WorksheetsIndustrial Pharmacy-I Quiz
Total questions: 60
Worksheet time: 20mins
Hausner Ratio is
Tapped density / Bulk density
Bulk density / Tapped density
Bulk volume / Void volume
Void volume / Bulk volume
An excellent choice of diluent for a compressed vaginal tablet formulation would be
Lactose
Starch
Talc
Sucrose
Poorly manufactured tablets may have small pinholes on the surface. This phenomenon is known as
Capping
Mottling
Cracking
Picking
A sweetener that is widely employed in chewable tablet formulas is
cyclamate sodium
glucose
mannitol
sucrose
The mesh size of USP disintegrator is
10
5-6
28-32
2.5
Which of these is used in enteric coated tablet
HPMC
CMC
CAP
All of the above
The disintegration time for sugar coated tablet is
15 minutes
30 minutes
60 minutes
75 minutes
Poor granule flow may cause……….
Double impression
Harder tablet
Weight variation
Picking
Shellac is used for the purpose of coating of tablets as
Polishing agent
Film-coating
Enteric coating agent
Sub-coating
The dosage forms which are prepared by forcing particles into close proximity to each other by powder compaction is…………
Tablets
Capsules
Suspensions
Solutions
……….are used to prevent brittling of the tablet
Plasticizer
Opacifier
Scales
Starch
For tablets, dissolution test is performed to assure the process of
Bio absorption
Deaggregation
Disintegration
Distribution
Cam track responsible for
Moving granules from the hopper to dies
Guiding the movement of punches
Moving of tablet
None of the above
Lactose is uses as…………
Lubricants
Glidents
Diluents
Disintegrants
RPM in Dissolution test of tablets?
50
100
as per specified in monograph
75
………. is an example of glidants
Colloidal silica
Lactose
Magnesium Carbonate
Sodium Alginate
On tablet coating……… is applied to reduce tackiness and cohesiveness of the tablets during drying stage
Dye
Dusting powder
Sucrose
Resin
……… is due to poor spreading of sprayed droplets over the tablet during coating
chipping
cracking
orange peel
blistering
………. tester is used for tablet hardness testing
Friabilator
Dissolution
Disintegration
Monsanto
In tablet coating polishing can be done by
Gelatin
PEG-4000
Cane sugar
Carnauba Wax
The purpose of parabens in syrup is as
Stabilizers
Preservatives
Buffers
Tonicity adjusters
Syrups cannot be sterilized by autoclaving because
they decompose by heat
they contain flavoring agents
they are filled in glass bottles
they are used by common people
The concentration of sucrose in Simple Syrup
40.74% w/w
60.70% w/w
66.70% w/w
70.50% w/w
For stable emulsion, the phase volume ratio is generally about
26/74
52/48
74/26
74/100
For an ideal suspension, the sedimentation volume should be
Equal to one
less than one
More than one
Zero
In the stability of emulsion, which instability step is prevented by emulsifiers?
Breaking
Coalescence
Creaming
Flocculation
A maximum sedimentation volume will be obtained when zeta potential is
Negative
Neutral
Positive
Zero
Electrical conductivity is……….. in O/W emulsion
Low
High
Fluctuates
Retards
Suspended particles become flocculated in a suspension, because
attractive forces between particles are appreciable
particles are packed closely
repulsive forces between particles are appreciable
vehicle rejects the particles
On commercial scale, emulsions are prepared by
Centrifugation
dialysis
freezing
homogenization
O/W emulsion requires emulgent of HLB
2-4
12-14
8-18
3-6
Consistency of emulsified cream depends on………….
Volume Ratio
Rate of cooling
res emulgent of HLB
2-4
12-14
8-18
3-6
Consistency of emulsified cream depends on………….
Volume Ratio
Rate of cooling
Emulsion index
Pyrex Index
………causes breaking of emulsion
Agitation
Heating
Stirring
Phase inversion
Temperature fluctuation causes……of emulsion
Breaking
Foaming
Grooving
Glazing
O/W is……
Water in oil emulsion
Micro emulsion
Oil in water emulsion
Macro emulsion
In stokes' relationship a parameter that greatly changes the velocity of setting is
density of the liquids
density of particle
radius of the particle
viscosity of the medium
Which one of the following properties is applicable to suspension?
Brownian movement
Laminar flow
rapid rate of sedimentation
Stokes' law
Deflocculated suspension shows which of the following rheological property?
Newtonian flow
Non-Newtonian
Both a and b
Thixotrophy
The formation of non-redispersible sediment in suspension is called as
Sedimentation
Caking
Cracking
Aggregation
Stoke's law cannot be used, if Reynolds's no. is more than
0.2
2
1.8
1
Preformulation studies are about ensuring
Stability
Safety
Efficacy
All of the above
X-ray diffraction pattern indicates
Solubility
Crystallinity
Functional groups
Permeability
Monotropic polymorph can change into another form
reversibly
irreversibly
does not change
None
The relationship between pH and the solubility and pKa value of an acidic drug is given by
Henderson Hasselbalch equation
Bragg's Equation
Noye's Whitney Equation
All of the above
The solubility of the pure form of API is determined by
Partition coefficient
Phase solubility study
Permeability study
All of the above
Carr's Index is related to
Flow property
Solubility
Partition coefficient
All of the above
Negative Log of acid dissociation constant is
pOH
pKa
pH
Log P
Infra-Red spectroscopy is used for determining
Particle size
Crystallinity
Functional groups
Shape
Amorphous forms shows?
Poor solubility
Good solubility
Long range order
None
Crystal form shows this structure
3D
2D
Short-range
None
DSC is
Differential scanning calorimeter
Differential scattering calorimeter
Digital scanning calorimeter
None
SEM can analyze
Crystalinity and solubility
Flow property
Shape and size
Complexity
Bragg's law defines
Solubility
Shape
Diffraction
All
Crystal forms shows
Rapid duration of action
Short duration of action
Long duration of action
Onset of action
Hot stage microscopy is an important tool in preformulation studies for the study of
Pseudopolymorphism
Paricle size measurement
Microbial contamination
Compaction behaviour
Which of the following techniques is not useful to detect polymorphs
DSC
HPLC
PXRD
Melting point determination
In preformulation study polymorphs can be detected by
Counter - current chromatography
Retractometry
High performance liquid chromatography
Differential scanning calorimeter
Which polymorphic form of a drug candidate has highest melting point
Unstable
Metastable
Hydrates
Stable
