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Total questions: 128
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A 60-year-old man has suffered a swelling in his right great toe after over eating blinjo crackers. He has a history of acute arthritis episodes affecting ankle and heels. The biopsy was then performed over him. The microscopic showed large collections of uric crystals and foreign body giant cells fill in the nodule. Your best diagnosis will be:
Synovitis chronic
Rheumatic fever
Osteo Arthritis
Gout disease
Rheumaoid arthritis
A 20 years old man worked a clerk for 5 years, since last month he has loss of sensation in his palmar and the 3 first digit. Some of the flexor muscles has no strength to move. The doctor diagnosed with Carpal Tunnel Syndrom. What nerve is most likey compressed?
N.medianus
N.radialis
N. ulnaris
N.digitalis ventralis
N.Musculocutaneus
What distinguishes cartilage from most other connective tissue?
It lacks blood vessels
Its extracellular matrix is rich in collagen
Its predominant cell type secretes both fibers and proteoglycans
Its predominant cell type is a mesenchymal derivative
It functions in mechanical support
A 34-year-old man presented with sudden excruciating pain in right arm and an inability to move after attempting to lift a weight equal to his body weight above his head in the gym. On physical examination, the patient was unable to move right shoulder, and squaring of right shoulder contour, internal rotation of the right shoulder is limited. Radiographs showed the anterior and inferior positions of the humeral head relative to the glenoid fossa. What is the most likely diagnosis for this?
Frozen Shoulder
Shoulder Bursitis
Impingement Syndrome
Rotator Cuff Tear
Anterior Shoulder Dislocation
A 58-year-old woman had a history of myocardial infarction and at this time has no symptom. Her lab shows Hb 11 g/dL (10-12), Ht 40% (37-45), Leu 6000 cells/uL (5000-10000), plt 300000/ul, serum uric acid: 11,3 mg/dL. Which of the following is the most appropriate treatment for the case above?
Sulfinpyrazone
Lifestyle modification
Allopurinol
Indomethacin
Colchicine
A 45 year-old man presented with acute pain of big toe and knee at night. Physical examination revealed inflammation of joints and a nodular lesion adjacent to the big toe. Joint fluid aspirate is performed. What fluid analysis test most likely establishes the diagnosis?
Total cell count and differential count
Cytology for malignant cell
Crystal identification by polarized microscopy
Gross appearance with assessment of viscosity
Gram stain and bacterial culture
35 years old man come with complaint of backpain and stiffness. The pain is chronic, not radiating and not changed with movement. On physical examination there's only slight tenderness and gibbus. What the most probable diagnosis?
Spondylarthrosis
Degenerative disc
Spondylitis
Spondylolisthesis
A 54 year-old nurse presents for evaluation of her arthritis. Her symptoms began several years ago with acute pain and swelling in the left ankle. This was followed 8 months later by pain and swelling in the left wrist and several joints of the fingers. Functional inquiry is otherwise completely negative. Physical examination reveals swelling and tenderness in the right 29, left 2"d 3/ metacarpophalangeal joints (MCPs), and the right 2", left 39 and 4" proximal interphalangeal (PIP) joints. There is no swelling in the elbows, wrists, knees or ankles. There are no cutaneous findings. Her general physical examination is normal. Which of the following tests will be most helpful in confirming diagnosis?
Rheumatoid factor
HLA-B27 antigen
Erythocyte sedimentation rate (ESR)
Check ANA
Serum uric acid
A female, 60 years old, complained about swelling on the right knee. No inflammation sign was found, and fluid is detected on suprapatellar space—no other joint involvement. What type of immune system is reflect the predominance cell in the case above?
Memory
Killer
Innate
Neutralizer
A 25-year-old woman presented with a firm mass in her left lateral pelvis. She felt pain in the area of the mass when lying on her side. Her past medical history was significant only for hypertension. Family history was negative for bone diseases.Physical exam revealed a bony mass that was immovable and attached to her left iliac wing. The mass was approximately 7 cm in greatest dimension. She felt mild pain with extremes of abduction and adduction of her left hip. A radiograph showed a mushroom-shaped bony excrescence joined to the iliac wing by a broad stalk. Computed tomography confirmed this and showed that the mass did not have a fibrous capsule. The patient underwent surgical removal of the suspicious bone lesion. Microscopic examination shows the findings in the figure. What is the most likely diagnosis?
Chondroma
Osteosarcoma
Osteomielitis
Osteochondroma
Ewing sarcoma
A19-year-old girl came to the clinic due to joint pain and swelling on both knee and left ankle with stiffness in the morning since 6 weeks ago. On physical examination, the involved joints were erythematous, warmth, slight tender on palpation, and limited active-passive motion. Laboratory findings showed hemoglobin 11 g/dL, leukocytes 11,500/mm3, platelets 400,000/mm?, negative ANA, positive RF, elevated C3, ESR and CRP. Which cytokine is the major target of treatment in this case?
Interferon y
IL-1
TGF B
TNFa
IL-6
When helping a baby delivery, a midwife noticed that there's assymetric number of thigh skinfolds, uneven knee levels and limitation of hip abduction. What diagnosis should be checked on the newborn?
Developmental dysplasia of the hip
Osteogenesis imperfecta
Congenital perthes disease
Athrogryphosis
Blount disease
An overweight female 60 years old presented with bilateral knee pain during activity, bowleg, and knee joint osteophyte on x-ray. What is the most appropriate treatment for this condition?
Weight loss
Knee tapping
Steroid injection
Knee unloading brace
What is an appropriate characteristic for type 1 skeletal muscle?
Rich vascularization
Large Diameter
Fast twitch glycolytic
High Glycolitic capacity
Low Oxydative capacity
A 45-year-old man has experienced pain in the area of the left hip and upper thigh for the past 7 months. On physical examination, there is tenderness on deep palpation of the left side of the groin. The range of motion at the left hip is decreased, but there is no swelling or warmth on palpation. Pelvic and left leg radiographs show an upper femoral metaphyseal mass lesion that erodes into the surrounding bone cortex. The proximal femur is excised and on sectioning has the gross appearance shown in the figure. Which of the following cell types is most likely to be proliferating in this mass?
Osteoclast
Plasma cell
Chondrocyte
Osteoblast
Primitive neuroectodermal cell
A patient suffered a complete tear of biceps brachii muscle at its insertion site at the radial tuberosity. For proper treatment, you must identify the damaged tissue. Which of the following tissue was damaged at the tear site?
Loose areolar connective tissue
Dense irregular connective tissue
Dense regular connective tissue
Reticular tissue
Elastic tissue
On first prenatal ultrasound exam, the fetus seems to have normal and complete limb, however when born the infant have only one hand. What error that most probably happen in growth and development?
Dysplasia
Malformation
Deformation
Disruption
Herniated intervertebral disc characterized by radiating pain due to compression of spinal nerve. Part of the anatomical structure that compresses the spinal nerve at herniated intervertebral disc is:
Annulus fibrosus
Intervertebral disc
Vertebral body
Vertebral arch
Nucleus pulposus
A child, 6 years old, present to emergency room with fever and pain over his left knee since yesterday. There is exquisite tenderness on left proximal tibia, and mild local swelling. No history of injury. What is the most appropriate laboratory work up should be done?
Liver function
ASTO
Rheumatoid factor
Blood culture
Electrolytes
A 52 year old man has been taking aspirin for rheumatoid arthritis for 8 months. Exacerbations are becoming worse, and she asks her physician about drugs that might stop the progression of the disease. Which of the following is the most appropriate drug of choice?
Celecoxib
Cholchicine
Methotrexate
Prednisone
Sodium diclofenac
A 8 year old boy came with pain on left hip and inability to walk. He was diagnosed with leg-calves and perthes disease. Which of the following happened on his left hip?
Dyschondrosis of medial physis of proximal femur
Avascular of capital epiphysis of the femur
Adecrease in the amount of normal Type | collagen
Displacement of the capital femoral epiphysis from the metaphysis through the physis
A 5-year-old girl is on skin traction after fractures her left femur 3 weeks ago. Now the physician removed the traction and found that the fracture fragment is not displaceable anymore but there is still some movement on fracture site with mild tenderness. What is the most likely phase of healing?
Hard callus phase
Clinical union phase
Soft callus phase
Initial bleeding phase
Proliferation phase
The major lubricant for diarthrotic joints is synthesized by
Nucleus pulposus
Synovial membrane
Fibrous capsule
Articular cartilage
Annulus fibrosus
30 years old woman have a chronic back pain and weak both lower legs, after series of examination the woman is diagnosed with tuberculous spondylitis. Which of the following test can set the definitive diagnosis?
Inhomogeneous appearance abscess in MRI
End plate destruction on vertebral x-ray
Positive result on tuberculin skin test
Positive culture of mycobacterium in biopsy result
A male, 65 years old, presented with pain in the right hip, especially during prolonged walking, since 3 years ago. She had painful and limited right hip internal rotation. What is the appropriate next step to confirm the diagnosis in this case?
Rheumatoid Factor and anti-CCP
CRP and ESR laboratory
Hipx-ray
Hip Ultrasound
A 47 year-old male presents to the Emergency Department with acute onset of lower back pain radiating posteriorly down the right leg into the outer edge of the foot. On examination, plantar flexion of the ankle is weakened and ankle reflexes are absent on the right side. What is the most likely diagnosis?
Acute disc prolapsed
Vertebral osteomyelitis
Mechanical back pain
Vertebral fracture
Spinal stenosis
An 80-year-old woman who lives independently at home presents with low back pain in the setting of a fall. She slipped on a wet floor in the kitchen. Blood tests reveal a haemoglobin of 10.5 g/dL (NR12.0 - 16.0 g/dL), a normal white blood cell count, but an elevated ESR. X-rays of the lumbosacral spine reveal a compression fracture of L4, and multiple lytic lesions of her thoracic spine are seen on chest X-ray. What is the most likely diagnosis?
Ankylosing spondylitis
Multiple myeloma
Fibromyalgia
Metastatic carcinoma
Osteoarthritis
An 85-year-old woman has been confined to a nursing home for the past 6 years. Bone density scans suggest that she has osteoporosis. Although the amount of calcium in her diet is adequate, she cannot absorb enough of it to maintain bone mineral density. One factor likely contributing to her condition is insufficient production of which substance in the dermis of her skin?
Vitamin D
Calcitonin
Parathormone
Melanin
Vitamin A
A 65-year-old woman reports pain on her knees and difficulty walking. She can walk in the grocery store, but the pain come when she tries to go up and down the stairs and when standing from a sitting position. She also felt stiffness on both of her knees. After seeing a doctor, she is diagnosed with 3™ stages of knee osteoarthritis. On physical examination, which muscles that most probable to became atrophy?
Anterior tibialis
Gastrocnemius
Hamstrings
Quadriceps
A 5 years old boy fall down when jumping on the bed. His mom brought him to ER few hour after the fall. The doctor diagnosed him with fracture of the forearm. Which fracture is common in children?
Burst fracture
Green stick fracture
Bennet's fracture
Coles' fracture
Montegia fracture
A 20 yrs old tennis champion complains a paralyzed to extend his antebrachii and his hand. What nerve is the most likely injured?
Ulnar n
Axillar n
Radial n
Musculocutaneus n
Median n
A 60 year old man complains about stiffness and pain in the back after activity. Radiographic examination reveals narrowing of L4-5, L5-S1 disc space. What is the most possible cause of the complaint?
Annulus fibrosus tear
Osteoporosis
Loss of nucleus pulposus chondroitin sulfate
Facet joint degeneration
Increase disc water content
Which of the following statements about pathogenic mechanisms in autoimmunity is CORRECT:
In Graves' disease, an auto-antibody found commonly in patients binds to the TSH receptor and kills the thyroid cell
In systemic lupus erythematosus, the various anti-nuclear antibodies produced in the patient are highly pathogenic because these can bind to the nuclear antigens and cause the cell to undergo apoptosis
Cytotoxic T cells do not play a major role in autoimmune diseases because the auto-antigens involved are either nucleic acids or carbohydrates
Rheumatoid factors are DNA-anti-DNA immune-complexes found in arthritic joints
Relief can be obtained in some autoimmune diseases by blocking the effects of the inflammatory cytokines produced
A 36-year-old woman has noted a nodule beneath the skin in her left groin since adolescence. On physical examination, the lesion has a 2-cm diameter and is nontender, soft, rubbery, and movable. Microscopic examination shows the findings in the figure. Which of the following cell types is most likely to comprise this lesion?
Fibroblast
Adipocyte
Endothelial cell
Skeletal muscle
Smooth muscle
A radiographic film from a 60-year old woman shows a complete right femoral neck fracture just only caused by a minor fall. In Examination serum calcium level is normal. Bone density examination shows T-score = -2.5 Which of the following condition factor is the most contributing factor for this fracture?
Vitamin D deficiency
Post menopausal bone loss
Osteomyelitis chronic
Parathyroid adenoma
Calcium deficiency
While examining a piece of tissue taken from the epiphyseal plate, you noticed large cells arranged in rows. Which of the following layers are you examining?
Calcified zone
Proliferative zone
Hypertrophy zone
Resting zone
What is the neuro muscular junction?
The the releasing place of the neurotransmitter acetylcholine (ACh) from post synaptic terminal
The part of the sarcoplasmic of the muscle cell that is in closest proximity to the synaptic end bulb
The meeting point of a nerve fibre and the muscle fibre that it supplies
The point of action potential traveling in the T tubules reaches the sarcoplasmic reticulum
The production place of the neurotransmitter acetylcholine (ACh) in post synaptic terminal
65 years old lady came to your office with complain if pain on her lower back. The pain especially felt after she plays with her 1years old grandson. Low Back Pain is always associated with:
Fever
Chronic Stress to the lumbar spine
Arthritis of facet joints
Prolapsed intervertebral disc
Back muscle tightness or spasm
A 65-year-old woman reports pain on her knees and difficulty walking. She can walk in the grocery store, but the pain come when she tries to go up and down the stairs and when standing from a sitting position. She also felt stiffness on both of her knees. After seeing a doctor, she is diagnosed with 3™ stages of knee osteoarthritis. What pathology in the knees that is the main cause that the knees become stiff?
Osteophyte formation
Cartilage destruction
Subchondral bone destruction
Capsular fibrosis
A 56-year-old female complaining of pain on her left knee, usually worse following activity since few months ago. There's also stiffness that worsen after sitting for prolonged periods of time. The findings from the conventional X-ray of left knee are narrowing of the joint-space, osteophytes formation, and subchondral sclerotic. What is the basic pathomechanism in the case above?
Porotic bone
Synovial membrane inflammation
Cartilage degradation
Meniscus tear
Ligament weakening
A male 60 years old complained of a sudden swelling of the left knee. The patient sometimes felt calf muscle spasms, otherwise healthy. He suffered several times left knee swelling before. There was a palpable bony enlargement of the knee. What is the least possible condition?
Gout arthritis
Septic arthritis
Rheumatoid arthritis
Knee osteoarthritis
Neoplams
While examining a piece of supporting tissue taken from a knee joint, you noticed many cells located in lacunae, some of which are grouped into clusters of two or more cells. The matrix is homogenous. Which of the following supportive tissue are you examining?
Fibrous cartilage
Hyaline cartilage
Compact bone
Elastic cartilage
A 40-yr-old man was admitted to hospital suffering from tuberculosis. A pathologist discovered central caseous necrosis surrounded by epithelioid macrophages in an area affected by the bacterial infection. Which type of inflammation is most likely associated with this patient's infection?
Chronic active
Chronic suppurative
Ulcer
Acute suppurative
Granulomatous
While examining a piece of supportive tissue taken from the vertebral column, you noticed rows of cells, in lacunae, between collagen fibers. Which of the following supportive tissue are you examining?
Fibrous cartilage
Hyaline cartilage
Elastic cartilage
Compact bone
A 20 year old girl had fractured her right humerus in a car accident 2 weeks ago. The fracture did not heal properly, and developed a purulent infection of the skin around the site of fracture. An X-ray revealed a focus bone loss near the lower end of the humerus. Curettage biopsy was performed. Microscopic appearance showed a sequestrum, inflammatory cells proliferation and granulation tissue. What is the most likely diagnosis base on microscopic appearance?
Acute Osteomyelitis
Osteoarthritis
Chronic non spesific osteomyelitis
Chronic spesific osteomyelitis
Rheumatoid arthritis
A male 60 years old complained of a sudden swelling of the left knee. The patient sometimes felt calf muscle spasms, otherwise healthy. He suffered several times left knee swelling before. There was a palpable bony enlargement of the knee. What is the appropriate next step to confirm the diagnosis in this case?
Knee Ultrasound
Joint aspiration and fluid analysis
Rheumatoid Factor and anti-CCP
CRP and ESR laboratory
A 5 years old boy fall down when jumping on the bed. His mom brought him to ER few hour after the fall. The doctor diagnosed him with fracture of the forearm. This boy was put on an arm cast for 4 weeks, on the 3" weeks. What would you probably see on the plain xray of the forarm?
Normal bone with periosteal thickening
Undistinguished fracture site
Osseous callus
Porotic bone on fracture site
Clear fracture line
Which area in cartilage is relatively proteoglycan-rich and collagen-poor?
Perichondrium
Interterritorial matrix
Fibrocartilage
Territorial matrix
Epiphyseal plate
A female 60 years old presents with severe bowlegs and pain in both knees during activities. What is the force change in this condition?
Increase Abduction moment
Decrease Extension moment
Increase rotation moment
Increase Adduction moment
Decrease flexion moment
Mr. Bachtiar, 75 years old, he suddenly could not walk because fell very pain in his right Leg. Which of these nerves make the basis of the lumbar plexus?
L5-S1
L1-L4
L1-L5
L2-L4
L2-L5
A 65-year-old man complaint about chronic right knee pain during activity. During arthroscopic examination, the physician found fibrillation and softening of tibial and femoral cartilage. What is the most probable substance that responsible for the cartilage condition?
TNF
Lipase
VEGF
Protease
IL1
A man 38 years old had upper arm muscle sore after he exercised weight training. He went to the doctor and doctor suggested weight training with the multigym and also aerobic training. What is the eccentric isotonic contraction?
The muscle lengthens as it contracts maintaining force and movement
The length of muscular remains constant during contraction
The maximal contraction at constant speed over the full range of movement
The muscle shortens to produce force and movement
Tension remains constant as the muscle shortens or lengthens
Which of the following most accurately describes compact bone?
Predominant bone type in the epiphysis of adult long bones
Lines the medullary (marrow) cavity
Also known as cancellous bone
Characterized by the presence of osteons
Forms the diploe in cranial bones
A 75 year-old widow complains of generalized aching in her bones, and a gradually increasing curvature of her upper spine. An X-ray shows osteopenia and vertebral changes. Serum calcium, phosphate, alkaline phosphatase and a blood screen, including ESR, are all normal.
What is the most likely cause of this condition?
Osteoporosis
Hyperparathyroidism
Multiple myeloma
Hyperthyroidism
Vitamin D deficiency
A15-year-old adolescent boy presented with a swelling of the distal femoral that was growing slowly during the 3-month period prior to presentation. The swelling became painful after a minimal injury caused by a fall. A firm, palpable mass was present on physical examination. The remainder of the findings from the examination were unremarkable. Radiography showed a heterogeneous mass measuring 8 cm in length on the distal femoral metaphysis. Magnetic resonance imaging demonstrated a well-defined periosteal lesion with a cortical lysis but without involvement of the medullary cavity. The gross appearance shown in the figure. What is the most likely diagnosis?
Enchondroma
Chondroma
Leiomyosarcoma
Fibrous dysplasia
Osteosarcoma
While moving into a new apartment a student lifting a heavy box of books experiences a sharp pain in his back, radiating down the anterior thigh and medial side of his leg. After several days of misery, he finally goes for treatment and is told that he has a herniated intervertebral disk at the L3 level which is compressing a spinal nerve where it exits the vertebral column. Where is the point of compression?
Foramen magnum
Vertebral foramen
Intervertebral foramen
Hiatus of the sacral canal
Central canal
A 50-year-old male, presented with right painful tibial bone fracture since 3 month before. X rays show segmental fracture on tibia diaphyses with minimal callus. One month latter, the pain still persists. Another x-ray was taken, with atrophic changes of bone at the facture site. What is the most likely diagnosis?
Malunion
Delayed Union
Reflex simphatetic dystrophy
Avascular necrosis
Non union
30 years old male has a chronic discharging sinus from his left leg. He had tibia fracture 1year before and was taken care by traditional bone setter. He is able to walk with some bowing and shortening of the left leg, only sometimes he feels pain on the leg. What is the most probable finding on leg x ray?
Involucrum
Fracture nonunion
Sun burst appearance
Abscess
Brodie's lesion
A 30-year-old man brought to your clinic after falling from 29 floor balcony 15 minutes ago. He is drowsy and barely conscious. On examination you found an oddly angled right femur with blood oozing from a pin point wound Which of the following category is best to describe this condition?
Open fracture grade 1
Open fracture grade 3B
Open fracture grade 3A
Open fracture grade 2
Open fracture grade 3C
A male 66 years old complained of a sudden swelling of the left knee. Synovial fluid analysis is taken and the result is The appearance of Calcium pyrophosphate dihydrate crystals. What is the possible condition?
Rheumatoid
Pseudogout
Osteoarthritis
Infection
Gout
What is the neurotransmitter in neuromuscular skeletal muscle junction?
Norephinephrine
Ephineprine
Acetyl choline
Dopamine
Serotonin
A 34 year old man came with pain in his left knee since 2 weeks especially in the morning more than 1.5 hours. He also felt pain in his achilles. 1 month before there was history of chronic diarrhea. The rheumatic factor was negative. What is the most probable diagnose for his problems?
Rheumatoid arthritis
Osteoarthritis
Reactive arthritis
Gout arthritis
Osteonecrosis
A male 68 years old presents with chronic left hip pain with osteophyte and joint space narrowing. The patient also has a history of peptic ulcers. What is the first line of pharmaceutical management in this patient?
Tramadol
Topical NSAID
COX-2 inhibitor
Hyaluronic acid injection
A 19-year-old with hormonal imbalances came to hospital for upper right femur fractured. The X-ray showed well circumscribed lesion and a partly cystic. A curretage biopsy was performed and its microscopic showed fibrous tissue proliferated that containing “claw (U)-shape” configuration of bone trabeculas. What is the most likely diagnosis you may describe to him?
Ganglion cyst
Fibrous dysplasia of the bone
Chondroblastoma
Osteomyelitis tuberculosa
Osteomyelitis chronic
Quasimoto, the "Hunchback of Notre Dame", suffered from an abnormal thoracic curvature called kyphosis. In this condition the accentuated convexity of the curvature is:
Posterior
Caudal
Lateral
Anterior
Media
A 10-year-old boy was brought to a clinic because of back pain for around one month, especially while bending. His mother also noted that her son’s left shoulder is slightly higher than the right. On physical exam the doctor found that Adam’s test was positive but no length discrepancy. What is the most appropriate examination do diagnose this patient?
Standing PA & mp; lateral X-ray
Supine lateral X-ray
Spine MRI
Left lateral decubitus X-ray
Spine CT-scan
What will happen in the forcible over stretch muscle?
Muscle atrophy
Muscle contracture
Muscle dystrophy
Muscle injury
Musclespasticity
Amin 15 years old boy felt down from the stairs then the radiograph showed that his joint between clavicle and scapula was fracture. What part of the scapula articulates with the clavicle?
Spine process
Acromion
Coracoid process
Supraglenoid tubercule
Infraspinous fossa
Mr. Budi, 54 years old was felt down when he was hit by the truck. The radiograph demonstrated the fracture of fibula. Which nerve of the leg wraps around the neck of fibula?
Femoral
Deep fibular
Tibial
Superficial fibular
Common fibular
A0 year-old boy developed high fever, chills, and worsening leg pain. His upper left leg started to hurt 3 to 4 days ago, and last night he began limping. His parent reports no history of trauma to the area. His only past medical history is two episode of otitis media (infection in the ear) at age 2 and 7. There were localized tenderness and swelling over the left distal femur. WBC count is 11.500 cells/uL; normal differential count, but ESR is 58 mm/hour. The blood cultures obtained and revealed Gram (+) cocci. How is the boy getting this illness?
Lymphogenic
Direct spread
Air-borne
Hematogenous
Fecal-oral
A mother come to outpatient department because of concern that her 9 months old baby boy seems to have bow leg. When the boy starts to stand she noticed that both of his leg seems bowing on the knee. There's no history of trauma or other anomaly. What would probably be the problem?
Post traumatic bow leg
Infection
Congenital demoral deficiency
Unilateral blount disease
Normal knee
A6 year-old has had a hard painless lump on the medial aspect of his knee for at least eight years. It caused no problems until he was kicked in the area of the lump during football game
what is most likely diagnosis?
Osgood-Schlatter disease
Osteochondritis
Osteomalacia
Osteosarcoma
Osteochondroma
A 30-year-old woman has experienced pain in the area of hands and feet. On physical examination, there is a mass and slowly growing, no erythema or warmth. A radiograph shows a 7-cmn mass in the metaphyseal region of small tubular bones of the hands and feet. Microscopic examination shows the findings in the figure. What is the most likely diagnosis?
Chondroma
Osteitis fibrosa cystica
Osteoblastoma
Plasmacytoma
Giant cell tumor
A female, 60 years old, complained about swelling on the right knee. No inflammation sign was found, and fluid is detected on suprapatellar space—no other joint involvement. In this case, the synovium is predominance by:
Lymphocyte T
Lymphocyte B
Macrophage
Neutrophil
A 38-year-old woman has recent onset of cold ngers, joint pain, fever, weight loss, and a facial rash. Examination reveals a symmetrical inammatory arthropathy, a rash over her face and neck, and lymphadenopathy. Investigations reveal thrombocytopenia, normal urine examination, and a strongly positive anti nuclear antibodies (ANA). What is the most likely diagnosis?
Rheumatoid arthritis
Gout
Systemic lupus erythematosus
Septic arthritis
Acute osteoarthritis
A male 70 years old presents with chronic left hip pain with osteophyte and joint space narrowing. The patient also has a history of peptic ulcers. What is the first line of pharmaceutical management in this patient?
Hyaluronic acid injection
Tramadol
Topical NSAID
COX-2 inhibitor
A 6 months old baby presents with fever, drowsy, irritable, and swelling of her left hip. She doesnt want to move her left extremity. X ray show metaphyseal proximal femoral bone destruction and hip joints swelling. The most common cause of this condition is
Streptococcus group B
Gram negative bacilli
Staphylococcus aureus
Pseudomonas aeroginosa
A 55 year old male has a history of episodes of a painless nodule with overlying ulcerated skin at his big toe. Beneath the eroded skin is a chalky white deposit of soft material surrounded by erythematous soft tissue. Microscopic appears a collection of lamentous urate crystals. This nodule is most consistent with which of the following lesions?
Tophus
Osteophyte
Furuncle
Pannus
Granuloma
While examining a “bony” tissue taken from the epiphyseal plate, you noticed several layers of cells. One of these layers consists of rows of attened cells, arranged like a stack of coins. Which of the following layers are you examining?
Hypertrophied zone
Proliferative zone
Calcied zone
Reserve/resting zone
A patient, male 50 years old, presents to a clinic with briefly left knee stiffness in the morning and pain following prolonged walking. On x-ray examination, a knee osteophyte was found. The disease processes arise from all these tissue, except:
Peripheral blood vessels
Bone
Intraarticular fat
Cartilage
Synovium
A 60-year-old woman came with a complete left femoral neck fracture after fell from tricycle (becak). The bone mineral density examination showed it is less than -2.5. Microscopic examination showed that the bone cortex becomes thinner and the trabeculae have less complex branching. The most significant contributing factor for this fracture is:
Immobilization osteoporosis
Multiple myeloma
Senile osteoporosis
Vitamin D deciency
Hyperthyroid
Female, 60 years old, complaint about pain and stiffness of her left knee. The doctor nds cartilage softening during knee arthroscopy. What is the earliest change that happened at the cartilage?
Decrease collagen
Decrease proteoglycan
Chondroblast death
Vascular invasion
A 76 year-old lady developed vertebral osteomyelitis. Her blood culture grew Gram-positive cocci arranged in clusters. What is the most likely etiological agent?
Streptococcus pyogenes
Staphylococcus aureus
Streptococcus pneumoniae
Enterococcus faecalis
Viridans streptococci
A 5 years old boy fall down when jumping on the bed. His mom brought him to ER few hour after the fall. The doctor diagnosed him with fracture of the forearm. What is the phase of bone healing happening when this boy come to the ER?
Remodelling
Consolidation
Haematoma and inamation
Callus formation
6 months ago, 25 years old university student twisted her knee and heard a popping sound. Swelling developed within two-hours after the injury. Now, there is no more swelling but she feels her knee unstable. Which test would be most appropriate to use for examination of the cruciate ligaments of the knee?
Plain radiograph
Radio-isotope scan
Magnetic resonance imaging
Computed tomography
Ultrasound
Mrs Rani is 66 years old and has four adult children. She is on Hormone replacement therapy. She has always been a homemaker and a life-long non-smoker. She developed late onset asthma ve years ago, requiring regular oral as well as inhaled steroid therapy. Asthma has limited her physical activity, although she was never someone who enjoyed exercise anyhow. Two weeks ago, she tripped over her cat and fractured her left hip. Which investigation is the most useful to diagnose this patient?
Dual X-ray absorptiometry
Multiple-site magnetic resonance imaging
Femoral neck ultrasound
Plain X-ray of the spine
A 58 year-old woman was admitted to the hospital with a two-month history of pain, swelling and purulent discharge to her left lower leg. This occurred one year after sustaining a fracture to that area. Colonies grown from the purulent discharge on blood agar were convex and appeared golden yellow. What is the most likely diagnosis?
Wound infection caused by Sporothrix schenckii
Arthritis caused by Streptococcus pueumoniae
Osteoarthritis caused by Neisseria gonorrhoeae
Osteomyelitis caused by Staphylococcus aureus
Osteomyelitis caused by Haemophilus inuenzae
Mr. Adi, 34 years old was felt down when he climbed the tree. The radiograph demonstrated the fracture of talus. What is the most appropriate reason that fractures of the talus have minimal displacement?
It is a tiny bone
It is an irregular bone
It is place over the calcaneus
Attached muscles pull the fragments apart
Malleoli hold the fragments in place
A 20 year old man complains of sharp and almost constant pain in the region of the right knee. this pain has been present for two months and is associated with swelling of the knee. on admission to hospital a radiograph reported as follows: " bulky, scletorit lesion in the lower end of the femur. The lesion extends to the surrounding extra-osseus tissue with transverse 'sunray' streamers of radio-opacity". what is the most likely disorder of the bone?
Osteosarcoma
Hyperparathyroidism
Metastatic cancer
Osteomyelitis
Paget's disease
30 year old woman hit by a car, fell down on her arm. cannot abduct her arm. the radiograph showed fracture of proximal humerus, what vessel is the most possible injured?
ulnaris
axillaris
radialis
brachialis
profunda brachii
A man 30 years old felt very tired after half marathon training. What is the nerve for maintaining a muscle tonus in sustained stretch?
Static γ fiber to nuclear chain fiber of intrafusal skeletal muscle
Dynamic γ fiber to nuclear chain fiber of intrafusal skeletal muscle
Static γ fiber to nuclear bag fiber of intrafusal skeletal muscle
Dynamic γ fiber to nuclear bag fiber of intrafusal skeletal muscle
Static γ fiber to nuclear chain fiber of extrafusal skeletal muscle
A 15-year old girl complained of severe pain in his left knee after vigarous exercise for 4 weeks. The knee joint has been swollen and red then she cannot extend her leg. The doctors diagnosed her with stress fracture. The MRI showed tear of patella ligament. Which structure of the bone is inserted by those ligament?
Capitulum fibulae
Malleolus lateralis
Crista tibialis
Tuberositas tibia
Condyle medialis
A 50-year-old woman has experienced pain in lumbar joints for several months. Radiographic examinations show Bamboo’s spine. Physical examination reveals several nodules in her small joints in the hands and feet. Histology of the nodule after biopsy shows a central fibrinoid necrosis, surrounding by palisading epithelioid macrophages. The best diagnostic is
Rheumatoid arthritis
Osteoid osteoma
Gout diseases
Chronic osteomyelitis
Osteo-arthritis
Which of the following cell is the most involved in remodelling process?
Osteoblast
Osteocyte
Osteon
Osteoid
Osteoclast
A 10-year-old girl was admitted to the hospital due to a draining sinus on the right leg for 2 years. She has chronic osteomyelitis that is multi-resistant to antibiotics. What is the most probable cause of multi-resistance?
Abscess
Septicemia
Sequestrum
Involucrum
Cellulitis
12-year old boy admitted to hospital with the complaints of fever, chills, local swelling and pain at his left leg after an accident 3 weeks ago. An x-ray of his femur showed bone destruction, necrosis and new bone formation. A clinical diagnosis of bone infectionw was made. What additional diagnostic information should be obtained before this boy received his first dose of antibiotic?
Complete blood count
Serum creatinine and blood urea nitrogen (BUN)
MRI scan
Procalcitonin level
Culture of bone aspirate
Whike examining a piece of bone tissue you noticed a structure consisting of circular layers surrounding a tube in the centre. Which of the following structures are you examining?
Haversian canal
Lamellae generals
Lamella interstitials
System Havers
What is the definition of muscle tone
The resistance of the active or passive stretched muscle
The minimum resistance of the unstretch muscle
The maximum resistance of the moderate contraction muscle
The maximum resistance of the overstretch muscle
The minimum resistance of the overstretch muscle
A patient was hit by a motorcycle from the side. She has pain on shoulder and x ray fracture of proximal humerus then she cannot abduct her arm and impairment of muscle. What nerve is most likely affected
N. Ulnaris
N. Medianus
N. Radialis
N. Axillaris
N. Musculocutaneous
Which cell makes osteoid and promote mineralization in fracture healing leading to bone strength?
Osteoblast
Osteoclast
Chondroblast
Chondrocyte
Osteocyte
A man 58 years old felt his right arm muscle became easy to fatigue and weak after recovery from right arm bone fracture. Hisphysician said he got muscular atrophy and his connection between nerve and muscular was good. What is muscular disuse atrophy?
The reducing flow of nerve impulses to the inactive muscle because they are not used
The reducing flow of nerve impulses to the inactive muscle because a muscle's nerve impulses cease
The reducing flow of nerve impulses to the inactive muscle because the damage to the nerves that control them
The progressive degradative action of enzymes that is generally associated with severe cellular trauma
The muscle suffer a vital loss of protein and muscle fibers are replaced gradually by fat and connective tissue
In sciatica which muscle is most likely affected?
gracillis
adductor magnus
Sartorius
gastrocnemius
Rectus femoris
Radiograph shows fracture of proximal femur. What structure is most likely injured?
Condyles laterales
Epicondyles medialis
Linea aspera
Acetabulum
Trochanter major
A 30 year old woman was hit by bycicle and fell down on her arm, she cannot abduct her arm what muscle was most likely affected?
Deltoideus
Biceps brachii
Supraspinatus
Subscapularis
Teres mayor
On a regular checkup of a 6-week-old female infant you note positive Ortolani test on the left side. You suspect the patient is having DDH so you decided to refer the patient to orthopaedic specialist. On consultation, you try to explain to the parents the most probable initial treatment for this patient.
Observation
Closed reduction and internal fixation
Open reduction and internal fixation
Open reduction and cast
Conservative protection with Pavlik harness
In the impairment of muscle insterted to the proximal femur, what movement of the thigh is the most probably disturbed?
Medial rotation
Lateral Rotation
Flexion
Extension
Abduction
A man 38 years old had sore upper arm muscle after he helped to push a heavy cart to the side of street. He went to the doctor and doctor said possibly he had muscle strain.
A muscle strain is caused by:
Inflammation of ligament
Inflammation of muscle fibers
Over stretching ligament
Excessive stretching or working of the muscle
Very forceful, repetitive muscular activity
A 42-year-old woman came to the hospital with complains of sharp pain on the upper back in the last 5 months. She also said that 2 years ago she underwent bilateral ovarian cyst surgery. Physical exam reveals tenderness on the thoracic region, no swelling, and no redness. What is the most likely diagnosis in this case?
Posterior rib fracture
Muscle spasm
Herniated nucleus pulposus
Osteoporosis
Spondylitis
this guy cant extend his forearm, what muscle is prolly impaired
Supraspinatus
Subscapularis
Teres mayor
Triceps brachii
deltoideus
Mr Alan 48 years got infection and swelling at his hand. He went to the hospital and he was given the antibiotic. After 2 weeks his hand healed but he could not bend his finger normally. His doctor said his finger possibility suffered muscular necrosis and became contracture. What is the process in muscle contracture?
The non stretchy Fibrous tissue replace the connective tissue of the muscle fiber
The fat gradually replace the muscle fibers and connective tissue
The progressive degradative of muscle fiber
The non stretchy Fibrous tissue replace the normally stretchy (elastic) tissues
The Progressive loss of myofibril
Male 57 years old complaint of chronic right hip pain after sports activities. The doctor found osteophyte on hip x ray, and bone marrow lesion on MRI. Histologically, it contains vascular infiltration. What does the lesion on the case signify?
Effusion
Injury
Inflammation
Instability
Progression
Perferred treatment for infant diagnosed with CTEV or clubfoot
Stretching and serial casting with Ponseti method
Open reduction surgery
Bone reconstruction
Physiotherapy and observation
Soft tissue surgery
The most common sequelae of tuberculous spondylitis in adolescent are
Pathological dislocation
Bony ankylosis
Chronic osteomyelitis
Fibrous ankylosis
Vertebral body fusion
Which muscle is inserted into proximal femur
gluteus maximus
rectus femoris
semitendinosus
vastus medialis
biceps femoris
A woman 60 years old felt her muscle became easy to fatigue and weak. Her physician examined her and found her muscle tone and muscle strength is lesser than normal. What will happen in the length tension relationship if the muscle is over stretched?
The over stretched muscle will develop little tension
The over stretched muscle will produce a relatively maximum contraction
The over stretched muscle will produce a relatively weak contraction
The over stretch muscle will develop maximum tension
The over stretched muscle will produce an optimal contraction
Mrs Ani is a 50 year-old woman, has painful, symmetrical swelling of her metacarpophalangeal (MCP) joints, and has recently found it difficult to wash clothes. She gained some relief from ibuprofen tablets, which she was able to buy in a small quantity from pharmacy. What is the mechanism of the drug given above?
Inhibits cyclooxygenase enzymes
Selectively inhibit COX-2
Similar to anti-inflammatory corticosteroid
Increases the local production of prostaglandins at sites of inflammation
A 60 years old woman fell down then felt very pain in her right muscle of medial thigh and could not adduct her thigh which nerve is probably injured?
N. obturator internus
N. tibialis
N. Femoralis
N. peroneus superficialis
N. glutealis superior
What are special features of fractures in children that support the treatment plan of fracture (cast immobilization and closed reduction)?
Thick periosteum
More frequent torn ligament and dislocation
Frequent joint stiffness
Diagnostic problem due to secondary ossification of epiphyseal plate
A 35 year old man came to physician with solid mass in his right parietal. Physical examination noted that the tumor is not mobile but solid and hard consistency. The X-ray imaged neither distortion nor destruction on that right parietal's bone. Curettage biopsy was performed. What is the most likely diagnosis base on microscopic appearance?
Osteoma
Giant Cell tumor
Fibrous dysplasia
Chondroblastoma
Chondroma
A contraction in which the tension remains constant as the muscle shortens is said as
concentric contraction
eccentric contraction
isometric contraction
isokinetic contraction
isotonic contraction
Mrs Rani is 66 years old and has four adult children. She is on Hormone replacement therapy. She has always been a homemaker and a life-long non-smoker. She developed late onset asthma five years ago, requiring regular oral as well as inhaled steroid therapy. Asthma has limited her physical activity, although she was never someone who enjoyed exercise anyhow. Two weeks ago, she tripped over her cat and fractured her hip. What is most likely to cause bone loss?
Estrogen replacement therapy
Regular exercise
Large doses of glucocorticoids
Excess osteoblastic activity
claw hand which nerve
medianus
musculocutaneous
radialis
axillaris
ulnaris
5 years old boy presents to emergency department with intense pain on his left upper leg since yesterday.
He has refused to walk since yesterday because of pain. No history of injury. He has some fever and sore throat since 3 days ago. On physical examination, point tenderness was found on proximal left tibia. No abnormality detected on cruris x ray. What is the most appropriate response to this condition?
Hospital admission and IV antibiotic treatment
Cold pack several times a day
Outpatient follow up
Order Magnetic Resonance Imaging
Pain management
A 20 yrs old tennis champion complains a problem when the forearm is extended. The examination of X-ray shows fracture of distal humerus and the inferior fragment of humerus directed to the posterior part of the arm. What signs of nerve injured by the fracture above?
Inability to flex the wrist
Loss of sensation of palmar manus
Claw hand
Inability to extend the hand
Inability to extend the forearm
Before taking further treatment, the doctor gave her non-narcotic analgetic to reduce the inflammation and pain. It was also known that the patient are 6-month old pregnant. Which of the following is the most appropriate NSAID for this patient
Ibuprofen
Acetaminophen
Aspirin
Mefenamic acid
Methampyrone
A 65 year-old woman presents with pain, stiffness and swelling of her knees. Physical examination reveals marked knee crepitus. Reconstructive surgery is performed and the resected bone reveals destruction of the articular cartilage. Which of the following BEST describes the etiology of this woman's disease?
Deficient enzyme in the metabolic pathway involving tyrosine
Deposition of needle-shaped negatively birefringent crystals
Presence of anti-IgG autoantibodies
Wear and tear destruction of articular cartilage
A 65 year-old woman presents with pain, stiffness and swelling of her knees. Physical examination reveals marked knee crepitus. Reconstructive surgery is performed and the resected bone reveals destruction of the articular cartilage. Which of the following BEST describes the etiology of this woman's disease?
Deficient enzyme in the metabolic pathway involving tyrosine
Deposition of needle-shaped negatively birefringent crystals
Presence of anti-IgG autoantibodies
Wear and tear destruction of articular cartilage
A 19-year-old footballer was sidelined after falling in a game. You as a first aid team present found that his forearm is strangely angulated, no laceration on the skin, and neither paresthesia nor diminished distal pulse present. Which is the most appropriate FIRST step to help this patient?
Immobilize the forearm with a splint
Apply ice packs directly on the forearm
Try to re-aligned the forearm
Apply pressure to the forearm to stop swelling
