of acute poisoning?
Heavy Metals
Pesticides
Alkaloids
Gases
Acetaminophen can cause liver damage due to accumulation of toxic metabolite after how many hours of ingestion?
48 hours
6 hours
12 hours
24 hours
Antidote for acetaminophen poisoning is most helpful if given within how many hours?
24 hours
48 hours
12 hours
36 hours
All NPNs (urea, creatinine, uric acid, and ammonia) are increased in the plasma in renal impairment. What is this condition called?
Azotemia
Hypokalemia
Acidosis
Hypercalcemia
In cases of suspected renal impairment, what is the best lab evaluation?
GFR (Glomerular Filtration Rate)
Serum sodium
Urine glucose
Serum calcium
What is the formula for creatinine clearance calculation?
U creat/P creat X Volume 24hr urine/1440 (min/24hr)
P creat/U creat X Volume 24hr urine/1440 (min/24hr)
U creat/P creat X Volume 24hr urine/60 (min/hr)
U creat/P creat X Volume 12hr urine/1440 (min/24hr)
What is the source of creatinine in the body?
From creatine in muscle
From glucose in the liver
From fatty acids in adipose tissue
From hemoglobin breakdown
Which substances can interfere with the Jaffe reaction for creatinine measurement?
Glucose, ascorbic acid
Sodium chloride, potassium iodide
Calcium carbonate, magnesium sulfate
Urea, albumin
BUN increases in impaired renal function and rises more rapidly than which other substance?
Serum creatinine
Uric acid
Glucose
Calcium
Which method is used for the colorimetric detection of urea?
Urea reacts with diacetyl monoxime to form colored complex
Urea reacts with Benedict's reagent to form colored complex
Urea reacts with ninhydrin to form colored complex
Urea reacts with Fehling's solution to form colored complex
What is the normal BUN/creatinine ratio?
10:1-20:1
5:1-8:1
25:1-35:1
1:1-3:1
Uric acid is the end product of which metabolism?
Purine metabolism
Pyrimidine metabolism
Carbohydrate metabolism
Protein metabolism
Increase in plasma ammonia is toxic to which system?
CNS (Central Nervous System)
Musculoskeletal system
Integumentary system
Reproductive system
Which of the following is NOT a cause of hyperammonemia?
Advanced liver disease
Cirrhosis
Diabetes mellitus
Viral hepatitis
What hormone stimulates the pituitary to release TSH?
TRH
ACTH
FSH
GH
Which hormone stimulates the thyroid to produce both thyroxine (T4) and triiodothyronine (T3)?
TSH
ACTH
FSH
GH
In the tissues, T4 is converted to which physiologically active portion?
T3
T2
T4 sulfate
Reverse T3
What percentage of T4 is bound to TBG, TBPA, and albumin?
99.97%
98.5%
95%
99.5%
Which of the following is NOT a symptom of hyperthyroidism?
A) Weight loss
B) Heat intolerance
C) Weight gain
D) Nervousness
What is the most common cause of hyperthyroidism?
Grave's disease
Hashimoto's thyroiditis
Thyroid cancer
Iodine deficiency
Which of the following is associated with Hashimoto's Thyroiditis?
Increase T3 and T4
Decrease T3 and T4
Decrease TSH
No thyroid antibodies
Symptoms of hypothyroidism include:
Fatigue
Weight gain
Decreased mental and physical output
All of the above
Test for total T4 can be performed using which of the following methods?
RIA or EIA
ELISA only
Western Blot
PCR
Free T4 is separated by ________ dialysis.
equilibrium
reverse
osmotic
pressure
Direct T3 is measured by ________ or EIA.
RIA
ELISA
PCR
Western blot
Male sex hormones, secondary sexual characteristics are called ________.
Androgens
Estrogens
Insulins
Thyroxines
Androgens are secreted by the ________, adrenals and ovaries.
testes
pancreas
thyroid
pituitary
Female sex hormones are called ________.
Estrogens
Testosterones
Insulins
Adrenalins
Estradiol is responsible for ________ sexual characteristic.
secondary
primary
tertiary
quaternary
Which hormone increases in fetal development and monitors the integrity of the fetal placental unit?
Estrone
Estriol
Testosterone
Aldosterone
Aldosterone is produced in the ________ cortex of the adrenal gland.
outer
renal
cerebral
thymic
Which disease is associated with increased sodium, decreased potassium, and hypertension?
Addison's disease
Conn's disease
Cushing's syndrome
Neuroblastoma
Addison's disease is associated with which of the following?
Increase sodium & chloride
Decrease sodium & chloride
Increase cortisol
Increase hemoglobin
Fill in the blank: Decrease ACTH in damage to hypothalamus or pituitary, ______ ACTH in adrenal damage.
Increase
Decrease
No change in
Fluctuating
Cortisol is produced in the ______ cortex.
adrenal
cerebral
renal
thymic
Which of the following is NOT a function of cortisol?
Causes increase glucose through gluconeogenesis
Inhibits protein synthesis
Immunosuppressive and anti-inflammatory
Increases potassium excretion
Cushing's syndrome is associated with:
Increase cortisol
Decrease cortisol
Increase aldosterone
Decrease aldosterone
Which hormone is produced in the adrenal medulla?
Cortisol
Epinephrine
Gastrin
Serotonin
HVA is a metabolite of ______.
dopamine
serotonin
acetylcholine
norepinephrine
Metanephrines and VMA are metabolites of which hormone?
Cortisol
Epinephrine
Gastrin
Serotonin
Neuroblastoma is a fatal tumor in ______.
children
adults
elderly
infants
Which assay is the best screen for pheochromocytoma?
HVA in urine
Metanephrines in urine
VMA in urine
Cortisol in urine
Gastrin levels increase in which syndrome?
Addison's disease
Cushing's syndrome
Zollinger-Ellison syndrome
Conn's disease
