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WorksheetsMethemoglobinemia and ETC Quiz
Total questions: 20
Worksheet time: 10mins
Which form of hemoglobin contains iron in the ferric (Fe3+) state?
Oxyhemoglobin
Carboxyhemoglobin
Methemoglobin
Sulfhemoglobin
Which of the following is a feature of methemoglobinemia?
Increased oxygen binding
Improved tissue oxygenation
Cyanosis despite normal PaO2
Excess bilirubin
Which enzyme deficiency commonly leads to congenital methemoglobinemia?
Cytochrome oxidase
NADH methemoglobin reductase
Glucose-6-phosphatase
Superoxide dismutase
Which is a characteristic of adult hemoglobin (HbA)?
α2γ2
α2β2
α2δ2
α4
Which amino acid binds the heme group to the globin chain?
Glycine
Serine
Histidine
Arginine
Which statement is TRUE about Crigler-Najjar Syndrome?
It is an acquired disorder
It involves increased conjugated bilirubin
It results from a defect in UDP-glucuronyl transferase
It is due to hemolysis
Crigler-Najjar Syndrome is related to the metabolism of which compound?
Heme
Cholesterol
Creatinine
Glucose
How many ATP molecules are synthesized per NADH oxidized in ETC?
1
2
2.5
3
Which of the following is NOT a component of the electron transport chain?
Cytochrome c
Coenzyme Q
Succinate dehydrogenase
Pyruvate dehydrogenase
Which site in the ETC produces the most ATP?
Complex I
Complex II
ATP synthase
Complex IV
Which compound acts as an inhibitor of Complex IV in ETC?
Rotenone
Antimycin A
Cyanide
Malonate
Which shuttle transfers NADH from cytosol to mitochondria in the liver?
Glycerol-3-phosphate shuttle
Malate-aspartate shuttle
Carnitine shuttle
Urea cycle
Which is a characteristic of uncouplers?
They inhibit electron flow
They increase oxygen consumption
They increase ATP synthesis
They block Complex IV
Which compound is an uncoupler of oxidative phosphorylation?
Oligomycin
Rotenone
DNP (2,4-Dinitrophenol)
Cyanide
Which high-energy compound has a high phosphoryl transfer potential?
Glucose
AMP
ATP
Fructose
What is the main hypothesis explaining ATP generation in mitochondria?
Lock and key hypothesis
Chemiosmotic hypothesis
Fluid mosaic hypothesis
Substrate channeling
Which enzyme forms ATP from ADP using the proton gradient?
Cytochrome oxidase
Complex I
F0-F1 ATPase (ATP synthase)
NADH dehydrogenase
What is the major function of Coenzyme Q in the ETC?
Transfer of protons across inner membrane
Inhibits ATP synthesis
Transfers electrons from Complex III to IV
Transfers electrons from Complex I/II to Complex III
Which enzyme catalyzes the first step in heme synthesis?
ALA synthase
ALA dehydratase
Ferrochelatase
Porphobilinogen deaminase
Which molecule regulates ALA synthase activity?
Oxygen
Heme
Iron
Bilirubin
