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Total questions: 128

Worksheet time: 1hrs 4mins

Name
Class
Date
1.

A 60-year-old man has suffered a swelling in his right great toe after over eating blinjo crackers. He has a history of acute arthritis episodes affecting ankle and heels. The biopsy was then performed over him. The microscopic showed large collections of uric crystals and foreign body giant cells fill in the nodule. Your best diagnosis will be:

a)

Synovitis chronic

b)

Rheumatic fever

c)

Osteo Arthritis

d)

Gout disease

e)

Rheumaoid arthritis

2.

A 20 years old man worked a clerk for 5 years, since last month he has loss of sensation in his palmar and the 3 first digit. Some of the flexor muscles has no strength to move. The doctor diagnosed with Carpal Tunnel Syndrom. What nerve is most likey compressed?

a)

N.medianus

b)

N.radialis

c)

N. ulnaris

d)

N.digitalis ventralis

e)

N.Musculocutaneus

3.

What distinguishes cartilage from most other connective tissue?

a)

It lacks blood vessels

b)

Its extracellular matrix is rich in collagen

c)

Its predominant cell type secretes both fibers and proteoglycans

d)

Its predominant cell type is a mesenchymal derivative

e)

It functions in mechanical support

4.

A 34-year-old man presented with sudden excruciating pain in right arm and an inability to move after attempting to lift a weight equal to his body weight above his head in the gym. On physical examination, the patient was unable to move right shoulder, and squaring of right shoulder contour, internal rotation of the right shoulder is limited. Radiographs showed the anterior and inferior positions of the humeral head relative to the glenoid fossa. What is the most likely diagnosis for this?

a)

Frozen Shoulder

b)

Shoulder Bursitis

c)

Impingement Syndrome

d)

Rotator Cuff Tear

e)

Anterior Shoulder Dislocation

5.

A 58-year-old woman had a history of myocardial infarction and at this time has no symptom. Her lab shows Hb 11 g/dL (10-12), Ht 40% (37-45), Leu 6000 cells/uL (5000-10000), plt 300000/ul, serum uric acid: 11,3 mg/dL. Which of the following is the most appropriate treatment for the case above?

a)

Sulfinpyrazone

b)

Lifestyle modification

c)

Allopurinol

d)

Indomethacin

e)

Colchicine

6.

A 45 year-old man presented with acute pain of big toe and knee at night. Physical examination revealed inflammation of joints and a nodular lesion adjacent to the big toe. Joint fluid aspirate is performed. What fluid analysis test most likely establishes the diagnosis?

a)

Total cell count and differential count

b)

Cytology for malignant cell

c)

Crystal identification by polarized microscopy

d)

Gross appearance with assessment of viscosity

e)

Gram stain and bacterial culture

7.

35 years old man come with complaint of backpain and stiffness. The pain is chronic, not radiating and not changed with movement. On physical examination there's only slight tenderness and gibbus. What the most probable diagnosis?

a)

Spondylarthrosis

b)

Degenerative disc

c)

Spondylitis

d)

Spondylolisthesis

8.

A 54 year-old nurse presents for evaluation of her arthritis. Her symptoms began several years ago with acute pain and swelling in the left ankle. This was followed 8 months later by pain and swelling in the left wrist and several joints of the fingers. Functional inquiry is otherwise completely negative. Physical examination reveals swelling and tenderness in the right 29, left 2"d 3/ metacarpophalangeal joints (MCPs), and the right 2", left 39 and 4" proximal interphalangeal (PIP) joints. There is no swelling in the elbows, wrists, knees or ankles. There are no cutaneous findings. Her general physical examination is normal. Which of the following tests will be most helpful in confirming diagnosis?

a)

Rheumatoid factor

b)

HLA-B27 antigen

c)

Erythocyte sedimentation rate (ESR)

d)

Check ANA

e)

Serum uric acid

9.

A female, 60 years old, complained about swelling on the right knee. No inflammation sign was found, and fluid is detected on suprapatellar space—no other joint involvement. What type of immune system is reflect the predominance cell in the case above?

a)

Memory

b)

Killer

c)

Innate

d)

Neutralizer

10.

A 25-year-old woman presented with a firm mass in her left lateral pelvis. She felt pain in the area of the mass when lying on her side. Her past medical history was significant only for hypertension. Family history was negative for bone diseases.Physical exam revealed a bony mass that was immovable and attached to her left iliac wing. The mass was approximately 7 cm in greatest dimension. She felt mild pain with extremes of abduction and adduction of her left hip. A radiograph showed a mushroom-shaped bony excrescence joined to the iliac wing by a broad stalk. Computed tomography confirmed this and showed that the mass did not have a fibrous capsule. The patient underwent surgical removal of the suspicious bone lesion. Microscopic examination shows the findings in the figure. What is the most likely diagnosis?

a)

Chondroma

b)

Osteosarcoma

c)

Osteomielitis

d)

Osteochondroma

e)

Ewing sarcoma

11.

A19-year-old girl came to the clinic due to joint pain and swelling on both knee and left ankle with stiffness in the morning since 6 weeks ago. On physical examination, the involved joints were erythematous, warmth, slight tender on palpation, and limited active-passive motion. Laboratory findings showed hemoglobin 11 g/dL, leukocytes 11,500/mm3, platelets 400,000/mm?, negative ANA, positive RF, elevated C3, ESR and CRP. Which cytokine is the major target of treatment in this case?

a)

Interferon y

b)

IL-1

c)

TGF B

d)

TNFa

e)

IL-6

12.

When helping a baby delivery, a midwife noticed that there's assymetric number of thigh skinfolds, uneven knee levels and limitation of hip abduction. What diagnosis should be checked on the newborn?

a)

Developmental dysplasia of the hip

b)

Osteogenesis imperfecta

c)

Congenital perthes disease

d)

Athrogryphosis

e)

Blount disease

13.

An overweight female 60 years old presented with bilateral knee pain during activity, bowleg, and knee joint osteophyte on x-ray. What is the most appropriate treatment for this condition?

a)

Weight loss

b)

Knee tapping

c)

Steroid injection

d)

Knee unloading brace

14.

What is an appropriate characteristic for type 1 skeletal muscle?

a)

Rich vascularization

b)

Large Diameter

c)

Fast twitch glycolytic

d)

High Glycolitic capacity

e)

Low Oxydative capacity

15.

A 45-year-old man has experienced pain in the area of the left hip and upper thigh for the past 7 months. On physical examination, there is tenderness on deep palpation of the left side of the groin. The range of motion at the left hip is decreased, but there is no swelling or warmth on palpation. Pelvic and left leg radiographs show an upper femoral metaphyseal mass lesion that erodes into the surrounding bone cortex. The proximal femur is excised and on sectioning has the gross appearance shown in the figure. Which of the following cell types is most likely to be proliferating in this mass?

a)

Osteoclast

b)

Plasma cell

c)

Chondrocyte

d)

Osteoblast

e)

Primitive neuroectodermal cell

16.

A patient suffered a complete tear of biceps brachii muscle at its insertion site at the radial tuberosity. For proper treatment, you must identify the damaged tissue. Which of the following tissue was damaged at the tear site?

a)

Loose areolar connective tissue

b)

Dense irregular connective tissue

c)

Dense regular connective tissue

d)

Reticular tissue

e)

Elastic tissue

17.

On first prenatal ultrasound exam, the fetus seems to have normal and complete limb, however when born the infant have only one hand. What error that most probably happen in growth and development?

a)

Dysplasia

b)

Malformation

c)

Deformation

d)

Disruption

18.

Herniated intervertebral disc characterized by radiating pain due to compression of spinal nerve. Part of the anatomical structure that compresses the spinal nerve at herniated intervertebral disc is:

a)

Annulus fibrosus

b)

Intervertebral disc

c)

Vertebral body

d)

Vertebral arch

e)

Nucleus pulposus

19.

A child, 6 years old, present to emergency room with fever and pain over his left knee since yesterday. There is exquisite tenderness on left proximal tibia, and mild local swelling. No history of injury. What is the most appropriate laboratory work up should be done?

a)

Liver function

b)

ASTO

c)

Rheumatoid factor

d)

Blood culture

e)

Electrolytes

20.

A 52 year old man has been taking aspirin for rheumatoid arthritis for 8 months. Exacerbations are becoming worse, and she asks her physician about drugs that might stop the progression of the disease. Which of the following is the most appropriate drug of choice?

a)

Celecoxib

b)

Cholchicine

c)

Methotrexate

d)

Prednisone

e)

Sodium diclofenac

21.

A 8 year old boy came with pain on left hip and inability to walk. He was diagnosed with leg-calves and perthes disease. Which of the following happened on his left hip?

a)

Dyschondrosis of medial physis of proximal femur

b)

Avascular of capital epiphysis of the femur

c)

Adecrease in the amount of normal Type | collagen

d)

Displacement of the capital femoral epiphysis from the metaphysis through the physis

22.

A 5-year-old girl is on skin traction after fractures her left femur 3 weeks ago. Now the physician removed the traction and found that the fracture fragment is not displaceable anymore but there is still some movement on fracture site with mild tenderness. What is the most likely phase of healing?

a)

Hard callus phase

b)

Clinical union phase

c)

Soft callus phase

d)

Initial bleeding phase

e)

Proliferation phase

23.

The major lubricant for diarthrotic joints is synthesized by

a)

Nucleus pulposus

b)

Synovial membrane

c)

Fibrous capsule

d)

Articular cartilage

e)

Annulus fibrosus

24.

30 years old woman have a chronic back pain and weak both lower legs, after series of examination the woman is diagnosed with tuberculous spondylitis. Which of the following test can set the definitive diagnosis?

a)

Inhomogeneous appearance abscess in MRI

b)

End plate destruction on vertebral x-ray

c)

Positive result on tuberculin skin test

d)

Positive culture of mycobacterium in biopsy result

25.

A male, 65 years old, presented with pain in the right hip, especially during prolonged walking, since 3 years ago. She had painful and limited right hip internal rotation. What is the appropriate next step to confirm the diagnosis in this case?

a)

Rheumatoid Factor and anti-CCP

b)

CRP and ESR laboratory

c)

Hipx-ray

d)

Hip Ultrasound

26.

A 47 year-old male presents to the Emergency Department with acute onset of lower back pain radiating posteriorly down the right leg into the outer edge of the foot. On examination, plantar flexion of the ankle is weakened and ankle reflexes are absent on the right side. What is the most likely diagnosis?

a)

Acute disc prolapsed

b)

Vertebral osteomyelitis

c)

Mechanical back pain

d)

Vertebral fracture

e)

Spinal stenosis

27.

An 80-year-old woman who lives independently at home presents with low back pain in the setting of a fall. She slipped on a wet floor in the kitchen. Blood tests reveal a haemoglobin of 10.5 g/dL (NR12.0 - 16.0 g/dL), a normal white blood cell count, but an elevated ESR. X-rays of the lumbosacral spine reveal a compression fracture of L4, and multiple lytic lesions of her thoracic spine are seen on chest X-ray. What is the most likely diagnosis?

a)

Ankylosing spondylitis

b)

Multiple myeloma

c)

Fibromyalgia

d)

Metastatic carcinoma

e)

Osteoarthritis

28.

An 85-year-old woman has been confined to a nursing home for the past 6 years. Bone density scans suggest that she has osteoporosis. Although the amount of calcium in her diet is adequate, she cannot absorb enough of it to maintain bone mineral density. One factor likely contributing to her condition is insufficient production of which substance in the dermis of her skin?

a)

Vitamin D

b)

Calcitonin

c)

Parathormone

d)

Melanin

e)

Vitamin A

29.

A 65-year-old woman reports pain on her knees and difficulty walking. She can walk in the grocery store, but the pain come when she tries to go up and down the stairs and when standing from a sitting position. She also felt stiffness on both of her knees. After seeing a doctor, she is diagnosed with 3™ stages of knee osteoarthritis. On physical examination, which muscles that most probable to became atrophy?

a)

Anterior tibialis

b)

Gastrocnemius

c)

Hamstrings

d)

Quadriceps

30.

A 5 years old boy fall down when jumping on the bed. His mom brought him to ER few hour after the fall. The doctor diagnosed him with fracture of the forearm. Which fracture is common in children?

a)

Burst fracture

b)

Green stick fracture

c)

Bennet's fracture

d)

Coles' fracture

e)

Montegia fracture

31.

A 20 yrs old tennis champion complains a paralyzed to extend his antebrachii and his hand. What nerve is the most likely injured?

a)

Ulnar n

b)

Axillar n

c)

Radial n

d)

Musculocutaneus n

e)

Median n

32.

A 60 year old man complains about stiffness and pain in the back after activity. Radiographic examination reveals narrowing of L4-5, L5-S1 disc space. What is the most possible cause of the complaint?

a)

Annulus fibrosus tear

b)

Osteoporosis

c)

Loss of nucleus pulposus chondroitin sulfate

d)

Facet joint degeneration

e)

Increase disc water content

33.

Which of the following statements about pathogenic mechanisms in autoimmunity is CORRECT:

a)

In Graves' disease, an auto-antibody found commonly in patients binds to the TSH receptor and kills the thyroid cell

b)

In systemic lupus erythematosus, the various anti-nuclear antibodies produced in the patient are highly pathogenic because these can bind to the nuclear antigens and cause the cell to undergo apoptosis

c)

Cytotoxic T cells do not play a major role in autoimmune diseases because the auto-antigens involved are either nucleic acids or carbohydrates

d)

Rheumatoid factors are DNA-anti-DNA immune-complexes found in arthritic joints

e)

Relief can be obtained in some autoimmune diseases by blocking the effects of the inflammatory cytokines produced

34.

A 36-year-old woman has noted a nodule beneath the skin in her left groin since adolescence. On physical examination, the lesion has a 2-cm diameter and is nontender, soft, rubbery, and movable. Microscopic examination shows the findings in the figure. Which of the following cell types is most likely to comprise this lesion?

a)

Fibroblast

b)

Adipocyte

c)

Endothelial cell

d)

Skeletal muscle

e)

Smooth muscle

35.

A radiographic film from a 60-year old woman shows a complete right femoral neck fracture just only caused by a minor fall. In Examination serum calcium level is normal. Bone density examination shows T-score = -2.5 Which of the following condition factor is the most contributing factor for this fracture?

a)

Vitamin D deficiency

b)

Post menopausal bone loss

c)

Osteomyelitis chronic

d)

Parathyroid adenoma

e)

Calcium deficiency

36.

While examining a piece of tissue taken from the epiphyseal plate, you noticed large cells arranged in rows. Which of the following layers are you examining?

a)

Calcified zone

b)

Proliferative zone

c)

Hypertrophy zone

d)

Resting zone

37.

What is the neuro muscular junction?

a)

The the releasing place of the neurotransmitter acetylcholine (ACh) from post synaptic terminal

b)

The part of the sarcoplasmic of the muscle cell that is in closest proximity to the synaptic end bulb

c)

The meeting point of a nerve fibre and the muscle fibre that it supplies

d)

The point of action potential traveling in the T tubules reaches the sarcoplasmic reticulum

e)

The production place of the neurotransmitter acetylcholine (ACh) in post synaptic terminal

38.

65 years old lady came to your office with complain if pain on her lower back. The pain especially felt after she plays with her 1years old grandson. Low Back Pain is always associated with:

a)

Fever

b)

Chronic Stress to the lumbar spine

c)

Arthritis of facet joints

d)

Prolapsed intervertebral disc

e)

Back muscle tightness or spasm

39.

A 65-year-old woman reports pain on her knees and difficulty walking. She can walk in the grocery store, but the pain come when she tries to go up and down the stairs and when standing from a sitting position. She also felt stiffness on both of her knees. After seeing a doctor, she is diagnosed with 3™ stages of knee osteoarthritis. What pathology in the knees that is the main cause that the knees become stiff?

a)

Osteophyte formation

b)

Cartilage destruction

c)

Subchondral bone destruction

d)

Capsular fibrosis

40.

A 56-year-old female complaining of pain on her left knee, usually worse following activity since few months ago. There's also stiffness that worsen after sitting for prolonged periods of time. The findings from the conventional X-ray of left knee are narrowing of the joint-space, osteophytes formation, and subchondral sclerotic. What is the basic pathomechanism in the case above?

a)

Porotic bone

b)

Synovial membrane inflammation

c)

Cartilage degradation

d)

Meniscus tear

e)

Ligament weakening

41.

A male 60 years old complained of a sudden swelling of the left knee. The patient sometimes felt calf muscle spasms, otherwise healthy. He suffered several times left knee swelling before. There was a palpable bony enlargement of the knee. What is the least possible condition?

a)

Gout arthritis

b)

Septic arthritis

c)

Rheumatoid arthritis

d)

Knee osteoarthritis

e)

Neoplams

42.

While examining a piece of supporting tissue taken from a knee joint, you noticed many cells located in lacunae, some of which are grouped into clusters of two or more cells. The matrix is homogenous. Which of the following supportive tissue are you examining?

a)

Fibrous cartilage

b)

Hyaline cartilage

c)

Compact bone

d)

Elastic cartilage

43.

A 40-yr-old man was admitted to hospital suffering from tuberculosis. A pathologist discovered central caseous necrosis surrounded by epithelioid macrophages in an area affected by the bacterial infection. Which type of inflammation is most likely associated with this patient's infection?

a)

Chronic active

b)

Chronic suppurative

c)

Ulcer

d)

Acute suppurative

e)

Granulomatous

44.

While examining a piece of supportive tissue taken from the vertebral column, you noticed rows of cells, in lacunae, between collagen fibers. Which of the following supportive tissue are you examining?

a)

Fibrous cartilage

b)

Hyaline cartilage

c)

Elastic cartilage

d)

Compact bone

45.

A 20 year old girl had fractured her right humerus in a car accident 2 weeks ago. The fracture did not heal properly, and developed a purulent infection of the skin around the site of fracture. An X-ray revealed a focus bone loss near the lower end of the humerus. Curettage biopsy was performed. Microscopic appearance showed a sequestrum, inflammatory cells proliferation and granulation tissue. What is the most likely diagnosis base on microscopic appearance?

a)

Acute Osteomyelitis

b)

Osteoarthritis

c)

Chronic non spesific osteomyelitis

d)

Chronic spesific osteomyelitis

e)

Rheumatoid arthritis

46.

A male 60 years old complained of a sudden swelling of the left knee. The patient sometimes felt calf muscle spasms, otherwise healthy. He suffered several times left knee swelling before. There was a palpable bony enlargement of the knee. What is the appropriate next step to confirm the diagnosis in this case?

a)

Knee Ultrasound

b)

Joint aspiration and fluid analysis

c)

Rheumatoid Factor and anti-CCP

d)

CRP and ESR laboratory

47.

A 5 years old boy fall down when jumping on the bed. His mom brought him to ER few hour after the fall. The doctor diagnosed him with fracture of the forearm. This boy was put on an arm cast for 4 weeks, on the 3" weeks. What would you probably see on the plain xray of the forarm?

a)

Normal bone with periosteal thickening

b)

Undistinguished fracture site

c)

Osseous callus

d)

Porotic bone on fracture site

e)

Clear fracture line

48.

Which area in cartilage is relatively proteoglycan-rich and collagen-poor?

a)

Perichondrium

b)

Interterritorial matrix

c)

Fibrocartilage

d)

Territorial matrix

e)

Epiphyseal plate

49.

A female 60 years old presents with severe bowlegs and pain in both knees during activities. What is the force change in this condition?

a)

Increase Abduction moment

b)

Decrease Extension moment

c)

Increase rotation moment

d)

Increase Adduction moment

e)

Decrease flexion moment

50.

Mr. Bachtiar, 75 years old, he suddenly could not walk because fell very pain in his right Leg. Which of these nerves make the basis of the lumbar plexus?

a)

L5-S1

b)

L1-L4

c)

L1-L5

d)

L2-L4

e)

L2-L5

51.

A 65-year-old man complaint about chronic right knee pain during activity. During arthroscopic examination, the physician found fibrillation and softening of tibial and femoral cartilage. What is the most probable substance that responsible for the cartilage condition?

a)

TNF

b)

Lipase

c)

VEGF

d)

Protease

e)

IL1

52.

A man 38 years old had upper arm muscle sore after he exercised weight training. He went to the doctor and doctor suggested weight training with the multigym and also aerobic training. What is the eccentric isotonic contraction?

a)

The muscle lengthens as it contracts maintaining force and movement

b)

The length of muscular remains constant during contraction

c)

The maximal contraction at constant speed over the full range of movement

d)

The muscle shortens to produce force and movement

e)

Tension remains constant as the muscle shortens or lengthens

53.

Which of the following most accurately describes compact bone?

a)

Predominant bone type in the epiphysis of adult long bones

b)

Lines the medullary (marrow) cavity

c)

Also known as cancellous bone

d)

Characterized by the presence of osteons

e)

Forms the diploe in cranial bones

54.

A 75 year-old widow complains of generalized aching in her bones, and a gradually increasing curvature of her upper spine. An X-ray shows osteopenia and vertebral changes. Serum calcium, phosphate, alkaline phosphatase and a blood screen, including ESR, are all normal.

What is the most likely cause of this condition?

a)

Osteoporosis

b)

Hyperparathyroidism

c)

Multiple myeloma

d)

Hyperthyroidism

e)

Vitamin D deficiency

55.

A15-year-old adolescent boy presented with a swelling of the distal femoral that was growing slowly during the 3-month period prior to presentation. The swelling became painful after a minimal injury caused by a fall. A firm, palpable mass was present on physical examination. The remainder of the findings from the examination were unremarkable. Radiography showed a heterogeneous mass measuring 8 cm in length on the distal femoral metaphysis. Magnetic resonance imaging demonstrated a well-defined periosteal lesion with a cortical lysis but without involvement of the medullary cavity. The gross appearance shown in the figure. What is the most likely diagnosis?

a)

Enchondroma

b)

Chondroma

c)

Leiomyosarcoma

d)

Fibrous dysplasia

e)

Osteosarcoma

56.

While moving into a new apartment a student lifting a heavy box of books experiences a sharp pain in his back, radiating down the anterior thigh and medial side of his leg. After several days of misery, he finally goes for treatment and is told that he has a herniated intervertebral disk at the L3 level which is compressing a spinal nerve where it exits the vertebral column. Where is the point of compression?

a)

Foramen magnum

b)

Vertebral foramen

c)

Intervertebral foramen

d)

Hiatus of the sacral canal

e)

Central canal

57.

A 50-year-old male, presented with right painful tibial bone fracture since 3 month before. X rays show segmental fracture on tibia diaphyses with minimal callus. One month latter, the pain still persists. Another x-ray was taken, with atrophic changes of bone at the facture site. What is the most likely diagnosis?

a)

Malunion

b)

Delayed Union

c)

Reflex simphatetic dystrophy

d)

Avascular necrosis

e)

Non union

58.

30 years old male has a chronic discharging sinus from his left leg. He had tibia fracture 1year before and was taken care by traditional bone setter. He is able to walk with some bowing and shortening of the left leg, only sometimes he feels pain on the leg. What is the most probable finding on leg x ray?

a)

Involucrum

b)

Fracture nonunion

c)

Sun burst appearance

d)

Abscess

e)

Brodie's lesion

59.

A 30-year-old man brought to your clinic after falling from 29 floor balcony 15 minutes ago. He is drowsy and barely conscious. On examination you found an oddly angled right femur with blood oozing from a pin point wound Which of the following category is best to describe this condition?

a)

Open fracture grade 1

b)

Open fracture grade 3B

c)

Open fracture grade 3A

d)

Open fracture grade 2

e)

Open fracture grade 3C

60.

A male 66 years old complained of a sudden swelling of the left knee. Synovial fluid analysis is taken and the result is The appearance of Calcium pyrophosphate dihydrate crystals. What is the possible condition?

a)

Rheumatoid

b)

Pseudogout

c)

Osteoarthritis

d)

Infection

e)

Gout

61.

What is the neurotransmitter in neuromuscular skeletal muscle junction?

a)

Norephinephrine

b)

Ephineprine

c)

Acetyl choline

d)

Dopamine

e)

Serotonin

62.

A 34 year old man came with pain in his left knee since 2 weeks especially in the morning more than 1.5 hours. He also felt pain in his achilles. 1 month before there was history of chronic diarrhea. The rheumatic factor was negative. What is the most probable diagnose for his problems?

a)

Rheumatoid arthritis

b)

Osteoarthritis

c)

Reactive arthritis

d)

Gout arthritis

e)

Osteonecrosis

63.

A male 68 years old presents with chronic left hip pain with osteophyte and joint space narrowing. The patient also has a history of peptic ulcers. What is the first line of pharmaceutical management in this patient?

a)

Tramadol

b)

Topical NSAID

c)

COX-2 inhibitor

d)

Hyaluronic acid injection

64.

A 19-year-old with hormonal imbalances came to hospital for upper right femur fractured. The X-ray showed well circumscribed lesion and a partly cystic. A curretage biopsy was performed and its microscopic showed fibrous tissue proliferated that containing “claw (U)-shape” configuration of bone trabeculas. What is the most likely diagnosis you may describe to him?

a)

Ganglion cyst

b)

Fibrous dysplasia of the bone

c)

Chondroblastoma

d)

Osteomyelitis tuberculosa

e)

Osteomyelitis chronic

65.

Quasimoto, the "Hunchback of Notre Dame", suffered from an abnormal thoracic curvature called kyphosis. In this condition the accentuated convexity of the curvature is:

a)

Posterior

b)

Caudal

c)

Lateral

d)

Anterior

e)

Media

66.

A 10-year-old boy was brought to a clinic because of back pain for around one month, especially while bending. His mother also noted that her son’s left shoulder is slightly higher than the right. On physical exam the doctor found that Adam’s test was positive but no length discrepancy. What is the most appropriate examination do diagnose this patient?

a)

Standing PA & mp; lateral X-ray

b)

Supine lateral X-ray

c)

Spine MRI

d)

Left lateral decubitus X-ray

e)

Spine CT-scan

67.

What will happen in the forcible over stretch muscle?

a)

Muscle atrophy

b)

Muscle contracture

c)

Muscle dystrophy

d)

Muscle injury

e)

Musclespasticity

68.

Amin 15 years old boy felt down from the stairs then the radiograph showed that his joint between clavicle and scapula was fracture. What part of the scapula articulates with the clavicle?

a)

Spine process

b)

Acromion

c)

Coracoid process

d)

Supraglenoid tubercule

e)

Infraspinous fossa

69.

Mr. Budi, 54 years old was felt down when he was hit by the truck. The radiograph demonstrated the fracture of fibula. Which nerve of the leg wraps around the neck of fibula?

a)

Femoral

b)

Deep fibular

c)

Tibial

d)

Superficial fibular

e)

Common fibular

70.

A0 year-old boy developed high fever, chills, and worsening leg pain. His upper left leg started to hurt 3 to 4 days ago, and last night he began limping. His parent reports no history of trauma to the area. His only past medical history is two episode of otitis media (infection in the ear) at age 2 and 7. There were localized tenderness and swelling over the left distal femur. WBC count is 11.500 cells/uL; normal differential count, but ESR is 58 mm/hour. The blood cultures obtained and revealed Gram (+) cocci. How is the boy getting this illness?

a)

Lymphogenic

b)

Direct spread

c)

Air-borne

d)

Hematogenous

e)

Fecal-oral

71.

A mother come to outpatient department because of concern that her 9 months old baby boy seems to have bow leg. When the boy starts to stand she noticed that both of his leg seems bowing on the knee. There's no history of trauma or other anomaly. What would probably be the problem?

a)

Post traumatic bow leg

b)

Infection

c)

Congenital demoral deficiency

d)

Unilateral blount disease

e)

Normal knee

72.

A6 year-old has had a hard painless lump on the medial aspect of his knee for at least eight years. It caused no problems until he was kicked in the area of the lump during football game

what is most likely diagnosis?

a)

Osgood-Schlatter disease

b)

Osteochondritis

c)

Osteomalacia

d)

Osteosarcoma

e)

Osteochondroma

73.

A 30-year-old woman has experienced pain in the area of hands and feet. On physical examination, there is a mass and slowly growing, no erythema or warmth. A radiograph shows a 7-cmn mass in the metaphyseal region of small tubular bones of the hands and feet. Microscopic examination shows the findings in the figure. What is the most likely diagnosis?

a)

Chondroma

b)

Osteitis fibrosa cystica

c)

Osteoblastoma

d)

Plasmacytoma

e)

Giant cell tumor

74.

A female, 60 years old, complained about swelling on the right knee. No inflammation sign was found, and fluid is detected on suprapatellar space—no other joint involvement. In this case, the synovium is predominance by:

a)

Lymphocyte T

b)

Lymphocyte B

c)

Macrophage

d)

Neutrophil

75.

A 38-year-old woman has recent onset of cold ngers, joint pain, fever, weight loss, and a facial rash. Examination reveals a symmetrical inammatory arthropathy, a rash over her face and neck, and lymphadenopathy. Investigations reveal thrombocytopenia, normal urine examination, and a strongly positive anti nuclear antibodies (ANA). What is the most likely diagnosis?

a)

Rheumatoid arthritis

b)

Gout

c)

Systemic lupus erythematosus

d)

Septic arthritis

e)

Acute osteoarthritis

76.

A male 70 years old presents with chronic left hip pain with osteophyte and joint space narrowing. The patient also has a history of peptic ulcers. What is the first line of pharmaceutical management in this patient?

a)

Hyaluronic acid injection

b)

Tramadol

c)

Topical NSAID

d)

COX-2 inhibitor

77.

A 6 months old baby presents with fever, drowsy, irritable, and swelling of her left hip. She doesnt want to move her left extremity. X ray show metaphyseal proximal femoral bone destruction and hip joints swelling. The most common cause of this condition is

a)

Streptococcus group B

b)

Gram negative bacilli

c)

Staphylococcus aureus

d)

Pseudomonas aeroginosa

78.

A 55 year old male has a history of episodes of a painless nodule with overlying ulcerated skin at his big toe. Beneath the eroded skin is a chalky white deposit of soft material surrounded by erythematous soft tissue. Microscopic appears a collection of lamentous urate crystals. This nodule is most consistent with which of the following lesions?

a)

Tophus

b)

Osteophyte

c)

Furuncle

d)

Pannus

e)

Granuloma

79.

While examining a “bony” tissue taken from the epiphyseal plate, you noticed several layers of cells. One of these layers consists of rows of attened cells, arranged like a stack of coins. Which of the following layers are you examining?

a)

Hypertrophied zone

b)

Proliferative zone

c)

Calcied zone

d)

Reserve/resting zone

80.

A patient, male 50 years old, presents to a clinic with briefly left knee stiffness in the morning and pain following prolonged walking. On x-ray examination, a knee osteophyte was found. The disease processes arise from all these tissue, except:

a)

Peripheral blood vessels

b)

Bone

c)

Intraarticular fat

d)

Cartilage

e)

Synovium

81.

A 60-year-old woman came with a complete left femoral neck fracture after fell from tricycle (becak). The bone mineral density examination showed it is less than -2.5. Microscopic examination showed that the bone cortex becomes thinner and the trabeculae have less complex branching. The most significant contributing factor for this fracture is:

a)

Immobilization osteoporosis

b)

Multiple myeloma

c)

Senile osteoporosis

d)

Vitamin D deciency

e)

Hyperthyroid

82.

Female, 60 years old, complaint about pain and stiffness of her left knee. The doctor nds cartilage softening during knee arthroscopy. What is the earliest change that happened at the cartilage?

a)

Decrease collagen

b)

Decrease proteoglycan

c)

Chondroblast death

d)

Vascular invasion

83.

A 76 year-old lady developed vertebral osteomyelitis. Her blood culture grew Gram-positive cocci arranged in clusters. What is the most likely etiological agent?

a)

Streptococcus pyogenes

b)

Staphylococcus aureus

c)

Streptococcus pneumoniae

d)

Enterococcus faecalis

e)

Viridans streptococci

84.

A 5 years old boy fall down when jumping on the bed. His mom brought him to ER few hour after the fall. The doctor diagnosed him with fracture of the forearm. What is the phase of bone healing happening when this boy come to the ER?

a)

Remodelling

b)

Consolidation

c)

Haematoma and inamation

d)

Callus formation

85.

6 months ago, 25 years old university student twisted her knee and heard a popping sound. Swelling developed within two-hours after the injury. Now, there is no more swelling but she feels her knee unstable. Which test would be most appropriate to use for examination of the cruciate ligaments of the knee?

a)

Plain radiograph

b)

Radio-isotope scan

c)

Magnetic resonance imaging

d)

Computed tomography

e)

Ultrasound

86.

Mrs Rani is 66 years old and has four adult children. She is on Hormone replacement therapy. She has always been a homemaker and a life-long non-smoker. She developed late onset asthma ve years ago, requiring regular oral as well as inhaled steroid therapy. Asthma has limited her physical activity, although she was never someone who enjoyed exercise anyhow. Two weeks ago, she tripped over her cat and fractured her left hip. Which investigation is the most useful to diagnose this patient?

a)

Dual X-ray absorptiometry

b)

Multiple-site magnetic resonance imaging

c)

Femoral neck ultrasound

d)

Plain X-ray of the spine

87.

A 58 year-old woman was admitted to the hospital with a two-month history of pain, swelling and purulent discharge to her left lower leg. This occurred one year after sustaining a fracture to that area. Colonies grown from the purulent discharge on blood agar were convex and appeared golden yellow. What is the most likely diagnosis?

a)

Wound infection caused by Sporothrix schenckii

b)

Arthritis caused by Streptococcus pueumoniae

c)

Osteoarthritis caused by Neisseria gonorrhoeae

d)

Osteomyelitis caused by Staphylococcus aureus

e)

Osteomyelitis caused by Haemophilus inuenzae

88.

Mr. Adi, 34 years old was felt down when he climbed the tree. The radiograph demonstrated the fracture of talus. What is the most appropriate reason that fractures of the talus have minimal displacement?

a)

It is a tiny bone

b)

It is an irregular bone

c)

It is place over the calcaneus

d)

Attached muscles pull the fragments apart

e)

Malleoli hold the fragments in place

89.

A 20 year old man complains of sharp and almost constant pain in the region of the right knee. this pain has been present for two months and is associated with swelling of the knee. on admission to hospital a radiograph reported as follows: " bulky, scletorit lesion in the lower end of the femur. The lesion extends to the surrounding extra-osseus tissue with transverse 'sunray' streamers of radio-opacity". what is the most likely disorder of the bone?

a)

Osteosarcoma

b)

Hyperparathyroidism

c)

Metastatic cancer

d)

Osteomyelitis

e)

Paget's disease

90.

30 year old woman hit by a car, fell down on her arm. cannot abduct her arm. the radiograph showed fracture of proximal humerus, what vessel is the most possible injured?

a)

ulnaris

b)

axillaris

c)

radialis

d)

brachialis

e)

profunda brachii

91.

A man 30 years old felt very tired after half marathon training. What is the nerve for maintaining a muscle tonus in sustained stretch?

a)

Static γ fiber to nuclear chain fiber of intrafusal skeletal muscle

b)

Dynamic γ fiber to nuclear chain fiber of intrafusal skeletal muscle

c)

Static γ fiber to nuclear bag fiber of intrafusal skeletal muscle

d)

Dynamic γ fiber to nuclear bag fiber of intrafusal skeletal muscle

e)

Static γ fiber to nuclear chain fiber of extrafusal skeletal muscle

92.

A 15-year old girl complained of severe pain in his left knee after vigarous exercise for 4 weeks. The knee joint has been swollen and red then she cannot extend her leg. The doctors diagnosed her with stress fracture. The MRI showed tear of patella ligament. Which structure of the bone is inserted by those ligament?

a)

Capitulum fibulae

b)

Malleolus lateralis

c)

Crista tibialis

d)

Tuberositas tibia

e)

Condyle medialis

93.

A 50-year-old woman has experienced pain in lumbar joints for several months. Radiographic examinations show Bamboo’s spine. Physical examination reveals several nodules in her small joints in the hands and feet. Histology of the nodule after biopsy shows a central fibrinoid necrosis, surrounding by palisading epithelioid macrophages. The best diagnostic is

a)

Rheumatoid arthritis

b)

Osteoid osteoma

c)

Gout diseases

d)

Chronic osteomyelitis

e)

Osteo-arthritis

94.

Which of the following cell is the most involved in remodelling process?

a)

Osteoblast

b)

Osteocyte

c)

Osteon

d)

Osteoid

e)

Osteoclast

95.

A 10-year-old girl was admitted to the hospital due to a draining sinus on the right leg for 2 years. She has chronic osteomyelitis that is multi-resistant to antibiotics. What is the most probable cause of multi-resistance?

a)

Abscess

b)

Septicemia

c)

Sequestrum

d)

Involucrum

e)

Cellulitis

96.

12-year old boy admitted to hospital with the complaints of fever, chills, local swelling and pain at his left leg after an accident 3 weeks ago. An x-ray of his femur showed bone destruction, necrosis and new bone formation. A clinical diagnosis of bone infectionw was made. What additional diagnostic information should be obtained before this boy received his first dose of antibiotic?

a)

Complete blood count

b)

Serum creatinine and blood urea nitrogen (BUN)

c)

MRI scan

d)

Procalcitonin level

e)

Culture of bone aspirate

97.

Whike examining a piece of bone tissue you noticed a structure consisting of circular layers surrounding a tube in the centre. Which of the following structures are you examining?

a)

Haversian canal

b)

Lamellae generals

c)

Lamella interstitials

d)

System Havers

98.

What is the definition of muscle tone

a)

The resistance of the active or passive stretched muscle

b)

The minimum resistance of the unstretch muscle

c)

The maximum resistance of the moderate contraction muscle

d)

The maximum resistance of the overstretch muscle

e)

The minimum resistance of the overstretch muscle

99.

A patient was hit by a motorcycle from the side. She has pain on shoulder and x ray fracture of proximal humerus then she cannot abduct her arm and impairment of muscle. What nerve is most likely affected

a)

N. Ulnaris

b)

N. Medianus

c)

N. Radialis

d)

N. Axillaris

e)

N. Musculocutaneous

100.

Which cell makes osteoid and promote mineralization in fracture healing leading to bone strength?

a)

Osteoblast

b)

Osteoclast

c)

Chondroblast

d)

Chondrocyte

e)

Osteocyte

101.

A man 58 years old felt his right arm muscle became easy to fatigue and weak after recovery from right arm bone fracture. Hisphysician said he got muscular atrophy and his connection between nerve and muscular was good. What is muscular disuse atrophy?

a)

The reducing flow of nerve impulses to the inactive muscle because they are not used

b)

The reducing flow of nerve impulses to the inactive muscle because a muscle's nerve impulses cease

c)

The reducing flow of nerve impulses to the inactive muscle because the damage to the nerves that control them

d)

The progressive degradative action of enzymes that is generally associated with severe cellular trauma

e)

The muscle suffer a vital loss of protein and muscle fibers are replaced gradually by fat and connective tissue

102.

In sciatica which muscle is most likely affected?

a)

gracillis

b)

adductor magnus

c)

Sartorius

d)

gastrocnemius

e)

Rectus femoris

103.

Radiograph shows fracture of proximal femur. What structure is most likely injured?

a)

Condyles laterales

b)

Epicondyles medialis

c)

Linea aspera

d)

Acetabulum

e)

Trochanter major

104.

A 30 year old woman was hit by bycicle and fell down on her arm, she cannot abduct her arm what muscle was most likely affected?

a)

Deltoideus

b)

Biceps brachii

c)

Supraspinatus

d)

Subscapularis

e)

Teres mayor

105.

On a regular checkup of a 6-week-old female infant you note positive Ortolani test on the left side. You suspect the patient is having DDH so you decided to refer the patient to orthopaedic specialist. On consultation, you try to explain to the parents the most probable initial treatment for this patient.

a)

Observation

b)

Closed reduction and internal fixation

c)

Open reduction and internal fixation

d)

Open reduction and cast

e)

Conservative protection with Pavlik harness

106.

In the impairment of muscle insterted to the proximal femur, what movement of the thigh is the most probably disturbed?

a)

Medial rotation

b)

Lateral Rotation

c)

Flexion

d)

Extension

e)

Abduction

107.

A man 38 years old had sore upper arm muscle after he helped to push a heavy cart to the side of street. He went to the doctor and doctor said possibly he had muscle strain.
A muscle strain is caused by:

a)

Inflammation of ligament

b)

Inflammation of muscle fibers

c)

Over stretching ligament

d)

Excessive stretching or working of the muscle

e)

Very forceful, repetitive muscular activity

108.

A 42-year-old woman came to the hospital with complains of sharp pain on the upper back in the last 5 months. She also said that 2 years ago she underwent bilateral ovarian cyst surgery. Physical exam reveals tenderness on the thoracic region, no swelling, and no redness. What is the most likely diagnosis in this case?

a)

Posterior rib fracture

b)

Muscle spasm

c)

Herniated nucleus pulposus

d)

Osteoporosis

e)

Spondylitis

109.

this guy cant extend his forearm, what muscle is prolly impaired

a)

Supraspinatus

b)

Subscapularis

c)

Teres mayor

d)

Triceps brachii

e)

deltoideus

110.

Mr Alan 48 years got infection and swelling at his hand. He went to the hospital and he was given the antibiotic. After 2 weeks his hand healed but he could not bend his finger normally. His doctor said his finger possibility suffered muscular necrosis and became contracture. What is the process in muscle contracture?

a)

The non stretchy Fibrous tissue replace the connective tissue of the muscle fiber

b)

The fat gradually replace the muscle fibers and connective tissue

c)

The progressive degradative of muscle fiber

d)

The non stretchy Fibrous tissue replace the normally stretchy (elastic) tissues

e)

The Progressive loss of myofibril

111.

Male 57 years old complaint of chronic right hip pain after sports activities. The doctor found osteophyte on hip x ray, and bone marrow lesion on MRI. Histologically, it contains vascular infiltration. What does the lesion on the case signify?

a)

Effusion

b)

Injury

c)

Inflammation

d)

Instability

e)

Progression

112.

Perferred treatment for infant diagnosed with CTEV or clubfoot

a)

Stretching and serial casting with Ponseti method

b)

Open reduction surgery

c)

Bone reconstruction

d)

Physiotherapy and observation

e)

Soft tissue surgery

113.

The most common sequelae of tuberculous spondylitis in adolescent are

a)

Pathological dislocation

b)

Bony ankylosis

c)

Chronic osteomyelitis

d)

Fibrous ankylosis

e)

Vertebral body fusion

114.

Which muscle is inserted into proximal femur

a)

gluteus maximus

b)

rectus femoris

c)

semitendinosus

d)

vastus medialis

e)

biceps femoris

115.

A woman 60 years old felt her muscle became easy to fatigue and weak. Her physician examined her and found her muscle tone and muscle strength is lesser than normal. What will happen in the length tension relationship if the muscle is over stretched?

a)

The over stretched muscle will develop little tension

b)

The over stretched muscle will produce a relatively maximum contraction

c)

The over stretched muscle will produce a relatively weak contraction

d)

The over stretch muscle will develop maximum tension

e)

The over stretched muscle will produce an optimal contraction

116.

Mrs Ani is a 50 year-old woman, has painful, symmetrical swelling of her metacarpophalangeal (MCP) joints, and has recently found it difficult to wash clothes. She gained some relief from ibuprofen tablets, which she was able to buy in a small quantity from pharmacy. What is the mechanism of the drug given above?

a)

Inhibits cyclooxygenase enzymes

b)

Selectively inhibit COX-2

c)

Similar to anti-inflammatory corticosteroid

d)

Increases the local production of prostaglandins at sites of inflammation

117.

A 60 years old woman fell down then felt very pain in her right muscle of medial thigh and could not adduct her thigh which nerve is probably injured?

a)

N. obturator internus

b)

N. tibialis

c)

N. Femoralis

d)

N. peroneus superficialis

e)

N. glutealis superior

118.

What are special features of fractures in children that support the treatment plan of fracture (cast immobilization and closed reduction)?

a)

Thick periosteum

b)

More frequent torn ligament and dislocation

c)

Frequent joint stiffness

d)

Diagnostic problem due to secondary ossification of epiphyseal plate

119.

A 35 year old man came to physician with solid mass in his right parietal. Physical examination noted that the tumor is not mobile but solid and hard consistency. The X-ray imaged neither distortion nor destruction on that right parietal's bone. Curettage biopsy was performed. What is the most likely diagnosis base on microscopic appearance?

a)

Osteoma

b)

Giant Cell tumor

c)

Fibrous dysplasia

d)

Chondroblastoma

e)

Chondroma

120.

A contraction in which the tension remains constant as the muscle shortens is said as

a)

concentric contraction

b)

eccentric contraction

c)

isometric contraction

d)

isokinetic contraction

e)

isotonic contraction

121.

Mrs Rani is 66 years old and has four adult children. She is on Hormone replacement therapy. She has always been a homemaker and a life-long non-smoker. She developed late onset asthma five years ago, requiring regular oral as well as inhaled steroid therapy. Asthma has limited her physical activity, although she was never someone who enjoyed exercise anyhow. Two weeks ago, she tripped over her cat and fractured her hip. What is most likely to cause bone loss?

a)

Estrogen replacement therapy

b)

Regular exercise

c)

Large doses of glucocorticoids

d)

Excess osteoblastic activity

122.

claw hand which nerve

a)

medianus

b)

musculocutaneous

c)

radialis

d)

axillaris

e)

ulnaris

123.

5 years old boy presents to emergency department with intense pain on his left upper leg since yesterday.
He has refused to walk since yesterday because of pain. No history of injury. He has some fever and sore throat since 3 days ago. On physical examination, point tenderness was found on proximal left tibia. No abnormality detected on cruris x ray. What is the most appropriate response to this condition?

a)

Hospital admission and IV antibiotic treatment

b)

Cold pack several times a day

c)

Outpatient follow up

d)

Order Magnetic Resonance Imaging

e)

Pain management

124.

A 20 yrs old tennis champion complains a problem when the forearm is extended. The examination of X-ray shows fracture of distal humerus and the inferior fragment of humerus directed to the posterior part of the arm. What signs of nerve injured by the fracture above?

a)

Inability to flex the wrist

b)

Loss of sensation of palmar manus

c)

Claw hand

d)

Inability to extend the hand

e)

Inability to extend the forearm

125.

Before taking further treatment, the doctor gave her non-narcotic analgetic to reduce the inflammation and pain. It was also known that the patient are 6-month old pregnant. Which of the following is the most appropriate NSAID for this patient

a)

Ibuprofen

b)

Acetaminophen

c)

Aspirin

d)

Mefenamic acid

e)

Methampyrone

126.

A 65 year-old woman presents with pain, stiffness and swelling of her knees. Physical examination reveals marked knee crepitus. Reconstructive surgery is performed and the resected bone reveals destruction of the articular cartilage. Which of the following BEST describes the etiology of this woman's disease?

a)

Deficient enzyme in the metabolic pathway involving tyrosine

b)

Deposition of needle-shaped negatively birefringent crystals

c)

Presence of anti-IgG autoantibodies

d)

Wear and tear destruction of articular cartilage

127.

A 65 year-old woman presents with pain, stiffness and swelling of her knees. Physical examination reveals marked knee crepitus. Reconstructive surgery is performed and the resected bone reveals destruction of the articular cartilage. Which of the following BEST describes the etiology of this woman's disease?

a)

Deficient enzyme in the metabolic pathway involving tyrosine

b)

Deposition of needle-shaped negatively birefringent crystals

c)

Presence of anti-IgG autoantibodies

d)

Wear and tear destruction of articular cartilage

128.

A 19-year-old footballer was sidelined after falling in a game. You as a first aid team present found that his forearm is strangely angulated, no laceration on the skin, and neither paresthesia nor diminished distal pulse present. Which is the most appropriate FIRST step to help this patient?

a)

Immobilize the forearm with a splint

b)

Apply ice packs directly on the forearm

c)

Try to re-aligned the forearm

d)

Apply pressure to the forearm to stop swelling