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Endocrine System Quiz

Total questions: 79

Worksheet time: 42mins

Name
Class
Date
1.

The mechanism of the anti-inflammatory action of glucocorticoids:

a)

inhibit the activity of COX 1

b)

inhibit the activity of COX 2

c)

inhibit the activity of phospholipase A2

d)

stimulate opiate receptors

e)

stimulate benzodiazepine receptors

2.

Functional activity of the adrenal glands during long-term therapy with glucocorticoids:

a)

increases

b)

does not change

c)

decreases

d)

initially decreases, then increases sharply

e)

at the beginning it increases, then decreases

3.

Mineralocorticoid drugs include:

a)

insulin

b)

triamcinolone

c)

nandrolone

d)

deoxycortone

e)

prednisolone

4.

List anti-inflammatory drugs with steroid structure:

a)

suprastin, diprazine

b)

hydrocortisone, tavegil

c)

prednisone, hydrocortisone

d)

diphenhydramine, prednisone

e)

intal, hydrocortisone

5.

Anti-inflammatory, antiallergic and immunosuppressive effects are caused by:

a)

glucocorticoids

b)

anabolic steroids

c)

estrogens

d)

gestagens

e)

progestrogens

6.

Specify a synthetic glucocorticoid preparation:

a)

cortisol

b)

actrapid

c)

humulin

d)

prednisone

e)

hydrocortisone

7.

Which of the following side effects are most typical for prednisolone:

a)

osteoporosis, hyperglycemia, immunosuppression, increased blood pressure, edema

b)

dyspepsia, anemia, agranulocytosis, ulcerogenic deistane, hepatitis

c)

ulcerogenic effect, dyspepsia, inhibition of platelet aggregation

d)

drug dependence, depression of the thermoregulation center, addiction

e)

anti-inflammatory, antipyretic, analgesic effect

8.

What type of therapy includes long-term use of steroidal anti-inflammatory drugs (glucocorticoids)

a)

inhibitory

b)

replacement

c)

symptomatic

d)

preventive

e)

pulse therapy

9.

Steroid diabetes, steroid gastric ulcer, Itsenko-Cushing syndrome, immunodeficiency - characteristic complications of the drug:

a)

calcium-D3

b)

auronofik

c)

penicillamine

d)

methylprednisolone

e)

aflutol

10.

Prednisolone, dexamethasone, triamcinolone are drugs with the following characteristics:

a)

inhibit inflammatory reactions, which involve delayed-type hypersensitivity reactions

b)

inhibit COX, reduce the formation of prostaglandins, used for inflammatory diseases of the joints

c)

steroid hormones, have anti-inflammatory and immunosuppressive effects

d)

drugs necessary for the regeneration of bone and joint tissue, restoration of degenerative processes

e)

slow down the destruction of bone tissue and reduce calcium loss, accelerate the process of bone tissue restoration

11.

Deoxycortone (deoxycorticosterone) mainly affects

a)

carbohydrate metabolism

b)

protein metabolism

c)

water-salt metabolism

d)

lipid metabolism

e)

aldosterone

12.

Pharmacodynamics of Cabergoline:

a)

non-selective agonist of dopamine receptors, inhibits ACTH synthesis

b)

inhibitor of 17a-hydroxylase and 11B-hydroxylase

c)

selective agonist of dopamine receptors (subtypes 1 and 5), inhibits ACTH synthesis

d)

dopamine receptor antagonist, inhibits ACTH

e)

selective inhibitor of B-hydroxylase

13.

Osteoporosis, increased blood glucose concentration, increased blood pressure

a)

insulin, glucagon

b)

prednisolone, hydrocortisone

c)

retabolin, nerobol

d)

clomiphene, amoxiclav

e)

turinal, progesterone

14.

Side effects characteristic of deoxycorticosterone acetate:

a)

tachycardia, sweating, weakness, allergic reactions

b)

hypoglycemia, resistance, lipodystrophy

c)

hyperglycemia, osteoporosis, teratogenic effect, increased blood pressure

d)

leukopenia, lymphadenopathy, goiter effect

e)

pasty tissues, edema, ascites, increased blood pressure

15.

Indications for the use of dexomethasone

(a)  

16.

Inhibits the progression of glomerulonephritis because it has anti-inflammatory, desensitizing and immunosuppressive effects, stabilizes lysosomal enzymes, reduces the permeability of the basement membrane of glomerular capillaries

(a)  

17.

One of the statements is true that glucocorticoids

a)

inhibit microsomal oxidation of enzymes in the liver

b)

inhibit all phases of inflammation

c)

inhibit the conduction of impulses in the central nervous system

d)

stimulates the formation of prostaglandins

e)

cause an immunostimulating effect

18.

Side effects of mineralocorticoid drugs:

a)

pasty tissues, edema, ascites, increased blood pressure

b)

tachycardia, sweating, weakness, allergic reactions

c)

hypoglycemia, resistance, lipodystrophy

d)

hyperglycemia, osteoporosis, teratogenic effect, increased blood pressure

e)

leukopenia, lymphadenopathy, goiter effect

19.

Pharmacodynamics of Pasireotide:

a)

non-selective dopamine receptor agonist, inhibits ACTH synthesis

b)

inhibitor of 17a-hydroxylase and 11B-hydroxylase

c)

selective agonist of dopamine receptors (subtypes 1 and 5), inhibits ACTH

d)

dopamine receptor antagonist, inhibits ACTH synthesis

e)

selective inhibitor of B-hydroxylase

20.

Pharmacodynamics of Ketoconazole:

a)

non-selective dopamine receptor agonist, inhibits ACTH synthesis

b)

inhibitor of 17a-hydroxylase and 11B-hydroxylase

c)

selective agonist of dopamine receptors (subtypes 1 and 5), inhibits ACTH synthesis

d)

dopamine receptor antagonist, inhibits ACTH

e)

selective inhibitor of B-hydroxylase

21.

Note possible complications with long-term use of steroidal anti-inflammatory drugs

(a)  

22.

Indications for use of Pasireotide

a)

For short-term therapy of BIC in mild forms of the disease

b)

Before and after NIR radiation therapy

c)

For long-term therapy of severe forms of BIC

d)

Ineffective for all forms of BIC

e)

For the treatment of NIC and systemic lupus erythematosus

23.

Side effects of glucocorticoids associated with their mineralocorticoid activity:

a)

ulcerogenic effect, immunodeficiency

b)

catabolic, immunosuppressive

c)

hyperglycemia, redistribution of fats

d)

edema, increased blood pressure, osteoporosis

e)

lymphocytopenia, eosinophilia

24.

Deoxycorticosterone acetate (DOXA), deoxycorticosterone trimethyl acetate, fluorohydrocortisone acetate belong to the group:

a)

mineralocorticoids

b)

preparations of pituitary hormones

c)

preparations of hypothalamic hormones

d)

glucocorticoids

e)

antithyroid drugs

25.

The main indication for the use of this group of drugs is adrenal insufficiency:

a)

deoxycorticosterone, fluorohydrocortisone

b)

hydrocortisone, tavegil

c)

prednisolone, hydrocortisone

d)

diphenhydramine, prednisolone

e)

intal, hydrocortisone

26.

Drugs used for hypercortisolism:

a)

chlorpropamide, bucarban, tolinase

b)

peritol, parlodel, abergin

c)

insulin lente, insulinrap, monotard

d)

homophane, isophane NM, humulin

e)

metformin, glucobay, guarem

27.

Medicines for the treatment of Itsenko-Cushing's disease are represented by all means except:

a)

acting directly on the pituitary gland (cabergoline)

b)

adrenal 11B-hydroxylase blockers (metyrapone)

c)

blockers of 11B-hydroxylase and 17a-hydroxylase of the adrenal glands (ketoconazole)

d)

replacement therapy (prednisolone)

e)

blocking glucocorticoid receptors (mifepristone)

28.

Indications for the use of Ketoconazole

a)

For short-term therapy of BIC or mild forms of the disease

b)

Before and after NIR radiation therapy

c)

For long-term therapy of severe BIC

d)

Ineffective for all forms of NIC

e)

For the treatment of NIC and systemic lupus erythematosus

29.

A drug that causes osteoporosis by inhibiting protein synthesis

a)

parathyroid hormone

b)

vitamin D

c)

fluorine salts

d)

prednisone

e)

pamidronate

30.

Effective in myxedema:

a)

thyroidin, levothyroxine

b)

prednisolone, dexamethasone

c)

retabolia, nerobol

d)

actrapid, insulinran

e)

mercazodil, potassium iodide

31.

Replenishes iodine deficiency in goiter:

a)

Thyroidin

b)

Levothyroxine

c)

Potassium iodide

d)

Mercazolil

e)

Actrapid

32.

The following drug is used in diabetic coma:

a)

thyroidin, levothyroxine

b)

prednisolone, dexamethami

c)

retabolin, nerobol

d)

actrapid, insulrap

e)

thiamazole, potassium iodide

33.

Insulin preparations do not include:

a)

insulrap

b)

humulin

c)

glybutide

d)

semilente

e)

actrapid

34.

Biguanide derivatives include:

a)

chlorpropamide, bucardan

b)

glibenclamide, gliquidone

c)

insulin tape, insulinrap

d)

homophane, isophane NM

e)

metformin, buformin

35.

What pharmacological properties are characteristic of Levothyroxine:

a)

hypoglycemic, hypotensive, anti-inflammatory

b)

hypoglycemic, normalization of fat and protein metabolism

c)

hypoglycemic, increases lipolysis, reduces appetite and body weight

d)

eliminates hypoglycemic and cardiac stimulating effects

e)

anabolic effect, stimulation of tissue growth and differentiation

36.

Which of these side effects are most common for insulin preparations (Actrapid):

a)

tachycardia, sweating, weakness, allergic reactions

b)

hypoglycemia, allergic reactions, resistance, lipodystrophy

c)

hyperglycemia, osteoporosis, increased blood pressure, fat redistribution

d)

leukopenia, lymphadenopathy, goiter effect, rash

e)

pasty tissue, edema, ascites, increased blood pressure

37.

Characteristics of the drug Thiamazole

a)

causes a decrease in the synthesis of thyroxine in the gland by suppressing the enzyme oxidase

b)

tablets of 100 and 200 mcg of elemental supply, replenishes iodine deficiency in the body

c)

a synthetic combination drug containing both thyroid hormones (T3 and T4), as well as potassium iodide

d)

obtained from dried, defatted thyroid glands of slaughter cattle

e)

snitetic analogue of thyroxine, slowly absorbed, slowly excreted

38.

Characteristics of glybutide:

a)

sulfonylurea derivative of the 2nd generation, increases the secretion of endogenous insulin, reduces cholesterol levels, thins the blood, is effective for type 2 diabetes mellitus

b)

biguanide derivative, regulates metabolism and absorption of glucose, effective in type 2 diabetes mellitus

c)

glucocorticoid drug, used together with mineralocorticoids for hypocorticism

d)

mineralocorticoid drug, used together with glucocorticoids for hypocorticism

e)

insulin preparation, promotes the absorption of glucose by tissues, the conversion of glucose into glycogen, effective for type 1 diabetes mellitus

39.

In acute hypogycemia, the following methods are used:

a)

sulfonylurea derivatives, glucose

b)

prednisone, insulin, glucose

c)

glucagon, glucose, epinephrine

d)

actrapid, humulin, homofan

e)

Lugol's solution, Ringer-Lock's solution

40.

What pharmacological properties are characteristic of insulin:

a)

hypoglycemic, hypotensive, anti-inflammatory

b)

hypoglycemic, normalization of fat and protein metabolism

c)

hypoglycemic, increases lipolysis, reduces appetite and body weight

d)

eliminates hypoglycemia, cardiac stimulating effect

e)

anabolic effect, stimulation of tissue growth and differentiation

41.

For hyperlycemia, the following are used:

a)

sulfonylurea derivatives, glucose

b)

prednisone, insulin, glucose

c)

glucagon, glucose, epineprine

d)

actrapid, humulin, homofan

e)

Lugol's solution, Ringer-Lock's solution

42.

Please indicate specific side effects of triiodothyronine hydrochloride

a)

tachycardia, sweating, weakness, allergic reactions

b)

hypoglycemia, resistance, lipodystrophy

c)

hyperglycemia, osteoporosis, increased blood pressure

d)

leukopenia, lymphadenopathy, goiter effect

e)

hirsutism, hepatitis, libido disorders

43.

Side effects typical for thiamazole:

a)

tachycardia, sweating, weakness, allergic reactions

b)

hypoglycemia, resistance, lipodystrophy

c)

hyperglycemia, osteoporosis, teratogenic effect, increased blood pressure

d)

leukopenia, lymphadenopathy, goiter effect

e)

pasty tissue, edema, ascites, increased blood pressure

44.

The following drugs can cause insulin resistance, hypoglycemia, allergies, and lipodystrophy:

a)

butamide, glibenclamide, chlorpropamide

b)

prednisolone, hydrocortisone, dexamethasone

c)

retabolin, nerobol, methandrostenolone

d)

peritol, parloled, abergin

e)

homophane, humulin, actrapid

45.

The mechanism of action of insulin is characterized by the following:

a)

increase in the concentration of glucokinase and glycogen synthetase

b)

membrane stabilizing, stimulation of lipomodulin synthesis

c)

reduction of thyroxine synthesis in the gland by suppressing oxidase

d)

lymphocytopenia, inhibition of phagocytosis and phagocyte activity

e)

decreased production of releasing hormones in the hypothalamus

46.

Synthetic insulins include the following drugs

a)

chlorpropamide, bucarban, tolinase

b)

glibenclamide, gliquidone, diabenesis

c)

insulin lente, insulrap monotard

d)

homophane, isophane HM, humulin

e)

metformin, glucobai, guarem

47.

Indications for use of thyreocomb:

a)

hypothyroidism, myxedema, cretinism

b)

insulin-dependent diabetes

c)

hypogonadism, amenorrhea, dysmenorrhea, masculinization syndrome

d)

bronchial asthma, rheumatoid arthritis, glomerulonephritis

e)

DM-2 mild to moderate severity

48.

Increases oxygen consumption and heat production by all tissues, tissue growth and differentiation, increases the force of myocardial contraction, increased cardiac output, anabolic effect

(a)  

49.

The effect of this drug is associated with the presence of two hormones in it - thyroxine and triiodothyronine:

a)

Thyroidin

b)

Levothyroxine

c)

Potassium iodide

d)

Mercazolil

e)

Actrapid

50.

Synthetic analogue of thyroxine:

a)

Thyroidin

b)

Levothyroxine

c)

Potassium iodide

d)

Mercazolil

e)

Actrapid

51.

Inhibitor of thyroid hormone synthesis

a)

Thyroidin

b)

Levothyroxine

c)

Potassium iodide

d)

Mercazolil

e)

Actrapid

52.

Not used in the treatment of thyroid diseases

a)

Thyroidin

b)

Levothyroxine

c)

Potassium iodide

d)

Mercazolil

e)

Actrapid

53.

Biguanides include:

a)

chlorpropamide, bucarban

b)

glibenclamide, gliquidone

c)

insulin lente, insudrap

d)

homophane, isophane NM

e)

metformin

54.

Natural insulin preparations://

a)

chlorpropamide, bucarban, tolinase//

b)

glibenclamide, gliquidone, diabenez//

c)

insulin lente, insulinrap, monotard//

d)

homophane, isophane NM, humulin//

e)

metformin, glucobay, guarem

55.

Indications for the use of butamide

a)
mild diabetes
b)

hypothyroidism, myxedema, cretinism

c)

insulin-dependent diabetes mellitus

d)

hypogonadism, amenorrhea, dysmenorrhea

e)

bronchial asthma, rheumatoid arthritis

56.

Which drug is used in hyperglycemia

a)
actrapid, humulin, homophane
b)

sulfonylurea derivatives, glucose

c)

prednisone, insulin, glucose

d)

glucagon, glucose, epinephrine

e)

Lugol's solution, Ringer-Lock's solution

57.

Indications for the use of Actrapid:

a)

hypothyroidism, myxedema, cretinism

b)

insulin-dependent diabetes

c)

hypogonadism, amenorrhea, dysmenorrhea, masculinization syndrome

d)

bronchial asthma, rheumatoid arthritis, glomerulonephritis

e)

DM-2 of mild and moderate severity

58.

Characteristics of the preparation Potassium iodide:

a)

tablets of 100 and 200 micrograms of elemental iodine which makes up of iodine in the body

b)

synthetic combination drug containing both thyroid hormones (T3 and T4) and potassium iodide

c)

it is obtained from dried, fat-free thyroid glands of slaughtered cattle

d)

synthetic thyroxine analog slowly absorbed, slowly excreted

e)

causes a decrease in the synthesis of thyroxine in the gland by suppressing the enzyme oxidase

59.

Characteristics of thyroidin:

a)

it is obtained from dried, fat-free thyroid glands of slaughtered cattle

b)

synthetic thyroxine analog slowly absorbed, slowly excreted

c)

tablets of 100 and 200 micrograms of elemental iodine, which makes up for the lack of iodine in the body

d)

synthetic combination drug containing both thyroid hormones (T3 and T4) and potassium iodide

e)

causes a decrease in the synthesis of thyroxine in the gland by suppressing the enzyme oxidase

60.

When are iodine preparations used in large doses (Lugol's solution)?

a)

when preparing patients for thyroid surgery in order to reduce vascularization

b)

for prevention and treatment of iodine-deficient goiter

c)

to inhibit the synthesis of hormones in the thyroid gland

d)

for long-term treatment of myxedema

e)

for long-term treatment of thyrotoxicosis

61.

They increase oxygen consumption and heat production by tissues, stimulate tissue growth and differentiation, speed and strength of myocardial contractions, and have anabolic effects on the following drugs:

a)

thyroidin, levothyroxine

b)

prednisone, dexamethasone

c)

retabolin, nerobol

d)

actrapid, insulrap

e)

mercazolil, potassium iodine

62.

For thyrotoxicosis, the following can be used

a)

thiamazole, Lugol's solution

b)

thyreocomb, potassium iodide

c)

microdoses of potassium iodide, mercazolil

d)

Lugol's solution, levothyroxine

e)

radioactive iodine

63.

Indications for the use of thyreocomb

a)

hypothyroidism, myxedema, cretinism

b)

insulin-dependent diabetes mellitus

c)

hypogonadism, amenorrhea, dysmenorrhea

d)

bronchial asthma, rheumatoid arthritis

e)

mild diabetes

64.

What group of drugs does Ultratard belong to

a)

hypoglemic agent, a derivative of sulfonylurea

b)

hypoglemic agent derived from biguanides

c)

long-acting insulin preparations

d)

short-acting insulin preparations

e)

hormone preparation used for hypoglycemia

65.

Please indicate the pharmacological effects specific to Actrapid

a)

anabolic effect, stimulation of tissue growth and differentiation, cholesterol catabolism

b)

reduction of basal metabolism, lowering of temperature, elimination of tachycardia

c)

anti-inflammatory, anti-allergic, and immunosuppressive effects

d)

reduction of blood sugar, normalization of fat and protein metabolism

e)

stimulation of protein synthesis, increased muscle tissue mass and parenchymal organs

66.

Indications for the use of humulin

a)

hypothyroidism, myxedema, cretinism

b)

 insulin-dependent diabetes mellitus

c)

hypogonadism, amenorrhea, dysmenorrhea

d)

bronchial asthma, rheumatoid arthritis

e)

mild diabetes

67.

The mechanism of antithyroid action of thiamazole is characterized by the following:

a)

increase in the concentration of glucokinase and glycogen synthetase

b)

membrane stabilizing, stimulation of lipomodulin synthesis

c)

reduction of thyroxine synthesis in the gland by inhibiting oxidase

d)

lymphocytopenia, inhibition of phagocytosis and phagocyte activity

e)

decreased production of releasing hormones in the hypothalamus

68.

Mechanism of action of high-dose iodine preparations:

a)

increases the concentration of glucokinase

b)

membrane-stabilizing

c)

inhibition of the oxidase enzyme

d)

substitution therapy

e)

reduced production of releasing hormones

69.

Iodine preparations in microdoses of (100, 200 mcg) are used for?

a)

when preparing patients for surgery on the thyroid gland, in order to reduce vascularization

b)

for prevention and treatment of iodine-deficient goiter

c)

to inhibit the synthesis of hormones in the thyroid gland

d)

for long-term treatment of myxedema

e)

for long-term treatment of thyrotoxicosis

70.

What group of drug does glibenclamide belong to:

a)

hypoglycemic agent, sulfonylurea derivative

b)

hypoglemic agent derived from biguanides

c)

long-acting insulin preparation

d)

short-acting insulin preparation

e)

hormone preparation used for hypoglycemia

71.

What group of drugs does Glybutide belong to:

a)

hypoglycemic agent, sulfonylurea derivative

b)

hypoglycemic agent derived from biguanides

c)

long-acting insulin preparation

d)

short-acting insulin preparation

e)

hormone preparation used for hypoglycemia

72.

Characteristics of the drug Levothyroxine:

a)

synthetic thyroxine analog slowly absorbed, slowly excreted

b)

it is obtained from dried, fat-free thyroid glands of slaughtered cattle

c)

tablets of 100 and 200 micrograms of elemental iodine, which makes up for the lack of iodine in the body

d)

causes a decrease in the synthesis of thyroxine in the gland by suppressing the enzyme oxidase

e)

synthetic combination drug containing both thyroid hormones (T3 and T4) and potassium iodide

73.

Characteristics of the drug Thyreotom:

a)

synthetic combination drug containing both thyroid hormones (T3 and T4) and potassium iodide

b)

it is obtained from dried, fat-free thyroid glands of slaughtered cattle

c)

synthetic thyroxine analog slowly absorbed, slowly excreted

d)

causes a decrease in the synthesis of thyroxine in the gland by suppressing the enzyme oxidase

e)

tablets of 100 and 200 micrograms of elemental iodine, which makes up for the lack of iodine in the body

74.

Indications for the use of Thyreotom:

a)

hypothyroidism, myxedema, cretinism

b)

insulin-dependent diabetes

c)

hypogonadism, amenorrhea, dysmenorrhea

d)

bronchial asthma, rheumatoid arthritis

e)

mild diabetes

75.

Causes a decrease in thyroxine synthesis in the thyroid gland:

a)

thyroidin

b)

prednisone

c)

retaboline

d)

actrapid

e)

mercazolil

76.

Insulin preparations:

a)

chlorpropamide, bucarban, tolinase

b)

glibenclamide, gliquidone, diabeton

c)

peritol, parlodel, abergin

d)

homophane, isophane HM, humulin

e)

metformin, glucobai, guarem

77.

Most non-steroidal anti-inflammatory drugs (NSAIDs) show combined effects of:

a)

Anti-inflammatory, analgesic, antipyretic

b)

Antihistamine, analgesic, anti-inflammatory

c)

Immunosuppressive, antipyretic, antimicrobial

d)

Analgesic, immunosuppressive, antipyretic

e)

Antiallergic, hypotensive, duiretic

78.

Indicate the basic remedies for the treatment of rheumatoid arthritis:

a)

Calcium preparations

b)

cytostatics, gold preparations, immunomodulators

c)

glucocorticoids

d)

NSAID

e)

Antihistamines

79.

Show NSAIDs, a derivative of phenylacetic acid:

a)

Piroxicam

b)

Diclofenac sodium

c)

Ibuprofen

d)

Diazepam

e)

Dexamethasone

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