Font size
WorksheetsPharmacology Quiz
Total questions: 53
Worksheet time: 32mins
Pharmacodynamics is defined as…
What is Pharmacokinetic?
The four main processes in pharmacokinetics are…
ADME (Absorption, Distribution, Metabolism, Excretion)
Administration, Dilution, Monitoring, Elimination
Accumulation, Diffusion, Modification, Excretion
None of the above
Absorption is defined as…
Passage of drug into urine
Passage of drug into bile
Passage of drug from site of administration into bloodstream
Distribution of drug to tissues
Which is an enteral route of drug administration?
Oral
Intravenous
Intramuscular
Inhalation
Which is a parenteral route of drug administration?
Rectal
Oral
Intravenous
Sublingual
Which is a topical route of drug administration?
Rectal
Oral
Subcutaneous
Skin ointment
The cell membrane is mainly composed of…
Proteins only
Lipid bilayer with proteins
Carbohydrates only
RNA and DNA
Water moves freely across cell membranes by…
Active transport
Facilitated diffusion
Osmosis
Pinocytosis
Which is a type of passive transfer of drugs?
Active transport
Facilitated diffusion
Simple diffusion
Pinocytosis
Which process requires energy?
Filtration
Facilitated diffusion
Active transport
Osmosis
Which process involves engulfing particles into vesicles?
Exocytosis
Endocytosis (Pinocytosis)
Facilitated diffusion
Osmosis
Simple diffusion occurs…
Against concentration gradient
Along concentration gradient
Only with carriers
Only with energy
Which factor increases diffusion of a drug?
High ionization
High lipid solubility
High polarity
High hydrophilicity
The greater the lipid/water partition coefficient…
The slower the diffusion
The greater the diffusion
No effect on diffusion
Stops the diffusion
In alkaline urine, weak acids are…
More unionized
More ionized → excreted rapidly
Unaffected
Converted into bases
In acidic urine, weak bases are…
More ionized → excreted rapidly
More unionized → retained
Not excreted
Absorbed again
Cmax represents…
Lowest plasma concentration
Maximum plasma drug concentration (peak)
Time to reach peak concentration
Total drug absorbed
Tmax represents…
Total amount of drug absorbed
Time to reach peak plasma concentration
Maximum concentration of drug in plasma
Bioavailability
AUC represents…
Peak concentration of drug
Time of maximum concentration
Total exposure of body to drug (extent of absorption)
Elimination rate
Bioavailability is defined as…
Rate of drug distribution
Proportion of unchanged drug reaching systemic circulation
Rate of drug elimination
Binding of drug to protein
Which factor decreases bioavailability of oral drugs?
Hepatic first-pass metabolism
IV administration
High lipid solubility
Absence of metabolism
Which is an example of gut first-pass effect?
Gastric acid destruction of drug
Renal elimination
Hepatic metabolism
Biliary excretion
Factors that may alter bioavailability include…
Dosage form and drug formulation
Particle size and dissolution rate
Drug–drug interactions
All of the above
Weak acids are better absorbed in…
Alkaline medium
Acidic medium (stomach)
Neutral medium
Plasma only
Weak bases are better absorbed in…
Acidic medium
Alkaline medium (intestine)
Neutral medium
Plasma only
A drug with extensive first-pass metabolism will have…
High oral bioavailability
Low oral bioavailability
100% bioavailability
No systemic effect
ADME stands for…
Absorption, Distribution, Metabolism, Excretion
Administration, Dilution, Modification, Excretion
Accumulation, Diffusion, Monitoring, Elimination
Absorption, Dilution, Metabolism, Excretion
The ionized form of a drug is usually…
Lipid soluble
Polar and water soluble
Easily crosses membranes
Nonpolar
Drugs absorbed from GI tract first reach…
Systemic circulation
Portal circulation
Lymphatic circulation
Renal circulation
After absorption, drugs are distributed into…
Plasma, interstitial fluid, intracellular fluid
Plasma only
Bone only
Fat only
A drug confined only to blood compartment shows…
Single compartment distribution
Two compartment distribution
Multi-compartment distribution
Tissue reservoir distribution
Drugs of high molecular weight, such as heparin and dextran, are mainly…
Multi-compartment distributed
Single compartment (intravascular)
Tissue reservoir drugs
Two compartment distributed
Apparent volume of distribution (Vd) is defined as…
Real anatomical volume of blood
Hypothetical volume required to contain drug at plasma concentration
Total body water
Intracellular fluid only
Total drug amount in the body can be calculated as…
Dose ÷ Clearance
Vd × Plasma concentration
AUC ÷ Cmax
Bioavailability × Tmax
Vd is increased in all of the following EXCEPT…
Renal failure
Fluid retention
Liver failure
Dehydration
A patient with dehydration will show…
Increased Vd
Decreased Vd
No change in Vd
Infinite Vd
The major plasma protein binding drug is…
Globulin
Albumin
Fibrinogen
Transferrin
The free fraction of a drug is…
Pharmacologically active
Not filtered
Not metabolized
Inactive
Highly protein-bound drugs include all EXCEPT…
Phenylbutazone
Dicoumarol
Tolbutamide
Penicillin
Passage of drugs into CNS is limited by…
Placental barrier
Blood-brain barrier
Mucosal barrier
Lymphatic circulation
Only which type of drugs cross BBB easily?
Lipid soluble (non-ionized)
Water soluble
Large MW polar drugs
Protein-bound drugs
Placental barrier consists of…
Lipid cellular barrier (fetal villi epithelium + capillary endothelium)
Only maternal blood
Bone marrow cells
Amniotic fluid
The central nervous system (CNS) is composed of…
Brain and spinal cord
Brain only
Peripheral nerves
Autonomic ganglia
The peripheral nervous system (PNS) includes…
Only cranial nerves
Neurons outside brain and spinal cord
Brain and spinal cord
CNS glial cells
The PNS is divided into…
CNS and ANS
Somatic and autonomic nervous system
Sympathetic and parasympathetic
Sensory and motor
Somatic efferent neurons control…
Involuntary smooth muscle contraction
Voluntary skeletal muscle contraction
Endocrine secretion
Cardiac pacemaker
The autonomic nervous system (ANS) regulates…
Conscious skeletal muscle activity
Vital body functions without conscious effort
Higher cognitive functions
Vision and hearing
The ANS is divided into…
Sympathetic and somatic systems
Sympathetic, parasympathetic, enteric
Parasympathetic only
Motor and sensory
The sympathetic division is mainly active in…
Rest and digestion
Stressful situations (fight or flight)
Sleep regulation
Immune response
The parasympathetic division is mainly active in…
Exercise
Trauma
Rest-and-digest situations
Hypoglycemia
Which division is essential for life (digestion and elimination)?
Sympathetic
Parasympathetic
Somatic
Enteric only
Which ANS division usually balances sympathetic actions?
Somatic
Parasympathetic
Enteric
Central
