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Industrial Pharmacy-I Quiz

Total questions: 60

Worksheet time: 20mins

Name
Class
Date
1.

Hausner Ratio is

a)

Tapped density / Bulk density

b)

Bulk density / Tapped density

c)

Bulk volume / Void volume

d)

Void volume / Bulk volume

2.

An excellent choice of diluent for a compressed vaginal tablet formulation would be

a)

Lactose

b)

Starch

c)

Talc

d)

Sucrose

3.

Poorly manufactured tablets may have small pinholes on the surface. This phenomenon is known as

a)

Capping

b)

Mottling

c)

Cracking

d)

Picking

4.

A sweetener that is widely employed in chewable tablet formulas is

a)

cyclamate sodium

b)

glucose

c)

mannitol

d)

sucrose

5.

The mesh size of USP disintegrator is

a)

10

b)

5-6

c)

28-32

d)

2.5

6.

Which of these is used in enteric coated tablet

a)

HPMC

b)

CMC

c)

CAP

d)

All of the above

7.

The disintegration time for sugar coated tablet is

a)

15 minutes

b)

30 minutes

c)

60 minutes

d)

75 minutes

8.

Poor granule flow may cause……….

a)

Double impression

b)

Harder tablet

c)

Weight variation

d)

Picking

9.

Shellac is used for the purpose of coating of tablets as

a)

Polishing agent

b)

Film-coating

c)

Enteric coating agent

d)

Sub-coating

10.

The dosage forms which are prepared by forcing particles into close proximity to each other by powder compaction is…………

a)

Tablets

b)

Capsules

c)

Suspensions

d)

Solutions

11.

……….are used to prevent brittling of the tablet

a)

Plasticizer

b)

Opacifier

c)

Scales

d)

Starch

12.

For tablets, dissolution test is performed to assure the process of

a)

Bio absorption

b)

Deaggregation

c)

Disintegration

d)

Distribution

13.

Cam track responsible for

a)

Moving granules from the hopper to dies

b)

Guiding the movement of punches

c)

Moving of tablet

d)

None of the above

14.

Lactose is uses as…………

a)

Lubricants

b)

Glidents

c)

Diluents

d)

Disintegrants

15.

RPM in Dissolution test of tablets?

a)

50

b)

100

c)

as per specified in monograph

d)

75

16.

………. is an example of glidants

a)

Colloidal silica

b)

Lactose

c)

Magnesium Carbonate

d)

Sodium Alginate

17.

On tablet coating……… is applied to reduce tackiness and cohesiveness of the tablets during drying stage

a)

Dye

b)

Dusting powder

c)

Sucrose

d)

Resin

18.

……… is due to poor spreading of sprayed droplets over the tablet during coating

a)

chipping

b)

cracking

c)

orange peel

d)

blistering

19.

………. tester is used for tablet hardness testing

a)

Friabilator

b)

Dissolution

c)

Disintegration

d)

Monsanto

20.

In tablet coating polishing can be done by

a)

Gelatin

b)

PEG-4000

c)

Cane sugar

d)

Carnauba Wax

21.

The purpose of parabens in syrup is as

a)

Stabilizers

b)

Preservatives

c)

Buffers

d)

Tonicity adjusters

22.

Syrups cannot be sterilized by autoclaving because

a)

they decompose by heat

b)

they contain flavoring agents

c)

they are filled in glass bottles

d)

they are used by common people

23.

The concentration of sucrose in Simple Syrup

a)

40.74% w/w

b)

60.70% w/w

c)

66.70% w/w

d)

70.50% w/w

24.

For stable emulsion, the phase volume ratio is generally about

a)

26/74

b)

52/48

c)

74/26

d)

74/100

25.

For an ideal suspension, the sedimentation volume should be

a)

Equal to one

b)

less than one

c)

More than one

d)

Zero

26.

In the stability of emulsion, which instability step is prevented by emulsifiers?

a)

Breaking

b)

Coalescence

c)

Creaming

d)

Flocculation

27.

A maximum sedimentation volume will be obtained when zeta potential is

a)

Negative

b)

Neutral

c)

Positive

d)

Zero

28.

Electrical conductivity is……….. in O/W emulsion

a)

Low

b)

High

c)

Fluctuates

d)

Retards

29.

Suspended particles become flocculated in a suspension, because

a)

attractive forces between particles are appreciable

b)

particles are packed closely

c)

repulsive forces between particles are appreciable

d)

vehicle rejects the particles

30.

On commercial scale, emulsions are prepared by

a)

Centrifugation

b)

dialysis

c)

freezing

d)

homogenization

31.

O/W emulsion requires emulgent of HLB

a)

2-4

b)

12-14

c)

8-18

d)

3-6

32.

Consistency of emulsified cream depends on………….

a)

Volume Ratio

b)

Rate of cooling

33.

res emulgent of HLB

a)

2-4

b)

12-14

c)

8-18

d)

3-6

34.

Consistency of emulsified cream depends on………….

a)

Volume Ratio

b)

Rate of cooling

c)

Emulsion index

d)

Pyrex Index

35.

………causes breaking of emulsion

a)

Agitation

b)

Heating

c)

Stirring

d)

Phase inversion

36.

Temperature fluctuation causes……of emulsion

a)

Breaking

b)

Foaming

c)

Grooving

d)

Glazing

37.

O/W is……

a)

Water in oil emulsion

b)

Micro emulsion

c)

Oil in water emulsion

d)

Macro emulsion

38.

In stokes' relationship a parameter that greatly changes the velocity of setting is

a)

density of the liquids

b)

density of particle

c)

radius of the particle

d)

viscosity of the medium

39.

Which one of the following properties is applicable to suspension?

a)

Brownian movement

b)

Laminar flow

c)

rapid rate of sedimentation

d)

Stokes' law

40.

Deflocculated suspension shows which of the following rheological property?

a)

Newtonian flow

b)

Non-Newtonian

c)

Both a and b

d)

Thixotrophy

41.

The formation of non-redispersible sediment in suspension is called as

a)

Sedimentation

b)

Caking

c)

Cracking

d)

Aggregation

42.

Stoke's law cannot be used, if Reynolds's no. is more than

a)

0.2

b)

2

c)

1.8

d)

1

43.

Preformulation studies are about ensuring

a)

Stability

b)

Safety

c)

Efficacy

d)

All of the above

44.

X-ray diffraction pattern indicates

a)

Solubility

b)

Crystallinity

c)

Functional groups

d)

Permeability

45.

Monotropic polymorph can change into another form

a)

reversibly

b)

irreversibly

c)

does not change

d)

None

46.

The relationship between pH and the solubility and pKa value of an acidic drug is given by

a)

Henderson Hasselbalch equation

b)

Bragg's Equation

c)

Noye's Whitney Equation

d)

All of the above

47.

The solubility of the pure form of API is determined by

a)

Partition coefficient

b)

Phase solubility study

c)

Permeability study

d)

All of the above

48.

Carr's Index is related to

a)

Flow property

b)

Solubility

c)

Partition coefficient

d)

All of the above

49.

Negative Log of acid dissociation constant is

a)

pOH

b)

pKa

c)

pH

d)

Log P

50.

Infra-Red spectroscopy is used for determining

a)

Particle size

b)

Crystallinity

c)

Functional groups

d)

Shape

51.

Amorphous forms shows?

a)

Poor solubility

b)

Good solubility

c)

Long range order

d)

None

52.

Crystal form shows this structure

a)

3D

b)

2D

c)

Short-range

d)

None

53.

DSC is

a)

Differential scanning calorimeter

b)

Differential scattering calorimeter

c)

Digital scanning calorimeter

d)

None

54.

SEM can analyze

a)

Crystalinity and solubility

b)

Flow property

c)

Shape and size

d)

Complexity

55.

Bragg's law defines

a)

Solubility

b)

Shape

c)

Diffraction

d)

All

56.

Crystal forms shows

a)

Rapid duration of action

b)

Short duration of action

c)

Long duration of action

d)

Onset of action

57.

Hot stage microscopy is an important tool in preformulation studies for the study of

a)

Pseudopolymorphism

b)

Paricle size measurement

c)

Microbial contamination

d)

Compaction behaviour

58.

Which of the following techniques is not useful to detect polymorphs

a)

DSC

b)

HPLC

c)

PXRD

d)

Melting point determination

59.

In preformulation study polymorphs can be detected by

a)

Counter - current chromatography

b)

Retractometry

c)

High performance liquid chromatography

d)

Differential scanning calorimeter

60.

Which polymorphic form of a drug candidate has highest melting point

a)

Unstable

b)

Metastable

c)

Hydrates

d)

Stable