wayground logo

Free Printable Worksheets

Font size

S
M
L
XL
Worksheets

Where do blood cells come from?

Total questions: 96

Worksheet time: 48mins

Name
Class
Date
1.

What is hematopoiesis?

a)

The production and development of blood cells.

b)

The breakdown of glucose in the liver.

c)

The process of bone formation.

d)

The filtration of waste in the kidneys.

2.

Hematopoiesis begins with self-renewing ________ and ends with peripheral blood cells. Fill in the blank.

a)

hematopoietic stem cells (HSC)

b)

megakaryocytes

c)

erythrocytes

d)

lymphocytes

3.

Where does hematopoiesis primarily occur in adults?

a)

In the bone marrow

b)

In the liver

c)

In the spleen

d)

In the thymus

4.

Which of the following is NOT a lineage of blood cells?

a)

Erythrocyte

b)

Myeloid

c)

Lymphocyte

d)

Neuron

5.

Which cell type is at the origin of all blood cells?

a)

Hematopoietic stem cell (HSC)

b)

Erythrocyte

c)

Lymphocyte

d)

Megakaryocyte

6.

Hematopoiesis begins as early as the ________ after fertilization.

a)

19th day

b)

10th day

c)

25th day

d)

30th day

7.

Production of erythrocytes occurs ________ (Fill in the blank)

a)

in the bone marrow

b)

in the liver

c)

in the spleen

d)

in the kidneys

8.

Which of the following is NOT produced during embryonic hematopoiesis?

a)

Erythrocytes

b)

Macrophages

c)

Megakaryocytes

d)

Neurons

9.

The endoderm layer becomes which of the following?

a)

Circulatory system

b)

Digestive system

c)

Hair

d)

Muscular system

10.

The mesoderm layer becomes which of the following?

a)

Skin

b)

Liver

c)

Circulatory system

d)

Pancreas

11.

The ectoderm layer becomes which of the following?

a)

Pancreas

b)

Hair

c)

Liver

d)

Lungs

12.

Primitive erythropoiesis _____ erythrocyte production in the yolk sac.

a)

is

b)

are

c)

was

d)

will be

13.

Develop from clusters of cells in the mesenchyme called _____ (Fill in the blank)

a)

blood islands

b)

germ layers

c)

somites

d)

neural crests

14.

Primitive erythrocytes _____

a)

retain their nucleus

b)

lack any cytoplasm

c)

are multinucleated

d)

contain hemoglobin only after maturation

15.

What is the name of the clusters of cells in the mesenchyme that develop into blood cells?

a)

blood islands

b)

lymph nodes

c)

osteons

d)

islets of Langerhans

16.

At how many weeks of gestation does definitive erythropoiesis begin?

a)

Four weeks of gestation

b)

Six weeks of gestation

c)

Eight weeks of gestation

d)

Twelve weeks of gestation

17.

Definitive erythropoiesis begins in which region?

a)

Yolk sac

b)

Aorta-gonads-mesonephros (AGM) region

c)

Placenta

d)

Liver

18.

Erythrocytes arise from ________.

a)

HSCs

b)

Osteocytes

c)

Chondrocytes

d)

Neurons

19.

According to the diagram, which region in the embryo is responsible for definitive erythropoiesis?

a)

AGM region

b)

Yolk sac

c)

Liver

d)

Placenta

20.

AGM makes a wider range of hematopoietic cells than the yolk sac.

a)

True

b)

False

21.

Around the third month of fetal development, the liver is the primary site of blood cell production. Spleen produces ____________.

a)

lymphocyte

b)

erythrocyte

c)

platelet

d)

plasma cell

22.

Which organ is the primary site of blood cell production around the third month of fetal development?

a)

Spleen

b)

Liver

c)

Bone marrow

d)

Kidney

23.

Which type of hemoglobin replaces embryonic hemoglobin during fetal development?

a)

Hemoglobin A

b)

Hemoglobin S

c)

Hemoglobin F (Fetal)

d)

Hemoglobin C

24.

Myeloid lineage gives rise to which of the following?

a)

B cells and T cells

b)

Erythrocytes (RBCs), megakaryocytes/platelets, granulocytes, and monocytes

c)

Only erythrocytes

d)

Only lymphocytes

25.

Around which month of gestation does the bone marrow become the primary site of hematopoiesis?

a)

Third month

b)

Fifth month

c)

Seventh month

d)

Ninth month

26.

Bone marrow continues as the primary source of blood production after birth and during adult life.

a)

True

b)

False

27.

Fill in the blank: Around the seventh month of gestation, ______ becomes the primary site of hematopoiesis.

a)

bone marrow

b)

liver

c)

spleen

d)

yolk sac

28.

According to the graph, which organ is the main site of hematopoiesis during the early fetal months?

a)

Liver

b)

Yolk sac

c)

Spleen

d)

Bone marrow

29.

Which of the following is NOT an organ or tissue involved in adult hematopoietic tissue?

a)

Bone marrow (BM)

b)

Spleen

c)

Thymus

d)

Kidney

30.

Fill in the blank: The tissue and organs regulating the proliferation, maturation, and destruction of blood cells include ________, spleen, thymus, and lymph nodes + mucosa-associated lymphoid tissue (MALT).

a)

Bone marrow (BM)

b)

Liver

c)

Pancreas

d)

Kidney

31.

Which two organs does the class focus on, according to the notes on the slide?

a)

Bone marrow and Spleen

b)

Thymus and Spleen

c)

Bone marrow and Thymus

d)

Spleen and Lymph nodes

32.

Bone marrow (BM) is blood-forming tissue found between the ________ of spongy bone. Fill in the blank.

a)

trabeculae

b)

osteons

c)

lamellae

d)

canaliculi

33.

Name the two major types of cells found in bone marrow. Fill in the blanks: 1) Hematopoietic cells 2) ________

a)

Stromal cells

b)

Epithelial cells

c)

Neuronal cells

d)

Muscle cells

34.

What is the function of stromal cells in bone marrow?

a)

Provide structure support and cytokines to regulate hematopoiesis.

b)

Initiate muscle contraction in bone tissue.

c)

Produce antibodies to fight infections directly.

d)

Transport oxygen throughout the body.

35.

In the diagram, which part of the bone is labeled as 'compact bone'?

a)

The outer dense layer of the bone is labeled as 'compact bone'.

b)

The spongy inner region of the bone is labeled as 'compact bone'.

c)

The central cavity containing marrow is labeled as 'compact bone'.

d)

The cartilage covering the bone ends is labeled as 'compact bone'.

36.

The main function of the vascular compartment in bone marrow is:

a)

to provide a pathway for the exchange of cells and nutrients between the blood and bone marrow

b)

to store fat for energy reserves

c)

to produce bone matrix and support bone structure

d)

to regulate the immune response within the bone marrow

37.

Fill in the blank: The site of __________ and entry into the bloodstream is the vascular compartment of bone marrow.

a)

blood cell development

b)

bone formation

c)

fat storage

d)

hormone secretion

38.

Which of the following are included in the vascular compartment of bone marrow?

a)

Arterioles

b)

Capillaries

c)

Sinusoids

d)

All of the above

39.

Hematopoietic cells in bone marrow include all blood cells in different stages of development.

a)

True

b)

False

40.

The function of adipose tissue (fat cells) in the stromal cells of bone marrow is:

a)

to store energy and provide support to the bone marrow microenvironment

b)

to produce red blood cells

c)

to form the hard structure of bone

d)

to transport oxygen in the blood

41.

Erythroblasts compose _______ of marrow cells and are produced near venous sinuses.

a)

25-30%

b)

5-10%

c)

50-55%

d)

70-75%

42.

Erythroblasts develop in _______.

a)

erythroblastic islands

b)

lymph nodes

c)

alveoli

d)

glomeruli

43.

Erythroblastic islands contain a central macrophage surrounded by _______ in different states of maturation.

a)

erythroblasts

b)

lymphocytes

c)

megakaryocytes

d)

neutrophils

44.

Erythroblasts are the _______ version of RBC and detected in bone marrow.

a)

immature

b)

mature

c)

inactive

d)

fragmented

45.

Macrophages have two major functions in bone marrow: 1. Phagocytosis: Ingest ________ of maturing erythroblasts.

a)

nuclei

b)

mitochondria

c)

ribosomes

d)

cytoplasm

46.

Macrophages have two major functions in bone marrow: 2. Secretion of hematopoietic ________.

a)

cytokines

b)

enzymes

c)

hormones

d)

antibodies

47.

What are cytokines?

a)

Enzymes that digest food

b)

Signal proteins of immune systems

c)

Hormones that regulate blood sugar

d)

Structural proteins in muscles

48.

Granulocytes are produced in nests that are mainly seen close to the ________.

a)

arterioles

b)

veins

c)

lymph nodes

d)

capillaries

49.

Why do neutrophils come across more in BM smears?

a)

Because they are more abundant.

b)

Because they are larger in size.

c)

Because they stain darker.

d)

Because they are less fragile.

50.

Which of the following cell types is NOT labeled in the provided BM smear diagram?

a)

Neutrophilic metamyelocyte

b)

Promyelocyte

c)

Erythrocyte

d)

Myeloblast

51.

BM—Smear: Nuclei are clumped ____________.

a)

together

b)

apart

c)

randomly

d)

individually

52.

What type of cells are large, polyploid (DNA content > 2N) cells?

a)

Megakaryocytes

b)

Erythrocytes

c)

Neutrophils

d)

Lymphocytes

53.

What do megakaryocytes produce after cytoplasmic fragmentation?

a)

Platelets

b)

Red blood cells

c)

White blood cells

d)

Plasma cells

54.

Where are megakaryocytes located?

a)

Near vascular sinus

b)

Inside lymph nodes

c)

Within alveoli

d)

In the renal cortex

55.

Identify the cell labeled in the diagram and describe its function.

a)

The cell labeled in the diagram is a megakaryocyte. Its function is to produce platelets after cytoplasmic fragmentation.

b)

The cell labeled in the diagram is an erythrocyte. Its function is to transport oxygen in the blood.

c)

The cell labeled in the diagram is a lymphocyte. Its function is to produce antibodies for immune response.

d)

The cell labeled in the diagram is a neutrophil. Its function is to engulf and destroy bacteria.

56.

What are lymphocytes produced in?

a)

Lymphoid aggregates near arterioles

b)

Bone marrow sinusoids

c)

Red blood cells

d)

Platelets

57.

Mature lymphocytes may aid in hematopoiesis by releasing _________.

a)

cytokines

b)

antibodies

c)

hormones

d)

enzymes

58.

Plasma cells have a lot of ______ apparatus in them.

a)

Golgi

b)

Mitochondria

c)

Lysosome

d)

Endoplasmic reticulum

59.

Plasma cells are B cells that produce _________.

a)

antibodies

b)

hormones

c)

enzymes

d)

neurotransmitters

60.

What is attached to the nucleus in plasma cells?

a)

Perinuclear halo

b)

Mitochondria

c)

Ribosome

d)

Nucleolus

61.

Identify the cell shown in the image labeled 'Plasma cell'.

a)

Plasma cell

b)

Neutrophil

c)

Eosinophil

d)

Monocyte

62.

Adipocytes are cells whose cytoplasm is mostly replaced with a single _________.

a)

fat vacuole

b)

nucleus

c)

mitochondrion

d)

lysosome

63.

Which of the following is a function of adipocytes in bone marrow?

a)

Mechanically control the volume of BM

b)

Produce red blood cells

c)

Absorb nutrients

d)

Secrete digestive enzymes

64.

Adipocytes provide steroids and cytokines that influence hematopoiesis and maintain osseous bone integrity.

a)

True

b)

False

65.

Identify the large, clear cells present in the bone marrow smear.

a)

Adipocytes

b)

Osteoclasts

c)

Megakaryocytes

d)

Plasma cells

66.

BM—Composition: The BM region lining the ________________ of bone is called the endosteal compartment. (Fill in the blank)

a)

inner surfaces

b)

outer surfaces

c)

marrow cavity

d)

periosteum

67.

BM—Composition: Hemopoietic cells in the endosteal compartment are mainly ________________.

a)

dormant HSCs

b)

mature erythrocytes

c)

adipocytes

d)

megakaryocytes

68.

Which of the following are stromal cells found in the endosteal compartment?

a)

Osteoclasts

b)

Osteoblasts

c)

Adipose cells

d)

All of the above

69.

What is the main function of the endosteal compartment in bone?

a)

Site of bone remodeling

b)

Production of red blood cells

c)

Storage of fat

d)

Attachment of muscles

70.

What is the primary function of osteoblasts in a BM-Smear?

a)

Destroy old bone

b)

Form new bone

c)

Transport oxygen

d)

Produce antibodies

71.

What is the maximum diameter of osteoblasts as mentioned in the BM-Smear slide?

a)

10 mcM

b)

20 mcM

c)

30 mcM

d)

50 mcM

72.

Osteoblasts resemble plasma cells except that the perinuclear halo is ______ from the nuclear membrane.

a)

detached

b)

attached

c)

continuous

d)

fused

73.

The cytoplasm of osteoblasts may be less ______ compared to plasma cells.

a)

basophilic

b)

acidophilic

c)

eosinophilic

d)

chromophilic

74.

Osteoblasts are normally found ______ in a BM-Smear.

a)

in groups

b)

scattered singly

c)

within sinusoids

d)

lining blood vessels

75.

Plasma cells are more purple-blueish compared to osteoclasts.

a)

True

b)

False

76.

What is the primary function of osteoclasts?

a)

Build bone

b)

Breakdown bone

c)

Transport oxygen

d)

Produce hormones

77.

Osteoclasts develop from which type of cells?

a)

Osteoblasts

b)

HSCs

c)

Megakaryocytes

d)

Erythrocytes

78.

Which of the following best describes the morphology of osteoclasts?

a)

Uninucleated cells

b)

Multinucleated cells

c)

Small round cells

d)

Spindle-shaped cells

79.

Osteoclasts are larger than osteoblasts, reaching up to ______ in diameter.

a)

100 mcM

b)

10 mcM

c)

1 mm

d)

500 nm

80.

Osteoclasts resemble megakaryocytes except their nuclei are ______ and often contain nucleoli.

a)

discrete

b)

fused

c)

lobulated

d)

fragmented

81.

Refer to the images of BM smears. Which cell type is shown in the images?

a)

Osteoblasts

b)

Osteoclasts

c)

Erythrocytes

d)

Lymphocytes

82.

For a new blood cell to reach circulation, it needs to squeeze through which cells of the blood vessel?

a)

Platelet cells

b)

Endothelial cells

c)

Red blood cells

d)

Macrophages

83.

BM—Blood Cell Egress: The process of a new blood cell reaching circulation is driven by ________.

a)

cytokines

b)

antibodies

c)

platelets

d)

hormones

84.

The stroma in bone marrow is composed of reticular cells, collagenous fibers, and extracellular matrix.

a)

True

b)

False

85.

BM—Blood Cell Egress: Which of the following is NOT labeled in the bone marrow diagram?

a)

Stem cell

b)

Platelets

c)

Neuron

d)

Macrophage

86.

During the first four years of life, what are nearly all marrow cavities composed of?

a)

Adipocytes (yellow marrow)

b)

Hematopoietic cells (red marrow)

c)

Compact bone

d)

Cartilage

87.

After four years of age, what happens to the red marrow in the shafts of long bones?

a)

It is gradually replaced by adipocytes (yellow marrow).

b)

It increases in volume and activity.

c)

It turns into compact bone tissue.

d)

It becomes the primary site of white blood cell destruction.

88.

By age 25, hematopoiesis is limited to the marrow of which bones?

a)

Skull, ribs, sternum, scapulae, clavicles, vertebrae, pelvis, upper half of sacrum, proximal end of long bones.

b)

Femur, tibia, fibula, humerus, radius, ulna only.

c)

Mandible, maxilla, nasal bones, zygomatic bones only.

d)

Phalanges, metacarpals, metatarsals, tarsals only.

89.

Red marrow continues to decrease with age.

a)

True

b)

False

90.

In the diagram, which color represents red marrow and which color represents yellow marrow?

a)

Red color represents red marrow and yellow color represents yellow marrow.

b)

Yellow color represents red marrow and red color represents yellow marrow.

c)

Both red and yellow colors represent red marrow.

d)

Both red and yellow colors represent yellow marrow.

91.

BM Hypoplasia: Hematopoietic tissue becomes ____________.

a)

inactive

b)

hyperactive

c)

fibrotic

d)

calcified

92.

Which of the following is NOT a cause of BM Hypoplasia?

a)

Autoimmune disorders

b)

Chemicals

c)

Toxins

d)

Viral infections

e)

Medications/drugs

93.

In BM Hypoplasia, fat cells increase providing a cushion for the marrow.

a)

True

b)

False

94.

You see excessive production of fat cells in BM Hypoplasia.

a)

True

b)

False

95.

What is a key feature seen in BM Hypoplasia?

a)

Excessive production of fat cells

b)

Increased number of megakaryocytes

c)

Hypercellular bone marrow

d)

Increased erythropoiesis

96.

What is BM Hyperplasia?

a)

Non-cancerous increase in blood cells

b)

Cancerous decrease in blood cells

c)

Non-cancerous decrease in blood cells

d)

Cancerous increase in blood cells

Similar Resources on Wayground

Information and Communication Technology- Pretest

100 questions

Information and Communication Technology- Pretest

quiz

Worksheet

•

University

ty_ebanat?

97 questions

ty_ebanat?

quiz

Worksheet

•

University

Basic GK 3

100 questions

Basic GK 3

quiz

Worksheet

•

1st Grade - Professio...

Environmental Sustainability

100 questions

Environmental Sustainability

quiz

Worksheet

•

12th Grade - University

Thinking skills

100 questions

Thinking skills

quiz

Worksheet

•

University

IBU KOTA PROVINSI INDONESIA

100 questions

IBU KOTA PROVINSI INDONESIA

quiz

Worksheet

•

5th Grade - University

THERMAL ENGINEERING II MCQ (MODEL EXAM - 5)

100 questions

THERMAL ENGINEERING II MCQ (MODEL EXAM - 5)

quiz

Worksheet

•

University

Vocabulary Workshop Unit 1-6

100 questions

Vocabulary Workshop Unit 1-6

quiz

Worksheet

•

5th Grade - University