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WorksheetsNeurotransmitters and Cholinesterase Quiz
Total questions: 20
Worksheet time: 10mins
Major neurotransmitter released at end organ effectors of the sympathic division of the autonomic nervous system is:
Adrenaline
Noradrenaline
Dopamine
Acetylcholine
Which neurotransmitter is released at the ganglion (the first hand-off step) in the sympathetic nervous system?
Norepinephrine
Epinephrine
Acetylcholine
Dopamine
Which of the following statements is TRUE?
Hemicholinium prevents the release of ACh from storage vesicles
Botulinum toxin increase the ACh release
Pralidoxime reactivates acetylcholine esterase
Vesamicol inhibit the uptake of choline
Acetylcholine is not used commercially because:
Long duration of action
Costly
Rapidly destroyed in the body
Crosses blood brain barrier
A patient Raj Kishore was given pilocarpine. All of the following can be the features seen in him except:
Sweating
Salivation
Miosis
Cycloplegia
Cholinesterase activators are useful for treatment of which poisoning?
Paraquat
Parathion
Carbamates
Organochlorocompounds
The cardiac muscarinic receptors:
Are of the M1 subtype
Are of the M2 subtype
Are of the M3 subtype
Are of the Nm subtype
A direct acting cholinomimetic that is lipid soluble and has been used in the treatment of glaucoma is:
Carbachol
Physostigmine
Pilocarpine
Neostigmine
The following inhibitor binds only to the ani-onic site of the cholinesterase enzyme:
Neostigmine
Physostigmine
Edrophonium
Dyflos
Lallu, a farmer comes to you in the emergency in comatose state. Platient had profuse sweating and lacrimation. Diarrhea and urination were apparent. On examination pupil was constricted and BP of the farmer was 80/60 mm Hg. You make a diagnosis of anticholinesterase poisoning. You decide to administer him atropine. All of the following actions will be reversed by atropine except:
Hypotension
Central excitation
Muscle paralysis
Bronchoconstriction
The organophosphates produce irreversible inhibition of cholinesterase because:
They bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind acetylcholine
Regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules
Phosphorylation results in rapid degradation of enzyme molecules
They are neither metabolized nor excreted from the body
Neostigmine is preferred over physostigmine for treating myasthenia gravis because:
It is better absorbed orally compared to physostigmine
It has longer duration of action compared to physostigmine
It has additional direct agonistic action on Nm receptors
It penetrates blood-brain barrier in the central nervous system
Edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its:
Shorter duration of action
Longer duration of action
Direct action on muscle end-plate
Selective inhibition of true cholinesterase
Which of the following is a relatively cerebroselective anticholinesterase found to afford symptomatic improvement in Alzheimer's disease:
Donepezil
Gemfibrozil
Pyridostigmine
Pyritinol
Pilocarpine reduces intraocular tension in open angle glaucoma by:
Contracting sphincter pupillae
Increasing tone of ciliary muscle
Reducing aqueous formation
Enhancing uveo-scleral outflow
Neostigmine is beneficial in cobra envenomation because:
It binds to and inactivates cobra toxin
It reverses coma due to cobra toxin
It counteracts the cardio-depressant action of cobra toxin
It antagonizes the paralysing action of cobra toxin
A suspected case of poisoning has been brought to the casualty with weakness, fainting, involuntary passage of urine and stools, profuse sweating, salivation, watering from nose and eyes. His pulse is 120/min, low volume, BP 90/60 mm Hg, respiration shallow, pupil constricted, muscles flabby with occasional fasciculations. Which is the most likely type of poisoning:
Belladonna
Barbiturate
Anticholinesterase
Dicophane (DDT)
Which is the most important drug in the treatment of organophosphate poisoning:
Atropine sulfate
Pralidoxime
Diazepam
Adrenaline
Anticholineesterase with effect on CNS is:
Neostigmine
Pyridostigmine
Physostigmine
Edrophonium
Pralidoxime can reactivate cholinesterase enzyme that has been inactivated by:
Carbamate anticholinesterases
Organophosphate anticholinesterases
Both carbamate and organophosphate anticholinesterases
Reversible anticholinesterases
