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PODA III EXAM 3- Fall 2025

Total questions: 39

Worksheet time: 22mins

Name
Class
Date
1.

WOTF is a DNA-containing Virus?

a)

EEE (Eastern Equine Encephalitis) Virus

b)

Rotavirus

c)

Rabies Virus

d)

Vaccinia

e)

Measles

2.

What causes the Multifocal Leukoencephalitis/Encephalopathy?

a)

Echovirus

b)

Variola virus

c)

John Cunningham Virus

d)

Machupo virus

e)

CMV (cytomegalovirus)

3.

WOTF is NOT a component of the QUAD pill (Stribild)?

a)

Elvitegravir

b)

Cobicistat

c)

A nucleotide

d)

Tenofovir Alafenamide

e)

Emtricitabine

4.

Ara-C (Cytarabine) is beneficial in the management of WOTF?

a)

Acute Granulocytic Leukemia

b)

Shingles

c)

Burkitts Lymphoma

d)

Acute and Chronic Myelogenous Leukemia (AML/CML)

e)

Chickenpox

5.

Amantadine (Gocovri) is beneficial in the treatment of WOTF?

a)

EPS (extrapyramidal syndrome)

b)

HIV/AIDS (no longer clinically relevant)

c)

Parkinsons Disease

d)

Dyskinesia

e)

Restless Leg Syndrome

6.

WOTF works by binding to GP 120, therefore preventing the connection of virus?

a)

Selzentry

b)

Ibalizumab

c)

Peramivir

d)

Pleconaril

e)

Temsavirbrand: (Fostemsavir)

7.

WOTF works by inhibiting DNA terminase?

a)

Denavir

b)

Entecavir

c)

Adefovir

d)

Eteplirsen

e)

Letermovir

8.

WOTF inhibits the DNA repair enzyme Enzyme apex nuclease 1?

a)

Brivudine - main indication: shingles

b)

Amantadine

c)

Zidovudine

d)

Trifluridine

9.

WOTF is a purine analog that is employed in the treatment of CMV-induced retinitis?

a)

Acyclovir

b)

Ganciclovir - IV, PO, eye insert, eye drops

c)

Vibrudine

d)

Sidofovir

e)

PFA (phophonoforfic acid)

10.

WOTF is LEAST LIKELY to be observed as an adverse effect of Tenofovir (Viread)?

a)

Fanconi syndrome

b)

Increase in bone density

c)

Renal insufficiency

d)

Non-specific GI adverse effects (N/V/D)

e)

Osteomalacia

11.

WOTF produces its pharmacological effect by inhibiting the protein kinase activity of CMV enzyme called pUL97?

a)
Valganciclovir
b)
Acyclovir
c)
Foscarnet
d)
Ganciclovir
e)

Maribavir- Livintencity

12.

WOTF is an antisense oligonucleotide that you can use to treat hepatitis B?

a)

Fomivirsen

b)

Bepiroversen

c)

Afovirsen

d)

Mipomersen

e)

Eteplirsen

13.

WOTF is not a common characteristic of the Protease Inhibitors that you use for aids

a)

Fecal excretion

b)

Hypoglycemia

c)

Inhibition of cleavage of the HIV encoded gag pol polyprotein

d)

Metabolism by CYP3A4

e)

Oral administration

14.

WOTF is an adverse effect of AZT? SATA

a)

Lypodystrophy

b)

Myositis

c)

Enlargement of the liver

d)

Lactic acidosis

e)

Muscle weakness/fatigue

15.

WOTF is an AE of Azidothymidine? SATA (all NRTI can cause this)

a)

hyperpigmentation of skin and nails

b)

hyperlipidemia and hyperglycemia

c)

granulocytopenia

d)

microcytic anemia

e)

wernicke's syndrome

16.

WOTF is an adverse effect of Atazanavir( Reyataz)?

a)

A decrease in bilirubin levels (NO B/C hyperbilirubinemia is an ADA)

b)

Kidney stones "nephrolithiasis"

c)

Gallstones "cholelithiasis"

d)

Yellowing of the sclera/ "scleral icterus"

e)

Prolongation of the PR interval

17.

What is the dosage of Acyclovir when it is being used to treat shingles?

a)

200 mg PO QD

b)

800 mg PO QD

c)

400 mg IV QD

d)

800 mg 5 times a day

18.

WOTF is true about Efavirenz?

a)

It has an autoinduction property

b)

It is administered QHS

c)

It has a half-life of 40-55 hrs

d)

It is a substrate for 3A4

e)

It can be administered IV

19.

WOTF would be an adverse effect of Efavirenz?

a)

Insomnia

b)

Somnolence

c)

Bad dreams

d)

GI adverse effects

e)

Fatigue

20.

WOTF is a vector of St. Louis Encephalitis Virus?

a)

Aedes Egipty

b)

Culex Tarsalis

c)

Culex Univittatus

d)

Culiseta Melanura

e)

Aedes Abopictus

21.

WOTF is an A/E of Foscarnet?

a)

Hallucination and Seizures

b)

Irritability and Parasthesia

c)

first degree of AV Block

d)

Circumoral paresthesis

e)

Numbness and Hallucination

22.

Raltegravir (Isentress) can produce all of the following as adverse effects

a)

Myopathy

b)

TEN- Toxic epidermal necrolysis

c)

SJS- steven johnson syndrome

d)

Decreased CPK

e)

Suicidal Ideation

23.

WOTF is MOST LIKELY to increase the hepatotoxicity of Raltegravir/ Isentress?

a)

Methotrexate/Trexall

b)

Tylenol

c)

Maraviroc/ Selzentry

d)

INH (Isoniazid)

e)

Nizoral (ketaconazole)

24.

WOTF is best classified as an NNRTI?

a)

Etravirine

b)

Nevirapine

c)

Lamivudine - NRTI

d)

Rilpivirine

e)

Tiplenavir

25.

WOTF is a component of Symtuza?

a)

Cobicistat

b)

Emtricitabine (M-10)

c)

Darunavir

d)

Tenofovir Alafenamide Fumarate

e)

Tenofovir Disoproxil

26.

WOTF will enhance/increase the hematologic toxicity of AZT when administered concurrently with AZT?

a)

Endomethacin

b)

Acetaminophen

c)

Acyclovir

d)

Probenecid

e)

Aspirin

27.

A patient who is receiving Mavyret for their treatment of Hepatitis C is actually receiving WOTF?

a)

Glecaprevir

b)

Tenofovir Disoproxil Fumarate

c)

Paritaprevir

d)

Sofosbuvir

e)

Pibrentasvir

28.

WOTF products contain Dolutegravir?

a)

Juluca

b)

Epzicom

c)

Cabenuva

d)

Dovato

e)

Triumeq

29.

WOTF is an inhibitor of NS5B polymerase inhibitor for Hep C virus? (Look for ~buvir)

a)

Ombitasvir

b)

Dasabuvir

c)

Voceprevir

d)

Voxilaprevir

e)

Sofosbuvir

30.

WOTF statement is true about lenacapravir/ (Sunlenca)?

a)

It is metabolized by 3A4 and UGT 1A1

b)

It is primarily excreted through the renal system

c)

It is administered orally and intravenously

d)

Has a high PPB capability

e)

It is administered concurrently with islatravir (for optimum effectiveness)

31.

WOTF is least likely to be classified as a pyrimidine nucleoSIDE antiviral agent?

a)

Ara- A

b)

Idoxuridine

c)

Trifluridine (Vipotic®)

d)

Fiac

e)

Ara-C (Arabinoside Cytosine)

32.

All of the following are inhibitors of HIV protease except one?

a)

Saquinavir

b)

Ritonavir

c)

Telaprevir

d)

Darunavir

e)

Atazanavir

33.

WOTF will exacerbate a skin reaction, like TENS, that is a manifestation of the AE of Raltegravir (Isentress ®)?

a)

Isoniazid (INH)

b)

Tylenol

c)

Atorvastatin

d)

Methotrexate (MTX)

e)

Darunavir

34.

To which of the following virus groups does the causative agents of Bolivian hemorrhagic fever belong?

a)

picornavirus

b)

rhabdovirus

c)

orthomyxovirus

d)

arenavirus

e)

papovavirus

35.

WOTF is used to treat Hepatitis C?

a)

Nusinersen

b)

Hepcinat

c)

ara-A

d)

Baraclude

e)

Hepsera

36.

WOTF is an appriopriate dose of Acyclovir for the treatment of 'chickenpox'?

a)

800 mg po qd

b)

400 mg po qd

c)

200 mg IV qd

d)

200 mg IV TID

e)

400 mg po QID

37.

WOTF statements about Atazanavir (Reyataz) is False?

a)

It inhibits CYP 3A4

b)

It undergoes renal excretion primarily

c)

It is a substrate for CYP 3A4

d)

it is administered orally with food

e)

it should not be administered concurrently with omeprazole

38.

WOTF is BEST classified as a Non-Nucleoside Reverse Transcriptase Inhibitor?

a)

Epivir

b)

Intelence

c)

Dolutegravir

d)

Pifeltro

e)

Aptivus

39.

Which of the following is BET classified as a Chemokine receptor inhibitor?

a)

a. Enfuvirtide

b)

b. Zanamivir

c)

c. Mogamulizumab (Poteligeo)

d)

d. Taribavirin

e)

e. Vidarabine