WorksheetsISD2-P4
Total questions: 68
Worksheet time: 34mins
Name
Class
Date
1.
Chronic inflammatory autoimmune disease which includes swelling in joints
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
2.
Inflammation of blood vessels
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
3.
It primarily affects the upper respiratory tract, lungs, and kidneys
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
4.
Laboratory diagnosis
✓ Nasal or oral inflammation with oral ulcers or purulent or bloody nasal discharge
✓ Abnormal chest X-ray, showing presence of nodules, fixed infiltrates, or cavities
✓ Urinary sediment with microhematuria or RBC cast
✓ Granulomatous inflammation or biopsy.
If you meet 2 out of 4 of this criteria, you can be diagnosed with this disease.
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
5.
Dry eyes, dry mouth
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
6.
▪ It is characterized by chronic inflammation of the exocrine glands, most notably the ocular and salivary glands
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
7.
It is characterized with a classic butterfly rash across the nose and cheeks
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
8.
Strongly associated with HLA-DR3
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
9.
Environmental factors though to play a role in SLE include UV light, certain medications (Procainamide, Hydralazine, Isoniazid), and possibly infectious agents
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
10.
It can be characterized as a chronic, symmetric, and erosive arthritis of the peripheral joints that can also affect multiple organs such as heart and lungs
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
11.
Women are 3x more likely to be affected as men
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
12.
Strongly associated with HLA-DR4, HLA-DRB
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
13.
Strongest environmental risk factor of this disease is believed to be cigarette smoking
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
14.
group of immunoglobulins that interacts specifically with the Fc portion of IgG molecules
a)
Rheumatoid factor
b)
Anti-cyclic citrullinated peptide
15.
more specific antibody marker for RA
a)
Rheumatoid factor
b)
Anti-cyclic citrullinated peptide
16.
Laboratory diagnosis
✓ Decreased complement proteins
✓ Presence of anti-nuclear antibodies
✓ LE Cells - a neutrophil that has engulfed the antibody-coated nucleus of another neutrophil
✓ Demonstration of anti-phospholipid antibodies
✓ Demonstration of anti-cardiolipin antibodies
a)
Systemic Lupus Erythematosus
b)
Rheumatoid Arthritis
c)
Granulomatosis with Polyangiitis
d)
Sjogren's syndrome
17.
Principle: Indirect immunofluorescence
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
18.
It is the most widely used and accepted test
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
19.
Standard substrate used: Human epithelial cell line (Hep-2)
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
20.
Microtiter plate well containing a suspension of polystyrene microspheres that are coated with individual nuclear antigens or with Hep-2 extract
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
21.
Antibodies in the patient serum will bind only to the beads containing their specified antigens
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
22.
Phycoerythrin-labeled anti-human IgG is added
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
23.
Bead suspension is analyzed for fluorescence by a flow cytometer that has two lasers, one that identifies each bead and another that detects the amount of fluorescent conjugate attached
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
24.
▪ Used to detect antibodies to dsDNA
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
25.
Trypanosome has a circular organelle called a kinetoplast that is composed mainly dsDNA
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
26.
Used to determine the immunologic specificity of a positive FANA test
a)
Fluorescent Antinuclear Antibody test
b)
Microsphere Multiplex Immunoassay
c)
Immunofluorescent using Crithidia lucilliae
d)
Ouchterlony test
27.
Uniform staining of the entire nucleus
a)
Homogenous
b)
Peripheral
c)
Speckled
d)
Nucleolar
e)
Centromere
28.
Diffuse staining is throughout the nucleus, but greater intensity around the outer circle surrounding the nucleus
a)
Homogenous
b)
Peripheral
c)
Speckled
d)
Nucleolar
e)
Centromere
29.
Discrete, fluorescent specks throughout the nucleus
a)
Homogenous
b)
Peripheral
c)
Speckled
d)
Nucleolar
e)
Centromere
30.
Prominent staining of nucleoli
a)
Homogenous
b)
Peripheral
c)
Speckled
d)
Nucleolar
e)
Centromere
31.
Numerous discrete speckles are seen
a)
Homogenous
b)
Peripheral
c)
Speckled
d)
Nucleolar
e)
Centromere
32.
Pattern most frequently identified in RA is often..
a)
Homogenous
b)
Peripheral
c)
Speckled
d)
Nucleolar
e)
Centromere
33.
Detection of Anti-cyclic citrullinated peptide in RA is mainly performed using..
a)
IF
b)
ELISA
c)
PCR
d)
Ouchterlony
34.
In SLE, what is the most frequently reported manifestation?
a)
joint manifestation
b)
skin manifestation
c)
nephritis
d)
renal failure and infection
e)
heart disease
35.
In SLE, what is the most common sign?
a)
joint manifestation
b)
skin manifestation
c)
nephritis
d)
renal failure and infection
e)
heart disease
36.
In SLE, what is the major cause of illness and death?
a)
joint manifestation
b)
skin manifestation
c)
nephritis
d)
renal failure and infection
e)
heart disease
37.
In SLE, what is the most common cause of death?
a)
joint manifestation
b)
skin manifestation
c)
nephritis
d)
renal failure and infection
e)
heart disease
38.
In SLE, the most common cause of death is often followed by?
a)
joint manifestation
b)
skin manifestation
c)
nephritis
d)
renal failure and infection
e)
heart disease
39.
Rare Systemic rheumatic disease (SARD) that is characterized by excessive fibrosis and vascular abnormalities that affect the skin and joints and progress over time to involve internal organs, most commonly the esophagus, lower gastrointestinal tract, lungs, hear, and kidneys
a)
Scleroderma
b)
Mixed Connective Tissue Disease
c)
Other inflammatory myopathies
40.
▪ Overlap syndrome of limited cutaneous scleroderma combined with clinical features of SLE, polymyositis, and RA
a)
Scleroderma
b)
Mixed Connective Tissue Disease
c)
Other inflammatory myopathies
41.
Group of diseases characterized by chronic inflammation of the skeletal muscles (myositis) and progressive muscle weakness
a)
Scleroderma
b)
Mixed Connective Tissue Disease
c)
Other inflammatory myopathies
42.
Anti-dsDNA
a)
Peripheral or homogenous
b)
Homogenous only
c)
Coarse speckled
d)
Finely speckled
43.
Antihistone
a)
Peripheral or homogenous
b)
Homogenous only
c)
Coarse speckled
d)
Finely speckled
44.
Anti-DNP
a)
Peripheral or homogenous
b)
Homogenous only
c)
Coarse speckled
d)
Finely speckled
45.
Anti-Sm
a)
Peripheral or homogenous
b)
Homogenous only
c)
Coarse speckled
d)
Finely speckled
46.
Anti-RNP
a)
Peripheral or homogenous
b)
Homogenous only
c)
Coarse speckled
d)
Finely speckled
47.
Anti-SS-A/Ro
a)
Peripheral or homogenous
b)
Homogenous only
c)
Coarse speckled
d)
Finely speckled
48.
Anti-SS-B/La
a)
Peripheral or homogenous
b)
Homogenous only
c)
Coarse speckled
d)
Finely speckled
49.
Antinucleolar
a)
Atypical speckled
b)
Fine cytoplasmic speckling
c)
Immunofluroescent pattern-Discrete speckled
d)
Prominent staining of nucleoli can be smooth, clumpy or speckled)
e)
Not detected on routine screen
50.
Anti-ssDNA
a)
Atypical speckled
b)
Fine cytoplasmic speckling
c)
Immunofluroescent pattern-Discrete speckled
d)
Prominent staining of nucleoli can be smooth, clumpy or speckled)
e)
Not detected on routine screen
51.
Anti-Jo-1
a)
Atypical speckled
b)
Fine cytoplasmic speckling
c)
Immunofluroescent pattern-Discrete speckled
d)
Prominent staining of nucleoli can be smooth, clumpy or speckled)
e)
Not detected on routine screen
52.
Anti-Sci-70
a)
Atypical speckled
b)
Fine cytoplasmic speckling
c)
Immunofluroescent pattern-Discrete speckled
d)
Prominent staining of nucleoli can be smooth, clumpy or speckled)
e)
Not detected on routine screen
53.
Autoantibody-Anti-Centromere
a)
Atypical speckled
b)
Fine cytoplasmic speckling
c)
Immunofluroescent pattern-Discrete speckled
d)
Prominent staining of nucleoli can be smooth, clumpy or speckled)
e)
Not detected on routine screen
54.
Disease association -CREST syndrome
a)
Antinucleolar
b)
Anti-Scl-70
c)
Anti-Jo-1
d)
Autoantibody-Anti-Centromere
55.
Disease association -polymyositis
a)
Antinucleolar
b)
Anti-Scl-70
c)
Anti-Jo-1
d)
Autoantibody-Anti-Centromere
56.
SCLERODERMA, systemic sclerosis
a)
Antinucleolar
b)
Anti-Scl-70
c)
Anti-Jo-1
d)
Autoantibody-Anti-Centromere
57.
most specific for SLE
a)
Anti-dsDNA
b)
Anti-ssDNA
c)
Antihistone
d)
Anti-DNP
e)
Anti-Sm
58.
Typically selected for SLE
a)
Anti-dsDNA
b)
Anti-ssDNA
c)
Antihistone
d)
Anti-DNP
e)
Anti-Sm
59.
specific for lupus
a)
Anti-dsDNA
b)
Anti-ssDNA
c)
Antihistone
d)
Anti-DNP
e)
Anti-Sm
60.
Sheep cell agglutination test (Rose Waaler test)
Latex fixation test (Singer and Plotz)
Sensitized alligator erythrocytes test (Cohen et al)
a)
Detection of Rheumatoid Arthritis
b)
Manual agglutination tests for RF uses charcoal or latex particles coated with IgG
61.
Bentonite flocculation test (Bloch and Bunim) Labeled immunoassays
a)
Detection of Rheumatoid Arthritis
b)
Manual agglutination tests for RF uses charcoal or latex particles coated with IgG
62.
Diffuse, granular staining in the cytoplasm of neutrophils, fading toward the outer edges of the cells
a)
c-ANCA
b)
p-ANCA
63.
Fluorescence surrounding lobes of the neutrophil nuclei, blending them together
a)
c-ANCA
b)
p-ANCA
64.
Autoantigens: Positively charged antigens including MPO
a)
c-ANCA
b)
p-ANCA
65.
Autoantigen: PR3 antigen
a)
c-ANCA
b)
p-ANCA
66.
Associated with Granulomatosis with polyangiitis
a)
c-ANCA
b)
p-ANCA
67.
Associated with Microscopic polyangiitis (MPA)
a)
c-ANCA
b)
p-ANCA
68.
Associated with Eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss syndrome)
a)
c-ANCA
b)
p-ANCA
100 %
